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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7153690 | Real-time component monitoring and replenishment system for multicomponent fluids A multicomponent fluid composition monitoring and compositional control system, in which a component analysis is effected by titration or other analytical procedure, for one or more components of interest, and a computational means then is employed to determine and ... | 12/26/2006 |
| 6875613 | Biological fluid constituent sampling and measurement devices and methods A device for accessing biological fluid, sampling biological fluid constituents and determining the concentration of at least one target constituent within the accessed biological fluid is provided. The device has at least one micro-piercing member used to penetrate... | 04/05/2005 |
| 6846639 | Method for detecting pathogens attached to specific antibodies The use of impedance measurements to detect the presence of pathogens attached to antibody-coated beads. In a fluidic device antibodies are immobilized on a surface of a patterned interdigitated electrode. Pathogens in a sample fluid streaming past the electrode att... | 01/25/2005 |
| 6803228 | Method for making a biochip and biochip The present invention relates to a method to produce a biochip and to a biochip, said biochip being composed particularly of biological probes grafted onto a conductive polymer. The method according to the invention comprises the following steps: | 10/12/2004 |
| 6593090 | High resolution DNA detection methods and devices The present invention provides methods and devices for detecting a target nucleic acid molecule. A set of oligonucleotide probes integrated into an electric circuit, where the oligonucleotide probes are positioned such that they can not come into contact ... | 07/15/2003 |
| 6576460 | Filtration-detection device and method of use The present invention relates to a filtration-detection device for detecting or quantifying an analyte in a test sample including a filtration device having a first binding material immobilized thereto, wherein the first binding material is capable of bin... | 06/10/2003 |
| 6537822 | Method for analyzing free fluorine in solutions containing hydrofluoric acid solution, and apparatus for practicing the method Free fluorine is measured in a hydrofluoric acid-containing solution with a coexistent metallic ion based on a total fluorine concentration, a total acid concentration, a metallic ion concentration, the equilibrium constant of hydrofluoric acid, and equil... | 03/25/2003 |
| 6509148 | Method for fabricating biosensors using hydrophilic polyurethane Disclosed is a method for fabricating biosensors, using hydrophilic polyurethane. Bio-active reagents, including enzymes, antibodies, antigens, cells and receptors, are mixed with hydrophilic polyurethane and the mixture is directly coated over a signal t... | 01/21/2003 |
| 6495372 | Field test apparatus and method for analysis of coolants and heat-exchange fluids A test method and apparatus for determining the content of carboxylic acid-based corrosion inhibitors in a coolant or heat exchange fluid. The amount of acidic reagent added to the coolant or fluid between two pH equilibrium points is measured to determin... | 12/17/2002 |
| 6399303 | High resolution DNA detection methods and devices The present invention provides methods and devices for detecting a target nucleic acid molecule. A set of oligonucleotide probes integrated into an electric circuit, where the oligonucleotide probes are positioned such that they can not come into contact ... | 06/04/2002 |
| 6337051 | Device for detecting formation of a second liquid phase This invention relates to monitors used in the oxidation of hydrocarbons to respective acids, which monitors are capable to detect formation of a second liquid phase in the reaction mixture. The reactions are conducted in a single liquid phase, and format... | 01/08/2002 |
| 6183695 | Reagentless oxidation reactor and methods for using same An improved apparatus and method is disclosed utilizing hydrogen absorption in combination with photolysis and/or electrolysis for in situ generation, i.e., without the need for adding chemical oxidizing agents, or enhancement of oxidizing conditions used... | 02/06/2001 |
| 6060023 | Molecular sensing apparatus A molecular sensing apparatus comprises a first electrode (10), a second electrode (12), a first molecule (20), a second molecule (22), and a third molecule (34). The first molecule (20) has a first chain of nucleic bases (30) and a first group (24). The ... | 05/09/2000 |
| 5827482 | Transistor-based apparatus and method for molecular detection and field enhancement Binding of a molecule to a molecular receptor is sensed using a transistor having a gate located at a binding site. The channel conductance of the transistor is modified by a charge associated with the molecule when the molecule binds with the molecular r... | 10/27/1998 |
| 5653939 | Optical and electrical methods and apparatus for molecule detection A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is applied. Each test site includes probes formed therein to b... | 08/05/1997 |
| 5618495 | Colorimetric titration method and apparatus The invention relates to colorimetric titration method, a titrator and colorimeter device. The titrating apparatus comprises radiant energy means for producing radiant energy. The device includes means for modulating an amplitude of an intensity of the ra... | 04/08/1997 |
| 5466589 | Coated substrates employing oriented layers of mutant heme proteins and methods of making and using same The present invention is directed to coated substrates having a coating of biological macromolecules, preferably proteins, which are capable of being immobilized on a substrate surface and have a marker. These proteins usually are mutant proteins obtained... | 11/14/1995 |
| 5380490 | Apparatus for measuring a test specimen An apparatus is so constructed as to measure a specific substance in a test specimen by the degree of the aggregation of carrier particles in a reaction solution in which the test specimen is mixed with the carrier particles which carry a substance specif... | 01/10/1995 |
| 5364594 | Method and apparatus for the coulometric detection of dissolved gases particularly TCO2 in seawater A system for coulometric TCO2 analysis wherein a sample bottle is pressurized by a head space gas having a CO2 composition which approximates the dissolved CO2 concentration in the sample. The head space gas transfers to s... | 11/15/1994 |
| 5302253 | On-line acid monitor and neutralizer feed control of the overhead water in oil refineries A method and apparatus for automatically measuring the acidity of overhead water in an oil refinery, and dispensing a neutralizing agent into the refinery system at a rate responsive to that measurement. A sample of overhead water is collected and passed ... | 04/12/1994 |
| 5296193 | Combined titration apparatus A titration apparatus, which operated volumetrically and/or coulometrically, includes a basic apparatus with a control and actuation arrangement for the volumetric metering of reagents, a metering unit for the volumetric titration removably attached to th... | 03/22/1994 |
| 5254461 | Method of and apparatus for determining microorganism populations electrochemically A method of determining populations of live, whole bacteria electrochemically. The bacteria are filtered, and the filtrate is employed in association with an electrochemical measuring unit to determine the bacteria density. In accordance with a flow-throu... | 10/19/1993 |
| 5196345 | Method for controlling the removal of acidic metal carbonyl hydride from product streams A method for determining the concentration of an acidic metal carbonyl hydride in an organic liquid by measuring the conductivity or pH of the liquid. The air addition to a continuous air demetallating unit may be controlled by feedback from the conductiv... | 03/23/1993 |
| 5186895 | Method and apparatus for automatic analysis of fluid composition involving a time-dependent variation thereof An automatic analytical apparatus in which a series of operations ranging from the sampling into a treating receptacle, pretreatment, analysis and discharge of a fluid sample to the preparation for the next analysis are repeated automatically in order, wh... | 02/16/1993 |
| 5141717 | Carbon monitor containing anion exchange resin Apparatus for measuring the concentration of carbon compounds in water, the apparatus including a reaction zone for converting such carbon compounds to free and/or combined carbonaceous acids, a device for introducing at least a portion of the water to be... | 08/25/1992 |
| 5096669 | Disposable sensing device for real time fluid analysis A system comprising a disposable device and hand held reader can perform a variety of electrochemical measurements on blood or other fluids. In operation, a fluid sample is drawn into the disposable device through an orifice by capillary action. The orifi... | 03/17/1992 |
| 5091317 | Analysis of acidic metal carbonyl hydride containing streams A method for determining the concentration of an acidic metal carbonyl hydride in an organic liquid by measuring the conductivity or pH of the liquid. The air addition to a continuous air demetallating unit may be controlled by feedback from the conductiv... | 02/25/1992 |
| 5006312 | Gravimetric titration apparatus for the determination of the iodine number of carbon black A gravimetric method for determining the iodine adsorption number of carbon black is disclosed. The concentration of an accurately weighed iodine solution is determined by titrating with a standardized titrant and determining the concentration of the iodi... | 04/09/1991 |
| 5002892 | Gravimetric determination of the iodine number of carbon black A gravimetric method for determining the iodine adsorption number of carbon black is disclosed. The concentration of an accurately weighed iodine solution is determined by titrating with a standardized titrant and determining the concentration of the iodi... | 03/26/1991 |
| 4950610 | Titrating apparatus and method Titration apparatus includes two cells that receive and contain liquids and are transparent to light. A liquid having an unknown characteristic and mixed with an indicator that is optically responsive to a titrant is disposed in the cells. Light is transm... | 08/21/1990 |
| 4920056 | Apparatus and method for automated microbatch reaction Apparatus and method for automatic microbatch reaction including a reactor having a reaction chamber, such as a 1.5 milliliter plastic centrifuge tube having a conical bottom. An automatically actuated injection valve is used to inject less than 1 millili... | 04/24/1990 |
| 4899398 | In-tank toilet dispenser Treatment of water-containing reservoirs with a cleaning composition including a water-dissipatable polyester polymer, the polyester polymer concentration in the reservoir being in an amount effective to capture heavy metal ions, thereby inhibiting staini... | 02/13/1990 |
| 4865992 | System and method for quantitative analysis of a solution A system and method for quantitative analysis of a solution to determine the concentration of a chemical species in the solution. The system includes a reaction vessel; a source of at least one liquid reagent for reacting with the chemical species being t... | 09/12/1989 |
| 4859608 | Method and apparatus for titrimetric content determination in a chemical solution In a new method for the titrimetric determination of the contents in a chemical solution, wherein a quantity of a reaction component, corresponding in each case to the change of a certain physical-chemical magnitude or a value derived from that, is added ... | 08/22/1989 |
| 4814281 | Differential conductivity sulfate monitor A differential conductivity sulfate monitor for determining the sulfate concentration of a fluid sample by monitoring the cation conductivity of the fluid sample before and after sulfate has been removed therefrom. The cation conductivities of the fluid s... | 03/21/1989 |
| 4541902 | Analytical method for determining formaldehyde in electroless copper plating bath An analytical method for determining by potentiometric titration formaldehyde in an electroless copper plating bath, which comprises using a hydroxylamine salt such as hydroxylamine hydrochloride as the titrant and using a silver electrode as the indicato... | 09/17/1985 |
| 4526755 | Gas analyzer or the like An analyzer for natural gas to determine the existence of and concentration of wanted and unwanted sulfur compounds and odorizing agents.... | 07/02/1985 |
| 4348359 | Device for determining various types of trace nitrogen An apparatus for determining various types of trace nitrogen having a measuring system which includes, a reaction section with a catalyst for reduction, an acidic gas removal section with a solid alkaline substance, heating sections for heating the reacti... | 09/07/1982 |
| 4334881 | Method and apparatus for automatic end-point detection in tripolyphosphate sequestration of hardness A method and apparatus for automatic end-point detection in tripolyphosphate sequestration of hardness are disclosed. A desired approximate 1:1 molar ratio of the hardness elements calcium (Ca) and magnesium (Mg) to sodium tripolyphosphate in a wash water... | 06/15/1982 |
| 4312715 | Method and an apparatus for electrochemical analysis An autotitration method for electrochemically determining the concentration of a substance (S) contained in a fluid, which is arranged to flow past a generator electrode (2) and downstream thereof a detector electrode (3), said substance being capable of ... | 01/26/1982 |
