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| Number | Title | Issue Date |
| 7851744 | Mass spectrometer A Matrix Assisted Laser Desorption Ionization ion source or ion imaging device is disclosed comprising a laser (1) and a zoom lens (3, 4, 5). The zoom lens (3, 4, 5) is arranged to be able to vary the magnification of a laser beam which is direc... | 12/14/2010 |
| 7834314 | Ion detection using a pillar chip Methods and assemblies for ion detection in samples using a chip with elevated sample zones, also known as a “pillar chip.” Methods include analyzing such a sample by desorbing a sample from a chip, producing a described ion sample and detecting the same. The ch... | 11/16/2010 |
| 7667194 | Method of producing microarray A method of producing a microarray including: (A) ejecting a liquid sample from an outlet onto an inspection carrier to form inspection spots, inspecting the resultant inspection spots for their quality to determine whether the inspected spots are defective or succe... | 02/23/2010 |
| 7442921 | Protein profiles with atmospheric pressure ionization The invention relates to the acquisition of mass spectra of complex protein mixtures, often called protein profiles, for example to search for biomarkers which indicate stress situations, or to identify microbes. Up to now protein profiles have been acquired using i... | 10/28/2008 |
| 7435951 | Ion source sample plate illumination system The invention provides a mass spectrometry system ion source containing a sample plate and an illumination device that is configured to produce a light beam that contacts the sample plate surface to define a grazing angle between the light beam and the sample plate ... | 10/14/2008 |
| 7423261 | Curved conduit ion sampling device and method An ion sampling apparatus for use in a mass spectrometry system. The ion sampling apparatus includes a target support for receiving a sample, an irradiation source for emitting energetic radiation or particles toward the target support, and a conduit having a curved... | 09/09/2008 |
| 7423260 | Apparatus for combined laser focusing and spot imaging for MALDI A MALDI ion source includes a sample plate for receiving a sample, a laser for producing laser radiation to ionize the sample, a first optical element arranged so as to direct the laser radiation along a first optical path toward the target area, and a second optica... | 09/09/2008 |
| 7408153 | Apparatus for detecting chemical substances and method therefor An apparatus for detecting chemical substances which is high in sensitivity and selectivity is provided. An organic acid or an organic acid salt is used to generate an organic acid gas from an organic acid gas generator 3 to be mixed with a sample gas ... | 08/05/2008 |
| 7405398 | Mass spectrometer interface A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a ... | 07/29/2008 |
| 7399957 | Coded mass spectroscopy methods, devices, systems and computer program products A coded mass spectrometer incorporates a spatial or temporal code to reduce the resolution/sensitivity dichotomy inherent in mass spectrometry. The code is used to code one or more portions of a mass spectrometer. Coding patterns, such as Hadamard codes, Walsh codes... | 07/15/2008 |
| 7381373 | System and method for preparative mass spectrometry A preparative mass spectrometer system includes an ionizer which converts the mixture into gas phase ions of the molecules in the mixture, and a separator which separates the ions according to their mass to charge ratio or mobility. The separator is a linear ion tra... | 06/03/2008 |
| 7378651 | High field asymmetric waveform ion mobility spectrometer FAIMS Disclosed is an apparatus for separating ions including a plurality of first electrode portions, each first electrode portion of the plurality of first electrode portions having a first length and an outer surface that is at least partially curved in a direction tra... | 05/27/2008 |
| 7361311 | System and method for the preparation of arrays of biological or other molecules A method of separating species in a mixture of molecules, particles or atoms and collecting the separated species is described. The method comprises the steps of converting by ionization the species in the mixture to gas phase ions, separating the gas phase ions acc... | 04/22/2008 |
| 7355172 | Liquid cheromatography/mass spectrometry apparatus A liquid chromatography/mass spectrometry apparatus combines a chromatograph having a liquid delivery part for delivering mixed multiple solvents, and a mass spectrometer having an ionization part for spraying and ionizing. The apparatus has a storing part for stori... | 04/08/2008 |
| 7351955 | Reduction of chemical noise in a MALDI mass spectrometer by in-trap photodissociation of matrix cluster ions A MALDI mass spectrometer includes a radiation source, such as a gas or solid state laser, that emits a beam of radiation (typically in the UV or IR wavelengths) directed along the central axis of a linear ion trap in which analyte ions and matrix cluster ions are c... | 04/01/2008 |
| 7342223 | Mass spectrometer for biological samples The mass spectrometer according to the present invention includes a light source for emitting pulse light including a plurality of wavelengths; an ionizer for ionizing molecules of a sample by irradiating the light from the light source to the sample; and a mass ana... | 03/11/2008 |
| 7339165 | Dual outlet pyrolyzer for biological agent detection system A chemical biological detection system detects the presence of biological agents in the air. The system includes a pyrolyzer having an inlet through which air is drawn into the pyrolyzer and a pyrotube that collects a sample of particles extracted from the air. The ... | 03/04/2008 |
| 7332715 | Atmospheric pressure ion source high pass ion filter For generation and delivery of ions from an ionization chamber through an ion entrance orifice to a mass analyzer operating at high vacuum, high pass ion filtration is effected within the ionization chamber by application of electrical potentials to an electrode ass... | 02/19/2008 |
| 7276103 | Method and device for separating molecules having different excitation spectra The invention relates to a method for the separation of molecules having different excitation spectra, which form components of a gas. The molecules are excited by laser pulses in a way that the molecules to be separated are transferred into a state of excitation du... | 10/02/2007 |
| 7271384 | Mass spectrometric substance identification The invention relates to the identification of substance ions, which are usually generated by electro spray ionization after separation by liquid chromatography or capillary electrophoresis, with the help of libraries with mass spectra. The substance ions are freque... | 09/18/2007 |
| 7238936 | Detector with increased dynamic range A detector assembly has a current measuring device with a saturation threshold level, and a gain variation means. A signal is generated in response to the particles detected, a first data point corresponding to a peak of interest is acquired from the signal. If the ... | 07/03/2007 |
| 7200198 | Recirculating target and method for producing radionuclide An apparatus for producing a radionuclide includes a target chamber, a particle beam source operatively aligned with the target chamber, and a regenerative turbine pump for circulating a target fluid through the target chamber via first and second liquid transports.... | 04/03/2007 |
| 7196525 | Sample imaging Systems and methods of generating ions at atmospheric pressure are presented. These systems and methods include spatially dependent analysis of a sample using an effusive ionization source. Systems and methods of isolating samples at atmospheric pressure are present... | 03/27/2007 |
| 7173240 | Electrospray devices for mass spectrometry An electrospray device for a mass spectrometry system is described. The electrospray device comprises a body portion and a tip portion extending from the body portion. The tip portion comprises a polymeric material. The electrospray device also comprises a hydrophob... | 02/06/2007 |
| 7141807 | Nanowire capillaries for mass spectrometry A capillary for a mass spectrometry system is described. The capillary comprises a channel and a tip, and at least one of the channel and the tip comprises a nanowire material. ... | 11/28/2006 |
| 7122791 | Capillaries for mass spectrometry A capillary for a mass spectrometry system is described. The capillary comprises a channel and a tip, and at least one of the channel and the tip comprises a carbon nanotube material that provides a hydrophobic surface. ... | 10/17/2006 |
| 7030373 | MALDI plate construction with grid A MALDI plate construction is provided to support a sample in a manner to effect mass spectrometry of the sample. The plate construction comprises a sample receiving surface, a plate holder for retaining the sample receiving surface and an electrically conductive gr... | 04/18/2006 |
| 7015464 | Apparatus for detecting chemical substances and method therefor An apparatus for detecting chemical substances which is high in sensitivity and selectivity is provided. An organic acid or an organic acid salt is used to generate an organic acid gas from an organic acid gas generator to be mixed with a sample gas for introduction... | 03/21/2006 |
| 6992285 | Method and apparatus for analyzing a substance using MSn analysis A method of and apparatus for analyzing a substance takes a stream of ions in said substance and supplies the ions to a collision cell including a quadrupole rod set for guiding the ions and a buffer gas. An RF voltage is applied to the quadrupole rod set to guide i... | 01/31/2006 |
| 6960760 | Mass spectrometer An ion tunnel ion trap comprises a plurality of electrodes having apertures. The ion tunnel ion trap is preferably coupled to a time of flight mass analyser. ... | 11/01/2005 |
| 6930304 | Process and apparatus for isotope separation in low-gravity environment A process and apparatus for separating element isotopes in a microgravity or low-gravity environment using electromagnetic radiation, e.g., sunlight, to heat and ionize a stream of raw materials, followed by electromagnetic separation, and collection of the desired ... | 08/16/2005 |
| 6844546 | Explosive detection system An explosive detection system including a sample injection region, an ion source region for generating ions of a sample injected by the ion injection region, a mass analysis region for analyzing mass of the ions, a heater for heating the sample injection region and ... | 01/18/2005 |
| 6833544 | Method and apparatus for multiple stages of mass spectrometry A method of and apparatus for analyzing a stream of ions first subjects astream of ions to a first mass analysis step, to select ions having a mass-to-charge ratio in a first desired range; this enables a mass analyzer with highresolution to be used. The selected io... | 12/21/2004 |
| 6806468 | Capillary ion delivery device and method for mass spectroscopy A system and method for mass spectrometry in which the system includes at least one ion source which produces ions, a mass spectrometer having an inlet orifice configured to accept the ions, and a capillary ion delivery device which detachably interfaces to the inle... | 10/19/2004 |
| 6670606 | Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis The use of a segmented-ion trap with collisional damping is disclosed to improve performance (resolution and mass accuracy of single stage and tandem time-of-flight mass spectrometers. In the case of single stage spectrometers ions are directly injected f... | 12/30/2003 |
| 6661001 | Extended bradbury-nielson gate A method and apparatus for analyzing ions by determining times of flight include using a deflector to direct ions away from their otherwise intended or parallel course. Deflectors are used as gates, so that particular ions may be selected for deflection, ... | 12/09/2003 |
| 6617576 | Cycloidal mass spectrometer with time of flight characteristics and associated method A method of separating ions according to mass in a mass spectrometer includes establishing a stream of ions traveling in a generally cycloidal path in an electric field and a magnetic field, subsequently causing the electric field to terminate for a prede... | 09/09/2003 |
| 6614018 | Process and apparatus for continuous-feed all-isotope separation in microgravity using solar power A process and apparatus for separating element isotopes in space by heating a stream of raw materials using concentrated sunlight and ionizing radiation, followed by electromagnetic separation, and collection of the desired isotopes in appropriate recepta... | 09/02/2003 |
| 6610976 | Method and apparatus for improved signal-to-noise ratio in mass spectrometry A method and apparatus for increasing the signal-to-noise ratio in a range of mass-to-charge ratios of a mass spectrum. Initially ions of interest and background ions having mass-to-charge ratios within the range of mass-to-charge ratios are generated. Th... | 08/26/2003 |
| 6573110 | Combinatorial chemistry system and method of use A combinatorial chemistry system allows for the dual processing of different molecules coated on a library of beads. The system includes beads coated with different molecules on each bead, a bead holder, screening equipment and characterization equipment.... | 06/03/2003 |
