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| Number | Title | Issue Date |
| 7632502 | Cell wall mannoproteins and active epitopes from and antibodies recognizing them An isolated surface protein known as mp58 is provided from the yeast Candida albicans which has specific active peptide and carbohydrate regions and immunogenic epitopes therein and which elicits strong antibody responses during candidiasis. Antibodies raised... | 12/15/2009 |
| 7416725 | Compositions and methods of using galectin-8 as an inhibitor of tumor cell growth The present invention provides compositions that enhance or inhibit the interactions of galectin-8 and galectin-8-like proteins with other extracellular matrix proteins or cell surface receptors, and methods for the use thereof as physiological modulators of cell ad... | 08/26/2008 |
| 7399470 | Sandwich immunoassay kits for detecting ciguatoxin CTX3C A sandwich immunoassay kit for detecting ciguatoxins based on a combination of two anti-ciguatoxin CTX3C monoclonal antibodies produced by hybridomas, 3D11 (deposited at IPOD, AIST under accession number FMRM PB-8293) and 10C9 (FMRM PB-8292). In particular, one of t... | 07/15/2008 |
| 7364733 | Antibody to receptor on the surface of activated T-cells: ACT-4 The invention provides purified ACT-4 receptor polypeptides, antibodies against these polypeptides and nucleic acids encoding ACT-4 receptor polypeptides. Also provided are methods of diagnosis and treatment using the same. ACT-4 receptors are preferentially express... | 04/29/2008 |
| 7314632 | exotoxin A-like chimeric immunogens This invention provides Pseudomonas exotoxin A-like chimeric immunogens that include a non-native epitope in the Ib domain of Pseudomonas exotoxin. Methods of eliciting an immune response using these immunogens also are provided. ... | 01/01/2008 |
| 7291606 | Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging. ... | 11/06/2007 |
| 7259247 | Anti-human T-cell costimulating polypeptide monoclonal antibodies A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the monoclonal antibodies, the use as medicaments of substances which inhibit the ... | 08/21/2007 |
| 7253263 | Complementarity determining region-grafted antibody against ganglioside GD3 and derivative of antibody against ganglioside GD3 The present invention relates to a human CDR-grafted antibody against ganlioside GD3 (hereinafter referred to “GD3”), derivatives of an anti-GD3 antibody and cytokine, and use for treatment and diagnosis of the antibody and the derivatives. ... | 08/07/2007 |
| 7244430 | Binding molecules capable of neutralizing West Nile virus and uses thereof The invention provides human binding molecules specifically binding to West Nile virus and having West Nile virus neutralizing activity, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of i... | 07/17/2007 |
| 7241592 | Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermi... | 07/10/2007 |
| 7235644 | Vaccine against Gram-negative bacterial infections A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LP... | 06/26/2007 |
| 7198787 | Method of killing target cells in harvested cell populations with one or more immuno-toxins A method for killing unwanted target cells in a cell population comprising nucleated cells harvested from peripheral blood, or CD-34+ or similar early progenitor cells selected from the above nucleated cells or from bone marrow aspirates, in which method the cell po... | 04/03/2007 |
| 7189395 | Complexes of immunoglobulins and polysaccharides for oral and transmucosal absorption The present invention relates to complexes consisting of immunoglobulins and polysaccharides for oral and transmucosal use. The polysaccharides comprised in the complexes according to the invention form an envelope which protects and carries immunoglobulins a... | 03/13/2007 |
| 7175990 | Method of determining endometrial receptivity The present invention provides a method of predicting the probability of a successful pregnancy, either a naturally achieved pregnancy or a pregnancy resulting from an assisted reproductive technology, based on the level of L-selectin ligand expressed by uterine epi... | 02/13/2007 |
| 7147850 | Therapeutic binding agents against MUC-1 antigen and methods for their use The invention provides therapeutic compositions comprising binding agents that specifically bind to tumor-associated MUC-1 and reduce, reverse or prevent their effects in cancer. More particularly, the invention provides therapeutic compositions that comprise a bind... | 12/12/2006 |
| 7135301 | Detection and treatment of prostate cancer An antigen is shown to be associated with prostate cancer, and is useful for new methods and compositions for diagnosing or treating prostate cancer. This is particularly useful for individuals with prostate cancer who test negative for Prostate Specific Antigen. Ad... | 11/14/2006 |
| 7105303 | Antibodies to hepatitis C virus asialoglycoproteins Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more simi... | 09/12/2006 |
| 7074403 | Immunotherapy of autoimmune disorders using antibodies which target B-cells Antibodies that bind with a B-cell antigen provide an effective means to treat autoimmune disorders. Antibodies and fragments, which may be conjugated or naked, are used alone or in multimodal therapies. The antibodies may be bispecific antibodies which may be produ... | 07/11/2006 |
| 7064191 | Process for purifying antibody The present invention relates to a process for purifying an antibody having a desired property, which comprises using a substance having an affinity to a carbohydrate binding to the antibody; a medicament comprising, as an active ingredient, the antibody purified by... | 06/20/2006 |
| RE39138 | Monoclonal antibody specific for advanced glycosylation endproducts in biological samples The present invention relates to monoclonal antibodies to advanced glycosylation endproducts formed in vivo and cross-reactive with advanced glycosylation endproducts formed in vitro, and to methods of diagnosis and therapy based thereon. More particularly, the inve... | 06/20/2006 |
| 7060495 | Fusion proteins for prodrug activation The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity to a cytotoxic compound (drug), where the antigen binding region is ... | 06/13/2006 |
| 7041634 | Method of inhibiting immune system destruction of transplanted viable cells This invention provides a method of inhibiting viable cells transplanted into a subject from being destroyed by the subject's immune system which comprises: a) containing the viable cells, or tissue comprising the viable cells, prior to transplantation within a devi... | 05/09/2006 |
| 7030225 | Antibodies to JTT-1 protein, cells secreting such antibodies, and methods of making such antibodies A cell surface molecule that is expressed specifically in thymocytes, lymphocytes activated by ConA-stimulation, and peripheral blood lymphocytes. This molecule is involved in signal transmission of the secondary signal (costimulatory signal) essential for the activ... | 04/18/2006 |
| 7025963 | Vaccine against Gram-negative bacterial infections A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LP... | 04/11/2006 |
| 6972125 | Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant r... | 12/06/2005 |
| 6946130 | Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided. ... | 09/20/2005 |
| 6919080 | Polypeptide for Haemophilus paragallinarum and process for preparing the same A novel peptide obtained from Haemophilus paragallinarum has been found useful for preventing avian infectious coryza. This polypeptide induces production of hemagglutination-inhibition antibody and prevents infection and onset of avian infectious coryza. The... | 07/19/2005 |
| 6913747 | Humanized immunoglobulin reactive with B7 therewith The invention relates to humanized anti-B7-2 and anti-B7-1 antibodies, wherein each comprise a variable region of non-human origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune... | 07/05/2005 |
| 6913746 | Complexes of immunoglobulins polysaccharides for oral and transmucosal absorption The present invention relates to complexes consisting of immunoglobulins and polysaccharides for oral and transmucosal use. The polysaccharides comprised in the complexes according to the invention form an envelope which protects and carries immunoglobulins a... | 07/05/2005 |
| 6884417 | Monoclonal antibodies immunoreactive with lipopolysaccharide binding protein (LBP) and methods of their use The present invention concerns a method of treating LBP-mediated LPS-induced myeloid cell activation comprising administering a therapeutically effective amount of an anti-LBP monoclonal antibody molecule. A therapeutic composition comprising anti-LBP antibody molec... | 04/26/2005 |
| 6881406 | Modulation of systemic memory T cell trafficking Methods are provided to specifically modulate the trafficking of systemic memory T cells, particularly CD4+ T cells, without affecting naive T cells or intestinal memory T cells. It is shown that systemic memory T cells, which are characterized as CD45Ra− | 04/19/2005 |
| 6872392 | Humanized antibodies Chimeric human antibody expression vectors are constructed by inserting the heavy chain variable region-encoding cDNA and antibody light chain variable region-encoding cDNA isolated from hybridomas producing a mouse or rat monoclonal antibody reacting with the gangl... | 03/29/2005 |
| 6818213 | Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-t... | 11/16/2004 |
| 6815169 | Identification and expression of a novel kinesin motor protein The invention provides isolated nucleic acid and amino acid sequences of TL-γ, antibodies to TL-γ, methods of screening for TL-γ modulators using biologically active TL-γ, and kits for screening for TL-γ modulators. ... | 11/09/2004 |
| 6808710 | Downmodulating an immune response with multivalent antibodies to PD-1 The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in... | 10/26/2004 |
| 6805862 | Anti-idiotypic antibody which induces an immune response against a glycosphingolipid and use thereof The present invention provides an anti-idiotypic monoclonal antibody which specifically induces an immune response against a glycosphingolipid. Additionally, this invention provides a method of producing the anti-idiotypic monoclonal antibody. Finally, this inventio... | 10/19/2004 |
| 6803039 | Human monoclonal antibody against a costimulatory signal transduction molecule AILIM Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal antibodies capable of binding to AILIM and capable of controlling a variety... | 10/12/2004 |
| 6790661 | System for detecting bacteria in blood, blood products, and fluids of tissues The invention provides methods for screening for the presence of a clinically relevant amount of bacteria in donor blood or a blood product from a donor mammal, particularly blood or a blood product that will be transferred from the donor mammal to a recipient mamma... | 09/14/2004 |
| 6783760 | Combined cancer treatment methods using therapeutic conjugates that bind to aminophospholipids Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-t... | 08/31/2004 |
| 6770277 | Recombinant DNase B derived from streptococcus pyogenes The gene for Streptococcus pyogenes DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform Escherichia coli, allowing efficient and rapid production of the DNase in E. coli without the necessity of growing l... | 08/03/2004 |
