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| Number | Title | Issue Date |
| 7300662 | Drug/drug delivery systems for the prevention and treatment of vascular disease A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia f... | 11/27/2007 |
| 7261735 | Local drug delivery devices and methods for maintaining the drug coatings thereon Local drug delivery medical devices are utilized to deliver therapeutic dosages of drugs, agents or compounds directly to the site where needed. The local drug delivery medical devices utilize various materials and coating methodologies to maintain the drugs, agents... | 08/28/2007 |
| 7247299 | Antimicrobial compounds from for use against animal and human pathogens Antimicrobial compounds from Bacillus subtilis for use against animal and human pathogens. A novel strain of Bacillus subtilis was isolated from the gastrointestinal tract of poultry and was found to produce a factor or factors that have excellent inhi... | 07/24/2007 |
| 7229473 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 06/12/2007 |
| 7223286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/29/2007 |
| 7217286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/15/2007 |
| 7195640 | Coated medical devices for the treatment of vulnerable plaque Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of bioc... | 03/27/2007 |
| 7186826 | Phosphorus-containing compounds and uses thereof This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA— in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may... | 03/06/2007 |
| 7109018 | Transformant producing secondary metabolite modified with functional group and novel biosynthesis genes An objective of the present invention is to provide a transformant altered so as to produce a secondary metabolite in which a benzene ring of the secondary product is modified at the para-position with a functional group containing a nitrogen atom. A transformant ac... | 09/19/2006 |
| 7097972 | Method and composition for regulating apoptosis This invention provides non-naturally occurring and isolated naturally occurring nucleic acid molecules which encode proteins designated pro-Yama, p11 Yama and p20 Yama. This invention also provides recombinant polynucleotides coding for these proteins. Also provide... | 08/29/2006 |
| 7026330 | Methods for treatment of acute lymphocytic leukemia Methods for treating patients having an early B cell derived acute lymphoblastic leukemia with rapamycin or a derivative thereof are provided. Also provided are methods for treating patients having an early B cell derived acute lymphoblastic leukemia with rapamycin ... | 04/11/2006 |
| 7025975 | Galenical formulations A pharmaceutical composition containing macrolide, e.g. a rapamycin compound in an emulsion preconcentrate or microemulsion preconcentrate for oral administration. The carrier medium for the rapamycin compound includes a hydrophilic phase, a lipophilic phase and a s... | 04/11/2006 |
| 6995134 | Use of yneS, essential bacterial genes and polypeptides Disclosed is a gene, termed “S-yneS,” found in Streptococcus pneumoniae, which is essential for survival for a wide range of bacteria. This gene and the S-yneS polypeptide that it encodes, as well as homologs and orthologs thereof (collectively referred t... | 02/07/2006 |
| 6855524 | Method for producing exopolysaccharides The invention concerns a method for producing exopolysaccharides by fermenting micro-organisms characterised in that it consists in carrying out the fermentation in a nutrient medium comprising at least a source of carbon available to the micro-organisms and at leas... | 02/15/2005 |
| 6509373 | Strain of streptomyces, and relevant uses thereof Disclosed is a new Streptomyces candidus strain, and relevant uses thereof.... | 01/21/2003 |
| 6423337 | Porous structure comprising fungi cell walls The present invention relates to a porous structure of prepared fungal cell wall components, whereby the cell wall material is derived from a fungi selected from the division Zygomycota, the fungal material in the form of a suspension is subjected to dryi... | 07/23/2002 |
| 6193964 | Strain of streptomyces, and relevant uses thereof Disclosed is a new Streptomyces candidus strain, and relevant uses thereof.... | 02/27/2001 |
| 5985325 | Rapamycin formulations for oral administration This invention provides rapamycin solid dosage unit which comprises a core and a sugar overcoat, said sugar overcoat comprising rapamycin, one or more sugars, and one or more binders.... | 11/16/1999 |
| 5674484 | Continuous cell line and vaccine against avian coccidia A non-lymphoid continuous cell line adapted for propagation of avian coccidia is provided. This cell line is useful for the production of vaccine antigens for prophylactic treatment of poultry, particularly in a vaccine for coccidia.... | 10/07/1997 |
| 5665728 | Method of treating hyperproliferative vascular disease This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of rapamycin alone or in combination with mycophenolic acid.... | 09/09/1997 |
| 5646160 | Method of treating hyperproliferative vascular disease with rapamycin and mycophenolic acid This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of rapamycin alone or in combination with mycophenolic acid.... | 07/08/1997 |
| 5641485 | Caledothricins used in the treatment mycotic diseases Physiologically active caledothricins A-I and their salts, which are useful for the treatment of mycotic diseases. Also strains belonging to the genus Pseudomonas capable of producing the caledothricins upon cultivation.... | 06/24/1997 |
| 5567676 | Glycopeptide antibiotics The present invention concerns new antiobiotic substances demoninated de-acyl antibiotics A40926, de-acyl antibiotic A 40926P and antibiotic A 40926 amino glucronyl aglycon, and the use of these substances in the treatment of infectious diseases involving... | 10/22/1996 |
| 5563146 | Method of treating hyperproliferative vascular disease This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of rapamycin alone or in combination with mycophenolic acid.... | 10/08/1996 |
| 5561138 | Method of treating anemia This invention provides a method of treating immune related anemia in a mammal which comprises administering rapamycin to said mammal orally, parenterally, intravascularly, intranasally, intrabronchially, transdermally, rectally.... | 10/01/1996 |
| 5516686 | Fungicidal antibiotic producing Streptomyces sp. NCIMB 40212 The Antibiotic Complex AB-023 and its components: Antibiotic AB-023a and ibiotic AB-023b are disclosed, which are obtained by the controlled aerobic culture of Streptomyces sp. NCIMB 40212 in an aqueous nutrient culture substrate. Antibiotics AB-023 disp... | 05/14/1996 |
| 5460814 | Fermentation broth and microorganisms which produce them The present invention relates to the compound A of the formula (A), the related compound B, carboxylic acid derived from acid anhydride group of these compounds and esters and salts thereof, microorganisms for producing the compounds, methods for producin... | 10/24/1995 |
| 5456910 | Antibiotic stalobacins Novel antibiotic stalobacins A to I having physico-chemical properties as shown in Tables 1 to 4 are provided, which are excellent antibiotics showing marked effects on Gram-positive bacteria.... | 10/10/1995 |
| 5455240 | Modulators of pneumococcal adhesion to cellular targets involving the platelet activating factor receptor, and uses thereof The present invention relates to compositions and methods for preventing pneumococcal infection. In particular, the invention relates to identification of the major reception for Streptococcus pneumoniae on activated human cells, and diagnostic and therap... | 10/03/1995 |
| 5451403 | A87689 compounds Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C1-6 -alkyl ether and C1-6 -alkanoyl ester derivatives and ... | 09/19/1995 |
| 5397570 | Antibiotics AB-023 and process for preparing them The Antibiotic Complex AB-023 and its components: Antibiotic AB-023a and ibiotic AB-023b are disclosed, which are obtained by the controlled aerobic culture of Streptomyces sp. NCIMB 40212 in an aqueous nutrient culture substrate. Antibiotics AB-023 disp... | 03/14/1995 |
| 5350579 | A87689 compounds employed as a phospholipase A2 (PLA2) inhibitor to treat inflammatory diseases Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C1-6 -alkyl ether and C1-6 -alkanoyl ester derivatives and ... | 09/27/1994 |
| 5346919 | Anti-bacterial substances and microorganisms which produce them The present invention relates to the compound A of the formula (A), the related compound B, carboxylic acid derived from acid anhydride group of these compounds and esters and salts thereof, microorganisms for producing the compounds, methods for producin... | 09/13/1994 |
| 5306496 | Antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3, process for producing the same, and use of the same Novel antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3 having antibacterial, antineoplastic, immunomodulation, and liver regeneration promoting activities are provided. NK374186A, NK374186B, NK374186B3 and NK374186C3 are obtained by culturing N... | 04/26/1994 |
| 5296597 | Amide derivatives of Partricin A & Partricin B The present invention is directed towards a series of secondary and tertiary amide derivatives of Partricin A & Partricin B attached at the C-18 carboxyl group. The compounds can be used in the treatment of hypercholesteremia and hyperlipemia conditions, ... | 03/22/1994 |
| 5288711 | Method of treating hyperproliferative vascular disease This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of a combination of rapamycin and heparin.... | 02/22/1994 |
| 5279829 | Fungicidal antibiotic from Streptomyces NCIMB 40212 An Antibiotic Complex AB-023 and its components: Antibiotic AB-023a and Abiotic AB-023b are disclosed, which are obtained by the controlled aerobic culture of Streptomyces sp. NCIMB 40212 in an aqueous nutrient culture substrate. Antibiotic AB-023 displa... | 01/18/1994 |
| 5278064 | Amycolatopsis mediterranei strains useful to prepare A87689 compounds Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C1-6 -alkyl ether and C1-6 -alkanoyl ester derivatives and ... | 01/11/1994 |
| 5275817 | Physiologically active kanglemycin C Novel physiologically active substance, kanglemycin C, having a molecular weight of 326 and is isolated from the fermentation broth of Nocardia mediterranei var. kanulensis 1747-64 which belongs to the genus Nocardia. Kanglemycin C has an immunosuppressiv... | 01/04/1994 |
| 5239064 | A59770 antibiotics A novel antibiotic complex, A59770, individual factors and derivatives thereof, are provided. The A59770 compounds are useful as pesticides, particularly as rodenticides. Further provided are methods for reducing a rodent population, rodenticidal composit... | 08/24/1993 |
