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| Number | Title | Issue Date |
| 8153581 | Process for producing an injectable medicament preparation The invention relates to a method for producing injectable medicament preparations containing a therapeutically and/or diagnostically effective substance which is comprised of an active agent, of a spacer molecule and of at least one protein-binding molecule. After ... | 04/10/2012 |
| 8147798 | Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or structures 1-45 and imaging the patient. After said imaging, at least one anti... | 04/03/2012 |
| 8129121 | Regulation of lipid droplet formation by modulation of FIT1 and FIT2 and uses thereof This invention provides methods of regulating fat storage in tissue by modulating the levels of Fibrate Induced Transcript 1 (FIT1) and/or Fibrate Induced Transcript 2 (FIT2), as well as diagnostic screens for disorders and conditions involving regulation of fat sto... | 03/06/2012 |
| 8105567 | Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy Compounds of the formula: Wherein R is selected from the group consisting of H, NH2, and NHBoc; and R′ is selected from the group consisting of H, CH2Ph and tBu, option... | 01/31/2012 |
| 8101156 | Methods of manufacturing copolymers with zwitterionic moieties and dihydroxyphenyl moieties and use of same Copolymers are manufactured to include a zwitterionic monomer (e.g., methacryloyloxyethyl phosphorylcholine monomer), a dihydroxyphenyl derivatized monomer, and optionally one or more additional monomers. The dihydroxyphenyl derivatized monomer gives the copolymers ... | 01/24/2012 |
| 8038983 | Fluorinated carbohydrate conjugates Disclosed are novel conjugates that include fluorinated carbohydrate molecules and methods for synthesizing the conjugates. The fluorinated carbohydrate molecule may include a radioisotope. The method of synthesizing the conjugate is useful for labeling selected mol... | 10/18/2011 |
| 7943117 | Method for testing radiochemical purity of Tc-99m-TRODAT-1 The present invention is to invent a novel method for testing the radiochemical purity of Tc-99m-TRODAT-1 through a high performance liquid chromatography on a widely available C-18 column. ... | 05/17/2011 |
| 7919071 | Contrast agent The present invention relates to a contrast agent of Formula I V-L-Z Formula I where V is a non-peptidic vector having affinity for the Angiotensin II receptor, L is a bond, a spacer or a linker moiety and Z represents a moiety detectable in an in vivo imaging proce... | 04/05/2011 |
| 7875258 | Technetium-dipyridine complexes, and methods of use thereof One aspect of the invention relates to novel complexes of technetium (Tc) with various heteroaromatic ligands, e.g., pyridyl and imidazolyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspe... | 01/25/2011 |
| 7842278 | Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole co... | 11/30/2010 |
| 7790140 | Compositions for delivery of therapeutics and other materials, and methods of making and using the same In part, the present invention is directed to biocompatible compositions comprising a carrier with a first metal binding domain, a metal ion, an active agent with second metal binding domain and optionally a protective chain covalently attached to the polymeric carr... | 09/07/2010 |
| 7785565 | Metal chelators and methods of their use Metal chelators of Formula I and Formula II are disclosed: or a pharmaceutically acceptable salt thereof. Also disclosed are metal chelator-targeting moiety co... | 08/31/2010 |
| 7785564 | Design and synthesis of renal dipeptidase inhibitors Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and ... | 08/31/2010 |
| 7754188 | Radiolabeled cannabinoid-1 receptor modulators The present invention relates to particular radiolabeled Cannabinoid-1 (CB1) receptor modulators, and methods of using these modulators for labeling and diagnostic imaging of Cannabinoid-1 receptors in mammals, particularly humans. In addition, intermediates useful ... | 07/13/2010 |
| 7731936 | Metal complexes based on tetrathiol ligands and their use in nuclear medical diagnostics and endoradionuclide therapy and method for producing said metal complexes Provided are radiolytically and metabolically stable metal complexes based on tetrathiol ligands useful for nuclear medical diagnostics and in endoradionuclide therapy. Methods for their preparation are also provided. The complexes can have a central ligand, Y, that... | 06/08/2010 |
| 7718160 | Radiolabeled compounds and liposomes and their method of making and using same The invention, in one aspect, relates to radiolabeled compounds. The invention also relates to radiolabeled liposomes and methods of making and using thereof. The invention also relates to kits for preparing radiolabeled liposomes. ... | 05/18/2010 |
| 7713514 | Multicomponent assemblies having enhanced binding properties for diagnosis and therapy An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regul... | 05/11/2010 |
| 7635463 | Compositions for delivery of therapeutics and other materials This disclosure relates to compositions for delivering agents to a subject, and in particular, to compositions for delivery of therapeutic agents or diagnostic agents in the presence or absence of targeting moieties. In part, this disclosure relates to compositions ... | 12/22/2009 |
| 7632484 | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases... | 12/15/2009 |
| 7597875 | Chelator conjugates The present invention relates to improved chelator conjugates with biological targeting molecules, suitable for forming metal complexes with radiometals. The radiometal complexes, especially with the radiometal99mTc, are useful as radiopharmaceuticals. | 10/06/2009 |
| 7556794 | Pendant fatty acid imaging agents The disclosure provides pendant fatty acid compounds for use in diagnostic imaging, (particularly the cardiovascular system), as well as kits comprised of the same. The disclosure also provides for a method administering a imaging agent with a high specificity for t... | 07/07/2009 |
| 7541019 | Process for the production of DTPA-bis anhydride Process for the production of DTPA-bis(anhydride) by reacting DTPA with acetic anhydride in pyridine under elevated temperature wherein the molar amount of pyridine is equal to or less than 6 times the molar amount of DTPA. ... | 06/02/2009 |
| 7438891 | Imaging agents for early detection and monitoring of cardiovascular plaque The present invention relates in part to a method of imaging cardiovascular plaque formation in a mammal comprising administering to the mammal an effective amount of 18F-2-fluorodeoxy-D-glucose and then detecting the 18F-2-fluorodeoxy-D-glucos... | 10/21/2008 |
| 7438894 | Dyes for organ function monitoring Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for opti... | 10/21/2008 |
| 7435555 | Asparagine hydroxylation of the CAD domain of a HIF protein A target asparagine residue of HIF 1 alpha and 2 alpha is hydroxylated at high oxygen tension to render HIF as a weak transcription factor. An asparagine hydroxylase hydroxylation motif and binding motif is proposed. A method of screening for agonists or antagonists... | 10/14/2008 |
| 7431915 | Peptides whose uptake by cells is controllable A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not signific... | 10/07/2008 |
| 7427390 | Radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous properties, in particular with re... | 09/23/2008 |
| 7427391 | Formulations for use in medical and diagnostic procedures The present invention relates to formulations for use in medical or diagnostic procedures comprising a stabilizing agent alone or in combination with an osmotic agent. In one embodiment, the stabilizing agent is a natural hydrocolloid, preferably locust bean gum, an... | 09/23/2008 |
| 7427389 | Diagnostic agents for positron emission imaging using radiolabeled halogenated xanthenes New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene deri... | 09/23/2008 |
| 7425317 | Avidin dimers effective in increasing the concentration of radioactive biotin in pretargeted radioimmunotherapy Dimers of avidin and streptavidins (diavidins) are described wherein the linker is suberate, which in turn, is bound to different functional groups (—NH2 o-COOH) of avidin. As compared to avidin, the diavidins have shown the ability to increase the amount of label... | 09/16/2008 |
| 7425318 | Amyloid plaque aggregation inhibitors and diagnostic imaging agents This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregat... | 09/16/2008 |
| 7419654 | Charge neutral complexes of paramagnetic metals as intracellular magnetic resonance imaging contrast agents A contrast agent for magnetic resonance imaging comprising a complex of a paramagnetic cation, preferably Gd+3, Dy+3, and Fe+3 with three equivalents of a charge neutralizing chelator that provides a lipid soluble complex of the para... | 09/02/2008 |
| 7419653 | Method for preparing radiolabeled thymidine having low chromophoric byproducts The invention is a method and related precursor for preparing 18F-FLT. The precursor has a butoxycarbonyl protecting group at the 5′-position that results in low amounts of chromophoric byproducts being formed during deprotection. The method for prepari... | 09/02/2008 |
| 7413727 | Contrast agents The invention provides a composition of matter of the formula (I): V-L-R, where V is a vector moiety having affinity for an angiogenesis-related endothelias cell receptor, L is a linker moiety or a bond and R is a detectable moiety, characterised in that V is a non-... | 08/19/2008 |
| 7408046 | Treatment of bone-associated cancers The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 08/05/2008 |
| 7407646 | Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or different from the first hydrophilic polymer, wherein the superparamagnetic i... | 08/05/2008 |
| 7407645 | Bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands The present invention is directed to bioconjugates of complexes represented by the formula: wherein R, R′, R1, R′1, R2, R′2, R3, R′3, R4, ... | 08/05/2008 |
| 7408050 | Modified CpG oligodeoxynucleotide with improved immunoregulatory function The present invention relates to a modified CpG oligodeoxynucleotide (ODN) which is prepared by coupling a consecutive sequence of deoxyribothymine (dT) to the 3′-terminus of CpG ODN having immunoregularory function, thereby improving immunoactivity of splenocytes... | 08/05/2008 |
| 7404963 | Flagellin-based adjuvants and vaccines The present invention provides adjuvants, vaccines and related methods that are useful in eliciting immune responses, particularly immune responses against tumor antigens. We discovered that flagellin is capable of inhibiting tolerance when it is administered in con... | 07/29/2008 |
| 7399460 | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the α, γ, or bis isomers of folate receptor-binding analogs of folate, a me... | 07/15/2008 |
