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| Number | Title | Issue Date |
| 8057797 | Method of preparing enriched antibodies for detecting mycobacterial infection The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is enriched by having been raised in an environment that maintains antigenicall... | 11/15/2011 |
| 7615222 | Enriched antibody for detecting mycobacterial infection, methods of use and diagnostic test employing same The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is enriched by having been raised in an environment that maintains antigenicall... | 11/10/2009 |
| 7344703 | Mycobacterial sulfation pathway proteins and methods of use thereof Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, di... | 03/18/2008 |
| 7335480 | Enriched antibody for detecting mycobacterial infection, methods of use and diagnostic test employing same The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is enriched by having been raised in an environment that maintains antigenicall... | 02/26/2008 |
| 7335369 | Fusion proteins of antigens and their uses The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three... | 02/26/2008 |
| 7311922 | Fusion proteins of mycobacterium tuberculosis The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase se... | 12/25/2007 |
| 7264815 | Process for producing a recombinant protein in a mycobacterium host plasmid pJAM2 This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic exchange experiments, indicate that the des gene may be essential to the ... | 09/04/2007 |
| 7261897 | Fusion proteins of mycobacterium tuberculosis The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera ... | 08/28/2007 |
| 7256178 | Physiologically active substances Compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same: (I) wherein W represents and R3, R7, R16, R17 | 08/14/2007 |
| 7192721 | Universal rapid test and method for detection of tuberculosis in multiple host species A universal test apparatus for detecting tuberculosis (TB) in any of many different species of non-primate mammals is provided. The universal test apparatus includes a test site having a mycobacterial antigen cocktail comprising ESAT-6/CFP10 and 16 kDa/MPB83 polyfus... | 03/20/2007 |
| 7186412 | Fusion proteins of The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera ... | 03/06/2007 |
| 7094403 | superoxide dismutase The invention relates to Mycobacterium tuberculosis superoxide dismutase antibodies, methods of using them for detection of M. tuberculosis, methods of testing for an inhibitor of an M. tuberculosis superoxide dismutase, and methods of detecting... | 08/22/2006 |
| 7087713 | Compounds and methods for diagnosis and immunotherapy of tuberculosis Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA m... | 08/08/2006 |
| 7067136 | Method of screening anti-mycobacterial molecules This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic exchange experiments, indicate that the des gene may be essential to the ... | 06/27/2006 |
| 7064195 | Fusion proteins of mycobacterium tuberculosis antigens and their uses The present invention relates to fusion proteins of Mycobacterium tuberculosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis antigens, and a fusion protein of two M. tuberculosis ... | 06/20/2006 |
| 6977075 | Photosensitizer conjugates for targeting intracellular pathogens The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is assoc... | 12/20/2005 |
| 6977069 | Fusion proteins of Mycobacterium tuberculosis antigens and their uses The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three... | 12/20/2005 |
| 6974580 | Mycobacterial sulfation pathway proteins and methods of use thereof Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, di... | 12/13/2005 |
| 6949345 | Identification and cloning of a mycobacterial antigen corresponding to a heparin-binding haemagglutinin The present invention relates to peptide sequences enabling mycobacteria to adhere to host cells (e.g., epithelial cells). More particularly, the invention relates to a mycobacterial heparin-binding haemagglutinin type antigen from M. bovis ECG or M. tuber... | 09/27/2005 |
| 6887481 | Bacterial-derived molecules and therapeutic and diagnostic uses therefor The present invention relates generally to molecules derived from a Mycobacterium species and recombinant, synthetic, derivative, homologue and analogue forms of said molecules. The molecules of the present invention are useful in diagnostic assays for Myc... | 05/03/2005 |
| 6863895 | Mycobacterial sulfation pathway proteins and methods of use thereof Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, di... | 03/08/2005 |
| 6858213 | Mycobacterial sulfation pathway proteins and methods of use thereof Novel mycobacterial sulfation pathway enzymes and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, dia... | 02/22/2005 |
| 6841159 | Rapid lateral flow assay for determining exposure to Mycobacterium tuberculosis and other mycobacteria An assay method and kit is disclosed for detecting the presence of at least one predesignated, target antibody to a mycobacterium in a sample selected from one or more patient bodily fluids. The method comprises the following steps: (a) contacting the sample of one ... | 01/11/2005 |
| 6821769 | IniB, iniA and iniC genes of mycobacteria and methods of use This invention relates to the identification, cloning, sequencing and characterization of the iniB, iniA and iniC genes of mycobacteria which are induced by a broad class of antibiotics that act by inhibiting cell wall biosynthesis, including the first line antitube... | 11/23/2004 |
| 6780418 | Reagents and immunoassay for the detection and quantitative determination of mycothiol and precursors thereof A method of detecting a member of the taxa actinomycetos is provided. A method also is provided for detecting mycothiol or precursor thereof. An antibody is provided which binds to mycothiol or a mycothiol precursor. A method is further provided for diagnosis of a s... | 08/24/2004 |
| 6733983 | Method for identifying a mycobacterium species The invention relates to a method for identifying a Mycobacterium species comprising the steps of: a) contacting at least one immuno-cross reactive antigen component of a mycobacterial species with a sample of a body fluid of a human or animal individual;... | 05/11/2004 |
| 6680055 | Mycolactone and related compounds, compositions and methods of use The present invention provides, inter alia, polyketide macrolides including a polyketide macrolide of the structure ##STR1## wherein R1 -R5 are the same or different and each is independently selected from the group consisting of hyd... | 01/20/2004 |
| 6660264 | Treatment of intracellular infection An agent for combating an intracellular microbial infection comprises a phage component and, associated therewith, a targeting moiety which directs the agent to a target cell and initiates delivery of the phage into the target cell. Once inside the target... | 12/09/2003 |
| 6641814 | Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis The present invention is based on the identification and characterization of a number of M. tuberculosis derived novel proteins and protein fragments (SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 17-23, 42, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72-86... | 11/04/2003 |
| 6627198 | Fusion proteins of Mycobacterium tuberculosis antigens and their uses The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M.... | 09/30/2003 |
| 6610298 | Photosensitzer conjugates for targeting intracellular pathogens The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder th... | 08/26/2003 |
| 6585976 | Mycobacterium strain with modified ERP gene and vaccine composition containing same The invention concerns Mycobacterium strains whereof the erp gene is modified and a vaccine composition containing same. The modification of the erp gene decreases the virulence and the persistence of the Mycobacterium strains.... | 07/01/2003 |
| 6582925 | Desaturase antigen of mycobacterium tuberculosis The use of genetic methodology based on the fusion of the proteins with the alcaline phosphatase (Lim et al., 1995) has allowed the isolation of a new exported protein of M. tuberculosis. In the present article, first of all the isolation of a gene encodi... | 06/24/2003 |
| 6573064 | Method of screening anti-mycobacterial molecules This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic exchange experiments, indicate that the des gene may be essent... | 06/03/2003 |
| 6559295 | Mycobacterium fol A gene that encodes for the enzyme dihydrofolate reductase The invention relates to the nucleic acid sequence and amino acid sequence of dihydrofolate reductase (DHFR) from mycobacteria and to expression of recombinant DHFR protein. Utilizing the recombinant protein, novel therapies and diagnostic strategies can ... | 05/06/2003 |
| 6555653 | Compounds for diagnosis of tuberculosis and methods for their use Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits... | 04/29/2003 |
| 6544522 | Fusion proteins of mycobacterium tuberculosis antigens and their uses The present invention relates to fusion proteins of Mycobacterium tuberclosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis antigens, and a fusion protein of two M. tuberculosis antigen... | 04/08/2003 |
| 6517845 | Mycobacterium tuberculosis superoxide dismutase The invention relates to Mycobacterium tuberculosis superoxide dismutase antibodies, methods of using them for detection of M. tuberculosis, methods of testing for an inhibitor of an M. tuberculosis superoxide dismutase, and methods of detecting tuberculo... | 02/11/2003 |
| 6506384 | Early detection of mycobacterial disease A number of protein and glycoprotein antigens secreted by Mycobacterium. tuberculosis (Mt) have been identified as "early" Mt antigens on the basis early antibodies present in subjects infected with Mt prior to the development of detectable clinical disea... | 01/14/2003 |
| 6416962 | Method and device for identifying a mycobacterium species responsible for a mycobacterial infection The invention relates to a method for identifying a Mycobacterium species responsible for a mycobacterial infection in human or animal, comprising selecting a suitable mycobacterial species and strain; preparing at least one mycobacterial antigen, respect... | 07/09/2002 |
