Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
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| Number | Title | Issue Date |
| 7981859 | Glycopeptide composition with improved antibiotic activity A glycopeptide composition with improved antibiotic activity is disclosed, along with a method of preparing such a composition and a pharmaceutical composition made therefrom. ... | 07/19/2011 |
| 7317001 | Use of ramoplanin to treat diseases associated with the use of antibiotics The invention features a method of treating or preventing a disease associated with the use of antibiotics in a patient in need thereof by administering to the patient ramoplanin in an amount and for a duration effective to treat said disease. The disease may be cau... | 01/08/2008 |
| 7235651 | Genes and proteins involved in the biosynthesis of lipopeptides Genes and proteins involved in the biosynthesis of lipopeptides by microorganisms, in particular the nucleic acids forming the biosynthetic locus for the A54145 lipopeptide from Streptomyces fradiae and the A54145-like lipopeptide from Streptomyces refuine... | 06/26/2007 |
| 7196059 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moi... | 03/27/2007 |
| 7165012 | Method and system for computer-assisted test construction performing specification matching during test item selection A method and system for constructing a test using a computer system that performs specification matching during the test creation process is disclosed. A test developer determines one or more test item databases from which to select test items. The test item databas... | 01/16/2007 |
| 7138487 | Extractive purification of lipopeptide antibiotics The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics, such as those having a cyclic peptide or cyclic depsipeptide core, in high yield and purity. In particular, there is provided a method of extract... | 11/21/2006 |
| 7125844 | Dabderivatives of lipopeptide antibiotics and methods of making and using the same The present invention provides Dab9 derivatives of amphomycin-type lipopeptide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing such compounds, and methods of using the compounds in... | 10/24/2006 |
| 7030082 | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith Pharmaceutical compositions that include a drug and/or drug-oligomer conjugate, a fatty acid component and a bile salt component, or a bile salt component without a fatty acid component are described. The drug can be covalently coupled to an oligomeric moiety. The f... | 04/18/2006 |
| 7011831 | Recombinant α-galactosidase A therapy for Fabry disease Fabry disease results from an X-linked deficiency in the enzyme α-galactosidase A. The present invention is directed to recombinant human α-galactosidase A and provides baculovirus expression vectors and recombinant virus that provide stable expression of extracel... | 03/14/2006 |
| 6995134 | Use of yneS, essential bacterial genes and polypeptides Disclosed is a gene, termed “S-yneS,” found in Streptococcus pneumoniae, which is essential for survival for a wide range of bacteria. This gene and the S-yneS polypeptide that it encodes, as well as homologs and orthologs thereof (collectively referred t... | 02/07/2006 |
| 6960564 | Echinocandin pharmaceutical formulations containing micelle-forming surfactants Pharmaceutical formulations are described comprising an echinocandin compound or echinocandin/carbohydrate complex and a pharmaceutically acceptable micelle-forming surfactant in a non-toxic aqueous solvent such that the solubilization of the echinocandin compound i... | 11/01/2005 |
| 6911318 | Bacterial transglycosylases: assays for monitoring the activity using Lipid II substrate analogs and methods for discovering new antibiotics This invention provides a direct method for monitoring bacterial transglycosylase activity using labeled substrates produced by chemo-enzymatic synthesis wherein the labels are selected to permit the detection of both polymeric and non-polymeric products simultaneou... | 06/28/2005 |
| 6391851 | Hydrochlorides of vancomycin antibiotics and process for producing the same Process for producing a hydrochloride of a vancomycin antibiotic, comprising subjecting an aqueous solution of a hydrochloride of a vancomycin antibiotic to a primary freezing at from -1° C. to -20° C. for a time sufficient to grow ice crystals, to form... | 05/21/2002 |
| 6322286 | Vibrating screed and method of making same A vibrating screed for processing a floor layer, more particularly a so-called vibrating beam, of the type including a vibrating board (2), a vibrating mechanism (3) cooperating with the vibrating board, and a handle (4) whereby the vibrating mechanism co... | 11/27/2001 |
| 6187800 | Method for the prevention and treatment of mastitis A method for treating or preventing mastitis in mammals is disclosed. The method contemplates the intramammary injection or dipping the teat with micrococcin antibiotics, preferably micrococcin P1 or P2, which do not interfere with the production of chees... | 02/13/2001 |
| 6103231 | Antibiotic stalobacins Novel antibiotic stalobacins H-1 and I-1 having physico-chemical properties as shown in Table 4 are provided, which are excellent antibiotics showing marked effects on Gram-positive bacteria.... | 08/15/2000 |
| 5736510 | Antibiotics 10381v, w, x,y, z1, z2, pre-b and t Antibiotics 10381v, w, x, y, z1, z2, pre-b and t are antibiotics producible by culturing the microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. The structure of Antibiotic 10381y is given below as formula IV. These antibioti... | 04/07/1998 |
| 5567676 | Glycopeptide antibiotics The present invention concerns new antiobiotic substances demoninated de-acyl antibiotics A40926, de-acyl antibiotic A 40926P and antibiotic A 40926 amino glucronyl aglycon, and the use of these substances in the treatment of infectious diseases involving... | 10/22/1996 |
| 5514662 | Use of amphotericin B derivatives as protease inhibitors The invention is directed toward the use of amphotericin B and derivatives thereof as inhibitors of serine-proteases and for applying these inhibitors for the production of medicinal products intended for the treatment of infection by the human immunodefi... | 05/07/1996 |
| 5466450 | Antiviral antibiotic BU-4224V A novel antibiotic complex designated BU-4224V produced by fermentation of Kibdelosporangium albatum sp. nov. Strain R761-7. The complex may be separated chromatographically into bioactive components designated BU-4224V A, B1, B2, an... | 11/14/1995 |
| 5446022 | WF11243 substance The present invention relates to a novel polypeptide having the following presumed structure: ##STR1## and the compound has both excellent fungicidal and protozoicidal effects.... | 08/29/1995 |
| 5364624 | WS7622A mono- or di-sulfate, process for preparation thereof and use thereof A degenerative disease selected from the group consisting of cystic fibrosis, chronic bronchitis and bronchiectasia is treated by administering to a subject a therapeutically effective amount of WS7622A mono-or disulfate or pharmaceutically acceptable sal... | 11/15/1994 |
| 5292510 | WS7622A mono- or di- sulfate, process for preparation thereof and use thereof WS7622A mono- or di-sulfate and pharmaceutically acceptable salts thereof. WS7622A exhibits human leukocyte elastase-inhibiting activity.... | 03/08/1994 |
| 5256646 | Antiviral antibiotic BU-4224V A novel antibiotic complex designated BU-4224V produced by fermentation of Kibdelosporangium albatum sp. nov. Strain R761-7. The complex may be separated chromatographically into bioactive components designated BU-4224V A, B1, B2, an... | 10/26/1993 |
| 5239064 | A59770 antibiotics A novel antibiotic complex, A59770, individual factors and derivatives thereof, are provided. The A59770 compounds are useful as pesticides, particularly as rodenticides. Further provided are methods for reducing a rodent population, rodenticidal composit... | 08/24/1993 |
| 5229362 | Antibiotic A10255 complex and factors, and process and production therefor Newly-discovered antibiotic A10255 factors B, C, E, F, G, H, and J are produced by submerged aerobic fermentation of Streptomyces gardneri NRRL 15537 and NRRL 18260 or an A10255-producing variant or mutant thereof. The antibiotics are active against a wid... | 07/20/1993 |
| 5213797 | A80407 antibiotics New glycopeptide antibiotic A80407, comprising A80407A and A80407B, is produced by Kibdelosporangium philippinensis strains NRRL 18198, and NRRL 18199 or A80407-producing mutants of these strains. The A80407 antibiotics have excellent activity against Gra... | 05/25/1993 |
| 5192742 | Compounds and compositions for the treatment of bacterial infections in animals New glycopeptide antibiotics MM 49728, MM 55266, MM 55267/1, MM 55267/2 and MM 55268 are produced by fermentation of Amycolatopsis sp. NCIB 40089.... | 03/09/1993 |
| 5171740 | Coumamidine compounds A mixture of new coumamidine compounds are produced by a microorganism, belonging to the genus Saccharopolyspora. The compounds have antibiotic activity against a broad spectrum of bacteria.... | 12/15/1992 |
| 5167958 | WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use for treatment of pulmonary emphysema and adult respiratory distress syndrome A method of treating pulmonary emphysema or adult respiratory distress syndrome in a subject in need thereof which comprises administering to the subject an effective amount of WS7622A, B, C and/or D, derivatives thereof, or their pharmaceutically accepta... | 12/01/1992 |
| 5165931 | Peptifluorin and neopeptifluorin Two related, novel antibiotic substances, peptifluorin and neopeptifluorin, are prepared by cultivation of strains of Pseudomonas fluorescens, A. T. C. C. No. 53,958 and A. T. C. C. No. 55,129, respectively.... | 11/24/1992 |
| 5132112 | HS-142-1 compounds Compounds comprising a linear 댡.fwdarw.6 glucan esterified by caproic acid, the number of D-glucose residues being from 7 to 40 and the number of caproic acid residues being from 2 to 30, may be be obtained by fermentation of a microorganism of the... | 07/21/1992 |
| 5021240 | WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use thereof The present invention relates to new WS7622A, B, C and/or D substances, derivatives thereof and pharmaceutical compositions containing the new substances as active ingredients.... | 06/04/1991 |
| 5013550 | Antibiotics called "chloropolysporins B and C", a process for their preparation, and their therapeutic and veterinary use Novel compounds, called chloropolysporins B and C, and salts thereof have antibiotic properties and would appear to be members of the class of glycopeptide antibiotics containing chlorine. They may be produced by cultivating a suitable strain of microorga... | 05/07/1991 |
| 4999196 | Compound DC-107 produced by Streptomyces sp. A novel compound, DC-107, is produced by culturing a microorganism belonging to the genus Streptomyces. It is useful as a medicine because of its antibacterial and anti-tumor activity.... | 03/12/1991 |
| 4994270 | A54145 antibiotics and process for their production New peptide antibiotic A54145, individual A54145 components A, A1, B, B1, C, D, E and F and their pharmaceutically acceptable salts, are useful antibacterial agents which also improve growth performance in animals, especially poultry... | 02/19/1991 |
| 4956180 | AB-006 antibiotics and process for their production AB-006 Antibiotics and their AB-006 and AB-006b Antibiotic components, obtained by controlled aerobic culture of Streptomyces s.p. NCIB 12425, in an aqueous nutrient culture is disclosed. The AB-006 Antibiotics show biological activity, and in particular ... | 09/11/1990 |
| 4940586 | Skin permeation enhancer compositions using sucrose esters A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predomi... | 07/10/1990 |
| 4935238 | Antibiotic A 40926 complex and its pure factors PA, PB, A, B and B0 The present invention concerns a new antibiotic substance arbitrarily denominated antibiotic A 40926 complex and its factors antibiotic A 40926 factor A, antibiotic A 40926 factor B, antibiotic A 40926 factor B0, antibiotic A 40926 factor PA an... | 06/19/1990 |
| 4918054 | Antibiotics called `chloropolysporins B and C`, a process for their preparation, and their therapeutic and veterinary use Novel compounds, called chloropolysporins B and C, and salts thereof have antibiotic properties and would appear to be members of the class of glycopeptide antibiotics containing chlorine. They may be produced by cultivating a suitable strain of miroorgan... | 04/17/1990 |
