Famous Patents
3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 7846445 | Methods for production of unstructured recombinant polymers and uses thereof The present invention provides methods of using unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages ... | 12/07/2010 |
| 7435790 | Dihydroxypropyl cysteine peptide and agent containing this peptide The invention relates to a S-(2,3-dihydroxypropyl)-cysteine peptide which has two long-chain fatty acids bonded in the form of esters at the dihydroxypropyl group, and which has the following sequence: DhcGN NDE SNI SFK EK. The invention relat... | 10/14/2008 |
| 7413739 | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments. ... | 08/19/2008 |
| 7387772 | Chimeric, human and humanized anti-CSAP monoclonal antibodies The present invention provides humanized, chimeric and human anti-CSAp antibodies and anti-CSAp antibody fusion proteins that are useful for the treatment and diagnosis of various cancers, including colon cancer. ... | 06/17/2008 |
| 7344703 | Mycobacterial sulfation pathway proteins and methods of use thereof Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, di... | 03/18/2008 |
| 7320791 | Monoclonal antibody for analysis and clearance of polyethylene glycol and polyethylene glycol-modified molecules A novel anti-polyethylene glycol monoclonal antibody and its preparation are disclosed. Such an antibody can be used for determining polyethylene glycol concentration in vitro or accelerating the clearance of a polyethylene glycol containing compound from the blood ... | 01/22/2008 |
| 7314632 | exotoxin A-like chimeric immunogens This invention provides Pseudomonas exotoxin A-like chimeric immunogens that include a non-native epitope in the Ib domain of Pseudomonas exotoxin. Methods of eliciting an immune response using these immunogens also are provided. ... | 01/01/2008 |
| 7291673 | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments. ... | 11/06/2007 |
| 7070778 | Therapeutical combination against cancer The present invention relates to compositions and methods for treating humans and warm-blood animals suffering from cancer. More particularly, a therapeutical treatment in which a monoclonal antibody is administered with either β-(1,3)-glucan like laminarin or a ol... | 07/04/2006 |
| 6977075 | Photosensitizer conjugates for targeting intracellular pathogens The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is assoc... | 12/20/2005 |
| 6974580 | Mycobacterial sulfation pathway proteins and methods of use thereof Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, di... | 12/13/2005 |
| 6806253 | Immunodulatory complex and use thereof in helicobacter diseases A therapeutical vaccine complex having activity specific for Helicobacter bacteria as well as non-specific immunomodulation activity for regulating the natural defenses of the body. The drug is also useful for preventing relapses, particularly in cases of res... | 10/19/2004 |
| 6756037 | Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups The present invention is directed to polymer conjugates of biologically active agents and methods of preparing the same. In preferred aspects of the invention, the conjugates are of the formula wherein G is a linear or b... | 06/29/2004 |
| 6737057 | Compounds, compositions and methods for the endocytic presentation of immunosuppressive factors Immunomodulating agents comprising at least one Fc receptor ligand and at least one immunosuppressive factor are provided as are methods for their manufacture and use. The immunomodulating agents may be in the form of polypeptides or chimeric antibodies and preferab... | 05/18/2004 |
| 6660267 | Prevention and treatment of sepsis Compositions and methods are described for preventing and treating sepsis in humans and animals. Surgical patients, low birth weight infants, and burn and trauma victims can be treated prophylactically. Methods for treating acute infections are provided w... | 12/09/2003 |
| 6610298 | Photosensitzer conjugates for targeting intracellular pathogens The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder th... | 08/26/2003 |
| 6573242 | Dihydroxypropyl cysteine peptide and agent containing this peptide The invention relates to a S-(2,3-dihydroxypropyl)-cysteine peptide which has two long-chain fatty acids bonded in the form of esters at the dihydroxypropyl group, and which has the following sequence: Dhc GN NDE SNI SFK EK (SEQ ID No 1) ... | 06/03/2003 |
| 6562801 | PpGpp and pppGpp as immunomodulatory agents The present invention relates generally to the fields of immunopreventive therapy and vaccine development. More particularly, it concerns compositions and methods of use of the bacterial nucleotides ppGpp and pppGpp and their analogs as adjuvants that can... | 05/13/2003 |
| 6524823 | Vasopermeability-enhancing conjugates Liposomal conjugates having a clinically useful delivery vehicle linked to a biologically active species which acts to increase vascular permeability and expand blood volume at or in proximity to the tumor site are disclosed. The vehicle-linked species ma... | 02/25/2003 |
| 6440408 | Method of treatment A method of producing active immunity against a bacterial or protozoal disease in a subject comprises administering to the subject a vaccine conjugate comprising a live bacteria or protozoa and a neutralizing factor bound to the live bacteria or protozoa.... | 08/27/2002 |
| 6218371 | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines The present invention relates to synergistic combinations of immunostimulatory CpG oligonucleotides and immunopotentiating cytokines. In particular, the invention relates to methods of stimulating an immune response using the synergistic combination of co... | 04/17/2001 |
| 6099846 | Enhancement of B cell lymphoma and tumor resistance using idiotype/cytokine conjugates B cell lymphoma tumor-associated antigen or a fragment thereof containing an epitope are linked to an immune-enhancing cytokine, such as GM-CSF, IL-2, or IL-4 to form an immuno-complex. This immuno-complex elicits immune responses which are protective wit... | 08/08/2000 |
| 6093399 | Methods and compositions for the specific coagulation of vasculature Disclosed are various compositions and methods for use in achieving specific blood coagulation. This is exemplified by the specific in vivo coagulation of tumor vasculature, causing tumor regression, through the site-specific delivery of a coagulant using... | 07/25/2000 |
| 6051230 | Compositions for targeting the vasculature of solid tumors The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are target... | 04/18/2000 |
| 6027726 | Glycosylated protein-liposome conjugates and methods for their preparation The present invention provides glycosylated protein-liposome compositions which are useful for the targeted delivery of a therapeutic agent. The compositions contain an oxidized protein, typically an antibody, which is covalently attached to a lipid by me... | 02/22/2000 |
| 6019983 | Carrier system against GnRH The present invention is concerned with vaccination of mammals against GnRH. The vaccine comprises a GnRH peptide conjugate to E. coli fimbrial-filaments and elicits an immune response against GnRH.... | 02/01/2000 |
| 6007817 | Vasopermeability enhancing immunoconjugates Conjugates having a clinically useful delivery vehicle linked to a biologically active species which acts to increase vascular permeability and expand blood volume at or in proximity to the tumor site are disclosed. The vehicle-linked species may be, for ... | 12/28/1999 |
| 6004555 | Methods for the specific coagulation of vasculature Disclosed are various compositions and methods for use in achieving specific blood coagulation. This is exemplified by the specific in vivo coagulation of tumor vasculature, causing tumor regression, through the site-specific delivery of a coagulant using... | 12/21/1999 |
| 5942230 | Composition of immunotoxins and retinoids and use thereof The present invention relates to compositions of retinoids plus immunotoxins. More particularly this invention relates to the use of retinoids to potentiate the activity of immunotoxins for treatment of mammalian diseases.... | 08/24/1999 |
| 5925353 | Targeted radioimmunotherapy A stent for the inhibition of restentosis. The stent is coated with an antigen which can be bound by a labelled antibody. The antibody is preferably labelled with a radioactive source. After the stent has been placed in the blood vessel of the subject, th... | 07/20/1999 |
| 5874083 | Immunopotentiating complexes comprising TraT proteins Class of carrier molecules which when covalently linked to an immunogen enhances the host's immune response to that immunogen regardless of whether the complex of carrier and immunogen is administered parenterally, enterally, or orally to the host. In add... | 02/23/1999 |
| 5833985 | Bispecific molecules for use in inducing antibody dependent effector cell-mediated cytotoxicity Bispecific molecules comprising a non-immunoglobulin tumor cell specific ligand and an antibody which binds the Fc receptor of an effector cell at a site that is not inhibited by endogenous immunoglobulin are disclosed. The bispecific molecules can be use... | 11/10/1998 |
| 5714148 | Chemical compounds Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.... | 02/03/1998 |
| 5684145 | Carrier system against GNRH The present invention is concerned with vaccination of mammals against GnRH. The vaccine comprises a GnRH peptide conjugate to E. coli fimbrial-filaments and elicits an immune response against GnRH.... | 11/04/1997 |
| 5632990 | Treatment for tumors comprising conjugated antibody A5B7 and a prodrug A treatment for tumors to which antibody A5B7 binds is disclosed. A5B7 is a monoclonal antibody which binds to carcinoembryonic antigen. The treatment comprises administering to a host in need of such treatment an effective amount of a system which compri... | 05/27/1997 |
| 5620689 | Liposomes for treatment of B-cell and T-cell disorders A method of treating a subject having a disorder characterized by a neoplasm of B-lymphocyte or T-lymphocyte lineage cells is described. The method includes administering a suspension of liposomes having a surface coating of polyethylene glycol chains. At... | 04/15/1997 |
| 5443953 | Preparation and use of immunoconjugates The present invention relates to immunoconjugates comprising an antibody fragment which is covalently bound to a diagnostic or therapeutic principle through a carbohydrate moiety in the light chain variable region of the antibody fragment. The invention a... | 08/22/1995 |
| 5362491 | Modified biologically active protein composition A composition which comprises a modified biologically active protein consisting essentially of a biologically active protein bonded to lecithin via a covalent linkage and a protein inhibitor which does not inhibit the modified biologically active protein.... | 11/08/1994 |
| 5338542 | Disulfide linked immunotoxins with molecular groupings in the linker which cause steric hindrance to the disulfide linkage The efficacy of immunotoxins having an antibody that recognises a tumour associated antigen linked to a cytotoxin through a heterobifunctional agent of the disulphide type is improved by providing in the heterobifunctional agent a molecular grouping creat... | 08/16/1994 |
| 5185433 | Cross-linking protein compositions having two or more identical binding sites The present invention provides cross-linked protein compositions consisting of two or more units of a target-specific protein joined by binding sulfhydryl groups on the target-specific protein units to a sulfhydryl-selective cross-linking agent and a meth... | 02/09/1993 |
