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| Number | Title | Issue Date |
| 7011812 | Targeted combination immunotherapy of cancer and infectious diseases The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities, and wherein the therapeutic agents are delivered to the tumor sites usi... | 03/14/2006 |
| 7011816 | Labeling targeting agents with gallium-68 and gallium-67 A method and compositions are described for labeling a targeting agent with Ga-68, in which eluate from an acid-eluted Ge-68/Ga-68 generator is combined with a macrocycle-containing targetable agent. The labeling method and compositions disclosed ensure that a simpl... | 03/14/2006 |
| 7011817 | Hydrophilic cyanine dyes Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds may be conjugated to bioactive peptides, carbohydrates, hor... | 03/14/2006 |
| 7005517 | Paramagnetic metal-phthalocyanine complex compounds and contrast agent using the same The present invention provides a novel paramagnetic metal-phthalocyanine complexes and pharmaceutically acceptable salts thereof, which are useful as contrast agents for MRI(Magnetic Resonance Imaging), diagnostic X-ray imaging and computed tomography(CT). Th... | 02/28/2006 |
| 6998423 | Prevention of loss and restoration of bone mass by certain prostaglandin agonists Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders includ... | 02/14/2006 |
| 6998105 | Low density radionuclide-containing particulate material The invention relates to a particulate material consisting of a low density radiation-tolerant glass and a radionuclide incorporated into the low density glass or coated on the low density glass, the glass having a density of less than 2.5 g/cm3, processe... | 02/14/2006 |
| 6998500 | Selective androgen receptor modulators and methods of use thereof This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and a... | 02/14/2006 |
| 6995247 | Ac-HEHA and related compounds, methods of synthesis and methods of use The present invention provides an α-particle-emitting radioisotope chelation complex comprising 225Actinium (225Ac) and 1,4,7,10,13,16-hexaazacyclohexadecane-N,N′,N′,N′,N′,N′-hexaacetic acid (HEHA) (225Ac-HEHA). Also provi... | 02/07/2006 |
| 6991775 | Peptide-based multimeric targeted contrast agents Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents. ... | 01/31/2006 |
| 6991777 | Methods for in vivo evaluation of physiological conditions and/or organ or system function including methods to evaluate cardiopulmonary disorders such as chronic heart failure using polarized 129 Xe In certain embodiments, methods of the present invention obtain NMR spectroscopy signal data that corresponds to the behavior of the polarized 129Xe at a selected site(s) in selected environments in vivo. The gas exchange signal data can be used to evalua... | 01/31/2006 |
| 6989139 | Matrix metalloproteinase inhibitors Thus the present invention describes novel compounds comprising 1-10 targeting moieties; a chelator (Ch); and 0-1 linking groups (Ln) between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the che... | 01/24/2006 |
| 6989140 | Methods for cancer imaging Methods are provided for cancer and pre-cancer detection by increased uptake of fluorophore glucose or deoxyglucose conjugates in cancerous and pre-cancerous cells relative to normal cells. ... | 01/24/2006 |
| 6989138 | Stabilization of radiopharmaceutical compositions using hydrophilic thioethers and hydrophilic 6-hydroxy chromans Radiopharmaceutical compositions which are stabilized by addition of a mixture of a hydrophilic thioether and a hydrophilic 6-hydroxy-chroman derivative. ... | 01/24/2006 |
| 6982324 | Degradable macromolecular magnetic resonance imaging contrast agents and methods thereof Novel degradable macromolecular magnetic resonance imaging contrast agents for use in various diagnostic procedures, and methods for synthesizing, using and degrading these agents, are disclosed. The macromolecule contrast agents disclosed in various aspects of this... | 01/03/2006 |
| 6979431 | Method for labelling technetium or rhenium using borohydride exchange resin A method for labelling a sulfide compound with technetium or rhenium, comprising the reaction of a disulfide compound with pertechnetate or perrhenate in the presence of borohydride exchange resin to obtain a complex of technetium or rhenium with the sulfide compoun... | 12/27/2005 |
| 6979436 | Opioid metallopeptide compositions and methods Metallopeptides and metallopeptide combinatorial libraries specific for opioids receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-... | 12/27/2005 |
| 6977068 | Method for detection of fibrin clots A method for the detection of fibrin in a source, in particular the in vivo detection of a fibrin in a patient, the method comprising supplying to the source or patient an amount of a detectable reagent comprising a plurality of discrete particles, each of the parti... | 12/20/2005 |
| 6974567 | Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque Detectably labeled macrophage scavenger receptor antagonists useful for the diagnosis and monitoring of various cardiovascular diseases including but not limited to atherosclerosis, vulnerable plaque, coronary artery disease, renal disease, thrombosis, transient isc... | 12/13/2005 |
| 6962686 | Cell-specific gene delivery vehicles A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous physiological agents, particularly paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a... | 11/08/2005 |
| 6962687 | Method and means for detecting inflammatory processes A method of detecting inflammatory processes comprises (a) administering per-orally or per-rectally a composition comprising a diagnostically effective amount of L-[guanido-15N2]-arginine, L-[guanido-15N]-arginine, their mixtures and... | 11/08/2005 |
| 6962689 | High viscosity embolizing compositions Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter deliver. ... | 11/08/2005 |
| 6962690 | Tissue specific fluorescent chelates possessing long wavelength UV excitation Fluorescent chelates of lanthanide, terbium, europium and dysprosium with tetraazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These chelates are tissue specific imaging agents for soft tissue cancers. | 11/08/2005 |
| 6962820 | Analyte detection system An analyte detection system utilizing a combination of fluorescent labels for labeling particles and an analyte specific fluorescent analyte detection dye. The particles contain a combination of fluorescent labels for coding the particles and an analyte specific flu... | 11/08/2005 |
| 6961607 | Method for assessing myocardial angiogenesis Polymeric contrast agents are used to monitor myocardial neovascularization. The agent is injected and images of the myocardium are obtained at various time intervals after injection. Localized image enhancement indicates an area of increased angiogenesis. ... | 11/01/2005 |
| 6958141 | Rhenium and technetium complexes containing a hypoxia-localizing moiety Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radion... | 10/25/2005 |
| 6958140 | Methods of imaging and targeting vasculature Methods for imaging and targeting tumor vasculature are provided. Specifically, the methods for imaging and targeting tumor vasculature relate to using ephrin-B2 to image developing tumor vasculature and to target therapeutic agents to developing tumor vasculature. ... | 10/25/2005 |
| 6953570 | Porphyrins with enhanced multi-photon absorption cross-sections for photodynamic therapy A method of increasing the multi-photon absorption cross-section of a porphyrin-based photosensitizer by attaching at least one TPA-chromophore at the meso- or beta-positions of a porphyrin structure of the porphyrin-based photosensitizer, and at least one intersyst... | 10/11/2005 |
| 6951640 | Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula which selectively accumulate in neoplastic tissue within the irradiation volume and t... | 10/04/2005 |
| 6951639 | 1,4,7,10-tetraazacyclododecane butyltriols, processes for their production and pharmaceutical agents containing them 1,4,7,10-Tetraazacyclodedecane butyltriols of general formula IA in which R1 means hydrogen or a metal ion equivalent independent of one another and ... | 10/04/2005 |
| 6949347 | Multiplex analysis using membrane-bound sensitizers The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tag... | 09/27/2005 |
| 6946116 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregat... | 09/20/2005 |
| 6946115 | Prodrugs for phosphorus-containing compounds Prodrugs of formula I, their uses, their intermediates, and their method of manufacturing are described: and pharmaceutically acceptable prodrugs and salts thereof. ... | 09/20/2005 |
| 6939532 | Versatile hydrophilic dyes Dye-peptide conjugates useful for diagnostic imaging and therapy are disclosed. The dye-peptide conjugates include several cyanine dyes with a variety of bis- and tetrakis(carboxylic acid) homologues. The small size of the compounds allows more favorable delivery to... | 09/06/2005 |
| 6936240 | Method for the preparation of technetium or rhenium complex for radiopharmaceuticals The present invention relates to a method of preparing technetium or rhenium complex for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a reducing agent, wherein the reducing agent is a borohydride exchange res... | 08/30/2005 |
| 6936700 | Bridged aromatic substituted amine ligands with donor atoms The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hyd... | 08/30/2005 |
| 6933399 | Functionalized metal complexes Described herein are metal complexes having the formula wherein M is nickel, palladium, or platinum; Q1-Q4 are each independently sulfur, selenium, or tellurium; X1-X4 are ea... | 08/23/2005 |
| 6933391 | Methods of synthesizing heteroatom-bearing ligands and intermediate used therefor The invention provides improved and simplified methods of synthesizing ligands containing a heteroatom-bearing bridge using a novel intermediate compound. The ligands may be used to form metal complexes that are useful in diagnostic and therapeutic applications.... | 08/23/2005 |
| 6932960 | N-substituted 3-hydroxy-4-pyridinones and pharmaceuticals containing thereof N-substituted 3-hydroxy-4-pyridinones and metal chelates, methods of preparing N-substituted 3-hydroxy-4-pyridinones and metal chelates, and pharmaceutical compositions containing new N-substituted 3-hydroxy-4-pyridinones and/or their metal chelates. Use of N-substi... | 08/23/2005 |
| 6933108 | Methods and compositions for use in the treatment of filovirus mediated disease conditions Methods and compositions are provided for at least slowing the progression of a filovirus mediated disease condition in a host. In the subject methods, an effective amount of an agent that at least reduces the amount of folate receptor mediated filovirus cell entry ... | 08/23/2005 |
| 6926885 | In-vivo diagnostic method by means of near infrared radiation This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluoresc... | 08/09/2005 |
