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| Number | Title | Issue Date |
| 8007767 | Amino methyl imidazoles and related compounds as C5a receptor modulators Amino methyl imidazoles of Formula I are provided: wherein R, R1, R2, R3, R4, R5, and R6 are defined herein. Such compounds are ligands of C5a recept... | 08/30/2011 |
| 7404945 | Method of evaluating pharmacological effects of medicine A diagnostic reagent for use in the evaluation of a pharmacological effect of a medicine containing a pharmaceutical agent including an enzyme, an enzyme inhibitor or a receptor ligand or a prodrug of the pharmaceutical agent is provided. Further, a method of screen... | 07/29/2008 |
| 7402299 | Intracorporeal medicaments for photodynamic treatment of disease New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthe... | 07/22/2008 |
| 7384623 | High energy phototherapeutic agents High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive structures in diseased tissue, and methods of treating and imaging using ... | 06/10/2008 |
| 7374875 | Peptides having affinity for the gp120 viral protein and use thereof The present invention relates to a family of peptides exhibiting high affinity and specificity for the viral protein gp120, to methods for producing these peptides, and to the use of these peptides. ... | 05/20/2008 |
| 7354721 | Highly sensitive proteomic analysis methods, and kits and systems for practicing the same Methods of determining whether a sample includes one or more analytes, particularly proteinaceous analytes, of interest are provided. In the subject methods, an array of binding agents, where each binding agent includes an epitope binding domain of an antibody, is c... | 04/08/2008 |
| 7285266 | Cell-polymer fiber compositions and uses thereof The present invention relates to compositions comprising complexes of human cells and polymer fibers and methods of their use for therapeutic purposes. Methods of making such compositions are also provided. The present invention encompasses compositions comprising p... | 10/23/2007 |
| 7255851 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disea... | 08/14/2007 |
| 7252815 | Pathological tissue detection and treatment employing targeted benzoindole optical agents Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and pho... | 08/07/2007 |
| 7247501 | Imaging and targeting tumors using sickle cells According to the present invention, there is provided a delivery vehicle including sickle red blood cells carrying a moiety. The moiety can be any type of diagnostic or therapeutic agent. The present invention further provides for a method of diagnosing systemic hyp... | 07/24/2007 |
| 7211570 | Treatment of EBV and KHSV infection A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an effective amount of a 5-substituted uracil nucleoside or its pharmaceu... | 05/01/2007 |
| 7201892 | Pathological tissue detection and treatment employing targeted optical agents Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and pho... | 04/10/2007 |
| 7198774 | Non-invasive localization of a light-emitting conjugate in a mammal Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disea... | 04/03/2007 |
| 7186398 | Fe/Au nanoparticles and methods A novel nanoscale, metal particle containing Fe atoms and Au atoms in solid solution. The particle is superparamagnetic with a large magnetic susceptibility at room temperature, is resistant to oxidation, and can be readily functionalized for use in diverse applicat... | 03/06/2007 |
| 7128896 | Pathological tissue detection and treatment employing targeted benzoindole optical agents Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and pho... | 10/31/2006 |
| 7129327 | Polypeptide and protein derivatives and process for their preparation Protein and polypeptid derivatives and their salts are claimed characterized in that a protein or polypeptide is conjugated via an intermediate grouping containing at least one radical of the formula —C(R)═N— (or —N═C(R)—) or —CH(R)—NH— (or —NH... | 10/31/2006 |
| 7053210 | Efficient synthesis of pyropheophorbide a and its derivatives A process for the preparation of pyropheophorbide a and its derivatives, including 3-devinyl-3-(1′-hexyloxy)ethyl-pyropheophorbide-a, otherwise known as HPPH, is provided. The process involves treating chlorin e6, in the form of its trimethyl ester, wit... | 05/30/2006 |
| 7018613 | Preparations for evaluating eliminative ability of stomach Preparations whereby reduction or acceleration of the gastric emptying rate can be noninvasively evaluated: and a method of evaluating the gastric emptying rate by using these preparations. Thus, reduction or acceleration of the gastric emptying rate can be safely a... | 03/28/2006 |
| 6942771 | Microfluidic systems in the electrochemical detection of target analytes The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes. ... | 09/13/2005 |
| 6929620 | Injector for liquid medicine An injector for liquid medicine comprises a cylindrical body 1, first and second gasket 2, 3 contained in a lumen of cylindrical body 1. The cylindrical body 1 is provided with a fluid inlet 13 and a fluid outlet 14 in oppos... | 08/16/2005 |
| 6913767 | Compositions for microencapsulation of antigens for use as vaccines Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided which release antigen at desired intervals to provide boosts with an... | 07/05/2005 |
| 6818199 | Media and methods for enhanced medical imaging Metal nanoparticles are described that are useful for enhancing the contrast of x-rays or other radiation sources. A method is disclosed whereby the agents are administered intravenously or intra-arterially to detect coronary senses and other vascular features. It i... | 11/16/2004 |
| 6783751 | Method for labeling biopolymers using isotopes The invention relates to a novel method for the in-vivo labeling of biopolymers such as proteins, nucleic acids, lipids, carbohydrates and biodegradable plastic using isotopes, especially stabile isotopes. The invention also relates to the use of chemolithotrophic b... | 08/31/2004 |
| 6645464 | Loading metal particles into cell membrane vesicles and metal particular use for imaging and therapy Delivery of metal particles to living tissue, then applying external energy that interacts with the metal particles, is found to selectively increase the energy deposition and interaction surrounding the metal particles. The method is useful to improve tr... | 11/11/2003 |
| 6379647 | Use of mononuclear phagocytes in in vivo imaging of hypoxic/ischaemic tissue The invention relates to the imaging, preferably of hypoxic or ischaemic sites using mononuclear phagocytes. Specifically, the migratory behavior of the mononuclear phagocytes is exploited with a view to targeting imaging agents to sites that mononuclear ... | 04/30/2002 |
| 6361758 | Cosolvent formulations Stable pharmaceutical formulations of a therapeutic agent, a low molecular weight alcohol and a glycol derivative are disclosed. Preferred formulations include 19-nor-1,3ଲ,25-trihydroxy-9,10-secoergosta-5,7(E),22(E)-triene .... | 03/26/2002 |
| 6159443 | X-ray guided drug delivery A method of delivering an active agent to a target tissue, particularly neoplastic tissue, vascular anomaly or tumor tissue, in a vertebrate subject. The method includes the steps of exposing the target tissue to ionizing radiation; and administering a de... | 12/12/2000 |
| 6106836 | Container with freeze-dried vaccine components The present invention relates to a vaccine container that contains one or more freeze-dried vaccine components. The vaccine component or components are present in two or more freeze-dried bodies, at least one of which is a lyosphere. Furthermore, the inve... | 08/22/2000 |
| 6093381 | Modulation of the sensitivity of tumor cells to chemotherapeutics Disclosed is a method for improving the treatment of a cancer patient which is undergoing (adjuvant) chemotherapy. Prior to or concomitant with the patient receiving adjuvant chemotherapy, the patient is administered mitogenically stimulated lymph node ly... | 07/25/2000 |
| 5997846 | Method for detecting arthropods The present invention provides a method for detecting chitin-containing organisms on an area of a person or animal by contacting the particular area with a dye that is capable of biding to chitin and emitting fluorescence upon exposure to light. If a chit... | 12/07/1999 |
| 5985281 | Chemical compounds A two component system for therapeutic treatment of a host, having a first component comprising a targeting moiety capable of binding with a tumour associated antigen, linked to a mutated enzyme capable of converting a prodrug into an antineoplastic drug,... | 11/16/1999 |
| 5902583 | Genetic induction of receptors for targeted radiotherapy The present invention provides a method to achieve radioisotopic localization at tumor sites, i.e., a method of enhancing radiolabeled ligand localization to a tumor in an individual in need of such treatment, comprising the steps of: transducing the tumo... | 05/11/1999 |
| 5814295 | Determination of lymph nodes enriched in tumor reactive cells their proliferation and their use in adoptive cellular therapy The present invention is directed to a method for reliably determining lymph nodes enriched in tumor reactive cells, e.g., CD4+tumor-specific lymphocytes. This method includes the steps of administering to a patient an effective amount of a radiolabeled l... | 09/29/1998 |
| 5807840 | Method for treating canine distemper The present invention discloses a method for treating patients having the CDV associated symptoms or animals carrying or infected by the canine distemper virus (CDV) or having antibodies against the CDV using Product R, a peptide-nucleic acid preparation.... | 09/15/1998 |
| 5785949 | Measurement of liquid phase gastric emptying A drink adapted to be consumed by a patient to enable measurement of gastric emptying of the liquid phase, is a fruit juice having mixed and suspended therein a quantity of Spirulina platensis alga grown in a 13 CO2 atmosphere. These... | 07/28/1998 |
| 5725875 | Protective skin composition A protective cream composition contains 15 to 40 wt % of an alkali metal fatty acid salt having from 8 to 18 carbon atoms, an effective amount of a topical agent such as an antimicrobial compound, 5 to 20 wt. % of a polyol effective as an emollient, 0.5 t... | 03/10/1998 |
| 5707602 | Measurement of gastric emptying A biscuit adapted to be ingested by a patient to enable measurement of gastric emptying has added prior to baking Spirulina Platensis alga grown in a 13 CO2 atmosphere. These single cell organisms are oxidized after digestion in the ... | 01/13/1998 |
| 5703056 | Non-invasive imaging of gene transfer The subject invention provides a method of detecting gene transfer to and expression in a target tissue of a host subject comprising: (a) administering to the host subject a transfer vector containing a marker gene not naturally present in the host and no... | 12/30/1997 |
| 5690903 | Loading and conjugating cavity biostructures Methods for the preparation and use of a biological delivery system are disclosed. The method of preparation includes the loading of a non-biological material into a biostructure having a load-bearing structure. The method also includes the removal of som... | 11/25/1997 |
| 5665328 | Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles Compounds, compositions, their methods of preparation and use in binding bio-affecting substances to the surface membrane of bioparticles, such as enkaryotic cells, without producing appreciable detrimental effect on morphology or physiological function o... | 09/09/1997 |
