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| Number | Title | Issue Date |
| 8178834 | Ion detection and parameter estimation for N-dimensional data Methods and apparatus for LC/IMS/MS analysis involve obtaining noisy raw data from a sample, convolving the data with an artifact-reducing filter, and locating, in retention-time, ion mobility, and mass-to-charge-ratio dimensions, one or more ion peaks of the convol... | 05/15/2012 |
| 8173957 | Mass spectrometry with selective ion filtration by digital thresholding The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly- or multiply-charged ions by selective ion filtering ca... | 05/08/2012 |
| 8173956 | Dynamic pixel scanning for use with MALDI-MS A method for dynamic pixel mass spectrometric imaging, or dynamic pixel imaging is disclosed. The method includes striking a sample to be scanned with a laser beam so that the laser beam releases analytes from the sample. The laser beam and the sample are then displ... | 05/08/2012 |
| 8173958 | Mass spectrometer In a conventional mass spectrometer in which a pipe to be electrically heated is provided between a separation wall separating an ionization chamber for ionizing a sample and a separation wall separating an analysis chamber, and an ion in the ionization chamber is i... | 05/08/2012 |
| 8168944 | Methods and systems for providing a substantially quadrupole field with a higher order component A two-dimensional substantially quadrupole field is provided. The field comprises a quadrupole harmonic of amplitude A2 and an octopole harmonic of amplitude A4, wherein A4 is greater than 0.01% of A2, A4 is less than 5% of A2, and, for any other higher order harmon... | 05/01/2012 |
| 8168943 | Data-dependent selection of dissociation type in a mass spectrometer Methods and apparatus for data-dependent mass spectrometric MS/MS or MSn analysis are disclosed. The methods may include determination of the charge state of an ion species of interest, followed by automated selection of a dissociation type (e.g., CAD, ET... | 05/01/2012 |
| 8168945 | Method for generation and use of isotopic patterns in mass spectral data of simple organisms A method for identifying a biological analyte that is affected by a stressor is disclosed in which two substantially identical biological samples are provided, with a first sample being a control sample and a second sample being an experimental sample. The control s... | 05/01/2012 |
| 8164053 | Mass analyzer and mass analyzing method There has been a problem that both detection sensitivity and throughput cannot be improved simultaneously by a conventional MS/MS analysis method. A mass analyzer having an ion trap for ejecting ions in a specific mass range, a collisional dissociation part f... | 04/24/2012 |
| 8158930 | Method for simultaneous calibration of mass spectra and identification of peptides in proteomic analysis The invention relates to a mass spectrometry calibration system that may be performed in real-time using the information contained within a sample without the addition of specific calibrants. When applied to a sample, such as a proteomic sample, the calibration syst... | 04/17/2012 |
| 8158931 | Methods for detecting dihydrotestosterone by mass spectrometry Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample.... | 04/17/2012 |
| 8153960 | Mass spectrometer An ion guide or ion trap (1) is disclosed having an entrance electrode (2) and an exit electrode (3). The potential of the exit electrode (3) is periodically dropped for a relatively short period of time allowing some ions to escape from ... | 04/10/2012 |
| 8153962 | Mass spectrometry assay for congenital adrenal hyperplasia Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortis... | 04/10/2012 |
| 8153961 | Methods for acquisition and deductive analysis of mixed fragment peptide mass spectra A method for acquiring and analyzing polypeptide mass spectra comprising: creating first and second sets of fragmented ions using first and second fragmentation techniques; obtaining mass spectra of the first and second sets of fragmented ions; searching a database ... | 04/10/2012 |
| 8148678 | Systems and methods for reducing noise from mass spectra Systems and methods for reducing background noise in a mass spectrum. The method includes the following steps of: (a) obtaining an original mass spectrum; (b) determining a noise mass spectrum corresponding to background noise in the original mass spectrum; and (c) ... | 04/03/2012 |
| 8148677 | Peptide identification and quantitation by merging MS/MS spectra The present invention is directed to methods of merging spectral data resulting from collision fragmentation processes, such as, for example, Pulsed Q Dissociation (PQD), high-energy collision-induced dissociation (HCD), electron transfer disassociation (ETD), colli... | 04/03/2012 |
| 8148676 | Use of ionic matrices for maldi mass spectrometry analysis of tissue sections The invention concerns improved methods for studying peptides/proteins expression in a tissue section or for determining at least one compound, in particular a protein, expression map in a tissue section, using ionic MALDI matrices. ... | 04/03/2012 |
| 8143572 | Method and system of tandem mass spectrometry without primary mass selection for multicharged ions The invention proposes a method of tandem mass spectrometry for use in a mass spectrometer having a known characteristic function of the mass-to-charge ratio of the ions to be analysed, characterized in that it comprises the following steps: (a) providing a primary ... | 03/27/2012 |
| 8138472 | Molecular ion accelerator A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrome... | 03/20/2012 |
| 8134121 | Chromatographic mass spectrometer A chromatographic mass spectrometer 100, 150 is provided with a measuring portion 21 for measuring n-alkane of a number of different carbon numbers, and characterized by further having: a mass number storing portion 31 for storing the mass numbe... | 03/13/2012 |
| 8129675 | Neutral/ion reactor in adiabatic supersonic gas flow for ion mobility time-of-flight mass spectrometry The content of the invention comprises a concept of reactor for isolated ion transformations induced by collisions with neutral species. This reactor is also an interface between mobility cell and orthogonal injection TOFMS based on supersonic adiabatic gas flow wit... | 03/06/2012 |
| 8119982 | Method and system for mass spectrometry data analysis In the process of identifying a protein by analyzing and processing mass spectrum data obtained for each micro area (pixel) created by subdividing a two-dimensional area on a sample, mass windows including a peak or peaks on the mass spectrum of each pixel are set (... | 02/21/2012 |
| 8115166 | Method of controlling mass spectrometer and mass spectrometer A method of controlling a mass spectrometer comprises the steps of: supplying a current to a cathode electrode of an ion source having the cathode electrode and an anode electrode, and ionizing a molecules of a gas to be measured; selecting ions generated in the ion... | 02/14/2012 |
| 8110795 | Laser system for MALDI mass spectrometry Mass spectrometry with lasers generates ions from analyte molecules by matrix assisted laser desorption for a variety of different mass spectrometric analysis procedures. The mass spectrometers with laser systems supply laser light pulses having at least two differe... | 02/07/2012 |
| 8110794 | Soft ablative desorption method and system Methods and systems are provided for the soft desorption of analyte from a sample, in which an optical beam absorbed within an irradiate zone of the sample causes vibrational excitations of a component within the sample. The optical beam, providing sufficient energy... | 02/07/2012 |
| 8110793 | Tandem mass spectrometry with feedback control The invention relates to acquisition methods for fragment ion spectra of biopolymer molecules in tandem mass spectrometers which are coupled to separation devices. The invention provides a real-time method for calculating a quality coefficient for each fragment ion ... | 02/07/2012 |
| 8106350 | Correction of deadtime effects in mass spectrometry A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Qi which arrived in an ith time bin, wherein: Formula (I) and wherein qi is the actua... | 01/31/2012 |
| 8106351 | Mass spectrometry assay for plasma-renin Provided are methods for measuring renin activity in a plasma sample using mass spectrometry. The methods generally involve ionizing purified angiotensin 1 from the sample and detecting the amount of angiotensin 1 ions generated. The amount of detected angiotensin 1... | 01/31/2012 |
| 8101908 | Multi-resolution scan A multi-resolution mass spectrometer system and intra-scanning method is introduced to enhance the measured peak resolution at different regions of a given mass spectrum while not significantly increasing the total duration of the scan. Such an arrangement enables e... | 01/24/2012 |
| 8097844 | Mass-analysis method and mass-analysis apparatus Among various ions introduced into an ion trap 1, those ions which are within a predetermined mass range including the mass-to-charge ratio of an objective ion are selected. Then, the frequency of a capturing voltage is set so that the objective ion will be c... | 01/17/2012 |
| 8084733 | Systems and methods for decreasing settling times in MS/MS Systems and methods are provided for optimizing the performance of a mass spectrometer system when multiple measurements are made. For example, the total settling time of different components or stages of a mass spectrometer, such as a tandem mass spectrometer, are ... | 12/27/2011 |
| 8080782 | Dithered multi-pulsing time-of-flight mass spectrometer A detection signal generated in response to incident ions accelerated at temporally-irregular intervals having an average repetition rate greater than a reference repetition rate represents detection events each having an event time and an intensity. For each detect... | 12/20/2011 |
| 8076636 | Apparatus comprising an ion mobility spectrometer A mass spectrometer is disclosed comprising a first chamber (10) and a second chamber (5). The second chamber (5) is located downstream of the first chamber 10 and an inter-chamber aperture (12) is provided between the two chambers... | 12/13/2011 |
| 8076637 | Mass spectrometer A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals (13, 14, 15) having a plurality of frequency notches (16a; 16b; 16c) are applied sequential... | 12/13/2011 |
| 8067728 | Method of improving signal-to-noise for quantitation by mass spectrometry Selectivity of a measurement from a mass spectrometer is improved by selecting an extracted ion current window for the measurement after data acquisition. A plurality of mass spectra are acquired over a period of time. A first extracted ion current window is selecte... | 11/29/2011 |
| 8067729 | Mass analysis data analyzing apparatus and program thereof In a mass analysis data analyzing apparatus, centroid data is used as mass spectrum data to be analyzed. First, peaks on the centroid data are specified in order of intensity as a standard peak for identifying an isotopic cluster. The isotopic cluster is detected by... | 11/29/2011 |
| 8063357 | Mass spectrometer A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component an... | 11/22/2011 |
| 8063358 | Mass spectrometer A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analyzed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of eac... | 11/22/2011 |
| 8063360 | Data acquisition system for a spectrometer using various filters A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector, an initial processing module, and a spectra processing module. The initial processing module is provided for proc... | 11/22/2011 |
| 8063359 | Systems and methods for identifying substances contained in a material In one embodiment, a system and a method relate to generating a summed ion spectrum for a test sample, the summed ion spectrum identifying ion intensities at multiple different mass-to-charge ratios, and comparing the summed ion spectrum of the test sample with mult... | 11/22/2011 |
| 8053723 | Intrascan data dependency A mass spectrometer data dependent method and apparatus is introduced to alter scanning parameters based upon data acquired during that scan. Such a method an apparatus may include the identification of ion species of interest meeting user specified criteria so that... | 11/08/2011 |
