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| Number | Title | Issue Date |
| 8187602 | Anti-histone H1 monoclonal antibody and hybridoma for the production thereof The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation. ... | 05/29/2012 |
| 8187601 | Fibroblast growth factor receptor 3 (FGFR3) binding proteins Monoclonal antibodies that bind and inhibit activation of fibroblast growth factor receptor 3 (FGFR3) are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of FGFR3... | 05/29/2012 |
| 8182813 | Human C-FMS antigen binding proteins Antigen binding proteins that bind to human c-fms protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of c-fms to CSF-1, reduce monocyte mi... | 05/22/2012 |
| 8178096 | Use of an anti-CD151 antibody in the treatment of cancer The present invention relates to the use of at least one antibody, or a functional fragment thereof, which is capable of binding to the CD151 protein and thereby inhibiting tumor growth, in the preparation of a medicament intended for the treatment of cancer. | 05/15/2012 |
| 8173129 | Methods and compositions for treating autoimmune diseases The invention features methods for increasing or maintaining the number of functional cells of a predetermined type, for example, insulin producing cells of the pancreas, blood cells, spleen cells, brain cells, heart cells, vascular tissue cells, cells of the bile d... | 05/08/2012 |
| 8168187 | Nucleic acid and corresponding protein entitled 184P1E2 useful in treatment and detection of cancer A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 184P1E2 provides a ... | 05/01/2012 |
| 8163285 | Nogo-A binding molecules and pharmaceutical use thereof The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG with a dissociation constant | 04/24/2012 |
| 8158125 | B-cell epitope peptides of HSP 65, novel amino acid sequences, DNA encoding the amino acid sequences of said peptides, antibodies directed against said peptides and different uses thereof in the treatment of inflammatory and autoimmune diseases B-cell epitope peptides of HSP 65, particularly the peptides comprising the amino acid sequence substantially as denoted by SEQ ID: NOs. 1-5 and their biologically functional homologues and derivatives thereof. Also included are polyclonal and monoclonal antibodies ... | 04/17/2012 |
| 8153127 | Method of treating depression The present invention relates to a method for identifying a TMEFF2 modulator, comprising (a) contacting a cell which expresses TMEFF2 with a candidate compound to be tested; (b) measuring whether said compound to be tested decreases or increases the level of a const... | 04/10/2012 |
| 8137670 | Method of identifying membrane IgE specific antibodies and use thereof for targeting IgE producing precursor cells The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored IgE and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can medi... | 03/20/2012 |
| 8133488 | Methods and compositions for targeting polyubiquitin Anti-K63-linked polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided. ... | 03/13/2012 |
| 8124087 | Methods of controlling bone loss by inhibiting DKK1 The present invention is drawn to understanding lytic bone diseases. In this regard, the present invention discloses mechanism by which Wnt signaling antagonist inhibits bone differentiation. Also disclosed herein are methods to control bone loss, treat bone disease... | 02/28/2012 |
| 8114401 | antigens Proteins encoded by Chlamydia trachomatis which are immunogenic in humans as a consequence of infection have been identified using Western blots of two-dimensional electrophoretic maps. Several known immunogens were identified, as were proteins not previously... | 02/14/2012 |
| 8101181 | Antibodies that immunospecifically bind to B lymphocyte stimulator protein The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lym... | 01/24/2012 |
| 8097253 | Methods for inhibiting angiogenesis The present invention provides methods and compositions for modulating proliferation, differentiation, migration, and adhesion of cardiovascular cell types. ... | 01/17/2012 |
| 8093208 | Therapeutic peptides for the treatment of metastatic cancer Interaction between MUC1 and β-catenin can be interrupted using polypeptides or antibodies that specifically bind to the binding site on MUC1. Interruption provides the beneficial effect of inhibiting, reducing, and/or retarding invasiveness and metastasis. Fusion ... | 01/10/2012 |
| 8088381 | Methods of treatment of cardiovascular disease using anti-CTGF agents The present invention relates to methods for treating impaired cardiac function. Methods for treating various physiological and pathological features associated with cardiac dysfunction by administering an agent that inhibits the expression or activity of connective... | 01/03/2012 |
| 8084030 | Method of treating a patient having an autoimmune disorder by administering an antibody that binds human BCMA Therapeutic regimens for administration of BAFF antagonists for treatment of immunologic and related disorders are described. Regimens involve a short-term BAFF antagonist administration course followed by an extended no-treatment period prior the round of administr... | 12/27/2011 |
| 8080247 | Anti-IL-12 antibodies An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, i... | 12/20/2011 |
| 8075891 | Antibodies that bind ALS specific epitopes and methods of making The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion infections. The methods of the invention first block accessible polypeptide t... | 12/13/2011 |
| 8066997 | Modulation of activity of neurotrophins The present invention relates to methods for modulating the activity of one or more neurotrophins, such as neural growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4 (NT-4), in an animal and methods for treatment of a di... | 11/29/2011 |
| 8066999 | PEGylated Aβ fab A method to treat conditions associated with Aβ peptide activity both prophylactically and therapeutically is described. The method employs humanized antibody fragments that specifically bind human Aβ peptide between amino acid positions 13-28, wherein the antibod... | 11/29/2011 |
| 8066998 | Antibodies for norovirus Norovirus antigen peptides are described having an amino acid sequence selected from the group consisting of SEQ ID NOS: 1-16, or fragments thereof. Such peptides can be used in the preparation of antiviral therapies such as vaccines, methods of preparing antibodies... | 11/29/2011 |
| 8062637 | Methods of ameliorating inflammatory disease using an uPA antagonist The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in pa... | 11/22/2011 |
| 8038995 | Human N-type calcium channel isoform and uses thereof The invention pertains to a human N-type calcium channel isoform, hα1B+SFVG, which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of ... | 10/18/2011 |
| 8034341 | Methods of inhibiting tumor growth using blocking antibodies to IL-23R Provided are methods of treatment for tumors. In particular, methods are provided for modulating activity of a cytokine molecule and its receptor. ... | 10/11/2011 |
| 8034340 | Method for treating an immune disorder by decreasing NIK-SIVA complex formation Methods and agents for immune modulation and methods for identifying putative immune modulators are provided. ... | 10/11/2011 |
| 8034343 | Methods of treating inflammatory disorders of the lungs 2F1 polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing the polypeptides. Soluble 2F1 polypeptides find use in inhibiting prostaglandin synthesis and treating inflammation. ... | 10/11/2011 |
| 8034342 | Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric ... | 10/11/2011 |
| 8025880 | Immunoglobulin against The present invention relates to materials and methods for prevention, treatment and diagnosing of infections caused by Helicobacter pylori (H. pylori). More specifically the present invention relates to new specific variable antibody regions, derivati... | 09/27/2011 |
| 8017120 | Method for inhibiting bone resorption The invention is directed to a method of inhibiting bone resorption. The method comprises administering to a human an amount of sclerostin inhibitor that reduces a bone resorption marker level for at least 2 weeks. The invention also provides a method of monitoring ... | 09/13/2011 |
| 8003101 | Inflammatory mediator antagonists The present invention relates to methods of reducing cartilage degradation in a patient comprising administering to a patient in need thereof an effective amount of an antibody antagonist to the mature form of OSM. ... | 08/23/2011 |
| 7998481 | Modulation of NKG2D for treating or preventing solid organ allograft rejection The present invention relates to methods and compositions for treating and/or preventing autoimmune and/or inflammatory disease. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and... | 08/16/2011 |
| 7981419 | Method for treating hypophosphatemic bone diseases using FGF-23 antibody A method for treating a hypophosphatemic bone disease, such as X-linked hypophosphatemia (XLH). The method entails administering to a subject a pharmaceutical composition, which contains an antibody that binds to an FGF-23 polypeptide and a pharmaceutically acceptab... | 07/19/2011 |
| 7959917 | Binding members for IgE molecules This invention relates to binding members, especially antibody molecules, for IgE. The binding members are useful for, inter alia, treatment of disorders mediated by IgE including allergies and asthma. ... | 06/14/2011 |
| 7951372 | Method of treating psoriasis by administering IL-22 antibodies, or binding fragments thereof Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders. ... | 05/31/2011 |
| 7935341 | Antibodies to complementary peptides of thrombin or portions thereof Disclosed are antibodies and antigen-binding fragments that bind to a complementary peptide having an amino acid sequence that is encoded by the complement of a nucleotide sequence encoding thrombin or a portion thereof. Such antibodies and antigen-binding fragments... | 05/03/2011 |
| 7935342 | Methods for treating obesity by administering a trkB antagonist This invention relates to methods for treating obesity by peripheral administration of a trkB antagonist. The invention also relates to compositions and kits comprising a trkB antagonist. ... | 05/03/2011 |
| 7919091 | Lipolysis stimulated receptor (LSR) specific antibodies The present invention relates to antibodies specific for a receptor termed the Lipolysis Stimulated Receptor (LSR). Compositions comprising the antibodies are also provided. ... | 04/05/2011 |
| 7901681 | Trypanosome derived apoptotic factors (TAF) An antibody was raised against a synthetic 27 per peptide (ProEP2-1) blocked T. brucei and ProEP2-1-induced apoptosis in human brain vascular endothelial cells (HBVEC). The use of this and similar blocking antibodies have use both as diagnostic agents and in ... | 03/08/2011 |
