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| Number | Title | Issue Date |
| 8119101 | Anti-CD74 immunoconjugates and methods of use Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a li... | 02/21/2012 |
| 8067380 | Glutathione-based delivery system A delivery system is provided. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid d... | 11/29/2011 |
| 7829064 | Anti-CD74 immunoconjugates and methods Disclosed are compositions that include anti-CD74 immunoconjugates and a therapeutic and/or diagnostic agent. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. The compositions may ... | 11/09/2010 |
| 7749485 | Liposomal assembly for therapeutic and/or diagnostic use Composition for diagnostic or therapeutic use which comprises an assembly comprising an active agent. The assembly comprises a liposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the e... | 07/06/2010 |
| 7371722 | Pharmaceutical preparations and medicine capable of generating and/or containing thrombin The invention relates to a pharmaceutically active substance for producing a drug that is capable of generating thrombin or that contains thrombin and compositions comprising thereof. The pharmaceutically active substance contains (A) prothrombin (coagulation factor... | 05/13/2008 |
| 7371877 | Glycerol ester derivative A compound represented by the following general formula (IA) or a salt thereof: wherein Ar1 represents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Ar2 represents an... | 05/13/2008 |
| 7368129 | Amphiphilic materials and liposome formulations thereof Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydrophobic moi... | 05/06/2008 |
| RE40300 | Carbon dioxide enhancement of inhalation therapy The present invention provides a method of increasing the deposition of aerosolized drug in the respiratory tract of an individual or animal, comprising the step of administering said aerosolized drug in an air mixture containing up to about 10% carbon dioxide gas. | 05/06/2008 |
| 7354567 | Method of encapsulating metal complex within liposomes An object of the present invention is to provide a method of producing liposome wherein a complex of a short half-life metallic radioactive nuclide such as 99mTc and CD is encapsulated, with radiochemical yield and purity enabling practical application. T... | 04/08/2008 |
| 7329402 | Methods of imaging and treatment Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The... | 02/12/2008 |
| 7323297 | Stabilized polynucleotide complexes and methods The invention comprises stabilized polynucleotide complexes that have a cryoprotectant and are lyophilized. Cryoprotectant compounds comprise carbohydrates or sugars, preferably lactose and sucrose, but also glucose, maltodextrins, mannitol, sorbitol, trehalose, and... | 01/29/2008 |
| 7323594 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/29/2008 |
| 7309692 | Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1 The present invention provides novel compositions and methods for use in the treatment of cancer, specifically, in the treatment of chronic myelogenous leukemia (CML). The compositions contain antisense oligonucleotides that hybridize to Grb2 and Crk1 nucleic acids,... | 12/18/2007 |
| 7299587 | Method and apparatus for controlling pests A method of controlling pests, such as insects, by trapping and/or killing them wherein at least a part of a pest to be trapped or killed is exposed a composition comprising particles containing or consisting of at least one magnetic material. ... | 11/27/2007 |
| 7294511 | Methods for delivering nucleic acid molecules into cells and assessment thereof Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial ... | 11/13/2007 |
| 7288243 | Aerosol drug inhibition of lung metastases The present invention provides a method of inhibiting growth of lung metastases in an individual comprising the steps of administering a dose of a lipid-drug enhancer liposomal complex and, in sequence, administering a dose of a lipid-anticancer drug liposomal compl... | 10/30/2007 |
| 7285289 | Nanoparticle vaccines The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed on the carrier. Such antigen-displaying nanoparticles may also displa... | 10/23/2007 |
| 7285288 | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The compositions contain antisense oligonucleotides that hybridize to Bcl-2 n... | 10/23/2007 |
| 7279150 | Chelating agents with lipophilic carriers Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components. ... | 10/09/2007 |
| 7273951 | Polyhydroxy phenols and their use in binding p-selectin Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as polyhydroxy phenol-containing pharmaceutical and nutraceutical composi... | 09/25/2007 |
| 7264790 | 1,3-glyceride compound having two iodophenyl groups A compound represented by the following general formula (I) or a salt thereof: wherein Ar1 and Ar2 independently represent a substituted or unsubstituted aryl group having at least one iodin... | 09/04/2007 |
| 7255875 | Integrin targeted imaging agents Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific ... | 08/14/2007 |
| 7256182 | Gene delivery compositions and methods The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority ... | 08/14/2007 |
| 7238367 | Liposome loading with metal ions This invention relates to encapsulation of drugs and other agents into liposomes. ... | 07/03/2007 |
| 7229959 | Supplemented fibrin matrix delivery systems This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antibody. The composition may be further supplemented with, for example, one... | 06/12/2007 |
| 7220401 | Blood clot-targeted nanoparticles Emulsions comprising nanoparticles formed from high boiling perfluorochemical substances, said particles coated with a lipid/surfactant coating are made target-specific by directly coupling said nanoparticles to a targeting ligand. The nanoparticles may further incl... | 05/22/2007 |
| 7220853 | Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to Grb2 or Crk1 The present invention provides novel compositions and methods for use in the treatment of cancer, specifically, in the treatment of chronic myelogenous leukemia (CML). The compositions contain antisense oligonucleotides that hybridize to Grb2 and Crkl nucleic acids,... | 05/22/2007 |
| 7220400 | Compositions for delivering nucleic acids to cells Cyclic amidinium containing compounds and their methods of preparation are described. Compositions containing these compounds facilitate delivery of biologically active polymers to cells in vitro and in vivo. ... | 05/22/2007 |
| 7217427 | Polymersomes and related encapsulating membranes The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile mol... | 05/15/2007 |
| 7208173 | Mixed structures resulting from the incorporation of a biological macromolecule, especially of DNA, in a liquid crystal phase of amphiphiles, and vesicles obtained using these structures The invention relates to a structured mixed phase formed by the incorporation of a biological macromolecule into a liquid-crystal phase of amphiphiles, preferably a lamellar phase, wherein said biological macromolecule is present in said structured mixed phase in an... | 04/24/2007 |
| 7205006 | Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same A skin treatment composition comprising a Mahonia aquifolium extract in a liposome delivery system. The Mahonia aquifolium extract is present in the skin treatment composition in a range of from 5% to 20% by weight of the total composition. The skin tr... | 04/17/2007 |
| 7189411 | Peptide/lipid complex formation by co-lyophilization The invention relates to the formation of peptide/lipid vesicles and complexes through the co-lyophilization of peptides, preferably that are able to adopt an amphipathic alphahelical conformation, and one or more lipids. A single solution which solubilizes both the... | 03/13/2007 |
| 7189874 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S... | 03/13/2007 |
| 7173154 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 02/06/2007 |
| 7166297 | Lipid-based drug delivery systems against parasitic infections The present invention is directed to a lipid-based delivery system for administration of an active drug substance selected from lysolipid derivatives which are particularly useful in the treatment or detection of parasitic infections, especially parasitic infections... | 01/23/2007 |
| 7166745 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/23/2007 |
| 7157098 | Gene therapy of tumors using non-viral delivery system The present invention provides a pharmaceutical composition, comprising: (a) cationic lipids, wherein said lipids are a liposomal mixture of a diacyl-ethyl-phosphocholine and 1,2-diacyl-sn-glycero-3-phosphoethanolamine; and (b) a plasmid cDNA sequence encoding a pro... | 01/02/2007 |
| 7145039 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 12/05/2006 |
| 7122553 | Liposomal formulation of irinotecan The present invention is for novel compositions and methods for treating cancer, particularly, for treating cancer in mammals and more particularly in humans. The therapeutic compositions of the present invention include liposome entrapped irinotecan in which the li... | 10/17/2006 |
| 7105151 | Oxygen delivery agents and uses for the same The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery ag... | 09/12/2006 |
