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| Number | Title | Issue Date |
| 7658910 | Preparation of radiolabelled haloaromatics via polymer-bound intermediates According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate precursor insoluble polymer compounds used in the preparation of the radiola... | 02/09/2010 |
| 7438891 | Imaging agents for early detection and monitoring of cardiovascular plaque The present invention relates in part to a method of imaging cardiovascular plaque formation in a mammal comprising administering to the mammal an effective amount of 18F-2-fluorodeoxy-D-glucose and then detecting the 18F-2-fluorodeoxy-D-glucos... | 10/21/2008 |
| 7427389 | Diagnostic agents for positron emission imaging using radiolabeled halogenated xanthenes New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene deri... | 09/23/2008 |
| 7427390 | Radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous properties, in particular with re... | 09/23/2008 |
| 7413727 | Contrast agents The invention provides a composition of matter of the formula (I): V-L-R, where V is a vector moiety having affinity for an angiogenesis-related endothelias cell receptor, L is a linker moiety or a bond and R is a detectable moiety, characterised in that V is a non-... | 08/19/2008 |
| 7402299 | Intracorporeal medicaments for photodynamic treatment of disease New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthe... | 07/22/2008 |
| 7390668 | Intracorporeal medicaments for photodynamic treatment of disease New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthe... | 06/24/2008 |
| 7384623 | High energy phototherapeutic agents High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive structures in diseased tissue, and methods of treating and imaging using ... | 06/10/2008 |
| 7381400 | Injection of a radioactive dye for sentinel lymph node identification A one-step procedure for sentinel lymph node identification and biopsy using a single compound, a radiolabeled, low molecular weight dye (e.g., 125I-labeled methylene blue). This radiolabled dye is mixed with an unlabeled, similar molecular weight dye (e.... | 06/03/2008 |
| 7378079 | Agents for imaging and diagnostic methods using them The present invention provides novel compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their plasma membrane, while binding to a lesser degree to cells having membranes of normal organization, and their u... | 05/27/2008 |
| 7351398 | Stabilization of radiopharmaceutical compositions using hydrophilic thioethers Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic thioether. ... | 04/01/2008 |
| 7351401 | Thioflavin derivatives for use in the antemortem diagnosis of Alzheimers disease and in vivo imaging and prevention of amyloid deposition This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds.... | 04/01/2008 |
| 7351397 | Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy chromans Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic 6-hydroxy-chroman derivative. ... | 04/01/2008 |
| 7341709 | Compositions for labeling β-amyloid plaques and neurofibrillary tangles Compositions useful for labeling β-amyloid plaques and neurofibrillary tangles are provided. The compositions comprises compounds of formula (I): wherein R1 is selected from the group consisting of —C(O)-alkyl... | 03/11/2008 |
| 7338652 | Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene deri... | 03/04/2008 |
| 7335347 | Methods for purifying radiolabelled compounds One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a fluoroalkyl tin moiety; b) reacting the radiolabelled compound precursor with a... | 02/26/2008 |
| 7335652 | Neurofibrillary labels Disclosed are methods for determining the stage of neurofibrillary degeneration associated with a tauopathy in a subject believed to suffer from the disease, by (i) introducing into the subject a ligand capable of labeling aggregated paired helical filament (PHF) ta... | 02/26/2008 |
| 7329401 | Cyclooxygenase-2 selective agents useful as imaging probes and related methods This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2 selective agents inhibit cyclooxygenase-2 activity with greater poten... | 02/12/2008 |
| 7326403 | Radioactive iodine-labeled compound A radioactive iodine-labeled compound represented by the following formula (I): wherein X represents a radioactive iodine atom which may substitute at an arbitrary position on the benzene ring (preferably 12... | 02/05/2008 |
| 7314609 | Stereoisomers of fatty acid analogs for diagnostic imaging The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a fatty acid analog. The invention also provides methods for using the nov... | 01/01/2008 |
| 7312461 | Laparoscopic tumor therapy using high energy electron irradiation A laparoscopic tumor therapy method and an articulated electron beam transport system are provided for use with a high power, long focus electron source for tumor therapy. The high power, long focus electron source generates an e-beam. The e-beam is transported thro... | 12/25/2007 |
| 7304090 | Inhibition of the cystic fibrosis transmembrane conductance regulator chloride channel Fluorescein and derivatives have use in the treatment of a disease of a living animal body, including human, which disease is responsive to the inhibition of the cystic fibrosis transmembrane conductance regulator chloride channels, for instance polycystic kidney di... | 12/04/2007 |
| 7297325 | Hydrophilic light absorbing compositions for determination of physiological function Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for opti... | 11/20/2007 |
| 7291737 | Cocaine receptor binding ligands A class of binding ligands for cocaine receptors and other receptors in the brain. Specifically, a novel family of compounds shows high binding specificity and activity, and, in a radiolabeled form, can be used to bind to these receptors, for biochemical assays and ... | 11/06/2007 |
| 7273601 | Preparation of radiolabelled haloaromatics via polymer-bound intermediates According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate precursor insoluble polymer compounds used in the preparation of the radiola... | 09/25/2007 |
| 7270800 | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds.... | 09/18/2007 |
| 7264790 | 1,3-glyceride compound having two iodophenyl groups A compound represented by the following general formula (I) or a salt thereof: wherein Ar1 and Ar2 independently represent a substituted or unsubstituted aryl group having at least one iodin... | 09/04/2007 |
| 7250525 | Stilbene derivatives and their use for binding and imaging amyloid plaques This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregat... | 07/31/2007 |
| 7223519 | Imaging compositions and methods Imaging compositions and methods of using the compositions are disclosed. The imaging compositions are sensitive to low levels of energy such that upon application of the low levels of energy the compositions change color or shade. The compositions may be applied to... | 05/29/2007 |
| 7220730 | Cancer specific radiolabeled conjugates regulated by the cell cycle for the treatment and diagnosis of cancer Radiolabeled conjugates are disclosed which have a component that is effective to target tumor cells, which cells selectively take up and degrade the conjugate, thereby delivering to the tumor cell nucleus a radioisotope capable of being incorporated into the nuclea... | 05/22/2007 |
| 7217733 | ACE inhibitor derivatives ACE inhibitor nitroderivatives of formula (I): A—(X1—ONO2)s (I) having wider pharmacological activity and enhanced tolerability. They can be employed for treating cardiovascular and renal diseases and in... | 05/15/2007 |
| 7214686 | Pharmaceutical compositions and methods for effecting dopamine release Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attent... | 05/08/2007 |
| 7199132 | Tropane analogs and methods for inhibition of monoamine transport New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7-hydroxyl or ketone substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Ce... | 04/03/2007 |
| 7195751 | Compositions and kits pertaining to analyte determination This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce... | 03/27/2007 |
| 7194360 | Method of determining radioactive nuclides A method of simply and quickly determining α-ray releasing nuclides having long half-life without carrying out a chemical separation is provided. By inputting a data of pulses incident to an α-ray detector in a computer, obtaining time distribution of the i... | 03/20/2007 |
| 7189737 | Cocaine receptor binding ligands A class of binding ligands for cocaine receptors and other receptors in the brain. Specifically, a novel family of compounds shows high binding specificity and activity, and, in a radiolabeled form, can be used to bind to these receptors, for biochemical assays and ... | 03/13/2007 |
| 7182934 | Contrast agents The invention provides a composition of matter of formula I V-L-R (I) where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging o... | 02/27/2007 |
| 7172749 | Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharm... | 02/06/2007 |
| 7169377 | Radioligands for the TRP-M8 receptor and methods therewith One embodiment of the invention is a composition that comprises a radioactive [18F], [123I], [125I], or [131I]-N-radiohaloaryl-alkylcarboxamide molecule. The composition binds to the transient receptor potential-M8 (TRP-M8... | 01/30/2007 |
| 7166719 | Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy Provided herein are compounds for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In particular, photosensitizer compounds that collect in hyperproliferativ... | 01/23/2007 |
