Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7384606 | Bead dispensing system A bead dispensing system is provided for delivering small amounts of substances onto substrates. The system can include, for example, a movable support structure having an array of spaced-apart projections depending from its lower side. An attraction source, such as... | 06/10/2008 |
| 7384795 | Methods for verifying fluid movement Methods for using semiconductor nanocrystals for determining fluid movement, fluid dilution and fluid removal are described. Methods for using semiconductor nanocrystals for monitoring and quantifying the amounts of solid materials dissolved in a liquid are also des... | 06/10/2008 |
| 7381569 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurali... | 06/03/2008 |
| 7381571 | Device and method for analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurali... | 06/03/2008 |
| 7381570 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurali... | 06/03/2008 |
| 7378056 | Circuits for in vivo detection of biomolecule concentrations using fluorescent tags Methods are disclosed wherein labeled antibodies can be provided in vivo to tissue having antigens that specifically bind the labeled antibody. A first optical radiation is emitted into the tissue in vivo to excite the labeled antibody bound to the antigen in vivo. ... | 05/27/2008 |
| 7371538 | Microluminometer chip and method to measure bioluminescence An integrated microluminometer includes an integrated circuit chip having at least one n-well/p-substrate junction photodetector for converting light received into a photocurrent, and a detector on the chip for processing the photocurrent. A distributed electrode co... | 05/13/2008 |
| 7371247 | Method and apparatus for penetrating tissue A tissue penetrating system includes a plurality of penetrating members each having a tip. A penetrating member driver is coupled to the plurality of penetrating members. Each tip of a penetrating member is uncovered during launch of the penetrating member by the pe... | 05/13/2008 |
| 7371329 | Method for filtering particles from a fluid Methods for filtering particles from a fluid are disclosed, wherein an array of microstructures defining respective microchannels having respective minimum widths are used to separate the fluid from particles to be filtered. The fluid flows through the minimum width... | 05/13/2008 |
| 7372570 | Incident light redistribution to compensate for radial gradient in detector Nonuniformities in the efficiency of detection of individual fluorescing reaction mixtures in a well plate with a two-dimensional array well array are corrected. The nonuniformities arise both from the stimulation pattern and the detection pattern, and are corrected... | 05/13/2008 |
| 7368086 | Functionalized fluorescent nanocrystals, and methods for their preparation and use Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functi... | 05/06/2008 |
| 7361514 | System and method for gas discharge spectroscopy A system for identifying gases, the system having a plasma generator for generating a plasma using the gas to be identified and an array of detectors for detecting light emitted from the plasma. By analysing the output of the detectors, the gas can be identified. Th... | 04/22/2008 |
| 7354389 | Microarray detector and methods A detector for optical analysis of a biochip determines the focal position of a plurality of analytes on the biochip using one or more registration markers on the biochip, wherein the analytes and the registration marker are illuminated by different light sources. T... | 04/08/2008 |
| 7351374 | Surface plasmon enhanced illumination apparatus having non-periodic resonance configurations An apparatus configured to generate surface plasmon enhanced radiation comprises a metal film having first and second surfaces, and one or more resonance configurations formed in the metal film. An exemplary resonance configuration includes an aperture extending bet... | 04/01/2008 |
| 7348180 | Method of evaluating freshness of a fish product A method of evaluating freshness of a fish product by cutting a small quantity of sample from the fish product, adding an effective amount of a staining reagent containing at least one of a cell-permeant dye and a cell-impermeant fluorescent dye onto the sample, inc... | 03/25/2008 |
| 7349093 | Fluorescence measurement apparatus On a substrate 41 holding a sample to be detected, a dielectric multilayer 42 is disposed which reflects excitation light e1 supplied from above the substrate 41 and transmits fluorescence f1 emitted from the sample, and the excita... | 03/25/2008 |
| 7348181 | Self-encoding sensor with microspheres A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and ... | 03/25/2008 |
| 7336355 | Fluorescence spectroscopic apparatus There is provided a fluorescence spectroscopic apparatus includes an exciting optical unit configured to irradiate the same sample area with a plurality of excitation lights of different wavelength bands, an optical unit configured to repeatedly guide fluorescences ... | 02/26/2008 |
| 7335470 | Compilations of nucleic acids and arrays and methods of using them In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays, and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications, and the like, and the diagnosis or p... | 02/26/2008 |
| 7331931 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generato... | 02/19/2008 |
| 7332344 | Luminescence assays A method of detecting an analyte is described in which an up-converting luminescent species that is excited by absorption of long wavelength light is provided as a donor of energy to an acceptor species that can be bound to, or generated in proximity to, the lumines... | 02/19/2008 |
| 7329388 | Electrophoresis apparatus having staggered passage configuration An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a ... | 02/12/2008 |
| 7318907 | Surface plasmon enhanced illumination system Methods and apparatus for producing small, bright nanometric light sources from apertures that are smaller than the wavelength of the emitted light. Light is directed at a surface layer of metal onto a light barrier structure that includes one or more apertures each... | 01/15/2008 |
| 7316700 | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties A lancing device, an embodiment of which controls the advancement and retraction of a lancet by monitoring the position of the lancet in conjunction with a lancet controller which incorporates a feedback loop for modulating the lancet driver to follow a predetermine... | 01/08/2008 |
| 7314751 | Fluorescence detection system including a photonic band gap structure A fluorescence detection system includes a photonic band gap structure. An internal surface of the photonic band gap structure defines a core region, and is coated with a film formed of conjugated polymer molecules. The core region is filled with a sample fluid or g... | 01/01/2008 |
| 7310147 | Robotic apparatus for picking of cells and other applications with integrated spectroscopic capability A robotic apparatus of the kind having a sample manipulation head with associated positioning system mounted above the main bed of the apparatus, as used for picking of cells, in particular animal cells, or for other biological or chemical applications. An imaging s... | 12/18/2007 |
| 7304733 | Method and device for conducting the spectral differentiating, imaging measurement of fluorescent light A method and a device for image producing measurement of fluorescent light, according to which a sample containing fluorophores of different species is irradiated with excitation light of at least one excitation channel defined by its spectral properties. The fluore... | 12/04/2007 |
| 7300800 | Analyte detection system An analyte detection system utilizing a combination of fluorescent labels for labeling particles and an analyte specific fluorescent analyte detection dye. The particles contain a combination of fluorescent labels for coding the particles and an analyte specific flu... | 11/27/2007 |
| 7301628 | Method and apparatus for detecting biomolecular interactions Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light... | 11/27/2007 |
| 7292333 | Optical interrogation system and method for 2-D sensor arrays An optical interrogation system and method are described herein that can interrogate a two-dimensional (2D) array of optical sensors (e.g., grating coupled waveguide sensors) located in a 2D specimen plate (e.g., microplate). ... | 11/06/2007 |
| 7291117 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a voice coil based penetrating member driver. A plurality of penetrating members are included. A transport mechanism is configured to... | 11/06/2007 |
| 7288227 | Biochip reader with enhanced illumination and bioarray positioning apparatus A method of illumination and illumination apparatus are provided in a biochip reader. Illumination is provided by a non-collimated laser source or a light emitting diode (LED). The light is directed to opposing sides of a glass substrate by a pair of optical fiber b... | 10/30/2007 |
| 7289204 | Apparatus and sensing devices for measuring fluorescence lifetimes of fluorescence sensors An apparatus and devices for measuring fluorescence lifetimes of fluorescence sensors for one or more analytes, the apparatus comprising (c) one or more reference systems (3,6,7), said reference systems each comprising one or more reference light sources (... | 10/30/2007 |
| 7286221 | Arrayed sensor measurement system and method Optical interrogation systems and methods are described herein that are capable of measuring the angles (or changes in the angles) at which light reflects, transmits, scatters, or is emitted from an array of sensors or specimens that are distributed over a large are... | 10/23/2007 |
| 7286224 | Time-multiplexed scanning light source for multi-probe, multi-laser fluorescence detection systems An apparatus images a surface. An imager stage linearly translates the surface in a first direction. A light path has a first end defining an input aperture perpendicular to the first direction and parallel to the surface, and a second end defining an output apertur... | 10/23/2007 |
| 7282367 | Method for verifying amount of sample solution, method for controlling measurement system and method for measuring concentration of solution in apparatus for measuring optical characteristic A verification method of a sample solution amount includes the steps of: detecting at least one of a transmitted light component, a scattered light component and a reflected light component of a light by a photosensor while irradiating a sample solution, which is be... | 10/16/2007 |
| 7282349 | Solvatochromatic bacterial detection Solvatochromic dyes are used herein to indicate the presence of bacteria by incorporating them into various substrates such as films, woven and nonwoven fabrics, paper towels, coform and airlaid materials and bonded carded webs. These dyes change color in response t... | 10/16/2007 |
| 7279323 | Method for conducting receptor-ligand association reaction and reactor used therefor A method for conducting a receptor-ligand association reaction includes the steps of dipping a biochemical analysis unit including a substrate formed with a plurality of absorptive regions which contain receptors or ligands and are formed to be spaced apart from eac... | 10/09/2007 |
| 7279339 | Reagent for an immunoassay The present invention relates to (1) A reagent for an immunoassay of a target substance existing in a free form and a bound form in a specimen, comprising a latex 1 which is immobilized with a monoclonal antibody 1 for the target substance, and a latex 2 which has a... | 10/09/2007 |
| 7276368 | Enhanced waveguide and method The present invention provides an optical assay apparatus that includes a light source module and an optical sensor. The light source module produces light having a range of propagation angles. The sensor includes a light adjusting portion and an assay sensing porti... | 10/02/2007 |
