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| Number | Title | Issue Date |
| 8163288 | polypeptides and antibodies The invention relates to antigenic polypeptides expressed by pathogenic microbes, vaccines comprising said polypeptides; therapeutic antibodies directed to said polypeptides and methods to manufacture said polypeptides, vaccines and antibodies. ... | 04/24/2012 |
| 8007803 | Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.... | 08/30/2011 |
| 7892552 | Group B polypeptides nucleic acids and therapeutic compositions and vaccines thereof This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids encoding Group B streptococcal Ema polypeptides EmaA, EmaB, EmaC, EmaD and ... | 02/22/2011 |
| 7625561 | Diabody which specifically binds surface antigen I/II and methods of use thereof Common oral diseases such as periodontitis and dental caries can be prevented effectively by passive immunization. The present invention provides human single chain Fv (scFv) and diabody antibody fragments based on the binding characteristics of the murine monoclona... | 12/01/2009 |
| 7438912 | antigens I + II The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. agalactiae, methods for isolating such antigens and... | 10/21/2008 |
| 7368112 | fibrinogen binding protein gene The isolation of genes and proteins from Staphylococcus aureus is provided, and the nucleic acids coding for specific regions of the S. aureus CIfA protein are described. The nucleic acids encode proteins that can be useful as vaccines or in pharmaceut... | 05/06/2008 |
| 7364738 | Monoclonal antibodies to the CLFA protein and method of use in treating infections Monoclonal antibodies which can bind to the ClfA protein and which are generated from binding subdomains or active fragments of the ClfA protein from Staphylococcus aureus, including the active fragments proteins from its fibrinogen binding domain such as Clf... | 04/29/2008 |
| 7316910 | Rapid test for hemolytic streptococcus A reagent for the detection of an extracellular enzymatically active protein produced by a beta-hemolytic streptococcus bacteria found in a host biological fluid includes a proteinaceous substrate or a cholesterol-containing membrane substrate for the extracellular ... | 01/08/2008 |
| 7279162 | Isolated broadly reactive opsonic immunoglobulin for treating a pathogenic coagulase-negative staphylococcus infection The invention describes the identification, making, and isolation of immunoglobulin and antigen useful for preventing, diagnosing, and treating staphylococcal infections. The invention further describes an in vivo animal model useful for testing the efficacy of phar... | 10/09/2007 |
| 7267963 | Modified plant viruses and methods of use thereof The present invention relates to modulating the nature and/or level of an immune response to a molecule. In particular, the invention relates to effecting an increase in the TH1 immune response to molecules such as, but not limited to, antigens or immunogens. The in... | 09/11/2007 |
| 7252828 | Polysaccharide vaccine for infections The invention relates to compositions of the capsular polysaccharide/adhesin (PS/A) of staphylococci. The PS/A may be isolated or synthesized and includes various modifications to the structure of native PS/A based on the chemical characterization of PS/A. Th... | 08/07/2007 |
| 7250494 | Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro. The invention also provides antibodies h... | 07/31/2007 |
| 7241592 | Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermi... | 07/10/2007 |
| 7238351 | Immunogen adherence inhibitor directed to lactic acid producing organisms and method of making and using it The method of producing a microbial adherence inhibitor for administration to food animals to control the incidents of acidosis in food animals by preventing the adherence of colony-forming lactic acid producing bacteria in the rumen or intestinal tracts of the food... | 07/03/2007 |
| 7226590 | Antimicrobial composition This invention provides novel Streptococcus salivarius, compositions containing same, and use of S. salivarius strains as antimicrobial agents. The strains are bacterial inhibitors with respect to at least S. mutans and/or MS and therefore have ... | 06/05/2007 |
| 7220409 | Stabilization of immunoglobulins at low pH The present invention provides a method of stabilizing immunoglobulins in a solution having a pH below 4 by adding cereals or hydrolysed cereal products in an amount sufficient to prevent degradation. The present invention also provides a health drink or sports drin... | 05/22/2007 |
| 7217416 | Use of gamma globulin for the topical treatment of lesions of dermatitis The use of G class immunoglobulins, particularly immunoglobulins for intravenous use or for intramuscular use to produce a medicine for the local therapeutic treatment of dermatitis, particularly acne, contact dermatitis, atopic dermatitis, eczema and ichthyosis, ps... | 05/15/2007 |
| 7195763 | Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be highly conserved motifs in the surface protein... | 03/27/2007 |
| 7189404 | Strain selection of pneumococcal surface proteins The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the family having greater than or equal to 50% homology in aligned seque... | 03/13/2007 |
| 7183083 | Nucleic acid and amino acid sequences relating to for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the poly... | 02/27/2007 |
| 7169903 | Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria The present invention encompasses protective monoclonal antibodies that bind to peptidoglycan of Gram-positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and block nasal colonization by Gram-pos... | 01/30/2007 |
| 7160990 | Antibodies to a fibrinogen binding protein of staphylococcus epidermidis A new fibrinogen binding protein or polypeptide originating from coagulase negative staphylococci, biotechnological methods for producing the protein or polypeptide having fibrinogen binding activity and a recombinant DNA molecule coding for the protein (or f... | 01/09/2007 |
| 7128918 | antigens Streptococcus proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of ... | 10/31/2006 |
| 7115264 | Monoclonal antibodies to the fibronectin binding protein and method of use in treating or preventing infections Monoclonal antibodies which can bind to the Fnbp protein of Staphylococcus aureus and which are generated from a peptide from the D2 region of fibronectin binding protein B (Fnbp) of S. aureus are provided which can be useful in the treatment and prote... | 10/03/2006 |
| 7087228 | Preventing tooth decay and infective endocarditis using natural oligopeptides The present invention provides compositions, medicaments, and methods for the treatment or prophylaxis of conditions associated with the binding of Streptococcus mutans to teeth. Specifically, the present invention provides a method for preventing dental cari... | 08/08/2006 |
| 7078042 | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least o... | 07/18/2006 |
| 7067135 | Methods and compositions for the treatment and prevention of infections The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, Staphylococcus spp., particularly S. aureus. ... | 06/27/2006 |
| 7063980 | Pretreatment kit for saliva and pretreatment method for saliva A pretreatment kit and a pretreatment kit for saliva in identification and quantitative determination of mutans streptococci by immunochromatography utilizing an antigen-antibody reaction, which can remove aggregation caused by mucin and chain formation of mutans st... | 06/20/2006 |
| 7056510 | Streptococcus pneumoniae SP036 polynucleotides, polypeptides, antigens and vaccines The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneunoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. An... | 06/06/2006 |
| 7045132 | 37-kDa surface adhesin a protein The invention provides a nucleic acid encoding the 37-kDa protein from Streptococcus pneumoniae. Also provided are isolated nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. The invention also provides purified polyp... | 05/16/2006 |
| 7045131 | Staphylococcal immunotherapeutics via donor selection and donor stimulation A method and composition for the passive immunization of patients infected with or susceptible to infection from Staphylococcus bacteria such as S. aureus and S. epidermidis infection is provided that includes the selection or preparation of a d... | 05/16/2006 |
| 7030101 | Compositions of β-glucans and specific antibodies Compositions and kits comprising combinations of β-glucans and specific immunoglobulins are disclosed. The compositions and kits are useful in methods of preventing or treating infection by a pathogenic microorganism, in which β-glucan is administered to a subject... | 04/18/2006 |
| 7018986 | Use of beta glucans for the treatment of osteoporosis and other diseases of bone resorption The invention provides methods of using beta glucans to treat conditions associated with bone loss or low bone density as well as methods for promoting bone growth in situations where enhanced bone growth is desirable. In the invention methods beta glucans are admin... | 03/28/2006 |
| 7015007 | Capsular polysaccharide adhesin antigen, preparation, purification and use A substantially pure capsular exopolysaccharide adhesin of coagulase-negative staphylococcal strains, and a gonoral method to prepare such adhesins, are described. Vaccines composed of such adhesins, and uses of such adhesins to produce polyclonal and monoclonal ant... | 03/21/2006 |
| 6994855 | fibrinogen binding protein gene The invention relates to the isolation of the fibrinogen binding protein gene from Staphylococcus aureus and to the use of the fibrinogen binding protein and antibodies generated against it for wound healing, blocking adherence to indwelling medical devices, ... | 02/07/2006 |
| 6979446 | Monoclonal antibodies to the ClfA protein and method of use in treating or preventing infections Monoclonal antibodies which can bind to the ClfA protein and which are generated from binding subdomains or active fragments of the ClfA protein from Staphylococcus aureus, including the active fragments proteins from its fibrinogen binding domain such as Clf... | 12/27/2005 |
| 6923962 | Signal peptides, nucleic acid molecules and methods for treatment of caries The invention relates to a compound that competitively inhibits binding of CSP to S. mutans histidine kinase. The compound is preferably a peptide or an antibody. The compound is preferably a derivative of [SEQ ID NO:2], a fragment of [SEQ ID NO:2] or a deriv... | 08/02/2005 |
| 6908619 | Camp factor of streptococcus uberis The CAMP factor gene of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. CAMP factors can be used in vaccine compositions for the prevention and treatment of bacterial infections. ... | 06/21/2005 |
| 6841154 | Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and Staphylococcus aureus Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. aureus and to coagulase-negative bacteria, such as S. epidermidis and S. hemolyticus, are provided which can recognize s... | 01/11/2005 |
| 6835818 | Mutants of Streptococcal toxin C and methods of use This invention is directed to mutant SPE-C toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-C toxin has at least one amino acid change and is substantially non-l... | 12/28/2004 |
