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| Number | Title | Issue Date |
| 8084032 | Purification method which prevents denaturation of an antibody The present invention provides a method of purifying an antibody by protein A affinity chromatography. More specifically, the present invention provides a technique relating to an elution buffer solution which provides a good antibody recovery rate without denaturat... | 12/27/2011 |
| 7655233 | Optimal placement of a robust solvent/detergent process post viral ultrafiltration of an immune gamma globulin The solvent-detergent (S/D) process is used to inactivate enveloped viruses in plasma products. While concentrations of 1.0% detergent and 0.3% tri-n-butyl phosphate solvent have been considered necessary for robust removal of viral activity, we show the effectivene... | 02/02/2010 |
| 7452539 | Stabilizing polypeptides which have been exposed to urea Methods for stabilizing polypeptides, such as anti-HER2 antibodies, which have been exposed to urea. ... | 11/18/2008 |
| 7368542 | Method of altering the binding specificity of plasma proteins by oxidation-reduction reactions The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can... | 05/06/2008 |
| 7339037 | Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins The invention provides a method of inhibiting prophylactically or therapeutically an influenza viral infection in a host. The method comprises instilling into or onto a host a cell producing an antiviral protein, antiviral peptide, or antiviral conjugate comprising ... | 03/04/2008 |
| 7271251 | adhesin binding group antigen A novel Helicobacter pylori blood group antigen binding (BAB) adhesin protein was isolated and purified, whereby said protein or fractions thereof bind specifically to fucosylated blood group antigens. The protein sequence of said adhesin is disclosed in this... | 09/18/2007 |
| 7252799 | Methods for sterilizing preparations containing albumin Methods are disclosed for sterilizing preparations containing albumin to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, na... | 08/07/2007 |
| 7241592 | Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermi... | 07/10/2007 |
| 7186410 | Method for preparing human immunoglobulin concentrates for therapeutic use The invention concerns a method for preparing human immunoglobulin concentrates for therapeutic use, from plasma or a plasma fraction. The method comprises pre-purification and a single anion-exchange chromatography carried out at alkaline pH, thereby enabling the i... | 03/06/2007 |
| 7138120 | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products The present invention relates to a process for purifying immunoglobulin G from a crude immunoglobulin-containing plasma protein fraction. Said process includes a number of steps of which the anion exchange chromatography and the cation exchange chromatography are pr... | 11/21/2006 |
| 7125552 | Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates The method for immune serum globulin purification relates to the purification of immune globulins from blood plasma with a high degree of efficiency and a high rate of recovery. The immune globulin source is Cohn's fraction I+II+III or II+III prepared from plasma or... | 10/24/2006 |
| 7122641 | Methods for purifying protein A method is provided for separating a protein from one or more other proteins using hydroxyapatite chromatography in which the protein does not bind to hydroxyapatite but the other protein(s) does. In some embodiments, a second protein affixed to a solid support has... | 10/17/2006 |
| 7060268 | Protein formulation A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibod... | 06/13/2006 |
| 7041798 | Method for the chromatographic fractionation of plasma or serum, preparations, so obtained, and their use The invention relates to the fractionation of plasma or serum into at least one albumin fraction and one immunoglobulin fraction by hydrophobic interaction chromatography. The fractionation is carried out using an incremental salt gradient, especially an ammonium su... | 05/09/2006 |
| 7011825 | Erythropoietin solution preparation This invention provides an erythropoietin solution preparation containing an amino acid as a stabilizer, and having excellent long-term storage stability. ... | 03/14/2006 |
| 6893639 | Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates The method for immune serum globulin purification relates to the purification of immune globulins from blood plasma with a high degree of efficiency and a high rate of recovery. The immune globulin source is Cohn's fraction I+II+III or II+III prepared from plasma or... | 05/17/2005 |
| 6875432 | Reduced-viscosity concentrated protein formulations The present application concerns concentrated protein formulations with reduced viscosity, which are particularly suitable for subcutaneous administration. The application further concerns a method for reducing the viscosity of concentrated protein formulations.... | 04/05/2005 |
| 6875848 | Process for the production of virus-inactivated human gammaglobulin G The gammaglobulin is extracted from a fraction isolated by fractionation with ethanol in the presence of a carbohydrate, and after reducing the content of contaminants with PEG, it is applied to an anionic resin exchange column, an effluent being obtained in which t... | 04/05/2005 |
| 6870012 | Chain-extended peo/ppo/peo block copolymer, optionally with polyester blocks, combined with cellular or bioactive material A composition exhibiting reverse thermal gellation properties comprises a block polymer having the structure: {[An(BCB)An]}m wherein A is a polyester unit, B is a poly(ethylene oxide) unit, C is a poly(propylene o... | 03/22/2005 |
| 6773600 | Use of a clathrate modifier, to promote passage of proteins during nanofiltration The invention relates to the field of protein purification and the recovery of large proteinaceous material through small, nanometer sized, pore exclusion filters for removal of contaminants such as viral pathogens. ... | 08/10/2004 |
| 6696060 | Methods for sterilizing preparations of monoclonal immunoglobulins Methods are disclosed for sterilizing preparation of monoclonal immunoglobulins to reduce the level of active biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas, prions and parasites.... | 02/24/2004 |
| 6686191 | Preparation of virally inactivated intravenously injectable immune serum globulin Method of reducing the anticomplement activity (ACA) resulting from viral inactivation treatment of a solution of antibodies, the method comprising contacting the solution with a trialkylphosphate, such as tri-n-butyl phosphate, and a detergent, such as s... | 02/03/2004 |
| 6669940 | Recombinant fusobacterium necrophorum leukotoxin vaccine and preparation thereof The F. necrophorum gene expressing leukotoxin was sequenced and cloned. The leukotoxin open reading frame (lktA) is part of a multi-gene operon containing 9,726 bp, and encoding a protein containing 3,241 amino acids with an overall molecular weight of 33... | 12/30/2003 |
| 6646108 | Process for isolating IgG and IgA A method for the separation of IgG and IgA from an immunoglobulin-containing starting material is described, whereby the method is characterized in that (i) IgG and optionally IgA are adsorbed to a solid inorganic carrier material, (ii) IgA is isolated fr... | 11/11/2003 |
| 6544502 | Skin treatment with a water soluble antibiotic dissolved in an electrolyzed water A method for treating a skin condition by intimately combining a water soluble antibiotic with the keratin layer of the outermost layer of the cleansed epidermis. The antibiotic is dissolved in the alkaline fraction of an electrolyzed water. The solution ... | 04/08/2003 |
| 6524823 | Vasopermeability-enhancing conjugates Liposomal conjugates having a clinically useful delivery vehicle linked to a biologically active species which acts to increase vascular permeability and expand blood volume at or in proximity to the tumor site are disclosed. The vehicle-linked species ma... | 02/25/2003 |
| 6485725 | Room temperature storable immunoglobulin preparation for intravenous injection A method for producing an immunoglobulin preparation for intravenous injection, which comprises the steps of: fractionating an immunoglobulin-containing solution with 4 to 10 w/v% of polyethylene glycol having a molecular weight of from 1,000 to 10,000, a... | 11/26/2002 |
| 6372216 | Method of producing specific immunoglobin to block HCV infection A drug which protects individuals against hepatitis C virus (HCV) is made of HCV hyperimmune globulins, which guarantee a substantial hyperimmunity against HCV thanks to a substantial hyperconcentration of virus C neutralizing antibodies. This hyperconcen... | 04/16/2002 |
| 6338849 | Process of preparing immunoglobulin for intravenous injection by viruses double-sterilized without adding any protectant A process of preparing a double-sterilized immunoglobulin product for intravenous injection includes dissolving Cohn's component II in distilled ice water, and adjusting to the desired pH using acetic acid. A filter is used to remove alcohol and salt and ... | 01/15/2002 |
| 6281336 | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products The present invention relates to a process for purifying immunoglobulin G from a crude immunoglobulin-containing plasma protein fraction. Said process includes a number of steps of which the anion exchange chromatography and the cation exchange chromatogr... | 08/28/2001 |
| 6159471 | Room temperature storable immunoglobulin preparation for intravenous injection A method for producing an immunoglobulin preparation for intravenous injection, which comprises the steps of: fractionating an immunoglobulin-containing solution with 4 to 10 w/v % of polyethylene glycol having a molecular weight of from 1,000 to 10,000, ... | 12/12/2000 |
| 6096872 | Viral clearance process Methods for producing immunoglobulins and in particular anti-D immunoglobulin substantially free of virus and product resulting therefrom. Specifically provided are methods for nanofiltration of the anti-D immunoglobulin in high ionic strength buffer and ... | 08/01/2000 |
| 6090380 | Treatment of rheumatoid arthritis by oral administration of pooled human immunoglobulin Pooled human immunoglobulin may be administered orally to rheumatoid arthritis patients to treat the rheumatoid arthritic condition of those patients. Oral administration of pooled human immunoglobulin can result in significant clinical improvement in the... | 07/18/2000 |
| 6007979 | Method for reduction of the infectiousness of potentially infectious material A method for reduction of the viral infectiousness of potentially infectious material, such as human or animal body fluids or fractions derived therefrom from which biologically active substances can be isolated, wherein the infectiousness is due to non-l... | 12/28/1999 |
| 5770199 | Method for virus inactivation in the presence of polyalkylene glycol as well as the pharmaceutical preparation obtained therewith The invention relates to a pharmaceutical preparation comprising a plasma protein wherein said preparation is free of infectious agents as well as essentially free of denaturation products and is obtainable by a method that encompasses the following steps... | 06/23/1998 |
| 5700465 | Bovine serum and bovine IgG as preventives and therapeutives for bovine mastitis Immunoglobulin G-2 (IgG2), e g. bovine IgG2, and its reaction with neutrophils can be used to enhance the neutrophil's functional status in host animal defense against bacterial infections.... | 12/23/1997 |
| 5492694 | Fusobacterium leukotoxoid vaccine A method is provided for the enhanced elaboration of leukotoxin from F. necrophorum, and subsequent production of an inactivated leukotoxoid ruminant animal vaccine against F. necrophorum infection and consequent liver abscesses and/or foot rot in such an... | 02/20/1996 |
| 5455034 | Fusobacterium necrophorum leukotoxoid vaccine A method is provided for the enhanced elaboration of leukotoxin from F. necrophorum, and subsequent production of an inactivated leukotoxoid ruminant animal vaccine against F. necrophorum infection and consequent liver abscesses and/or foot rot in such an... | 10/03/1995 |
| 5419906 | Preparation of human immunoglobulin free of hepatitis C The effects of Cohn-Oncley cold alcohol fractionation on infectivity of two prototype retroviruses, mouse xenotropic type C and the LAV strain of AIDS retrovirus result in a significant reduction in retrovirus titer. At least a 100,000-fold reduction of L... | 05/30/1995 |
| 5258177 | IgA preparation and process of making the same A method of preparing an IgA rich preparation comprising exposing a plasma fraction to an amino acid, organic salt or inorganic salt with optional chromatographic treatment yielding a product suitable for use in medical conditions treatable with IgA.... | 11/02/1993 |
