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| Number | Title | Issue Date |
| 8003076 | Methods for conducting metabolic analyses The present invention provides methods and apparatus for purifying metabolites of interest and conducting metabolic analyses. The methods generally involve determining metabolic flux values for a plurality of target analytes by monitoring the relative isotope abunda... | 08/23/2011 |
| 7504086 | Structure and method for releasing substance therefrom A structure comprises at least a porous body holding a substance releasably, comprising a capping member for keeping the substance inside the pore and/or on at least a part of the entire surface of the porous body, and a connecting member for connecting the porous b... | 03/17/2009 |
| 7435406 | Methods for conducting metabolic analyses The present invention provides methods and apparatus for purifying metabolites of interest and conducting metabolic analyses. The methods generally involve determining metabolic flux values for a plurality of target analytes by monitoring the relative isotope abunda... | 10/14/2008 |
| 7402299 | Intracorporeal medicaments for photodynamic treatment of disease New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthe... | 07/22/2008 |
| 7384623 | High energy phototherapeutic agents High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive structures in diseased tissue, and methods of treating and imaging using ... | 06/10/2008 |
| 7364859 | Methods of using bioelastomers Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In ge... | 04/29/2008 |
| 7291598 | Nanoparticles for protein drug delivery The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery. ... | 11/06/2007 |
| 7264798 | Sensitization of chemotherapeutic agent resistant neoplastic cells with a virus The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using a virus, a method of treating proliferative disorders with a virus and chemotherapeutic agents, and a method for preventing a neoplasm fro... | 09/04/2007 |
| 7223388 | Modified reoviral therapy The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the Reoviridae virus is conjugated to a hydroxylated hydrocarbon or a polycation... | 05/29/2007 |
| 7201891 | Pharmaceutical preparation for the diagnosis of helicobacter pylori infection A coated preparation for the detection of a H. pylori infection according to a urea breath test protocol which comprises a core composition containing at least an isotope C-labeled urea, an excipient and a lubricant in defined proportions and covered with 0.1... | 04/10/2007 |
| 7198783 | Sensitization of neoplastic cells to radiation therapy with reovirus The present invention relates to methods of sensitizing neoplastic cells to irradiation by using oncolytic viruses, particularly reoviruses. Also provided are methods of treating or ameliorating a tumor with a combination of oncolytic viruses and radiotherapy. ... | 04/03/2007 |
| 7163678 | Reovirus for the treatment of ral-mediated cellular proliferative disorders Methods for treating proliferative disorders, by administering reovirus to a ral-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts target cancer cells. Proliferative disorders include but are not lim... | 01/16/2007 |
| 7014847 | Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The method comprises suppressing or otherwise inhibiting t... | 03/21/2006 |
| 6998105 | Low density radionuclide-containing particulate material The invention relates to a particulate material consisting of a low density radiation-tolerant glass and a radionuclide incorporated into the low density glass or coated on the low density glass, the glass having a density of less than 2.5 g/cm3, processe... | 02/14/2006 |
| 6986880 | Polymeric-matrix brachytherapy sources Therapeutic sources for use in the practice of brachytherapy comprise a radioactive composite that includes (a) a polymeric matrix and (b) a radioactive powder, e.g. Pd-103 or I-125, consisting essentially of very fine radioactive particles that are randomly and ess... | 01/17/2006 |
| 6979466 | Nanoscale particles having an iron oxide-containing core enveloped by at least two shells The invention relates to nanoscale particles suited especially for use in tumor therapy by hyperthermia. Said particles comprise a (preferably superparamagnetic) iron oxide-containing core and at least two shells surrounding said core. The (innermost) shell adjoinin... | 12/27/2005 |
| 6946117 | Stabilized preparations for use in nebulizers Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a stabilized colloidal system which may comprise a fluorochemical component. In particularly preferred embodiments, t... | 09/20/2005 |
| 6946525 | Composition comprising polymers having a star structure, the polymers, and their use A composition, comprising, in an appropriate medium, at least one polymer with a highly specific ordered structure is disclosed. These compositions find a specific application in the field of make-up and are capable of being applied to keratinous fibers, in particul... | 09/20/2005 |
| 6919067 | Compositions comprising a tissue glue and therapeutic agents The present invention concerns compositions comprising a radiotherapeutic agent, or an agent which can be converted to a radiotherapeutic, and a tissue glue. The compositions of the present invention are particularly useful for providing local radiotherapy. The pres... | 07/19/2005 |
| 6911219 | Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them This relates to partially acetalized polyvinyl alcohol embolization particles suitable for implanting in the human body, to compositions containing those particles, and to methods of making and using them. ... | 06/28/2005 |
| 6890512 | Methods of preventing aggregation of various substances upon rehydration or thawing and compositions obtained thereby The present invention encompasses methods to prevent aggregation of a wide variety of substances during freezing/thawing and/or dehydrating/rehydrating. The substances thus obtained and compositions comprising the substances are also encompassed by the invention. | 05/10/2005 |
| 6773928 | Compositions and methods for enhancing bioassay performance Compositions of matter and methods for enhancing bioassay performance are disclosed. More particularly, the composition of matter comprises a molecularly compact polymer-ligand conjugate capable of self-orienting on a surface to improve the orientation of the ligand... | 08/10/2004 |
| 6759028 | Methods for treating AVM's using radioactive compositions Disclosed are methods for treating AVMs in a mammal by use of a radiation composition. ... | 07/06/2004 |
| 6746661 | Brachytherapy seed A radiopaque brachytherapy seed for implantation into a subject includes a biocompatible component, a therapeutically active component including a non-radioactive drug, and a radiopaque marker. The biocompatible component is (a) physically associated with a therapeu... | 06/08/2004 |
| 6669623 | Medical preparation for treating arthrosis, arthritis and other rheumatic joint diseases A medical preparation for treating arthrosis, arthritis and other rheumatic joint diseases comprises a suspension consisting of one-shelled or multi-shelled nanoscalar particles composed of a core containing iron oxide and of an inner shell with groups ca... | 12/30/2003 |
| 6635234 | Preparation and use of radium-223 to target calcified tissues for pain palliation, bone cancer therapy, and bone surface conditioning Processes for the preparation, prepared solutions, and the use of radium-223 for the treatment of calcified tumors, bone tumors, treatment of bones, bone surfaces and soft tissues is described.... | 10/21/2003 |
| 6589502 | Radioisotope dispersed in a matrix for brachytherapy Therapeutic sources for use in the practice of brachytherapy are fabricated from radioactive composites of a radioactive powder of palladium-103, yttrium-90, phosphorus-32 or gold-198 and a biocompatible polymeric matrix. The particles of radioactive powd... | 07/08/2003 |
| 6565831 | Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The method comprises suppressing or otherwise i... | 05/20/2003 |
| 6537518 | Particulate material A particulate material comprises hollow or cup-shaped ceramic microspheres having a diameter in the range of from 5 to 200 microns, the microspheres being formed from a base material comprising greater than 70% by weight of yttria or another yttrium-conta... | 03/25/2003 |
| 6517809 | Process for preparing a reactive pharmaceutical product for the detection of gastrointestinal disorder caused by bacteria in the gastrointestinal superior tract The invention relates to the diagnosis in a human or lower animal subject of a gastrointestinal disorder of the upper gastrointestinal tract caused by bacteria using a breath test. In one aspect the invention provides a process for the preparation of a re... | 02/11/2003 |
| 6455024 | Inorganic materials for radioactive drug delivery Radiotherapy agents which are solid or porous particles are described. The particles are of an inorganic material containing a suitable radionuclide and having an average particle diameter of about 0.05 to 5000 microns.... | 09/24/2002 |
| 6410680 | Dendrimer constructs and metal complexes thereof having superoxide dismutase activity A metal-dendrimer complex in which the metal active site is deep within the three-dimensional dendrimer construct, has superoxide dismutase-like activity. In particular embodiments the complex is a copper(II)-dendrimer complex and the dendrimer construct ... | 06/25/2002 |
| 6391279 | Radioactive seeds for brachytherapy and a process for making the same Novel radioactive seeds for brachytherapy and a reproducible method of manufacturing the seeds is described, wherein the seeds contain either Pd-103 or I-125 disposed within a cured resin matrix.... | 05/21/2002 |
| 6352682 | Polymeric delivery of radionuclides and radiopharmaceuticals Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecul... | 03/05/2002 |
| 6333194 | Hydrogel compositions for controlled delivery of virus vectors and methods of use thereof The invention relates to compositions and methods for delivering a virus vector to an animal. The compositions include compositions which comprise a hydrogel matrix (e.g. a collagen matrix which can comprise a poloxamer or an alginate) containing a virus ... | 12/25/2001 |
| 6312679 | Dense star polymer conjugates as dyes Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the ... | 11/06/2001 |
| 6264913 | Non-invasive test for assessing bacterial overgrowth of the small intestine Provided herein is a novel breath test for assessing bacterial overgrowth. The test involves administration of a labeled sorbitol or sorbitol derivative to a subject and measurement of the label in breath and/or blood.... | 07/24/2001 |
| 6214315 | Radioactive embolizing compositions Disclosed are novel radioactive compositions which are particularly suited for treating solid mass tumors via catheter delivery.... | 04/10/2001 |
| 6171575 | Method of radioisotopic assessment of the integrity and function of the nose-brain barrier A radioisotopic assessment of the integrity of the nose-brain barrier was performed on an anosmic patient by spraying an aliquot of a mixture of 99mTc-DTPA and hyaluronidase onto the olfactory mucosa with the patient's head positioned vertically and subse... | 01/09/2001 |
| 6168777 | Methods for treating prostate tumors using radioactive compositions Disclosed are methods for treating solid mass prostate tumors in a male mammal by use of a radiation composition.... | 01/02/2001 |
