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| Number | Title | Issue Date |
| 6379969 | Optical sensor for sensing multiple analytes A device for analyzing simultaneously multiple analytes in a fluid of unknown composition. The device includes a plurality of sensors, a light source for providing light to shine on the sensors, light detectors, and a processor. The sensors are exposed to... | 04/30/2002 |
| 6372511 | Swabbing means and methods of use Swabbing structures and methods of use are provided that enable a test surface to be swabbed, and subsequently facilitate a quantitative determination of the quantities of analyte collected from the test surface. The swabbing structures include a pre-wett... | 04/16/2002 |
| 6372183 | Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same Automated measurement apparatus and methods for automated drug screening procedures are provided. The apparatus is capable of initiating and measuring rapid or transient events, such as cell receptor and/or ion channel activity. In particular, the apparat... | 04/16/2002 |
| 6372508 | Method and apparatus for measuring lipid peroxidation in biological fluids and suspensions of tissues The present invention relates to a method and apparatus for measuring the lipid peroxidation extent in biological fluids and suspensions of tissues, in which a specifically prepared lipids containing sample is exposed to heat so as to induce thermo-chemil... | 04/16/2002 |
| 6368869 | Metallic overcoating as a light attenuating layer for optical sensors A liquid permeable metallic coating is utilized in conjunction with a fluorescence based optical sensor. The metallic coating is deposited directly on, and is in physical contact with, the sensing membrane. The metallic coating does not require an interve... | 04/09/2002 |
| 6369893 | Multi-channel optical detection system An apparatus for thermally controlling and optically interrogating a reaction mixture includes a vessel [2] having a chamber [10] for holding the mixture. The apparatus also includes a heat-exchanging module [37] having a pair of opposing thermal plates [... | 04/09/2002 |
| 6366793 | Minimally invasive methods for measuring analtes in vivo Minimally invasive methods for measuring an analyte, such as glucose, contained in tile interstitial fluid of a body are provided. The methods include the steps of. (a) providing at least one sensor particle capable of generating a detectable analyte sign... | 04/02/2002 |
| 6362004 | Apparatus and method for using fiducial marks on a microarray substrate A microarray scanning system for conducting experiments on a planar substrate includes an apparatus for translating the secured substrate in two axes, the substrate having at least one fiducial mark on the planar substrate as a means for positioning and a... | 03/26/2002 |
| 6358748 | Microbend fiber-optic chemical sensor A microbend fiber-optic chemical sensor for detecting chemicals in a sample, and a method for its use, is disclosed. The sensor comprises at least one optical fiber having a microbend section (a section of small undulations in its axis), for transmitting ... | 03/19/2002 |
| 6352672 | Apparatus for measuring the luminescence emitted in a luminescent assay The present invention relates to an apparatus for measuring the luminescence emitted in a luminescent assay, which makes it possible to correct certain perturbations due to the measuring medium.... | 03/05/2002 |
| 6348322 | Method of screening for specific binding interactions A method for detecting the binding of a test compound to a probe molecule comprises providing a test compound, the test compound having a first fluorophore bound thereto, and providing a screening substrate. The screening substrate comprises a solid suppo... | 02/19/2002 |
| 6345191 | System for quantitative determination of the local distribution of a quantity to be measured A system for quantitative determination of the local distribution of a quantity to be measured, comprising a planar sensor film, which is applied to a measuring surface, such as the surface of a body organ, a skin area or a cell culture, and whose diffusi... | 02/05/2002 |
| 6340598 | Apparatus for multichannel fluorescent immunoassays Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture... | 01/22/2002 |
| 6338822 | Optical carbon dioxide sensors A sensor for the optical determination by fluorescence of carbon dioxide in liquid and gaseous media, which consist essentially of a carrier and a light-sensitive layer applied thereto. In addition to a polymer as a base substance and an anionic fluoresce... | 01/15/2002 |
| 6335201 | Method and apparatus for detecting enzymatic activity using molecules that change electrophoretic mobility The activity of intracellular chemical reactions of molecules is measured by the use of fluorescently labeled substrate molecules that undergo a change in electrophoretic mobility upon chemical reaction such as that catalyzed by an enzyme. Specificity is ... | 01/01/2002 |
| 6331438 | Optical sensors and multisensor arrays containing thin film electroluminescent devices Optical sensor, probe and array devices for detecting chemical biological, and physical analytes. The devices include an analyte-sensitive layer optically coupled to a thin film electroluminescent layer which activates the analyte-sensitive layer to provi... | 12/18/2001 |
| 6328931 | Analyte collection and assaying assembly Swabbing and assaying structures, and selected methods of use, enable a test surface to be swabbed, and subsequently facilitate a quantitative determination of the quantities of analyte collected from the test surface. The swabbing structures include a pr... | 12/11/2001 |
| 6328930 | Apparatus for performing diagnostic testing A hand-held portable diagnostic assay system for conducting and recording luminescent reactions for generating and recording luminescent read-out signals generated by a testing assembly and recordable on an image recording medium. A carrier assembly recei... | 12/11/2001 |
| 6326144 | Biological applications of quantum dots The present invention provides a composition comprising fluorescent semiconductor nanocrystals associated to a compound, wherein the nanocrystals have a characteristic spectral emission, wherein said spectral emission is tunable to a desired wavelength by... | 12/04/2001 |
| 6326213 | Acoustic standing-wave enhancement of a fiber-optic Salmonella biosensor A fluorescent fiber-optic biosensor system using ultrasonic concentration of particles and cells for the detection of Salmonella typhimurium. A biosensor test chamber serves as an ultrasonic standing-wave cell that allows microspheres or cells to be conce... | 12/04/2001 |
| 6323042 | Microcapillary-based flow-through immunosensor and displacement immunoassay using the same A displacement-type flow immunoassay is performed using a microcapillary passage. The inner wall of the microcapillary passage has immobilized thereon antibodies to the antigen of interest. Labeled antigen is immunologically bound to the immobilized antib... | 11/27/2001 |
| 6319705 | Microchip device for electrophoresis A microchip device for electrophoresis includes not only a microchip having a separation flow route for separating a sample electrophoretically and an electrical power source for applying a migration potential difference along the separation flow route bu... | 11/20/2001 |
| 6316274 | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide with an integral semi-cylindrical lens, and has multi-analyte features and calibration features, along with improved evanescent field int... | 11/13/2001 |
| 6312961 | Optical sensor using an immunological reaction and a fluorescent marker A biosensor comprises a waveguide into which light is coupled by a diffraction grating. The sample to be analyzed is placed on a reaction region in which a component of the immunological reaction is provided, for example antibodies or antigens. Fluorescen... | 11/06/2001 |
| 6309601 | Scanning optical detection system An optical detection system is adapted for detection of biological reactions. An excitation source illuminates a portion of an object to be examined, the portion preferably comprising one microlocation out of an array of microlocations. An intervening opt... | 10/30/2001 |
| 6309886 | High throughput analysis of samples in flowing liquid Apparatus and method enable imaging multiple fluorescent sample particles in a single flow channel. A flow channel defines a flow direction for samples in a flow stream and has a viewing plane perpendicular to the flow direction. A laser beam is formed as... | 10/30/2001 |
| 6310687 | Light detection device with means for tracking sample sites Apparatus and methods for optical detection with improved read speed and/or signal-to-noise ratio. These apparatus and methods may involve among others moving an sample substrate (108) while simulataneously detecting light transmitted from one or more sam... | 10/30/2001 |
| 6306610 | Biological applications of quantum dots The present invention provides a composition comprising fluorescent semiconductor nanocrystals associated to a compound, wherein the nanocrystals have a characteristic spectral emission, wherein said spectral emission is tunable to a desired wavelength by... | 10/23/2001 |
| 6303385 | Fluorescent N-alkylated acrylamide copolymers and optical pH sensors A water-insoluble copolymer which is composed of (a) from 39.9 to 60% by weight of N,N-dimethylacrylamide or N,N-dimethylmethacrylamide; (b) from 60 to 39.9% by weight of N-alkylated acryl amides or N-alkylated methacryl amides; (c) from 0.1 to 0.7% by we... | 10/16/2001 |
| 6300082 | Method and apparatus for measurement of the effect of test compounds on signal transduction at the level of biological receptors A method and apparatus for measuring binding between a plurality of molecules of a biological receptor protein and a plurality of molecules of a type which binds to said biological receptor is presented. Apparatus utilizes a sensor possessing a waveguide ... | 10/09/2001 |
| 6296810 | Apparatus for DNA sequencing The present invention provides a method and apparatus for automated DNA sequencing. The method of the invention includes the steps of: a) using a processive exonuclease to cleave from a single DNA strand the next available single nucleotide on the strand;... | 10/02/2001 |
| 6290912 | Read head for luminometer The read head for luminometer includes a housing that encloses a cylindrical core. The housing has a through opening that aligns with a central passageway of the cylindrical core to define a confinement space. The housing and the cylindrical core are form... | 09/18/2001 |
| 6287783 | Optical assay device and method The present invention involves an optical assay device and method of use for the detection of an analyte of interest in a sample that conveniently allows control of the flow characteristics of the sample through the device without significant user interve... | 09/11/2001 |
| 6284472 | Method for extending the range of an immunoassay Calibrating an immunoassay by generating two reaction rate measuring curves, from samples having higher and lower relative levels of antigen, extrapolating a combination of the curves to cover sample concentrations known to contain an excess of antigen re... | 09/04/2001 |
| 6280960 | Optical detection and analysis of sub-micron particles Method and apparatus for the single particle detection of submicron structures such as biological molecules and viruses utilises and optically transparent substrate coated with a thin film of metal illuminated with an optical beam incident at or close to ... | 08/28/2001 |
| 6277627 | Biosensor The present invention relates to a glucose biosensor comprising a genetically engineered Glucose Binding Protein (GBP). In a specific embodiment, the invention relates to a GBP engineered to include mutations that allow site specific introduction of envir... | 08/21/2001 |
| 6277651 | Diode laser electrochemical sensor for detecting chemical and biological analytes The present sensor allows the user of any diode laser structure to be employed to provide sensitive chemical and biological detector. A diode laser electrochemical sensor is described in U.S. Pat. No. 5,591,407 "Laser Diode Sensor". The present invention ... | 08/21/2001 |
| 6274086 | Apparatus for non-invasive imaging oxygen distribution in multi-dimensions A detection device for three-dimensional tissue oxygen measurement in animals and humans comprising an array of fiber optics effective for transmitting emitted phosphorescent light, and further comprising an array of phosphorescent detectors and an excita... | 08/14/2001 |
| 6274085 | Device for investigating non-linear optical behavior of a layer formed from first and second reactants A method and a device for optically ascertaining the mutual binding of a first and a second reactant are described. Use is made of the fact that a dipolar layer (7) having a non-linear optical behavior is formed upon a reaction between the two reactants. ... | 08/14/2001 |
| 6271042 | Biochip detection system A biochip detection system detects and locates samples that are labeled with multiple fluorescent tags and are located on a biochip. This biochip detection system includes a charge coupled device (CCD) sensor, a broad spectrum light source, a lens, a ligh... | 08/07/2001 |
