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| Number | Title | Issue Date |
| 8153134 | Anti-MDL-1 antibodies Antibodies to human MDL-1 are provided, as well as uses thereof, e.g., in treatment of immune disorders, in particular, infectious diseases and sepsis. ... | 04/10/2012 |
| 7931902 | Gene disruptions, compositions and methods relating thereto The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO3600... | 04/26/2011 |
| 7897150 | Canine lymphoma cell line and uses thereof An isolated canine peripheral T-cell lymphoma cell line, where the cell line is a canine-lymphoma cell line and uses thereof are disclosed. An isolated canine peripheral T-cell lymphoma cell line where the cell line is the canine-lymphoma cell line designated OSW (A... | 03/01/2011 |
| 7892553 | Materials and methods to reduce low density lipoprotein cholesterol The present invention pertains to nanoparticles, comprising a metal and/or polymer core, with 7-alpha hydroxylase, or an enzymatically active fragment thereof, nicotinamide adenine dinucleotide (NADH) and antibodies, or antibody fragments, specific for low density l... | 02/22/2011 |
| 7736650 | Anti-IL-12 antibody based vectors, host cells, and methods of production and uses Antibody expression vectors and plasmids can incorporate various antibody gene portions for transcription of the antibody DNA and expression of the antibody in an appropriate host cell. The expression vectors and plasmids have restriction enzyme sites that facilitat... | 06/15/2010 |
| 7429381 | Production and use of novel peptide-based agents for use with bi-specific antibodies The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a linker moiety. The linker moiety encompasses a hapten to which antib... | 09/30/2008 |
| 7390490 | Uses of anti-CX3CR1 antibody, anti-fractalkine antibody and fractalkine There are provided uses of an antibody directed to CX3CR1 and fractalkine. Killer lymphocytes can be readily identified, eliminated and separated by using an anti-CX3CR1 antibody. Further, there can be provided an antibody drug for suppressing chemotaxis and cytotox... | 06/24/2008 |
| 7390888 | Dendritic cell potentiation A molecule capable of potentiating immune responses is described, as well as methods for using the molecule to enhance immune responses and enhance dendritic cell function. Also described are compositions containing the molecule and methods for using the composition... | 06/24/2008 |
| 7381407 | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In p... | 06/03/2008 |
| 7381802 | Human antibodies that specifically recognize the toxin Cn2 from scorpion venom The present invention is directed to recombinant human antibodies specific for Cn2 toxin from C. noxius scorpion venom. The antibodies are able to recognize the toxin and preferably neutralize it as well as the whole venom of C. noxius scorpion. This i... | 06/03/2008 |
| 7378094 | Therapeutic uses of complement receptor 2 The present invention is directed to an immune complex composition, and a method of using that complex to enhance an in viva immune response against a preselected target antigen. The immune complexes of the present invention comprise a monoclonal antibody specific f... | 05/27/2008 |
| 7361345 | Anti-CD40 antibodies capable of blocking B-cell activation Methods for preventing or treating an antibody-mediated disease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the... | 04/22/2008 |
| 7361336 | Methods of cancer therapy targeted against a cancer stem line Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer t... | 04/22/2008 |
| 7354586 | Methods of treating arthritis and diabetic retinopathy with αβ-specific antibodies The present invention describes methods for inhibition angiogenesis in tissues using vitronectin αvβ3 antagonists, and particularly for inhibiting angiogenesis in inflamed tissues and in tumor tissues and metastases using therapeutic composit... | 04/08/2008 |
| 7329406 | Methods of treating psoriasis with αβ-specific antibodies The present invention describes methods for inhibition angiogenesis in tissues using vitronectin αvβ3 antagonists, and particularly for inhibiting angiogenesis in inflamed tissues and in tumor tissues and metastases using therapeutic composit... | 02/12/2008 |
| 7323171 | Methods of treating skin conditions using inhibitors of the CD2/LFA-3 interaction Methods of using inhibitors of the CD2/LFA-3 interaction in treating skin conditions characterized by increased T cell activation and abnormal antigen presentation in the dermis and epidermis in mammals, including humans. Such conditions include psoriasis, UV damage... | 01/29/2008 |
| 7291333 | Blockade of protein C activation reduces microvascular surgical blood loss A method of inhibiting microvascular bleeding is provided. Antibody to protein C administered to a patient in a pharmaceutically acceptable carrier prevents anticoagulation by greater than 90% of activated protein C in human plasma. ... | 11/06/2007 |
| 7291330 | MD-1 inhibitors as immune suppressants Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of an agent that inhibits MD-1 with or without an OX-2 protein or a nucleic acid encoding an OX-2 protein. The methods are useful in prevent... | 11/06/2007 |
| 7279158 | Methods for the treatment of inflammatory joint disease The use of compounds that block complement component C5 or its active fragments C5a and/or C5b (such compounds collectively referred to as “C5 blockers”) to treat established joint inflammation (arthritis) is disclosed. Administration of such C5 bl... | 10/09/2007 |
| 7276237 | Human Mob-5 (IL-24) receptors and uses thereof The present invention provides the receptors for Mob-5 (IL-24). One of the Mob-5 receptors comprises IL-22R1 and IL-20R2. Another Mob-5 receptor comprises IL-20R1 and IL-22R2. The invention also provides methods of inhibiting the Mob-5 receptor as well as methods of... | 10/02/2007 |
| 7267819 | Composition comprising and method of using angiopoietin-like protein 3 Angptl3 The present invention is directed to methods and means for making and using Angptl3 polypeptides. The invention specifically concerns the use of Angptl3 polypeptides in inducing liver regeneration and angiogenesis. Further methods include the use of Angptl3 polypept... | 09/11/2007 |
| 7259247 | Anti-human T-cell costimulating polypeptide monoclonal antibodies A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the monoclonal antibodies, the use as medicaments of substances which inhibit the ... | 08/21/2007 |
| 7250163 | Mammalian galanin receptors The present invention provides isolated mammalian GalR3 receptors, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the receptors using the host cells. This i... | 07/31/2007 |
| 7223842 | Detection of proteins whose absence is associated with a neoplasm This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in human patients, and methods of treating these patients. ... | 05/29/2007 |
| 7214787 | Recombinant vaccine against botulinum neurotoxin This invention is directed to preparation and expression of synthetic genes encoding polypeptides containing protective epitopes of botulinum neurotoxin (BoNT). The invention is also directed to production of immunogenic peptides encoded by the synthetic genes, as w... | 05/08/2007 |
| 7208150 | Analgesic from snake venom A substantially non-toxic fraction isolated from snake venom is disclosed, which fraction has an analgesic effect. The fraction has the characteristics of a fraction from snake venom purified on a Mono Q ion exchange column. Also described are a pharmaceutical compo... | 04/24/2007 |
| 7138502 | Antibodies to the propeptide of and methods of use Antibodies and agents which can bind to the propeptide of the Int1p protein of yeast microorganisms such as Candida albicans are provided which can be useful in methods for treating or preventing infections arising from such microorganisms. Microorganisms exp... | 11/21/2006 |
| 7135182 | Inhibition of transglutaminase-mediated microbial interaction with a mammalian host The infection of a mammalian host by a microorganism can be prevented or treated through the administration of substrates for transglutaminases or antibodies against such substrates that inhibit the transglutaminase-mediated interaction of the microorganism with the... | 11/14/2006 |
| 7132099 | Methods of modulating T lymphocyte costimulation with an antibody to an 8F4 polypeptide A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the monoclonal antibodies, the use as medicaments of substances which inhibit the ... | 11/07/2006 |
| 7125541 | Combined methods for tumor vasculature targeting and tumor treatment with radiotherapy The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the v... | 10/24/2006 |
| 7125551 | Methods for treatment of asthmatic disorders using a monoclonal antibody to 8F4 polypeptide The present invention relates to methods and compositions for the prevention and treatment and prevention of immune system disorders, including cancer, AIDS, asthmatic disorders, autoimmune diseases, organ transplant rejection and chronic viral diseases such as HCV ... | 10/24/2006 |
| 7112317 | Combined methods and compositions for tumor vasculature targeting and tumor treatment The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the v... | 09/26/2006 |
| 7097840 | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anri-ErbB rece... | 08/29/2006 |
| 7074403 | Immunotherapy of autoimmune disorders using antibodies which target B-cells Antibodies that bind with a B-cell antigen provide an effective means to treat autoimmune disorders. Antibodies and fragments, which may be conjugated or naked, are used alone or in multimodal therapies. The antibodies may be bispecific antibodies which may be produ... | 07/11/2006 |
| 7067132 | Antagonists of interleukin-15 Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are incapable of transducing a signal through either the β- or γ-subunit... | 06/27/2006 |
| 7060271 | Inhibitory immunoglobulin polypeptides to human PDGF beta receptor The present invention is directed towards immunoglobulin polypeptides that specifically bind to the extracellular domain of the human type beta PDGF receptor. The binding of the immunoglobulin polypeptides to the receptor inhibits PDGF-induced (or stimulated) recept... | 06/13/2006 |
| 7052694 | Dendritic cell potentiation A molecule capable of potentiating immune responses is described, as well as methods for using the molecule to enhance immune responses and enhance dendritic cell function. Also described are compositions containing the molecule and methods for using the composition... | 05/30/2006 |
| 7041292 | Treating prostate cancer with anti-ErbB2 antibodies The present application discloses treatment of prostate cancer with anti-ErbB2 antibodies. ... | 05/09/2006 |
| 7001597 | Methods for altering fertility The present invention relates to methods for enhancing fertility by reducing the activities and/or levels of circulating glycoprotein hormones having lutropin (LH) activity. The molecules of the invention are antibodies or other binding agents that reduce the biolog... | 02/21/2006 |
| 6998389 | Pharmaceutical composition comprised of spider venoms, the production thereof, and its use for treating tumor diseases The present invention describes pharmaceutically effective substances from the poison of spiders of the family of Sicariidae as well as their preparation and their use in medicine. ... | 02/14/2006 |
