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| Number | Title | Issue Date |
| 8148680 | Ion transfer arrangement with spatially alternating DC and viscous ion flow A method of transporting gas and entrained ions between higher and lower pressure regions of a mass spectrometer comprises providing an ion transfer conduit 60 between the higher and lower pressure regions. The ion transfer conduit 60 includes an elect... | 04/03/2012 |
| 8148679 | Efficient atmospheric pressure interface for mass spectrometers and method An ion transfer arrangement for transporting ions between higher and lower pressure regions of the mass spectrometer comprises an ion transfer conduit 60. The conduit 60 has an inlet opening towards a relatively high pressure chamber 40 and an o... | 04/03/2012 |
| 8008618 | Multipole ion guide for providing an axial electric field whose strength increases with radial position, and a method of operating a multipole ion guide having such an axial electric field A mass spectrometer having an elongated rod set, the rod set having a first end, a second end, a plurality of rods and a central longitudinal axis is described as is a method operating same. Embodiments involve a) admitting ions into the rod set; b) producing an RF ... | 08/30/2011 |
| 7994473 | Mass spectrometer with an electrostatic ion trap In a mass spectrometer with an electrostatic ion trap, the electrostatic ion trap has an outer electrode with an ion-repelling electric potential applied to it and a plurality of inner electrodes with ion-attracting potentials applied to each inner electrode. The ou... | 08/09/2011 |
| 7985950 | Parallel mass analysis A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time... | 07/26/2011 |
| 7982183 | Ion transfer tube with spatially alternating DC fields An ion transfer arrangement for transporting ions between higher and lower pressure regions of a mass spectrometer includes an electrode assembly (120) with a first plurality of ring electrodes (205) arranged in alternating relation with a second plura... | 07/19/2011 |
| 7960692 | Ion focusing and detection in a miniature linear ion trap for mass spectrometry A miniature linear ion trap (MLIT) with a length of less than 30 mm is provided for ion focusing in the axial plane. The MLIT has multipoles for applying an AC voltage to ions and tubular entrance and exit lenses for applying a DC voltage to the ions. In another asp... | 06/14/2011 |
| 7947948 | Two-dimensional radial-ejection ion trap operable as a quadrupole mass filter A two-dimensional radial-ejection ion trap is constructed from four apertured electrodes having inwardly facing hyberbolic surfaces, with each electrode being spaced from the centerline by a distance r that is greater than the hyperbolic radius r0 defined... | 05/24/2011 |
| 7928363 | Mass spectrometer A method is disclosed of identifying parent ions by matching daughter ions found to be produced at substantially the same time that the parent ions elute from a mixture. Ions emitted from an ion source (1) are transmitted to a fragmentation device (4) ... | 04/19/2011 |
| 7910878 | Method and apparatus for ion axial spatial distribution focusing The present invention provides a mass spectrometer including an ion source for generating pre-cursor ions, ion fragmentation means for generating fragment ions from the pre-cursor ions, a reflectron for focusing the kinetic energy distribution of the ions, and an io... | 03/22/2011 |
| 7888635 | Ion funnel ion trap and process An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of ˜1 Torr and provides for: 1) removal of low mass-to-cha... | 02/15/2011 |
| 7842917 | Method and apparatus for transmission mode ion/ion dissociation A method an apparatus for analyzing biomolecules is described. The method includes injecting and storing one species of ionized molecule in a linear ion trap and injecting second species of oppositely polarity ionized molecule such that the second species is transmi... | 11/30/2010 |
| 7829842 | Mass spectrometer arrangement with fragmentation cell and ion selection device A method of mass spectrometry having the steps of, in a first cycle: storing sample ions in a first ion storage device; ejecting the stored ions out of the first ion storage device into a separate ion selection device; selecting a subset of the ions in the ion selec... | 11/09/2010 |
| 7820966 | Mass spectrometer A mass spectrometer is disclosed comprising a High Pressure Liquid Chromatography system (10) which is interfaced to a combustion chamber (16) and isotope ratio mass analyser (19) by means of an Electrospray Ionisation ion source (11) and... | 10/26/2010 |
| 7807963 | Method and apparatus for an improved mass spectrometer An apparatus including a plurality of electrodes defining a trapping chamber of an ion trap, wherein at least one of the electrodes is a transparent electrode having at least a portion that is both optically transparent and electrically conductive; a controller conn... | 10/05/2010 |
| 7755034 | Ion trap and a method for dissociating ions in an ion trap A quadrupole ion trap includes a switch 3 for switching a trapping voltage between discrete voltage levels VH, VL. This creates a digital trapping field for trapping precursor ions and product ions in a trapping region of the ion trap. A... | 07/13/2010 |
| 7723677 | Wide range, very high resolution differential mobility analyzer (DMA) The present invention consists of a differential mobility analyzer (DMA) intended for achieving the electric field conditions necessary so that it has an component opposite to the drag flow. This electric field component opposite to the drag flow causes the main ele... | 05/25/2010 |
| 7626161 | Ion mobility separation devices The invention describes a system and method to separate ions (and charged particles) suspended in gas based on their ion electrical mobility. Most common ion mobility analyzers involve two parallel plate (or concentric cylinder) elements (electrodes) between which i... | 12/01/2009 |
| 7622712 | Method for operating an ion trap mass spectrometer system A method of operating a mass spectrometer system having an ion trap is provided. The method comprises encoding a selected characteristic in at least one of the first group of precursor ions and the first plurality of fragments, wherein the encoding operation is appl... | 11/24/2009 |
| 7622711 | Mass spectrometer A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (3) arranged upstream of a collision or fragmentation cell (5). Ions are separated according to their ion mobility within the ion mobility spectrometer or separator (... | 11/24/2009 |
| 7550719 | Electron beam source device available for detecting life span of filament An electron beam source device is provided in which the disconnection and deterioration of a filament of the electron beam source device can be accurately predicted and determined, so as to avoid an unnecessary resource waste and increase of cost due to a premature ... | 06/23/2009 |
| 7462820 | Isotope separation process and apparatus therefor A process and apparatus for separating element isotopes in space by imparting a velocity and direction to a body of material along a substantially linear path, heating and vaporizing the body and ionizing the material thereof as it flows along the path to produce a ... | 12/09/2008 |
| 7435951 | Ion source sample plate illumination system The invention provides a mass spectrometry system ion source containing a sample plate and an illumination device that is configured to produce a light beam that contacts the sample plate surface to define a grazing angle between the light beam and the sample plate ... | 10/14/2008 |
| 7435970 | Beam current meter It is possible to simplify the cooling mechanism of a superconductor, significantly reduce the cost, simplify the measurement work, and reduce the time required for measurement. A beam current meter includes: a cylindrical super conductor beam current sensor arrange... | 10/14/2008 |
| 7425699 | Mass spectrometry method and apparatus A mass spectrometer 10 comprises an ion source 12 which generates nebulized ions which enter an ion cooler 20 via an ion source block 16. Ions within a window of m/z of interest are extracted via a quadrupole mass filter 24 and pas... | 09/16/2008 |
| 7417226 | Mass spectrometer An Atmospheric Pressure Chemical Ionisation (“APCI”) ion source is disclosed comprising a housing 14 having a corona discharge chamber 1, a reaction chamber 2 and a passage 6 connecting the corona discharge chamber 1 to the rea... | 08/26/2008 |
| 7411187 | Ion trap in a semiconductor chip A micrometer-scale ion trap, fabricated on a monolithic chip using semiconductor micro-electromechanical systems (MEMS) technology. A single 111Cd+ ion is confined, laser cooled, and the heating measured in an integrated radiofrequency trap etched from a doped galli... | 08/12/2008 |
| 7397028 | Apparatus and method for gas flow management The invention described herein provides a mass spectrometry system, having an ion source including an ionization device for producing ions, a collection conduit adjacent to the ionization device for collecting ions produced by the ionization device, a first gas sour... | 07/08/2008 |
| 7397029 | Method and apparatus for ion fragmentation in mass spectrometry An apparatus for mass analyzing molecules includes a mass spectrometer configured to select precursor ions having a mass to charge ratio range, a metastable species generator configured to generate a metastable species for introduction into the mass spectrometer, an... | 07/08/2008 |
| 7391017 | Mass scale alignment of time-of-flight mass spectra The invention generates mass scale comparability between mass spectra which are acquired in time-of-flight mass spectrometers, particularly with ionization by matrix-assisted laser desorption. Always slightly distorted mass scales of different mass spectra from the ... | 06/24/2008 |
| 7391015 | System and method for data collection in recursive mass analysis Systems, methods, and computer programming for collecting data using a mass spectrometer comprising a particle detector or other mass analyzer. A data collection such as a tree or array structure which includes data records for storing detected data is maintained in... | 06/24/2008 |
| 7388195 | Apparatus and systems for processing samples for analysis via ion mobility spectrometry The invention provides an interface assembly for delivering an ionized analyte from an ionization apparatus into an ion mobility spectrometer. This allows analysis of biological and non-biological samples, even non-volatile solids, via differential mobility spectrom... | 06/17/2008 |
| 7384387 | High throughput mass spectrometry Apparatus and methods for high throughput mass spectrometry are provided. The methods involve sample preparation in an off-line parallel purification system. Such methods include but are not limited to the use of an appropriate buffer when generating samples or the ... | 06/10/2008 |
| 7385187 | Multi-reflecting time-of-flight mass spectrometer and method of use A multiple reflecting time-of-flight mass spectrometer (MR-TOF MS) and method of analysis are disclosed. The flight path of ions is folded along a trajectory by electrostatic mirrors. The longer flight path provides higher resolution while maintaining a moderate ins... | 06/10/2008 |
| 7381373 | System and method for preparative mass spectrometry A preparative mass spectrometer system includes an ionizer which converts the mixture into gas phase ions of the molecules in the mixture, and a separator which separates the ions according to their mass to charge ratio or mobility. The separator is a linear ion tra... | 06/03/2008 |
| 7381945 | Non-linear time-of-flight mass spectrometer A time-of-flight mass spectrometer has a first electrode, a second electrode spaced apart from the first electrode, a third electrode arranged between the first and second electrodes. The third electrode reserves a space for ions to travel between the first and seco... | 06/03/2008 |
| 7378649 | Simplex optimization methods for instrumentation tuning In some embodiments, a method of optimizing operating parameters of an analytical instrument (e.g. lens voltages of a mass spectrometer) includes steps taken to minimize the method duration in the presence of substantial instrument noise and/or drift. Some methods i... | 05/27/2008 |
| 7378651 | High field asymmetric waveform ion mobility spectrometer FAIMS Disclosed is an apparatus for separating ions including a plurality of first electrode portions, each first electrode portion of the plurality of first electrode portions having a first length and an outer surface that is at least partially curved in a direction tra... | 05/27/2008 |
| 7375320 | Virtual ion trap A virtual ion trap that uses electric focusing fields instead of machined metal electrodes that normally surround the trapping volume, wherein two opposing surfaces include a plurality of uniquely designed and coated electrodes, and wherein the electrodes can be dis... | 05/20/2008 |
| 7372020 | Ion counter Ions in a steady flow sample are counted by colliding the ions in a mixing chamber with a numerical excess of uncharged or neutral aerosol particles, suitably glycerol, entrained in air, to transfer respective charges from the ions to charge individual aerosol parti... | 05/13/2008 |
