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| Number | Title | Issue Date |
| 7608265 | Treatment for bacterial infections The present invention is concerned with compounds, medicaments and treatments for Clostridium difficile infection, together with novel isolated antibodies and their use in same. The present invention is also concerned with the treatment and prophylaxis of ... | 10/27/2009 |
| 7227010 | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain neurotoxins are a new class of zinc-endopeptidases that specifically cleave the... | 06/05/2007 |
| 7192596 | Recombinant toxin fragments A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be tran... | 03/20/2007 |
| 7037680 | Recombinant light chains of neurotoxins and light chain fusion proteins for use in research and clinical therapy Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain neurotoxins are a new class of zinc-endopeptidases that specifically cle... | 05/02/2006 |
| 6969520 | Active immunization against clostridium difficile disease The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile tox... | 11/29/2005 |
| 6916474 | Antibodies with increased affinities for anthrax antigens The invention overcomes the deficiencies of the prior art by providing antibody compositions having improved affinities for Bacillus anthracis antigens. The compositions have important thereapeutic and diagnostic applications, including treatment or detection... | 07/12/2005 |
| 6805857 | Method of modulating factor D, factor H and CD4 cell immune response with a polystyrene sulfonate, alginate, and saline infusion solution Anthrax bio-terrorism is a poor man's nuclear bomb with devastating effects on the freedom and economy of any nation. No nation is immune. Urgently, there is a need for life saving technology that can be readily available and deployed in real time. Polystyrene sulfo... | 10/19/2004 |
| 6743430 | Multicomponent vaccine containing clostridial and non-clostridial organisms in a low dose Disclosed herein is a multicomponent low dose vaccine comprising a safe and immunogenically effective combination of a protective antigen component or components of clostridial organism, a protective antigen component of a non-clostridial organism and an adjuvant. | 06/01/2004 |
| 6680168 | Passive immunization against clostridium difficile disease The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or c... | 01/20/2004 |
| 6667035 | Amino acid sequences for therapeutic and prophylactic use against diseases due to Clostridium difficile toxins The invention relates to monoclonal antibodies capable of recognizing and neutralizing epitopes from the ligand domain, the translocation domain or the catalytic domain of the enterotoxin (toxin A) and cytotoxin (toxin B) from Clostridium difficile, as we... | 12/23/2003 |
| 6656468 | Clostridial toxin disease therapy Treating humans and animals intoxicated with a bacterial toxin by administration of antitoxin. Avian antitoxin in an aqueous solution in therapeutic amount that is orally administrable.... | 12/02/2003 |
| 6517826 | Anionic polymers as toxin binders and antibacterial agents The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached ... | 02/11/2003 |
| 6517827 | Anionic polymers as toxin binders and antibacterial agent The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached ... | 02/11/2003 |
| 6461617 | Recombinant toxin fragments A polypeptide has first and second domains which enable the polypeptide to be translocated into a target cell or which increase the solubility of the polypeptide, or both, and further enable the polypeptide to cleave one or more vesicle or plasma-membrane... | 10/08/2002 |
| 6447785 | Method for treating hypercalcemia A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method for treating hyperthyroidism by local administration of a... | 09/10/2002 |
| 6290960 | Vaccine and antitoxin for the treatment of C. difficile disease The present investion provides vaccines capable of protecting a vaccinated recipient from the morbidity and mortality associated with C. difficile infection. These vaccines are produced with portions of C. difficile Toxin A, or Toxin B, or both. These por... | 09/18/2001 |
| 6214341 | Passive immunization against Clostridium difficile disease The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or c... | 04/10/2001 |
| 6203794 | Modification of clostridial toxins for use as transport proteins A chemical conjugate for treating a nerve cell related disorder is provided. The conjugate includes an active or inactive Clostridial toxin having specificity for a target nerve cell. The toxin is conjugated to a drug or other bioactive molecule without a... | 03/20/2001 |
| 6096310 | Oral immunotherapy of bacterial overgrowth The object of the present invention is the oral administration of animal immunoglobulins for the treatment of gastrointestinal disorders caused by bacterial and/or yeast overgrowth. Immunoglobulins derived from the blood, plasma or serum of animals, such ... | 08/01/2000 |
| 5773000 | Therapeutic treatment of clostridium difficile associated diseases The effective treatment of Clostridium difficile associated diseases, such as Clostridium difficile colitis, pseudomembranous colitis and antibiotic associated diarrhea, by administering an antibody having specific activity against Clostridium difficile c... | 06/30/1998 |
| 5762934 | Clostridium difficile toxin disease therapy The present invention includes methods and compositions for treating humans and other animals intoxicated with at least one clostridial toxin by administration of antitoxin. In particular, the antitoxin directed against these toxins is produced in avian s... | 06/09/1998 |
| 5736139 | Treatment of Clostridium difficile induced disease The present provides neutralizing antitoxin directed against C. difficile toxins. These antitoxins are produced in arian species using soluble recombinant C. difficile toxin proteins. The avian antitoxins are designed so as to be orally administrable in t... | 04/07/1998 |
| 5719267 | Clostridial toxin disease therapy Treating humans and animals intoxicated with a bacterial toxin by administration of antitoxin. Avian antitoxin in an aqueous solution in therapeutic amount that is orally administrable.... | 02/17/1998 |
| 5601823 | Avian antitoxins to clostridium difficle toxin A The present invention includes methods and compositions for treating humans and other animals intoxicated with at least one Clostridial toxin by administration of antitoxin. In particular, the antitoxin directed against these toxins is produced in avian s... | 02/11/1997 |
| 5599539 | Therapy for clostridial botulinum toxin Treating humans and animals intoxicated with a bacterial toxin by administration of antitoxin. Avian antitoxin in an aqueous solution in therapeutic amount that is orally administrable.... | 02/04/1997 |
| 5562907 | Method to prevent side-effects and insensitivity to the therapeutic uses of toxins Human-derived or human-compatible antitoxins are administered is an adjunct to therapy with a toxin, such as botulinum toxin or an immunotoxin, or as an adjunct to therapy with a combination of toxins, in order to reduce or prevent endogenous production o... | 10/08/1996 |
| 5130128 | Use of honey as vaccine Anti-honey food products are disclosed, such food products being obtained from animals hyperimmunized against at least one antigen found in honey, and preferably whole unfractionated honey. A vaccine producing said anti-honey food product is disclosed, sa... | 07/14/1992 |
| 4911910 | Purified equine immunologlobulins and method of use thereof Equine immunoglobulins are recovered from the pass-through fraction of a QAE column loaded with equine serum in an acidic buffer. The recovered antibodies are electrophoretically free of non-immunoglobulin proteins, including transferrin, and are recovere... | 03/27/1990 |
| 4550019 | Manufacture and use of fowl egg antibodies Immunological preparations are prepared by immunizing hens with an immunogen having a molecular or particle weight of at least 30,000, to a stage of hyper-immunization at which there occurs a plateau-like levelling-off of the antibody content of the serum... | 10/29/1985 |
| 4499073 | Intravenously injectable immune serum globulin A composition is disclosed which comprises a solution in a pharmaceutically acceptable carrier of an immune serum globulin, said solution having an ionic strength and a pH to maintain the monomer content and the actual and latent anticomplement activity o... | 02/12/1985 |
