Bizarre Patents
A coffin, for allowing inclination for display of a deceased person in a natural position.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8187599 | Compositions and methods for suppressing fibrocytes The present invention relates to the ability of anti-FcγR antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety of applications including treatment and prevention of conditions res... | 05/29/2012 |
| 8188058 | Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4-associated disorders The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic sepsis and necrotizing enterocolitis. ... | 05/29/2012 |
| 8187596 | Method of treating asthma or allergy by administering an IL-33 receptor antibody Provided herein are methods of modulating IL-33 activity, e.g., for the purpose of treating immune diseases and conditions, as well as methods of screening for compounds capable antagonizing IL-33 signaling. ... | 05/29/2012 |
| 8187598 | Methods of treating cancer by administering antibodies to CD200 Methods and compositions for regulating immunity are disclosed. For enhancing an immune response, agents that inhibit OX-2 are administered. Such methods are useful in treating cancer. For suppressing an immune response, an OX-2 protein or a nucleic acid encoding an... | 05/29/2012 |
| 8187594 | Transferrin receptor antibodies The invention provides further characterization of the disease and cancer-associated antigen, transferrin receptor. The invention also provides a novel family of antibodies that bind to the transferrin receptor, methods of diagnosing and treating various human cance... | 05/29/2012 |
| 8187595 | Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor-I The present invention provides αVβ3 integrin cysteine loop domain agonists and antagonists (including peptide agonists and antagonists and analogs thereof), along with methods of using the same. ... | 05/29/2012 |
| 8187593 | FcγRIIB specific antibodies and methods of use thereof The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The present invention also enco... | 05/29/2012 |
| 8187597 | Combination therapy for the treatment of ocular neovascular disorders The invention features methods for treating a patient diagnosed with, or at risk of developing, a neovascular disorder by administering a PDGF antagonist and a VEGF antagonist to the patient. The invention also features a pharmaceutical composition containing a PDGF... | 05/29/2012 |
| 8182810 | IL-B30 antibodies Purified genes encoding cytokine referred to as interleukin-B30 (IL-B30) from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic ki... | 05/22/2012 |
| 8182811 | Antibodies to CXCL13 The present invention relates to binding members, especially antibody molecules, for CXCL13. The binding members are useful for the treatment of disorders associated with CXCL13, including arthritic disorders such as rheumatoid arthritis. ... | 05/22/2012 |
| 8182809 | Methods for treating cancer by inhibiting MIC shedding Described herein are compositions and methods for treating cancer, comprising administering to an individual having cancer an agent to prevent MIC shedding (initiated at the alpha-3 ectodomain of MIC) by a tumor cell. Also provided herein are screening assays for id... | 05/22/2012 |
| 8178093 | Method for treating infectious disease using monoclonal antibodies The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcγ receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing... | 05/15/2012 |
| 8178092 | Methods of treating psoriasis by administration of antibodies to the p40 subunit of IL-12 and/or IL-23 The invention provides a method of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23. ... | 05/15/2012 |
| 8178094 | Methods for inhibiting tumor growth or reducing metastatic burden in a subject by administering FDF03 antibodies The present invention relates to methods for identifying and using modulators of FDF03 biological activity in vitro and in vivo that are useful in the treatment of cancer. ... | 05/15/2012 |
| 8178091 | Compositions and methods for the treatment of respiratory disorders Methods and compositions are provided for the treatment of acute lung injury and pulmonary fibrosis by administering inhibitors of IGF-1R signaling activity. ... | 05/15/2012 |
| 8173125 | Wise/Sost nucleic acid sequences and amino acid sequences The present invention relates to nucleic acid sequences and amino acid sequences which influence bone deposition, the Wnt pathway, ocular development, tooth development, and may bind to LRP. The nucleic acid sequence and polypeptides include Wise and Sost as well as... | 05/08/2012 |
| 8173122 | Methods of treatment using antibodies to neutrokine-alpha The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the huma... | 05/08/2012 |
| 8173123 | Methods of treating colitis involving IL-13 and NK-T cells Method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity (FIG. 3). The invention also provides a method of treating or preventin... | 05/08/2012 |
| 8173124 | Method to treat using antagonistic anti-hTNFSF13b human antibodies Human monoclonal antibodies that specifically bind to TNFSF13b polypeptides are disclosed. These antibodies have high affinity for hTNFSF13b (e.g., KD=10−8 M or less), a slow off rate for TNFSF13b dissociation (e.g., Koff=10âˆ... | 05/08/2012 |
| 8168181 | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling; variants and derivatives of the polynucleotides and corresponding polypeptides; uses of the polynucleotides, polypeptides, variants an... | 05/01/2012 |
| 8168179 | Treatment method using anti-PD-L1 antibody Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of th... | 05/01/2012 |
| 8168180 | Methods and compositions for modulating angiogenesis Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue and for assessing the malignancy of colon cancer tumors. ... | 05/01/2012 |
| 8168182 | Method for treating erectile dysfunction A medicament based on antibodies contains an activated form of ultra-low doses of monoclonal, polyclonal, or natural antibodies to endothelial nitric oxide synthase (NO synthase), the activated form being prepared by multiple consecutive dilutions and exposure to ex... | 05/01/2012 |
| 8168178 | Methods and compositions for regulating lymphocyte activity The present application is directed to the discovery that hedgehog gene products, and signal transduction pathways involving hedgehog, are involved in maturation of T lymphocytes. The invention provides a method to promote T lymphocyte development using low dose Hed... | 05/01/2012 |
| 8163280 | Antibodies to c-Met The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and ant... | 04/24/2012 |
| 8163281 | Treatment of drug-related side effect and tissue damage by targeting the CD24-HMGB1-Siglec10 axis The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding pr... | 04/24/2012 |
| 8163279 | IL3Rα antibody conjugates and uses thereof The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3Rα) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3Rα-expressing cell population, the meth... | 04/24/2012 |
| 8158123 | Method of inhibiting an activity of a gene product in a bone cell encoded by a nucleotide sequence comprising SEQ ID NO: 50 The present invention features methods of treating a bone resorption disease or a bone generating disease, methods for prognosing and/or diagnosing a bone resorption disease or a bone generating disease, methods for identifying a compound that modulates bone resorpt... | 04/17/2012 |
| 8153121 | Diagnosis and therapy of antibody-mediated inflammatory autoimmune disorders The invention provides a method of reducing the severity of an autoimmune condition associated with T-lymphocyte infiltration. The invention also provides a method of diagnosing or predicting the susceptibility to an autoimmune disease associated with fibroblast med... | 04/10/2012 |
| 8153122 | Pharmaceutical composition for treating cholangiocarcinoma, a method for inhibiting growth or invasion of cholangiocarcinoma and a method for treating cholangiocarcinoma Disclosed herein are a pharmaceutical composition for inhibiting the growth or metastasis of cholangiocarcinoma, comprising a L1CAM activity inhibitor or expression suppressor and a treatment method using the composition. This is based on the finding that L1CAM is o... | 04/10/2012 |
| 8153123 | Method for restoring dendritic cell populations The present invention provides methods for restoring and increasing dendritic cell populations in a subject by modulation of the lymphotoxin-β receptor (LTβR) via LTβR agonists. The invention also provides methods for screening for agents capable of restoring or ... | 04/10/2012 |
| 8153124 | Method for treating cancer using monoclonal antibodies The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcγ receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing... | 04/10/2012 |
| 8147829 | Anti-IGR-1R antibodies and uses thereof The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and ... | 04/03/2012 |
| 8147830 | Antibody fragment-polymer conjugates and uses of same Described are conjugates formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugates exhibit substantially improved half-life, mean residence time, and/or clea... | 04/03/2012 |
| 8147831 | Anti-CD19 antibodies The present invention provides humanized, chimeric and human anti-CD19 antibodies, anti-CD19 antibody fusion proteins, and fragments thereof that bind to a human B cell marker. Such antibodies, fusion proteins and fragments thereof are useful for the treatment and d... | 04/03/2012 |
| 8147828 | Methods and compositions for modulation of blood-neural barrier Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular... | 04/03/2012 |
| 8147827 | Tumor treatment The invention concerns an improved method for treating tumor, including cancer, which combines the administration of a chemotherapeutic agent and an antagonist of a gene product the expression of which is upregulated by the chemotherapeutic agent. The invention furt... | 04/03/2012 |
| 8142778 | Methods of treatment using CTLA-4 antibodies The present invention provides method of treatment using human sequence antibodies against human CTLA-4 linked to a cytotoxic agent. In particular, methods of treating cancer and autoimmune disease are provided. ... | 03/27/2012 |
| 8142779 | Treatment of follicular lymphomas using inhibitors of the LT pathway Therapeutic uses of inhibitors of the lymphotoxin pathway to treat tumors, specifically to treat follicular lymphomas. ... | 03/27/2012 |
| 8142776 | Reduced-viscosity concentrated protein formulations The present application concerns concentrated protein formulations with reduced viscosity, which are particularly suitable for subcutaneous administration. The application further concerns a method for reducing the viscosity of concentrated protein formulations.... | 03/27/2012 |
