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| Number | Title | Issue Date |
| 7348318 | α-Amino-N-(diaminophosphinyl)lactam derivatives There are disclosed a novel α-amino-N-(diaminophosphinyl)lactam derivative represented by general formula (1): wherein, for example, A is a hydrogen atom or a substituent such as a lower alkyl group or the like; W, X, Y an... | 03/25/2008 |
| 7247640 | Medicament for treatment of bone marrow suppression, for treatment of infectious diseases and for increasing the number of leukocytes A medicament for prophylaxis or treatment of bone marrow suppression, for treatment of infectious diseases and for increasing the number of leukocytes, which comprise as an active ingredient a sulphostin-related compound represented by general formula (I): | 07/24/2007 |
| 7121227 | Methods for raising pre-adult anadromous fish The invention relates to methods, compositions and kits for improving the raising of pre-adult anadromous fish, or preparing pre-adult anadromous fish for transfer to seawater. The methods involve adding at least one Polyvalent Cation Sensing Receptor (PVCR) modulat... | 10/17/2006 |
| 7011826 | Control of acidosis The present invention relates to a vaccine for the prevention of lactic acidosis in a vertebrate, said vaccine comprising at least one isolated microorganism, or fragment or fragments thereof, wherein said microorganism is capable of producing lactic acid within the... | 03/14/2006 |
| 6974832 | L-ascorbic acid and pectin composition The invention relates to compositions in the form of a powder or granules containing L-ascorbic acid and/or a pharmaceutically acceptable salt thereof, and pectin in a quantity within the range of about 0.1 to about 10% by weight. ... | 12/13/2005 |
| 6914045 | Glycopeptide antibiotics The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 ... | 07/05/2005 |
| 6844182 | Mutants which produce a potentiator of bacillus pesticidal activity This invention is directed to Bacillus mutants which produce a factor which potentiates the pesticidal activity of a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties. ... | 01/18/2005 |
| 6224864 | Antibiotic 10381A, and process for the preparation of anitbiotics 10381B Antibiotic 10381a1, wherein R is hydrogen, is a cytosine-containing antibiotic producible by culturing the novel microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. Derivatives wherein R is a C1 to C | 05/01/2001 |
| 6214340 | Physiologically active substance sulphostin, process for producing the same, and use thereof This invention provides a physiologically active substance having a strong dipeptidyl peptidase IV inhibitory activity. The physiologically active substance sulphostin is obtained by culturing a microorganism belonging to the genus Streptomyces and having... | 04/10/2001 |
| 5985274 | Antibiotic 10381A1 and process for the preparation of antibiotics 10381B Antibiotic 10381a1, wherein R is hydrogen, is a cytosine-containing antibiotic producible by culturing the novel microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. Derivatives wherein R is a C1 to C | 11/16/1999 |
| 5981234 | Use of antibiotics 10381b to promote growth Antibiotic 10381a1, wherein R is hydrogen, is a cytosine-containing antibiotic producible by culturing the novel microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. Derivatives wherein R is a C1 to C | 11/09/1999 |
| 5948405 | Fucans with low molecular weight having anticoagulant, antithrombinic and antithromobic activity Fucans with low molecular weight having anticoagulant, antithrombinic and antithrombotic activity. Fucan sulfates having molecular weight between 14000 and 29000 Dalton show a remarkable anticoagulant activity both in the global coagulation mechanism (APT... | 09/07/1999 |
| 5877147 | Compounds for medicinal use Muramyl peptide compounds are useful in the prophylaxis of cancers and particularly in the treatment of precancerous lesions associated with cancers of the mucosa or epithelium.... | 03/02/1999 |
| 5843890 | Antibiotic GE 2270 factors B1, B2, C1, C2, D1, D2, E and T The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors B1, B2, C1, C2, D1, D2, E and T, the addition salts thereof, the pharmaceutical composi... | 12/01/1998 |
| 5804186 | Nerve cell differentiation promoter A nerve cell differentiation promoter which comprises a physiologically active substance NK175203 or a pharmacologically acceptable salt thereof as an active ingredient is provided. It is expected that the nerve cell differentiation promoter of the presen... | 09/08/1998 |
| 5736510 | Antibiotics 10381v, w, x,y, z1, z2, pre-b and t Antibiotics 10381v, w, x, y, z1, z2, pre-b and t are antibiotics producible by culturing the microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. The structure of Antibiotic 10381y is given below as formula IV. These antibioti... | 04/07/1998 |
| 5695984 | Process for the preparation of antibiotics 10381B Antibiotic 10381a1, wherein R is hydrogen, is a cytosine-containing antibiotic producible by culturing the novel microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. Derivatives wherein R is a C1 to C | 12/09/1997 |
| 5567676 | Glycopeptide antibiotics The present invention concerns new antiobiotic substances demoninated de-acyl antibiotics A40926, de-acyl antibiotic A 40926P and antibiotic A 40926 amino glucronyl aglycon, and the use of these substances in the treatment of infectious diseases involving... | 10/22/1996 |
| 5514649 | Antibiotic GE 2270 factors C2a The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270 factor C2a, the addition salts thereof, the pharmaceutical compositions thereof and its use as medicament, particularly in the treatment of infectiou... | 05/07/1996 |
| 5505944 | Physiologically active substance NK175203, process for production thereof and pharmaceutical use thereof Physiologically active substance NK175203 is produced by culturing bacteria belonging to the genus Streptomyces and capable of producing the physiologically active substance NK175203, and collecting the produced and accumulated substance. The physiologica... | 04/09/1996 |
| 5401709 | Antibiotic AB-041 derived from Streptomyces sp. NCIMB 40428, herbicidal compositions, and methods of use The antibiotic AB-041 is described, obtained by controlled aerobic cultivation of Streptomyces sp. NCIMB 40428 in an aqueous culture medium. The antibiotic AB-041 exhibits biological activity, and in particular herbicidal activity.... | 03/28/1995 |
| 5364624 | WS7622A mono- or di-sulfate, process for preparation thereof and use thereof A degenerative disease selected from the group consisting of cystic fibrosis, chronic bronchitis and bronchiectasia is treated by administering to a subject a therapeutically effective amount of WS7622A mono-or disulfate or pharmaceutically acceptable sal... | 11/15/1994 |
| 5306496 | Antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3, process for producing the same, and use of the same Novel antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3 having antibacterial, antineoplastic, immunomodulation, and liver regeneration promoting activities are provided. NK374186A, NK374186B, NK374186B3 and NK374186C3 are obtained by culturing N... | 04/26/1994 |
| 5292510 | WS7622A mono- or di- sulfate, process for preparation thereof and use thereof WS7622A mono- or di-sulfate and pharmaceutically acceptable salts thereof. WS7622A exhibits human leukocyte elastase-inhibiting activity.... | 03/08/1994 |
| 5279826 | Prophylactic/therapeutic composition for disseminated intravascular coagulation, chronic respiratory tract infectious disease or chronic bronchitis A method for therapy of disseminated intravascular coagulation, or chronic respiratory tract infectious disease characterized by administering to a patient in need thereof an effective dose suitable for therapeutic treatment of said condition of WS7622A m... | 01/18/1994 |
| 5229362 | Antibiotic A10255 complex and factors, and process and production therefor Newly-discovered antibiotic A10255 factors B, C, E, F, G, H, and J are produced by submerged aerobic fermentation of Streptomyces gardneri NRRL 15537 and NRRL 18260 or an A10255-producing variant or mutant thereof. The antibiotics are active against a wid... | 07/20/1993 |
| 5139778 | Antibiotic GE 2270 factors A1, A2, A3 and H The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors A1, A2, A3 and H, the additional salts thereof, the pharmaceutical compositions thereof and their use as medicaments, pa... | 08/18/1992 |
| 5124150 | Process for preparing antiviral antibiotic BU-3889V Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A1, A2, A3, D1, D2 and D3, by fermentation of a BU-3889V producing strain of the new microorganism Amyco... | 06/23/1992 |
| 5098708 | Antiviral antibiotic BU-3889V Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A1, A2, A3, D1, D2 and D3, by fermentation of a BU-3889V producing strain of the new microorganism Amyco... | 03/24/1992 |
| 5037651 | Dihydro derivatives of LL-E33288 antibiotics Dihydro derivatives of LL-E33288, BBM-1075 FR-900405, FR-900406, PD 114759, PD 115028, CL-1577A, CL-1577B, CL-1577D, CL-1577E and CL-1724 antibiotics/antitumor agents are disclosed and described, including the degradation product of LL-E33288 antibiotics/... | 08/06/1991 |
| 5013550 | Antibiotics called "chloropolysporins B and C", a process for their preparation, and their therapeutic and veterinary use Novel compounds, called chloropolysporins B and C, and salts thereof have antibiotic properties and would appear to be members of the class of glycopeptide antibiotics containing chlorine. They may be produced by cultivating a suitable strain of microorga... | 05/07/1991 |
| 4999196 | Compound DC-107 produced by Streptomyces sp. A novel compound, DC-107, is produced by culturing a microorganism belonging to the genus Streptomyces. It is useful as a medicine because of its antibacterial and anti-tumor activity.... | 03/12/1991 |
| 4950477 | Method of preventing and treating pulmonary infection by fungi using aerosolized polyenes This invention concerns a method of preventing a pulmonary infection by a fungus in a subject susceptible to infection by the fungus comprising administering to the subject an amount per dose in an aerosol spray of a polyene or a pharmaceutically acceptab... | 08/21/1990 |
| 4921700 | BBM-1675c and d antitumor antibiotics There is provided new antitumor antibiotic substances designated herein as BBM-1675C and BBM-1675D, said substances being produced by selective chemical hydrolysis of the bioactive components BBM-1675A1 (esperamicin A1) or BBM-1675A | 05/01/1990 |
| 4918054 | Antibiotics called `chloropolysporins B and C`, a process for their preparation, and their therapeutic and veterinary use Novel compounds, called chloropolysporins B and C, and salts thereof have antibiotic properties and would appear to be members of the class of glycopeptide antibiotics containing chlorine. They may be produced by cultivating a suitable strain of miroorgan... | 04/17/1990 |
| 4900815 | Sulfated polysaccharide DS4152 A sulfated polysaccharide DS4152 useful as an angiogenesis inhibitor or antitumor agent is provided selectively. As the sodium salt, it has the following physicochemical characteristics. Molecular weight by the gel filtration method: 29,000&#b1;3,000. Ele... | 02/13/1990 |
| 4885170 | Antibiotic A80509 New antibiotic A80509, its C1 -C7 -alkyl ester derivatives and salts are useful antibacterial and anticoccidial agents and improve feed efficiency and growth in animals. Methods of making A80509 by fermentation of, and a biologically... | 12/05/1989 |
| 4806529 | Tetracycline activity enhancement Methods and products for overcoming bacterial resistance to tetracycline-type antibiotics by inhibiting the plasmid-mediated active efflux system for tetracycline in the resistant bacterial cell by administering with tetracycline efflux system blocking ag... | 02/21/1989 |
| 4785078 | Transformation product of thiosporamicin A new sulfur-containing polypeptide antibiotic produced by the hydrolysis of thiosporamicin (CP-46,192) is useful for the improving feed utilization efficiency in poultry and swine.... | 11/15/1988 |
| 4752469 | Potentiators of beta-lactam antibiotics Cultivation of the microorganism Chromobacterium violaceum A.T.C.C. No. 31532 yields two novel compounds which have been designated SQ 28,504 and SQ 28,546 in addition to EM5117, a previously disclosed antibacterial compound.... | 06/21/1988 |
