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| Number | Title | Issue Date |
| 8187571 | Pharmaceutical composition of nanoparticles The invention discloses a pharmaceutical composition of nanoparticles, wherein each nanoparticle comprises N-palmitoyl chitosan that is conjugated with at least two different moieties, the moieties including a donor moiety and an acceptor moiety having a distance of... | 05/29/2012 |
| 8168159 | Compounds for tumor diagnosis and therapy The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is produced within a specific site (e.g., tumor) at concentrations that ar... | 05/01/2012 |
| 8105568 | Vitamin receptor binding drug delivery conjugates The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins... | 01/31/2012 |
| 8097238 | Cell targeting conjugates The present invention relates to cell targeting conjugates and in particular, but not exclusively, to methods of their use in selectively eliminating and in selectively imaging target cells. The invention also relates to processes for production of the conjugates an... | 01/17/2012 |
| 8038985 | Pharmaceutical composition of nanoparticles The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeabi... | 10/18/2011 |
| 7906103 | Methods and compositions for targeted drug delivery Disclosed are Drug Delivery Molecules (DDMs) which both facilitate functional imaging, as by PET, MRI or SPECT, and create a biological effect and methods of their use. These DDMs which are variously designed to target specific receptors, internalized and then funct... | 03/15/2011 |
| 7601332 | Vitamin receptor binding drug delivery conjugates The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins... | 10/13/2009 |
| 7591995 | Cobalamin conjugates useful as imaging and therapeutic agents The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis. ... | 09/22/2009 |
| 7541020 | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 car... | 06/02/2009 |
| 7531162 | Transcobalamin receptor binding conjugates useful for treating abnormal cellular proliferation An agent, composition and method for the treatment, prophylaxis and/or diagnosis of proliferative disorders, which is highly and efficiently absorbed at the site of abnormal cellular proliferation is disclosed. ... | 05/12/2009 |
| 7498017 | Compositions for delivering nucleic acids to cells Cyclic amidinium containing compounds and their methods of preparation are described. Compositions containing these compounds facilitate delivery of biologically active polymers to cells in vitro and in vivo. ... | 03/03/2009 |
| 7462345 | Radionuclide labeling of vitamin Band coenzymes thereof A compound useful for in vivo imaging of organs and tumors is provided of formula: wherein is a cobalamin, is derived from a corrin car... | 12/09/2008 |
| 7438891 | Imaging agents for early detection and monitoring of cardiovascular plaque The present invention relates in part to a method of imaging cardiovascular plaque formation in a mammal comprising administering to the mammal an effective amount of 18F-2-fluorodeoxy-D-glucose and then detecting the 18F-2-fluorodeoxy-D-glucos... | 10/21/2008 |
| 7427391 | Formulations for use in medical and diagnostic procedures The present invention relates to formulations for use in medical or diagnostic procedures comprising a stabilizing agent alone or in combination with an osmotic agent. In one embodiment, the stabilizing agent is a natural hydrocolloid, preferably locust bean gum, an... | 09/23/2008 |
| 7407645 | Bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands The present invention is directed to bioconjugates of complexes represented by the formula: wherein R, R′, R1, R′1, R2, R′2, R3, R′3, R4, ... | 08/05/2008 |
| 7404489 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cy... | 07/29/2008 |
| 7399460 | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the α, γ, or bis isomers of folate receptor-binding analogs of folate, a me... | 07/15/2008 |
| 7351399 | Prodrugs for phosphorus-containing compounds Prodrugs of formula I, their uses, their intermediates, and their method of manufacture are described: and pharmaceutically acceptable prodrugs and salts thereof. ... | 04/01/2008 |
| 7344701 | Xanthene dyes The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like. Also provided are conjugates of the dyes, methods of preparing and usi... | 03/18/2008 |
| 7338940 | Cancer treatment including glycolytic inhibitors Glycolytic inhibitors are useful in the treatment of solid tumors by attacking anaerobic cells at the center on the tumor. 2-deoxyglucose, oxamate and various analogs thereof are identified as having a natural selective toxicity toward anaerobic cells, and will sign... | 03/04/2008 |
| 7335347 | Methods for purifying radiolabelled compounds One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a fluoroalkyl tin moiety; b) reacting the radiolabelled compound precursor with a... | 02/26/2008 |
| 7332181 | Composition for managing diabetes, obesity, and hyperlipidemia and associated methods A nutritional supplement includes a first formulation including minerals: chromium polynicotinate, magnesium glycinate, manganese sulfate, selenium, vanadyl sulfate, zinc gluconate, copper gluconate, iodine, and boron; and vitamins: vitamins C, B1, B2, B3, B6, and B... | 02/19/2008 |
| RE40059 | Sensitive substance encapsulation A process for stabilizing a sensitive substance; (a) plating a sensitive substance onto a solid carrier under a controlled atmosphere to reduce loss of the sensitive substance; (b) encapsulating the plated material under controlled atmosphere and airflow to reduce v... | 02/12/2008 |
| 7314609 | Stereoisomers of fatty acid analogs for diagnostic imaging The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a fatty acid analog. The invention also provides methods for using the nov... | 01/01/2008 |
| 7291606 | Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging. ... | 11/06/2007 |
| 7282194 | Nanoparticles for protein drug delivery The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery. ... | 10/16/2007 |
| 7272766 | Method of making tissue simulating analog materials and models made from same Disclosed herein are synthetic anatomical models, and methods of making and using same, that are designed to enable simulated use testing by medical device companies, medical device designers, individual inventors, or any other entity interested in the performance o... | 09/18/2007 |
| 7262020 | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol The invention relates to techniques for measuring and comparing relative molecular flux rates of different biological molecules by administering isotope-labeled water to one or more tissues or individuals and comparing the molecular flux rates of two or more biologi... | 08/28/2007 |
| 7238677 | Prevention of urogenital infections The invention provides hyaluronic acid compounds and derivatives thereof for preventing urogenital infections by a variety of pathogens, as well as compositions, articles and methods for treating and preventing urogenital infections. ... | 07/03/2007 |
| 7238338 | System and method for the large scale labeling of compounds with radiohalogens Disclosed are methods for manufacturing radiohalogen-labeled steroids, nucleosides, nucleotides and proteins, for example, pyrimidines and proteins. Methods according to the example embodiments specific to pyrimidines includes dissolving a halogenated pyrimidine to ... | 07/03/2007 |
| 7229636 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cy... | 06/12/2007 |
| 7220400 | Compositions for delivering nucleic acids to cells Cyclic amidinium containing compounds and their methods of preparation are described. Compositions containing these compounds facilitate delivery of biologically active polymers to cells in vitro and in vivo. ... | 05/22/2007 |
| 7220730 | Cancer specific radiolabeled conjugates regulated by the cell cycle for the treatment and diagnosis of cancer Radiolabeled conjugates are disclosed which have a component that is effective to target tumor cells, which cells selectively take up and degrade the conjugate, thereby delivering to the tumor cell nucleus a radioisotope capable of being incorporated into the nuclea... | 05/22/2007 |
| 7205385 | Polymerization method for the synthesis of polypeptide imaging agents A method for synthesizing extended poly(amino acids) conjugated to imaging agents, such as DTPA, is disclosed. The amino acid is initially conjugated to the imaging agent at the monomer stage, followed by formation of the corresponding N-carboxyanhydride. The method... | 04/17/2007 |
| 7194360 | Method of determining radioactive nuclides A method of simply and quickly determining α-ray releasing nuclides having long half-life without carrying out a chemical separation is provided. By inputting a data of pulses incident to an α-ray detector in a computer, obtaining time distribution of the i... | 03/20/2007 |
| 7186397 | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the α, γ, or bis isomers of folate receptor-binding analogs of folate, a me... | 03/06/2007 |
| 7179445 | Cobalamin conjugates useful as imaging and therapeutic agents The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis. ... | 02/20/2007 |
| 7176296 | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides The invention provides compounds having increased or reduced immunostimulatory effect, said compounds comprising a CpG dinucleotide and an immunomodulatory moiety wherein the increased or reduced immunomodulatory effect is relative to a similar compound lacking the ... | 02/13/2007 |
| 7160865 | Cancer treatment including glycolytic inhibitors Glycolytic inhibitors are useful in the treatment of solid tumors by attacking anaerobic cells at the center on the tumor. 2-deoxyglucose, oxamate and various analogs thereof are identified as having a natural selective toxicity toward anaerobic cells, and will sign... | 01/09/2007 |
| 7141233 | Radionuclide labeling of vitamin Band coenzymes thereof A compound useful for in vivo imaging of organs and tumors is provided of formula: wherein is a cobalamin, | 11/28/2006 |
