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...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 8110190 | Anti-idiotypic antibodies neutralizing the inhibitory activity of an inhibitory antibody directed against the C1 domain of Factor VIII The present invention is related to a monoclonal anti-idiotypic antibody directed against a Factor VIII inhibitor antibody binding to the C1 domain of Factor VIII, as well as to a cell line producing this monoclonal anti-idiotypic antibody, to the use of this monocl... | 02/07/2012 |
| 8071094 | Anti-idiotypic antibody neutralizing the inhibitor activity of a factor VIII inhibitor antibody The present invention is related to a monoclonal anti-idiotypic antibody directed against a Factor VIII inhibitor antibody binding to the domain A2 of Factor VIII, and to a cell line producing this monoclonal anti-idiotypic antibody, to the use of this monoclonal an... | 12/06/2011 |
| 8038993 | Cytotoxic antibodies directed against antibodies inhibiting factor VIII The invention relates to an anti-idiotypical antibody targeting an antibody inhibiting the human factor VIII, said inhibiting antibody targeting the C2 region of the human factor VIII, the variable region of each of the light chains thereof being encoded by a sequen... | 10/18/2011 |
| 8034338 | Immunogenic recombinant antibody The invention refers to an immunogenic recombinant antibody designed for immunization of primates comprising at least a part of a murine IgG2a subtype amino acid sequence and a mammalian glycosylation. ... | 10/11/2011 |
| 7892542 | Human anti-idiotypic antibody fragments that mimic HER-2/neu This invention relates to human anti-idiotypic antibody fragments, especially scFv, characterized by the ability to mimic Her-2/neu tumor associated antigen. These antibody fragments are promising candidates for active immunotherapy for cancer patients positive for ... | 02/22/2011 |
| 7744876 | Methods and compositions for treatment, prevention, suppression, and/or delaying the onset of type 1 diabetes The present invention relates generally to methods and compositions for treatment, prevention, suppression, and/or delaying the onset of type 1 diabetes. More specifically, the present invention relates to the administration of a fusion protein comprising at least o... | 06/29/2010 |
| 7582296 | Anti-idiotypic antibodies against factor VIII inhibitor and uses thereof The present invention discloses anti-idiotypic antibodies and fragments thereof against inhibitory Factor VIII anti-bodies, said inhibitory antibodies having an affinity for the C2 domain of Factor VIII. The anti-idiotypic antibodies of the present invention are abl... | 09/01/2009 |
| 7431925 | Internal image antibodies for optical imaging and therapy Methods using internal image antibodies for photodiagnosis and/or phototherapy. The internal image antibodies are conjugated with a photoactive molecule such as a dye or photosensitizer, to target specific regions, such as biological receptors. The photoactive molec... | 10/07/2008 |
| 7413736 | Humanization of an anti-carcinoembryonic antigen anti-idiotype antibody as a tumor vaccine and for targeting applications A humanized form of an anti-idiotype antibody to CEA, e.g., hWI2, has conserved immunoreactivity. The clinical benefits of anti-CEA antibodies are maximized by using the humanized anti-idiotype as a clearing agent for anti-CEA antibodies or antibody fragments. The h... | 08/19/2008 |
| 7399469 | Anti-LFL2 antibodies for the diagnosis, prognosis and treatment of cancer Particular anti-LFL2 antibody compositions are provided herein. These antibodies may be used for diagnosis, prognosis, therapeutic monitoring and treatment of cancer, especially breast cancer, head/neck cancer, lung cancer, ovarian cancer, stomach cancer and pancrea... | 07/15/2008 |
| 7348153 | Method for identifying and designing immunogenic peptides The invention provides a method for identifying peptides for use in increasing a cytotoxic T lymphocytes (CTL) response to an antigen. The method comprises the steps of comparing the amino acid sequence of the VH and/or VL portions of an anti-idiotypic monoclonal an... | 03/25/2008 |
| 7300651 | Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1 The present invention provides methods of delaying development of CEA-associated tumors using the anti-idiotype antibody 3H1, particularly in high-risk individuals. ... | 11/27/2007 |
| 7294687 | Parenteral formulations of a peptide for the treatment of systemic lupus erythematosus The subject invention provides a pharmaceutical composition comprising an aqueous carrier; from 0.1 mg/ml to 20 mg/ml of the composition of a pharmaceutically acceptable salt of a peptide having the structural formula NH2-... | 11/13/2007 |
| 7276238 | Methods for using chemokine teck Novel chemokines from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokines. Chemokine receptors are also provided. Methods of using said reagents and diagnostic kits are also provided. ... | 10/02/2007 |
| 7253275 | Porin B (PorB) as a therapeutic target for prevention and treatment of infection by The present invention features peptides of a PorB polypeptide, which PorB peptides are useful in production of antibodies that bind the full-length PorB polypeptide and as a therapeutic agent. In specific embodiments the invention features a composition comprising o... | 08/07/2007 |
| 7250164 | Vaccine composition for preventing meningococcal disease The present invention relates to an anti-idiotype antibodies directed against the monoclonal antibody (HmenB3) to Neisseria meningitidis serogroup B and hybridomas producing the anti-idiotype antibodies. This invention is also directed to vaccine compositions... | 07/31/2007 |
| 7241592 | Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermi... | 07/10/2007 |
| 7235380 | CDR-grafted anti-tissue factor antibodies and methods of use thereof The present invention provides CDR-grafted antibodies against human tissue factor that retain the high binding affinity of rodent monoclonal antibodies against tissue factor but have reduced immunogenicity. The present humanized antibodies are potent anticoagulants ... | 06/26/2007 |
| 7226603 | HBV core antigen particles with multiple immunogenic components attached via peptide ligands This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core antigen particles comprising immunogens, epitopes, or other related struct... | 06/05/2007 |
| 7217796 | Neutralizing human anti-IGFR antibody The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing th... | 05/15/2007 |
| 7204983 | Lipoglycan compositions and methods of treating parasitic infections A composition for and a method of eliciting in a vertebrate a protective immune response against an eukaryotic parasite are disclosed. The method includes administering to the vertebrate a composition having a carrier group coupled to an oligosaccharide obtained fro... | 04/17/2007 |
| 7198787 | Method of killing target cells in harvested cell populations with one or more immuno-toxins A method for killing unwanted target cells in a cell population comprising nucleated cells harvested from peripheral blood, or CD-34+ or similar early progenitor cells selected from the above nucleated cells or from bone marrow aspirates, in which method the cell po... | 04/03/2007 |
| 7189405 | Peptide mimics of conserved gonococcal epitopes and methods and compositions using them The present invention relates to peptide mimics of a conserved gonococcal epitope of Neisseria gonorrhoeae, which epitope is not found on human blood group antigens. This invention also relates to methods and compositions using such peptide mimics for the pro... | 03/13/2007 |
| 7147850 | Therapeutic binding agents against MUC-1 antigen and methods for their use The invention provides therapeutic compositions comprising binding agents that specifically bind to tumor-associated MUC-1 and reduce, reverse or prevent their effects in cancer. More particularly, the invention provides therapeutic compositions that comprise a bind... | 12/12/2006 |
| 7118744 | Immunogenic compositions for induction of anti-tumor immunity The invention relates to the use of an immunogen selected from the group consisting of (i) an anti-p53 mAb; (ii) a fragment of an anti-p53 mAb; (iii) a peptide based on a CDR of the heavy or light ... | 10/10/2006 |
| 7115715 | Anti-idiotype antibodies to MN proteins and MN polypeptides Herein disclosed is a novel oncogene named MN or alternatively MN/CA IX. Abnormal expression of the MN gene is shown to signify oncogenesis, and diagnostic/prognostic methods for pre-neoplastic/neoplastic disease to detect or detect and quantitate such abnormal MN g... | 10/03/2006 |
| 7105171 | Porin B (PorB) as a therapeutic target for prevention and treatment of infection by The present invention features peptides of a PorB polypeptide, which PorB peptides are useful in production of antibodies that bind the full-length PorB polypeptide and as a therapeutic agent. In specific embodiments the invention features a composition comprising o... | 09/12/2006 |
| 7090842 | Murine monoclonal anti-idiotype antibody 3H1 sequences for human carcinoembryonic antigen This invention provides compositions derived from the sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 3H1 and methods for using these compositions. ... | 08/15/2006 |
| 7083943 | Polynucleotides related to murine anti-idiotype antibody 11D10 and methods of use thereof The present invention provides a monoclonal and-idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D1... | 08/01/2006 |
| 7074613 | Monoclonal antibody directed against cells of human renal cell carcinoma The invention concerns a hybridome called 5C5 (CNCM no I-2184) and the monoclonal antibody 5C5 which it produces. Said monoclonal antibody which specifically recognises most human renal cell carcinomas, is developed for diagnosing, imaging and treating human renal c... | 07/11/2006 |
| 7053202 | Immunoglobulin DNA cassette molecules, monobody constructs, methods of production, and methods of use therefor Featured are DNA molecules, expression vectors, and host cells useful for creation of immunoglobulins, as well as novel immunoglobulin molecules termed monobodies. Additionally provided are methods of production of immunoglobulins, including monobodies, as well as m... | 05/30/2006 |
| 7053176 | Combination of C1-INH and lung surfactant for the treatment of respiratory disorders Pharmaceutical composition for the treatment of infant respiratory distress syndrome and acute lung injury (including adult respiratory distress syndrome) which contains C1 esterase inhibitor (C1-INH) and lung surfactant which comprises a lung surfactant protein. | 05/30/2006 |
| 7041288 | Anti-idiotypic antibodies against antibodies which inhibit the binding of immunoglobulin E to its high affinity receptors Antibodies and antibody fragments which are anti-idiotypic to an antibody that interferes with the binding of the Cε3 region of IgE to its high affinity receptor (mimobodies), particularly, which are anti-idiotypic to BSW17 (BSW17-mimobodies) are described, as well... | 05/09/2006 |
| 7026457 | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that upon lysing the transformed host cells to isolate the recombinantly ex... | 04/11/2006 |
| 7014847 | Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The method comprises suppressing or otherwise inhibiting t... | 03/21/2006 |
| 6951646 | Anti hepatitis C virus antibody and uses thereof Described are novel antibodies specifically recognizing conformation dependent epitopes of HCV glycoprotein E2 and that are capable aof neutralizing the binding of E2 protein onto susceptible cells. Furthermore, antigens and epitopes recognized by the above-describe... | 10/04/2005 |
| 6949244 | Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof The present invention provides a monoclonal anti-idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D... | 09/27/2005 |
| 6946256 | Cell regulatory genes, encoded products, and uses related thereto This application describes the cloning of p63, a gene at chromosome 3q27-29, that bears homology to the tumor suppressor p53. The p63 gene encodes at least six different isotypes. p63 was detected in a variety of human and mouse tissue and demonstrates remarkably di... | 09/20/2005 |
| 6932969 | Ig fractions having immunomodulatory activity The invention concerns a method for preparing Ig fractions from human polyvalent intravenous Immunoglobulins (IV Ig) which are in particular likely to be responsible for the immunomodulatory effect observed during the treatment of certain autoimmune diseases. The in... | 08/23/2005 |
| 6932968 | Erythropoietin (EPO) peptides and antibodies directed against these Erythropoietin (EPO) peptides and the use thereof for preparing epitope-specific anti-EPO antibodies are described. Also described are corresponding anti-EPO antibodies which take the form of polyclonal antibodies (antisera) or of monoclonal antibodies. These antibo... | 08/23/2005 |
