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"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| 8003075 | Diagnostic assay for human matrix GLA-protein and its use as a biomarker The present invention includes a diagnostic assay for the detection and determination of MGP in a human serum sample, which comprises the use of one or more antibodies, preferably monoclonal antibodies, specifically recognizing epitopes on and/or conformations of hu... | 08/23/2011 |
| 7625548 | Methods and apparatus for producing nanoscale particles Liquid nanoscale particle precursor materials for generating nanoscale particles include at least one high volatility carrier and a second component. A nanoscale particle generating device generates nanoscale particles by passing a liquid nanoscale particle precurso... | 12/01/2009 |
| 7402299 | Intracorporeal medicaments for photodynamic treatment of disease New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthe... | 07/22/2008 |
| 7384623 | High energy phototherapeutic agents High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive structures in diseased tissue, and methods of treating and imaging using ... | 06/10/2008 |
| 7384971 | Phytochemicals for the treatment of cervical dysplasia New compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3′diindolylmethane (LTr-1), acceptable carriers and/or excipients. These compositions are ... | 06/10/2008 |
| RE40300 | Carbon dioxide enhancement of inhalation therapy The present invention provides a method of increasing the deposition of aerosolized drug in the respiratory tract of an individual or animal, comprising the step of administering said aerosolized drug in an air mixture containing up to about 10% carbon dioxide gas. | 05/06/2008 |
| 7358222 | Preventing airway mucus production by administration of EGF-R antagonists Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks th... | 04/15/2008 |
| 7351798 | Stabilized protein crystals, formulations comprising them and methods of making them This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and composition... | 04/01/2008 |
| 7288243 | Aerosol drug inhibition of lung metastases The present invention provides a method of inhibiting growth of lung metastases in an individual comprising the steps of administering a dose of a lipid-drug enhancer liposomal complex and, in sequence, administering a dose of a lipid-anticancer drug liposomal compl... | 10/30/2007 |
| 7250152 | Supercritical fluids processing: preparation of protein microparticles and their stablilisation A process for the co-precipitation of a substance with a stabilizer therefor, by a gas anti solvent process comprising introducing into a particle formation vessel a supercritical fluid pure or mixed with a modifier; and a solution comprising said substance and said... | 07/31/2007 |
| 7235264 | Cerebral protection with a gas comprising xenon Xenon or xenon-containing gases and, where appropriate, an NO source are employed as medicament for cerebral protection. Cerebral protection is defined as reducing or preventing impairments of cerebral function of various causes, but especially secondary to perfusio... | 06/26/2007 |
| 7217409 | Alkanoic acid derivatives A method for treating respiratory disorders comprises administering to a patient a pharmaceutical aerosol formulation comprising: (i) a compound of formula (I) or a salt or solvate thereo... | 05/15/2007 |
| 7175886 | Apparatus and method for micron and submicron particle formation An apparatus is described for micron and submicron particles formation of a substance using the GAS process, comprising a particles formation vessel (22) and means for introducing a solution of the substance and a supercritical fluid into the particles format... | 02/13/2007 |
| 7150888 | Methods and apparatus to prevent colds, influenzaes, tuberculosis and opportunistic infections of the human respiratory system Strong vapors from eucalyptus oil and tea tree oil are inhaled periodically to prevent respiratory system diseases including colds, flus, pneumonia, tuberculosis, and opportunistic infections in individuals having cystic fibrosis. Apparatus for the periodic inhalati... | 12/19/2006 |
| 7048953 | Methods and apparatus to prevent, treat and cure infections of the human respiratory system by pathogens causing severe acute respiratory syndrome (SARS) Concentrated vapors from botanical essential oils are inhaled to prevent, treat and cure infections of the respiratory pathogens causing Severe Acute Respiratory Syndrome (“SARS”). These vapors are inhaled as a practical method to reduce the risks of infection b... | 05/23/2006 |
| 6977068 | Method for detection of fibrin clots A method for the detection of fibrin in a source, in particular the in vivo detection of a fibrin in a patient, the method comprising supplying to the source or patient an amount of a detectable reagent comprising a plurality of discrete particles, each of the parti... | 12/20/2005 |
| 6635234 | Preparation and use of radium-223 to target calcified tissues for pain palliation, bone cancer therapy, and bone surface conditioning Processes for the preparation, prepared solutions, and the use of radium-223 for the treatment of calcified tumors, bone tumors, treatment of bones, bone surfaces and soft tissues is described.... | 10/21/2003 |
| 6630121 | Supercritical fluid-assisted nebulization and bubble drying A method of making fine dry particles of substances is provided by forming a composition comprising a substance of interest and a supercritical or near critical fluid; rapidly reducing the pressure on said composition, whereby droplets are formed; and pas... | 10/07/2003 |
| 6596740 | Nicotine mucosal spray A composition for administration to the nasal mucosa of a subject comprises a solution of nicotine or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable solvent. The composition has a nicotine concentration less than 10 mg/ml. The... | 07/22/2003 |
| 6566324 | Preventing airway mucus production by administration of EGF-R antagonists Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to an... | 05/20/2003 |
| 6551989 | Preventing airway mucus production by administration of EGF-R antagonists Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to an... | 04/22/2003 |
| 6528312 | Use of G-actin for improving transfection of a polynucleotide into a cell Described is the use of a nuclease inhibitor or of interleukin-10 (IL-10) for the preparation of a therapeutic composition for improving transfection of a polynucleotide into a cell, and to compositions comprising a mixture of polynucleotide and nuclease ... | 03/04/2003 |
| 6503481 | Compositions for aerosolization and inhalation A composition used in combination with an electrohydrodynamic device capable of delivering an active ingredient to the aerodigestive system of the user. The composition comprises three or optionally four basic components: an active ingredient; a carrier m... | 01/07/2003 |
| 6455052 | Enteric coating, comprising alginic acid, for an oral preparation A composition for forming an enteric coating on a tablet, capsule or pellet for oral ingestion includes a liquid mixture of alginic acid particles dispersed in an aqueous solution of a binding agent of locust bean, gum, gelatine, vegetable hydrocolloids a... | 09/24/2002 |
| 6440393 | Carbon dioxide enhancement of inhalation therapy The present invention provides a method of increasing the deposition of aerosolized drug in the respiratory tract of an individual or animal, comprising the step of administering said aerosolized drug in an air mixture containing up to about 10% carbon di... | 08/27/2002 |
| 6406698 | Pharmaceutical composition comprising serum amyloid P component for prophylactic or therapeutic treatment of virus infections and a kit for detecting binding of compositions to virus components Pharmaceutical compositions comprising a protein serum amyloid P component (SAP) capable of binding viruses, especially myxovirus, e.g. influenza viruses and thereby preventing the transmission and infection with such viruses. Preferred is mucosal adminis... | 06/18/2002 |
| 6406745 | Methods for coating particles and particles produced thereby Methods of coating core materials by providing target materials and core materials; ablating the target materials to form ablated particulate target materials; and coating the core materials with said ablated particulate target materials; wherein the meth... | 06/18/2002 |
| 6325475 | Devices for presenting airborne materials to the nose An ink-jet dispenser for the micro-dispensation of airborne materials into an individual's airspace for inhalation or sniffing. The ink-jet dispenser will allow the study of temporal integration times, inter-nostril summation, backwards and forwards maski... | 12/04/2001 |
| 6271200 | Proteinic drug delivery system using aerosolized membrane-mimetic amphiphiles A mixed liposome pharmaceutical composition with multilamellar vesicles is provided. The vesicles are comprised of a pharmaceutical agent, membrane-mimetic amphiphiles and various phospholipids. A method of making the composition using high speed mixing o... | 08/07/2001 |
| 6264913 | Non-invasive test for assessing bacterial overgrowth of the small intestine Provided herein is a novel breath test for assessing bacterial overgrowth. The test involves administration of a labeled sorbitol or sorbitol derivative to a subject and measurement of the label in breath and/or blood.... | 07/24/2001 |
| 6211162 | Pulmonary delivery of protonated/acidified nucleic acids The present invention provides a method of treating bacterial respiratory infections by pulmonary administration of protonated/acidified nucleic acids. These modified nucleic acids are effective as bactericidal and/or bacteriostatic agents without regard ... | 04/03/2001 |
| 6171575 | Method of radioisotopic assessment of the integrity and function of the nose-brain barrier A radioisotopic assessment of the integrity of the nose-brain barrier was performed on an anosmic patient by spraying an aliquot of a mixture of 99mTc-DTPA and hyaluronidase onto the olfactory mucosa with the patient's head positioned vertically and subse... | 01/09/2001 |
| 5871771 | Micronized biodegradable particles, process for preparing them and use thereof The invention relates to micronized biodegradable particles, processes for preparing them and use thereof.... | 02/16/1999 |
| 5792057 | Ventilation imaging using a fine particle aerosol generator A method of diagnosing a patient is carried out by delivering an aerosolized dose of a radioactive formulation to a patient and making a ventilation image of radioactive material deposited in the lung. This image is compared with a separately generated im... | 08/11/1998 |
| 5759580 | Compositions containing micronized nebivolol The present invention relates to pharmaceutical compositions containing as active ingredient micronized nebivolol of formula (I) and ways of preparing said compositions. ##STR1##... | 06/02/1998 |
| 5670167 | Process for the production of medicament formulations A medicament compact is produced by placing loose powdered medicament in a mould having a longitudinal axis where a mandrel is positioned along the longitudinal axis of the mould compressing the medicament when a force parallel to the longitudinal axis is... | 09/23/1997 |
| 5451408 | Pain management with liposome-encapsulated analgesic drugs Liposome-encapsulated opioid analgesic agents delivered by the pulmonary route provide local, or systemic analgesia superior to that produced by the solution form of these agents administered by parentral (intravenous, intramuscular, or subcutaneous injec... | 09/19/1995 |
| 5391547 | Method using 5,10,15,20-tetrakis(4-carboxyphenyl)porphine for treating cancers of the lung Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with 67 Cu. The latter complex also provides a s... | 02/21/1995 |
| 5362473 | Radiolabelled particulate composition The invention relates to a metal-radionuclide-labelled particulate composition which may be used in the form of a dry aerosol for lung scintigraphy, in particular, for the examination of the mucociliary transport, or for radiotherapy. The composition comp... | 11/08/1994 |
| 5362474 | Method for detecting and locating inflammatory or tumor foci in a patient and diagnostic kit therefor The present invention relates to an aerosol composition containing a carrier agent capable of recognizing and binding to inflammatory and tumor foci mobilizing macrophages in their immediate environment, and an aerosol substrate, characterized in that the... | 11/08/1994 |
