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| Number | Title | Issue Date |
| 8187605 | Means for the inhibition of anti-β1-adrenergic receptor antibodies Embodiments of the present invention provide for novel peptides of use for detection and/or inhibition of anti-β1-adrenergic receptor antibodies. Certain embodiments concern uses of cyclic and/or linear peptides. In other embodiments, the present invention relates ... | 05/29/2012 |
| 8173132 | Nucleic acid and corresponding protein entitled 213P1F11 useful in treatment and detection of cancer A novel gene (designated 213P1F11) and its encoded protein, and variants thereof, are described wherein 213P1F11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 213P1F11 provides... | 05/08/2012 |
| 8168191 | Cytotoxic T lymphocyte The present invention relates to a T lymphocyte having an activity to induce a T lymphocyte recognizing an antigen and a technique to use the T lymphocyte. ... | 05/01/2012 |
| 8168190 | HBV core antigen particles with multiple immunogenic components attached via peptide ligands This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core antigen particles comprising immunogens, epitopes, or other related struct... | 05/01/2012 |
| 8158603 | Fragments of secreted frizzled related protein The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt prot... | 04/17/2012 |
| 8153590 | Antidotes for factor Xa inhibitors and methods of using the same The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The deri... | 04/10/2012 |
| 8147838 | Peptide The present invention relates to peptide epitopes of 5T4 antigen and their use in immunotherapy. In particular, the present invention relates to any one of the peptide epitopes as described herein as well as their used in diagnosis and therapy of cancer. ... | 04/03/2012 |
| 8147837 | Use of mycobacterial mannosylated lipoglycans peptide mimotopes for treating inflammation The present invention is based on the discovery that biological peptide-based mimotopes of mannose-containing cell-wall compounds of Mycobacterium tuberculosis, specifically, ManLAM, have an anti-inflammatory effect and immunoregulator effect in animal models... | 04/03/2012 |
| 8142787 | Recombinant chimeric antigens for diagnosis and prevention of scrub typhus Recombinant chimeric antigens comprising unmodified and modified reactive polypeptide fragments of expressed product of the recombinant 56 kDa proteins of multiple strain of scrub typhus, such as Karp, Kato (Ktr56), Gilliam (Gmr56), and TA763 (TAr56). The invention ... | 03/27/2012 |
| 8142786 | Method for inducing cell lysis with immunogenic portions of NY-ESO-1 protein The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts. ... | 03/27/2012 |
| 8129344 | Method of reducing cell death by administering a Sfrp polypeptide A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic condtions. ... | 03/06/2012 |
| 8128935 | DNA sequence and recombinant production of the grass pollen allergen Phl p 4 The present invention relates to the provision of the genetic sequence of the major grass pollen allergen Phl p 4. The invention also covers fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecu... | 03/06/2012 |
| 8124097 | Hybrid and chimeric polypeptides that regulate activation of complement A hybrid complement-regulating protein comprises a first functional unit of a first complement regulatory protein having complement regulating properties, a first spacer sequence of at least about 200 amino acids encoding a polypeptide that does not exhibit compleme... | 02/28/2012 |
| 8119139 | Immunotherapy against several tumors including neuronal and brain tumors The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL)... | 02/21/2012 |
| 8114407 | EphA2 T-cell epitopes and uses therefor EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative derivatives thereof. The EphA2 T-cell epitopes are useful in an assay, such as... | 02/14/2012 |
| 8110546 | VEGF antagonist formulations Formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided including a pre-lyophilized formulation, a reconstituted lyophilized formulation, and a stable liquid formulation. Preferably, the fusion protein has the sequ... | 02/07/2012 |
| 8106015 | Method for enhancing immune response with peptide An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide ... | 01/31/2012 |
| 8105603 | Polypeptides that bind APRIL The present invention relates to polypeptides that inhibit APRIL and/or BAFF binding to BCMA, nucleic acid molecules encoding the polypeptides, and compositions comprising the polypeptides. The present invention also relates to methods for treating an immune-related... | 01/31/2012 |
| 8105605 | Allergen formulation Provided is a pharmaceutical composition comprising tyrosine, an optionally modified allergen, and 3-DMPL, which is useful in the prevention and treatment of allergies. ... | 01/31/2012 |
| 8105604 | WT1 modified peptide The present invention discloses a cancer antigen peptide comprising the following amino acid sequence: Cys Tyr Thr Trp Asn Gln Met Asn Leu (Sequence ID No. 3), a cancer vaccine having this for its active ingredient, and a DNA vaccine having for its active ingredient... | 01/31/2012 |
| 8105602 | Urokinase-type plasminogen activator receptor epitope, monoclonal antibodies derived therefrom and methods of use thereof The present invention relates to antibodies, and antigen-binding fragments thereof, specific for urokinase-type plasminogen activator receptor (uPAR) and uses thereof for the treatment or prevention of cancer. In particular, the antibodies of the invention are speci... | 01/31/2012 |
| 8101186 | Peptides that block the binding of IgG to FcRn The invention relates to peptides which bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used for example, in treating autoimmune diseases and inflammato... | 01/24/2012 |
| 8097257 | MAGE3 polypeptides The present invention relates to novel MAGE3 polypeptides, including a fragment of MAGE3 fused to an immunological fusion partner, and compositions thereof. ... | 01/17/2012 |
| 8092806 | Chimeric proteins, their preparation and pharmaceutical compositions containing them The present invention relates to a chimeric protein comprising a cell-targeting agent and a Yersinia outer protein, connected by a translocating polypeptide. The invention further relates to the preparation and use of such chimeric protein. ... | 01/10/2012 |
| 8092807 | Modified leukocyte Ig-like receptor family members (LIRs) with increased affinity for class 1 MHC and their uses in modulating T-cell activation The present invention provides polypeptides having the property of binding to a given Class I pMHC CHARACTERISED IN THAT said polypeptide has a KD for the said given Class I pMHC of less than or equal to 1 μM and/or has an off-rate (koff) for ... | 01/10/2012 |
| 8088390 | Methods for the early diagnosis of ovarian cancer The present invention discloses the protease stratum corneum chymotryptic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these pept... | 01/03/2012 |
| 8088389 | Synthetic human genes and polypeptides and their use in the treatment of autoimmune diseases Synthetic human target autoantigen genes comprising sequences coding for at least two immunogenic epitopic clusters (hereinafter IEC) of autoantigen(s) related to a specific autoimmune disease, wherein said at least two IECs may be derived from a sole autoantigen or... | 01/03/2012 |
| 8088388 | Stabilized synthetic immunogen delivery system The present invention provides an immunostimulatory complex specifically adapted to act as adjuvant and as a peptide immunogen stabilizer. The immunostimulatory complex comprises a CpG oligonucleotide and a biologically active peptide immunogen. The immunostimulator... | 01/03/2012 |
| 8084035 | CD38 modulated chemotaxis The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with p... | 12/27/2011 |
| 8080251 | Antigenic peptides The present invention relates to peptide antigens of SEQ ID Nos. 1 to 10; repeat motif Gly-X-Gly-Asn-X-Gly of SEQ ID No. 11; and a method of developing drug against tuberculosis, said method comprising steps of targeting the proposed drug towards peptide antigens of... | 12/20/2011 |
| 8080252 | Compounds and methods of modulating angiogenesis A method of modulating angiogenesis in a tissue comprises administering to the tissue a therapeutically effective amount of an agent that modulates complex formation of αvβ3 integrin and VEGFR2. ... | 12/20/2011 |
| 8075898 | Mite allergen A safe and efficient recombinant mite allergen is provided as a therapeutic agent or a diagnostic agent for mite allergic diseases, which contains no anaphylaxis-inducing impurities. The following recombinant protein (a) or (b) is provided: (a) a protei... | 12/13/2011 |
| 8075900 | Melanoma associated peptide analogues and vaccines against melanoma The present invention is concerned with cancer treatment and diagnosis, especially with melanoma associated peptide analogues with improved immunogenicity, epitopes thereof; vaccines against melanoma, tumor infiltrating T lymphocytes recognizing the antigen and diag... | 12/13/2011 |
| 8075899 | Peptides of the A-chain of proinsulin or insulin The present invention relates generally to the field of immunotherapy and immunodiagnosis of autoimmune conditions. More particularly, the present invention provides peptides of the A-chain of proinsulin or insulin, which are recognized by or are specific for proins... | 12/13/2011 |
| 8075897 | Allergen peptide fragments and use thereof The present invention relates generally to in vivo methods and compositions designed for allergen specific immunotherapy. The compositions include contiguous overlapping peptide fragments which together form an entire amino acid sequence of an allergen. ... | 12/13/2011 |
| 8067009 | Metalloproteinase oligopeptides and their therapeutic use The invention discloses identification and therapeutic use of matrix metalloproteinase oligopeptides and peptidomimetics. The oligopeptides are used for making antibodies. The antibodies are used for diagnostic and treatment purposes of various diseases. In particul... | 11/29/2011 |
| 8067008 | Peptide inhibitors for mediating stress responses The present invention relates to peptides capable of inhibiting cellular and immune stress responses in a eukaryotic cell. The invention provides compositions and methods for the treatment of human degenerative diseases and inflammation, utilizing these peptides. | 11/29/2011 |
| 8057800 | Immunointeractive molecules and uses thereof The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with T lymphocytes in subjects having peanut allergy, or allergy to other tree nuts, and genetic sequences encoding same. These molecules ... | 11/15/2011 |
| 8057801 | Tick galectin A novel galectin, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the galectin, and a screening method for screening a substance capable of modifying the galectin, are disclosed. According to the gal... | 11/15/2011 |
| 8048424 | Insect poison allergens with reduced IgE reactivity and method for producing the same The invention relates to recombinant insect poison allergens and to a specific method for producing them. Said allergens can be varied according to whether they are produced using folds (conformations) that are identical or different to those that occur naturally. T... | 11/01/2011 |
