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| Number | Title | Issue Date |
| 8153132 | Antibodies immunoreactive with mutant hydroxypenylpyruvate dioxygenase Antibodies immunoreactive to mutant Pseudomonas HPPD are provided, and in an embodiment the mutant HPPD is one in which the wild-type HPPD is substituted at residue 336 with tryptophan for glycine. Also provided are hybridomas producing the antibodies, as wel... | 04/10/2012 |
| 8147836 | Compositions and methods for treating osteolytic disorders comprising MMP-14 binding proteins Provided are methods and compositions for using MMP-14 or MMP-9 binding proteins alone or in combination with other therapeutic agents to treat osteolytic disorders such as osteotropic cancer and osteoporosis. ... | 04/03/2012 |
| 8048847 | Derivatives of the IL-2 receptor gamma chain, their production and use This invention relates to the use of the IL-2 common gamma (cγc) and related molecules for the modulation of signal activities controlled by NIK, and some new such molecules. ... | 11/01/2011 |
| 7993646 | HK1-binding proteins The invention features hK1 binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides. ... | 08/09/2011 |
| 7968094 | Use of anti-tissue factor antibodies for treating thromboses Disclosed is a method for preventing or treating thrombosis in a mammal such as a primate and particularly a human patient. A preferred method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibo... | 06/28/2011 |
| 7862819 | Diacylglycerol O-acyltransferase 2α (DGAT2α) Nucleic acid compositions encoding mammalian DGAT2α polypeptide products with diglyceride acyltransferase activity, as well as the mammalian DGAT2α polypeptide products encoded thereby and methods for producing the same, are provided. The subject DGAT2α polypepti... | 01/04/2011 |
| 7829095 | Inhibitory monoclonal antibody against blood clotting factor VII-activating protease A monoclonal antibody which inhibits the blood clotting factor VII-activating protease and its proenzyme and a blood clotting factor VII-activating protease, stabilized by the addition of said monoclonal antibody, and its proenzyme are described. A suitable monoclon... | 11/09/2010 |
| 7824682 | Cardiac myosin light chain kinase-specific antibodies and methods of detecting The present disclosure provides a cDNA, protein sequence, and genomic structure of the human cardiac isoform of myosin light chain kinase (cMLCK), and describes mutations in the cMLCK gene that are associated with cardiac dysfunction. Methods are provided for identi... | 11/02/2010 |
| 7754216 | Method of treating multiple sclerosis with anti-K6 antibody Methods and kits for treating inflammatory conditions are described that include modulating kallikrein 6 protease activity. ... | 07/13/2010 |
| 7749503 | 3-deoxyglucosone and skin The invention relates to a method of removing 3-deoxyglucosone and other alpha-dicarbonyl sugars from skin. The invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin. The invention al... | 07/06/2010 |
| 7658923 | Anti-CD26 monoclonal antibodies as therapy for diseases associated with cells expressing CD26 Therapeutic methods comprising administering anti-CD26 antibodies for the prevention and treatment of cancers and immune diseases associated with expressing CD26 are provided. The invention describes various types of anti-CD26 antibodies and modes of administration.... | 02/09/2010 |
| 7622117 | 3-deoxyglucosone and skin The invention relates to a method of removing 3-deoxyglucosone and other alpha-dicarbonyl sugars from skin. The invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin. The invention al... | 11/24/2009 |
| 7537762 | Human monoclonal antibodies to activin receptor-like kinase-1 The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathw... | 05/26/2009 |
| 7510710 | Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a UCP and/or Fas antibody or other inhibitor, or combination thereof, and a therapeutically acceptable amount of a fatty acid metabolism inhibitor and/or a the... | 03/31/2009 |
| 7479277 | Method for reducing intraocular pressure using integrin-linked kinase inhibitor Methods for treating increased intraocular pressure by administering agents that interfere with activities of integrin-linked kinase. By interfering with the ability of integrin-linked kinase to couple integrin signaling to the actin cytoskeleton, aqueous humor outf... | 01/20/2009 |
| 7439331 | Inhibition of complement activation The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including ... | 10/21/2008 |
| 7419665 | Monoclonal antibodies for detection of urinary trypsin inhibitors Certain monoclonal antibodies are able to detect urinary trypsin inhibitors (UTIs) that are characteristic of disease in humans. In particular, the UTIs include AMBK, Bikunin, Uristatin, Uristatin-1, Uristatin-2, as defined herein, also including the fragments and a... | 09/02/2008 |
| 7416730 | Derivatives of the IL-2 receptor gamma chain, their production and use This invention relates to the use of the IL-2 common gamma chain (cγc) and related molecules for the modulation of signal activities controlled by NIK, and some new such molecules. ... | 08/26/2008 |
| 7403883 | Three-dimensional in-vitro spinal models and methods of analyzing substance distribution therein An in-vitro model apparatus of a human spine and methods for detecting and analyzing substance distribution patterns therein. In one embodiment, the model apparatus includes a column body defining a passageway that substantially mimics the size, shape, and structure... | 07/22/2008 |
| 7378091 | Antibodies against carbonic anhydrase IX (CA IX) tumor antigen The present invention relates generally to the generation and characterization of anti-CA IX monoclonal antibodies. The invention further relates to the use of such anti-CA IX antibodies in the diagnosis and treatment of disorders associated with increased activity ... | 05/27/2008 |
| 7361644 | Specific antagonist for both E- and P-selectins Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-med... | 04/22/2008 |
| 7358352 | Nucleic acids encoding human TNF-α convertase The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and; recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention fu... | 04/15/2008 |
| 7348413 | Cancerous disease modifying antibodies The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the produ... | 03/25/2008 |
| 7344713 | Decreased fat absorption with an anti-lipase antibody A method for the decrease of fat absorption in a mammal, wherein the animal is orally fed an antibody produced against lipase, an enzyme which is required for fat absorption. ... | 03/18/2008 |
| 7320879 | Method of determining site-specificity and kit therefor The invention relates to a method of determining the binding site specificity of an analyte to a ligand having at least two different binding sites, which method comprises immobilizing the ligand to a solid support, mixing the analyte with a reversibly binding refer... | 01/22/2008 |
| 7312321 | Antibody to human enzymes of the metalloprotease family This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhib... | 12/25/2007 |
| 7309693 | Preventives and remedies for pulmonary hypertension The present invention provides a prophylactic and/or therapeutic agent for pulmonary hypertension, comprising an antagonistic mutein of MCP-1 or a salt thereof, a DNA molecule comprising a nucleotide sequence encoding the antagonistic mutein of MCP-1, or a neutraliz... | 12/18/2007 |
| 7297336 | Factor IXa specific antibodies displaying factor VIIIa like activity Ligands such as antibodies that can bind factor IX/factor IXa and increase the procoagulant activity of factor IXa (FIXa), pharmaceutical compositions containing such ligands, methods for treating patients afflicted with blood coagulation with such ligands, and a nu... | 11/20/2007 |
| 7282477 | Cystatin C as an antagonist of TGF-β and methods related thereto Disclosed are Cystatin C (CysC) homologues, including CystC homologues that act as antagonists or inhibitors of transforming growth factor-β (TGF-β). Also disclosed are methods to identify CystC homologues that are antagonists or inhibitors of TGF-β and compositi... | 10/16/2007 |
| 7273610 | Endotheliase-2 ligands Proteins that bind to ET2, such as immunoglobulins that inhibit ET2 with high affinity and selectivity, are provided. The ET2 binding proteins can be used to treat a variety of disorders, including angiogenesis-associated disorders. ... | 09/25/2007 |
| 7258971 | Methods and compositions for treating urological disorders using carboxypeptidase Z identified as 8263 The present invention relates to methods for the diagnosis and treatment of a urological disorder or urological disorders. Specifically, the present invention identifies the differential expression of Carboxypeptidase Z, identified as “8263” gene in tissues rela... | 08/21/2007 |
| 7259138 | Anti-tumor agents A method for treating subjects with abnormal cell proliferation is provided. The method involves administering to subjects in need of such treatment an effective amount of an agent of Formula I, to inhibit cell proliferation such as that associated with tumor growth... | 08/21/2007 |
| 7244604 | HDAC9 polypeptides and polynucleotides and uses thereof The present invention features substantially pure HDAC9, HDAC9a, HDAC9(ΔNLS), HDAC9a(ΔNLS), an HDRP(ΔNLS) polypeptides, and isolated nucleic acid molecules encoding those polypeptides. The present invention also features vectors containing HDAC9, HDAC9a, HDAC9(Δ... | 07/17/2007 |
| 7238729 | Silica mesoporous aerogels having three-dimensional nanoarchitecture with colloidal gold-protein superstructures nanoglued therein This disclosure describes the first viable non-enzyme protein encapsulated within an aerogel. In this, a large excess of cyt c is added to a commercial buffered Au sol solution ( ) which results in the formation of a gold˜protein-protein superstructure in the absen... | 07/03/2007 |
| 7230153 | Multilayer conductive appliance having wound healing and analgesic properties A dressing for promoting healing and pain relief of the body of a living organism having a pathologic condition has at least one layer of conductive material having a resistance no greater than 1000 Ω/cm2. When placed proximate a portion of the body of t... | 06/12/2007 |
| 7226594 | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberranty expressed in the cancers listed in Table I. Consequently, ... | 06/05/2007 |
| 7217796 | Neutralizing human anti-IGFR antibody The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing th... | 05/15/2007 |
| 7214373 | Methods, compositions and kits relating to chitinases and chitinase-like molecules and inflammatory disease The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic rhinitis, scleroderma, and the like), relating to inhibiting a chitinase-li... | 05/08/2007 |
| 7198788 | Anti-CD26 monoclonal antibodies as therapy for diseases associated with cells expressing CD26. Therapeutic methods comprising administering anti-CD26 antibodies for the prevention and treatment of cancers and immune diseases associated with expressing CD26 are provided. The invention describes various types of anti-CD26 antibodies and modes of administration.... | 04/03/2007 |
| 7195926 | Antibodies to a cathepsin C homolog The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode RCP, expression... | 03/27/2007 |
