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| Number | Title | Issue Date |
| 8124051 | Complex drug delivery composition and method for treating cancer The present invention relates to compositions and methods for producing a complex drug delivery system which specifically targets cancer cells, has an increase in cellular uptake, is cytotoxic, and suppresses antiapoptotic cellular defenses. ... | 02/28/2012 |
| 8084015 | Stabilized synthetic immunogen delivery system The present invention provides an immunostimulatory complex specifically adapted to act as adjuvant and as a peptide immunogen stabilizer. The immunostimulatory complex comprises a CpG oligonucleotide and a biologically active peptide immunogen. The immunostimulator... | 12/27/2011 |
| 8021644 | Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis The present invention relates to biochemical methods for determining reverse cholesterol transport. Specifically, the rates of the two arms of reverse cholesterol transport (HDL or first arm and post-HDL or second arm) are obtained by measuring the flow of unlabeled... | 09/20/2011 |
| 7815893 | Hydroxyalkyl starch derivatives The present invention relates to a method of producing a hydroxyalkyl starch derivative comprising reacting hydroxyalkyl starch of formula (I) at its reducing end which is not oxidized prior to said reaction, with a compound of formula (II) R′NH—R″ (II) wherei... | 10/19/2010 |
| 7666390 | DTPA derivatives and metal complexes thereof, and radiation source and contrast agent including the metal complexes The present invention relates to diethylenetriamine pentaacetic acid (DTPA) derivates and metal complexes thereof, and radiation sources and contrast agents including the metal complexes. More particularly, the present invention relates to DTPA derivatives, which co... | 02/23/2010 |
| 7404969 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfect... | 07/29/2008 |
| 7358223 | Biodegradable cationic polymers Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells. ... | 04/15/2008 |
| 7351398 | Stabilization of radiopharmaceutical compositions using hydrophilic thioethers Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic thioether. ... | 04/01/2008 |
| 7351397 | Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy chromans Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic 6-hydroxy-chroman derivative. ... | 04/01/2008 |
| 7344700 | Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy Provided is a class of radiolabeled androgen receptor targeting agents (ARTA), useful for prostate cancer imaging and in treating or preventing prostate cancer. The agents define a new-subclass of radiolabeled compounds, which are selective androgen receptor modulat... | 03/18/2008 |
| 7341709 | Compositions for labeling β-amyloid plaques and neurofibrillary tangles Compositions useful for labeling β-amyloid plaques and neurofibrillary tangles are provided. The compositions comprises compounds of formula (I): wherein R1 is selected from the group consisting of —C(O)-alkyl... | 03/11/2008 |
| 7320890 | Soluble steroidal peptides for nucleic acid delivery Amphiphilic lipopeptide compositions for gene delivery are disclosed. An illustrative amphiphilic lipopeptide composition includes a human protamine 2 peptide conjugated to a hydrophobic moiety. Illustrative hydrophobic moieties include sterols, bile acids, and fatt... | 01/22/2008 |
| 7300662 | Drug/drug delivery systems for the prevention and treatment of vascular disease A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia f... | 11/27/2007 |
| 7229473 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 06/12/2007 |
| 7223286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/29/2007 |
| 7217286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/15/2007 |
| 7202330 | RGD (Arg-Gly-Asp) coupled to (neuro)peptides The invention relates to compounds having a binding affinity for both the αvβ3 receptor and a (neuro)peptide receptor, in particular the somatostatin receptor, which compound comprises a first peptide part comprising at least once the amino acid sequence Arg-Gly-A... | 04/10/2007 |
| 7195750 | Clinical parameters for determining hematologic toxicity prior to radioimmunotherapy New clinical parameters are reported which may serve as predictors of the hematological toxicity associated with therapeutic radiolabeled antibodies, particularly those antibodies which target lymphoma cells which have a tendency to localize to the bone marrow. ... | 03/27/2007 |
| 7128895 | Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability The use of contrast agents of molecular weight lower than 5000 Dalton and including at least one residue of a biliary acid for the preparation of diagnostic contrast compositions for the microvascular permeability assessment is disclosed. ... | 10/31/2006 |
| 7122516 | Stabilized bioactive peptides and methods of identification, synthesis and use An intracellular selection system allows concurrent screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive pe... | 10/17/2006 |
| 7101532 | Liposome containing hydrophobic iodine compound A liposome containing a hydrophobic iodine compound such as a 1,3,5-triiodobenzene derivative having at least one substituent containing 18 or more carbon atoms as a membrane component, and an X-ray contrast medium containing the liposome for use in radiography of a... | 09/05/2006 |
| 7067109 | Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-t... | 06/27/2006 |
| 7067113 | Methods for identifying compounds for regulating muscle mass or function using dopamine receptors Screening methods for identifying compounds that bind to or activate (D1 or D5 dopamine receptors individually or in combination) or potentially regulate skeletal muscle mass or function in vivo. Also disclosed are screening methods for identif... | 06/27/2006 |
| 7041839 | Steroidal antiestrogens and antiandrogens and uses thereof The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human, believed to be at risk of suffering from a hormone-responsive disorde. In a... | 05/09/2006 |
| 6989138 | Stabilization of radiopharmaceutical compositions using hydrophilic thioethers and hydrophilic 6-hydroxy chromans Radiopharmaceutical compositions which are stabilized by addition of a mixture of a hydrophilic thioether and a hydrophilic 6-hydroxy-chroman derivative. ... | 01/24/2006 |
| 6902718 | Stabilization of radiopharmaceutical compositions using hydrophilic thioethers Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic thioether. ... | 06/07/2005 |
| 6887861 | Compounds for intracellular delivery of therapeutic moieties to nerve cells A method for improving intracellular administration of a therapeutic agent is provided comprising: contacting cells with a compound comprising a charged derivative of a therapeutic agent having a therapeutic activity, the charged derivative being conjugated to a pro... | 05/03/2005 |
| 6881396 | Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy-chromans Radiopharmaceutical compositions which are stabilized by addition of a hydrophilic 6-hydroxy-chroman derivative. ... | 04/19/2005 |
| 6818199 | Media and methods for enhanced medical imaging Metal nanoparticles are described that are useful for enhancing the contrast of x-rays or other radiation sources. A method is disclosed whereby the agents are administered intravenously or intra-arterially to detect coronary senses and other vascular features. It i... | 11/16/2004 |
| 6737039 | Methods for detecting lesions in dense breast tissue using LHRH antagonists Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a period of time sufficient to reduce the density of breast tissue prio... | 05/18/2004 |
| 6696038 | Cationic lipopolymer as biocompatible gene delivery agent A biodegradable, novel cationic lipopolymer comprising a branched polyethylenimine(PEI), a cholesterol derived lipid anchor, and a biodegradable linker which covalently links the branched PEI and cholesterol derived lipid anchor. One example of such a nov... | 02/24/2004 |
| 6635234 | Preparation and use of radium-223 to target calcified tissues for pain palliation, bone cancer therapy, and bone surface conditioning Processes for the preparation, prepared solutions, and the use of radium-223 for the treatment of calcified tumors, bone tumors, treatment of bones, bone surfaces and soft tissues is described.... | 10/21/2003 |
| 6613736 | System and method for treating eye and nerve diseases in diabetic and non-diabetic patients The present invention is a system and method capable of increasing retinal and neural glucose oxidation by enhancing pyruvate dehydrogenase activity and therefore treats retinopathy and central nervous system disorders in both diabetic and non-diabetic pa... | 09/02/2003 |
| 6540979 | Methods for detecting lesions in dense breast tissue using LHRH antagonists Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a period of time sufficient to reduce the density of breast ... | 04/01/2003 |
| 6518246 | Pharmaceutical composition and method for the treatment of neoplastic cells A pharmaceutical composition and method, for treating human or non-human neoplastic disorders, e.g. colorectal disorders, comprising the administration of pharmaceutically effective amounts of galanin, octreotide and serotonin in a pharmaceutically accept... | 02/11/2003 |
| 6455025 | Polysaccharide-peptide derivatives Polysaccharide-somatostatin analogs of the formula: ##STR1## wherein the somatostatin analog is directly or indirectly coupled from a terminal N-amino group of the somatostatin analog to a polysaccharide, and the polysaccharide-somatostatin analog is prov... | 09/24/2002 |
| 6251363 | Diagnostic and therapeutic alkylenediamine compounds and process Diamine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The diamine compounds or serotonin are characterized by the formula: ##STR1## l, ... | 06/26/2001 |
| 6143729 | Compounds related to the amidinium family, pharmaceutical compositions containing same, and uses thereof Novel amidinium derivatives of formula (I), wherein R1 is a cholesterol derivative or an alkylamino-NR'R" grouping, and each of R2 and R3 is independently a hydrogen atom or a grouping of formula (II), wherein each of R4 and R5 is independently a hydrogen... | 11/07/2000 |
| 6056942 | 5-HT1A ligands Selective 5-HT1A antagonists radiolabelled with 3 H or 11 C are radiolabelled ligands useful, for example, in pharmacological screening procedures and in positron emission tomography (PET) studies.... | 05/02/2000 |
| 6051209 | Determining effects of external stimuli on the brain using pet A method of evaluating the effects of administering an external stimuli or treatment such as a psychoactive compound, a drug, or an environmental influence like temperature, noise, vibration, light and similar sensory-perceived influences, on a subject's ... | 04/18/2000 |
