Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 8182788 | Method for obtaining a 2- F fluor-2-deoxy-D-glucose F-FDG-solution The invention relates to a method for improving one or more physical/chemical characteristics, like reduced radiolysis of and the ability to autoclave, a 18F-fluor-deoxy-glucose (18F-FDG)-solution, which method comprises the steps of a) provision of a 18F-fluor-deox... | 05/22/2012 |
| 8178076 | Diagnosis and assessment of skeletal related disease using calcium 41 A method of determining calcium metabolism in a patient comprises the steps of administering radioactive calcium isotope 41Ca to the patient, allowing a period of time to elapse sufficient for dissemination and reaction of the radioactive calcium isotope ... | 05/15/2012 |
| 8173102 | Tame based chelators and uses thereof New bifunctional chelation complexes are described. These are based on the structure of the so-called “TAME-HexA” molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes. ... | 05/08/2012 |
| 8137656 | Method and apparatus for synthesis of [C]phosgene using concentrated [C] carbon monoxide with UV light Methods and systems for labeling synthesis of phosgen by UV light are provided. Methods of synthesizing labeled compounds useful as PET tracers from labeled phosgen are also provided. The resultant carbon-isotope labeled compounds are useful as radio-pharmaceuticals... | 03/20/2012 |
| 8133471 | CLK-peptide and SLK-peptide The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen type-IV with substantially greater affinity than to the native triple helical form of collagen type-... | 03/13/2012 |
| 8128905 | Stabilized uncoated particles of reversed liquid crystalline phase materials Uncoated particles of reversed cubic phase or reversed hexagonal phase material containing an active disposed within are provided. The uncoated particles have an ionic charge that is sufficient to stabilize them in dispersion in a liquid, e.g. a polar solvent. The a... | 03/06/2012 |
| 8128906 | Stabilized uncoated particles of reversed liquid crystalline phase materials Uncoated particles of reversed cubic phase or reversed hexagonal phase material containing an active disposed within are provided. The uncoated particles have an ionic charge that is sufficient to stabilize them in dispersion in a liquid, e.g. a polar solvent. The a... | 03/06/2012 |
| 8124050 | Method for coating the internal surface of a reaction vessel A method for coating the internal surfaces of a reaction vessel having a small internal diameter comprises the steps of (i) introducing into the reaction vessel a solution of one or more monomers in a suitable solvent; (ii) introducing a flow of an inert gas through... | 02/28/2012 |
| 8114379 | Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process Piperidine or piperazine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The compounds are characterized by the formulae: | 02/14/2012 |
| 8097237 | Non-invasive diagnostic agents of cancer and methods of diagnosing cancer, especially leukemia and lymphoma The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tis... | 01/17/2012 |
| 8097236 | Devices and methods for the treatment of cancer The invention relates to the treatment of cancer. In particular the invention relates to an internal therapeutic product comprising: (i) an anti-cancer component selected from one or both of: a radionucleotide, a cytotoxic drug; and (ii) a silicon component selected... | 01/17/2012 |
| 8066970 | Contrast agents The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic centr... | 11/29/2011 |
| RE42748 | Oral DTPA for radionuclide chelation A composition for oral radionuclide chelation therapy comprises a DTPA chelate selected from Zn-DTPA and Ca-DTPA and a permeation enhancer that preferentially increases jejunal uptake of the DTPA chelate. The composition has a DTPA chelate bioavailability of at leas... | 09/27/2011 |
| 8012454 | Embolization A particle includes a ferromagnetic material, a radiopaque material, and/or an MRI-visible material. ... | 09/06/2011 |
| 8012455 | Radioactive source materials formable into various shapes The present invention provides an integral source material, the integral source material has at least one nuclide that is an integral source material having at least one nuclide that is activatable by exposure to radiation, the nuclide is a chemically bound constitu... | 09/06/2011 |
| 8007766 | Microwave method for preparing radiolabelled gallium complexes The present invention relates to a method of producing radiolabelled gallium complexes that could be used as diagnostic agents, e.g. for positron emission tomography (PET) imaging. ... | 08/30/2011 |
| 7976823 | Ferromagnetic particles and methods Ferromagnetic particles and methods are disclosed. ... | 07/12/2011 |
| 7959900 | Particulate materials and compositions for radio therapy Timed-bioresorbable particulates, particularly microspheres or fibers, may be used as a vehicle for delivery of radioisotopes, such as Y-90 and Pd-103 for localized radiotherapy, or as an embolic device. These particulates may also be embedded in polymers, or disper... | 06/14/2011 |
| 7947253 | Perturbed membrane-binding compounds and methods of using the same The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis or activated platelets. The invention further provides methods for uti... | 05/24/2011 |
| 7914767 | Oral DTPA for radionuclide chelation A composition for oral radionuclide chelation therapy comprises a DTPA chelate selected from Zn-DTPA and Ca-DTPA and a permeation enhancer that preferentially increases jejunal uptake of the DTPA chelate. The composition has a DTPA chelate bioavailability of at leas... | 03/29/2011 |
| 7914766 | Inorganic resins for clinical use of Bi generators Applicant's invention is a radionuclide generator resin material for radiochemical separation of daughter radionuclides, particularly 213Bi, from a solution of parental radionuclides, the resin material capable of providing clinical quantities of 213... | 03/29/2011 |
| 7901665 | Conjugated macromolecules A method of conjugating a carboxylate-containing molecule to an amine-containing macromolecule to form a substituted macromolecule is provided. The method includes (a) forming a first solution by dissolving a substance comprising at least one macromolecule having fr... | 03/08/2011 |
| 7887782 | Radiotherapeutic formulations containing 224RA and a method for their production The invention relates to novel radiotherapeutic formulations containing 224Ra and methods for their production. The invention discloses, in particular, radiotherapeutic formulations comprising at least one salt of the isotope 224Ra, which are c... | 02/15/2011 |
| 7829063 | Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents. ... | 11/09/2010 |
| 7824659 | Methods of making radiolabeled tracers and precursors thereof The present disclosure relates to a solid-phase process for the production of radiolabeled tracers, in particular for the production of 18F-labeled compounds which may be used as Positron Emission Tomography (PET) radiolabeled tracers. The disclosure also... | 11/02/2010 |
| 7780947 | Tame based chelators and uses thereof New bifunctional chelation complexes are described. These are based on the structure of the so-called “TAME-HexA” molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes. ... | 08/24/2010 |
| 7776309 | Preparation and use of alkylating agents Methods of alkylating target compounds are disclosed. The alkylating agent can be radiolabelled. In some instances, the alkylating agent is synthesized and then reacted with a target compound without an intervening purification step. The method comprises | 08/17/2010 |
| 7771704 | Radioactive transition metal-imido hetero-diphosphine complexes, their preparation and radiopharmaceutical compositions thereof The present invention provides radioactive metal heterocomplexes of formula (I): [(Me=N—R)L1L2]+Z− wherein Me, R, L1L2 and Z− have the meanings indicated in the description. The complexes includ... | 08/10/2010 |
| 7767193 | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The ar... | 08/03/2010 |
| 7744851 | Methods and agents for preparing F-radiolabeled fluorinating agents The present invention is directed to a method for preparing an anhydrous 18F-radiolabeled fluorinating agent by a nucleophilic reaction of a hydrated 18F-radiolabeled fluoride ion source with an unsaturated carrier compound; treating the 1... | 06/29/2010 |
| 7722855 | Extracellular vesicles from non-pathogenic amoebae useful as vehicle for transferring a molecule of interest to an eukaryotic cell The invention relates to membrane vesicles from non-pathogenic amoeba, in particular from the amoeba Dictyostelium discoideum, containing a molecule of therapeutic interest, to a method of preparing such vesicles and to the use of said vesicles as a vehicle f... | 05/25/2010 |
| 7722856 | Process for the production of a radioactive aerosol A method for forming an inhalable isotope compound suitable for use in patient medical diagnosis, the method comprising the steps of: (a) electrolytic loading of a carbon crucible with the isotope; (b) sublimating any isotope carrier in the crucible; (c) ablating th... | 05/25/2010 |
| 7700073 | Use of NF-κB inhibition in combination therapy for cancer The use of NF-κB inhibitors to enhance the cytotoxic effects of chemotherapy or radiation therapy in the treatment of neoplastic conditions is described. ... | 04/20/2010 |
| 7670590 | Perturbed membrane-binding compounds and methods of using the same The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis or activated platelets. The invention further provides methods for uti... | 03/02/2010 |
| 7666389 | Method of imaging cell death in vivo A method of imaging apoptosis in vivo, using radiolabeled annexin, is described. ... | 02/23/2010 |
| 7517517 | Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands The present invention is concerned with radiolabelled quinoline and quinolinone derivatives according Formula (I-A)* or (I-B)* showing metabotropic glutamate receptor antagonistic activity, in particular mGlu1 receptor activity, and their preparation; it further rel... | 04/14/2009 |
| 7510698 | Vaccines The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccine compositions are potent induces of a range of immune responses. ... | 03/31/2009 |
| 7494642 | Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid The present invention relates to novel modified fatty acid analogs, where a positron or gamma-emitting label is placed at a position on a fatty acid backbone and an organic substituent is substituted at the 2,3; 3,4; 4,5; 5,6 and other sequence positions of a fatty ... | 02/24/2009 |
| 7459141 | Technetium-99m-labeled organic germanium nanocolloids, method of preparing the same and use thereof Disclosed relates to organic germanium nanocolloids, to which technetium-99m (99mTc), a radionuclide, is labeled, method of the same, and a spleen-imaging agent including the same. According to the invention, 99mTc-labeled organic germanium nan... | 12/02/2008 |
| 7449170 | Materials and methods for controlling isotope effects during fractionation of analytes Compositions and methods for controlling or eliminating isotope effects during fractionation of chemically equivalent but isotopically distinct compounds. Isotope coding agents contain heavy isotopes other than deuterium. The invention facilitates intelligent data a... | 11/11/2008 |
