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| Number | Title | Issue Date |
| 6372130 | Non-polar media for polynucleotide separations Nonporous beads having an average diameter of about 0.5-100 microns are suitable for chromatographic separation of mixtures of polynucleotides when the beads comprise a nonporous particle which are coated with a polymer or which have substantially all sur... | 04/16/2002 |
| 6365050 | Method for stopless and splitless flow field-flow fractionation An improved flow field-flow fractionation (flow FFF) process has been developed which permits the high-resolution separation of analytes without stopping or reversing the axial flow, introducing additional axial flow streams, or further splitting the axia... | 04/02/2002 |
| 6365049 | Separation of platinum group metals Methods and apparatus for the interseparation of platinum group metals (PGMs) are disclosed, in particular it relates to methods and apparatus for the interseparation of one or more of iridium, rhodium and platinum from their chlorocomplexes using gel chr... | 04/02/2002 |
| 6358418 | Packing material for high-performance liquid chromatography There is provided a packing material having a carrier coated with a substance having a separating capacity for high-performance liquid chromatography, wherein the performance of the packing material can be sufficiently exhibited with little dispersion of ... | 03/19/2002 |
| 6355791 | Polynucleotide separations on polymeric separation media Non-polar polymeric separation media, such as beads or monoliths, are suitable for chromatographic separation of mixtures of polynucleotides when the surface of the media are unsubstituted or substituted with a hydrocarbon group having from one to 1,000,0... | 03/12/2002 |
| 6355417 | Band array display of polynucleotide separations A method and apparatus for representing double stranded nucleic acid fragments which have been separated by a chromatographic process as an array of bands which can be accurately quantified, optimized and stored. Using, for example, a Matched Ion Polynucl... | 03/12/2002 |
| 6352644 | Method of manipulating the chemical properties of water to improve the effectiveness of a desired process The method of the present invention is adapted to manipulate the chemical properties of water in order to improve the effectiveness of a desired process. The method involves heating the water in the vessel to subcritical temperatures between 100° to 374Â... | 03/05/2002 |
| 6346194 | Chromatographic process using a chiral stationary phase based on yohimbine A chromatographic process for separating racemic mixtures using a set of chiral stationary phases based on yohimbine and its derivatives has been developed. In particular, the hydroxyl functionality of yohimbine and its analogs is covalently bonded via a ... | 02/12/2002 |
| 6346616 | Chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides, polymerizable and cross-linkable, their synthesis and their use as sources of novel support materials There are described chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides as novel compounds which are polymerizable and cross-linkable, and a method for obtaining them; novel support materials obtained from said derivative... | 02/12/2002 |
| 6344145 | Device to improve detection in electro-chromatography Apparatus and method for improving the resolution of non-pressure driven capillary chromatographic systems, and particularly for capillary electrochromatography (CEC) systems. By reducing the cross-sectional area of a packed capillary column by means of a... | 02/05/2002 |
| 6342161 | Method for high resolution liquid chromatographic separation of double-stranded DNA Mixtures of dsDNA fragments are separated by Matched Ion Polynucleotide Chromatography (MIPC) using an isocratic mobile phase to elute polynucleic acid from an MIPC column. The use of isocratic elution conditions provides a marked improvement in the separ... | 01/29/2002 |
| 6342160 | Method for screening chromatographic adsorbents The invention discloses a method for rapid identification of a candidate selective separation material by placing small samples of the candidate material in an array of vials and adding a solution of the analytes to be separated. The solution is allowed t... | 01/29/2002 |
| 6340432 | Method of making a chiral stationary phase based on yohimbine A chromatographic process for separating racemic mixtures using a set of chiral stationary phases based on yohimbine and its derivatives has been developed. In particular, the hydroxyl functionality of yohimbine and its analogs is covalently bonded via a ... | 01/22/2002 |
| 6337214 | Detection of DNA, RNA and proteins using a test column with two snares Methods and apparatuses are disclosed for detecting the presence of a test material in a test sample. The test sample is introduced into a test column which has at least two snares. One of the snares has a control capture material for detection of the pre... | 01/08/2002 |
| 6337021 | Chiral separation of enantiomers by high-speed countercurrent chromatography Preparative-scale separations of chiral compounds were achieved by high-speed countercurrent chromatography (HSCCC) using a multilayer coil planet centrifuge equipped with a 325 mL capacity column. The separations were performed by two different procedure... | 01/08/2002 |
| 6331250 | Method and equipment for chromatographic separation At least 2 different packings differing in the resolution of components contained in a starting fluid material such as a starting solution material and desired to be separated are used in a coexistent state to adjust the resolution of the components. The ... | 12/18/2001 |
| 6328885 | Current-efficient suppressors A method and apparatus for increasing the current efficiency of suppressor and suppress-like pretreatment devices is disclosed for the purpose of suppressing a high concentration of eluent without the detrimental effects of excess heat generation. The met... | 12/11/2001 |
| 6325937 | Process and means for down stream processing Support beads for downstream processing comprising a polymer, esp. a polysaccharide, matrix into which glass or silica particles, preferably quartz particles, have been incorporated, and their use in downstream processing, especially stabilized fluidized ... | 12/04/2001 |
| 6326203 | Method and apparatus for growing cells using gas or liquid aphrons A method and bioreactor (10) apparatus is described for maintaining cells in a culture medium containing gas or liquid aphrons. A preferred microbubble generator (42, 42A) of a gas which is necessary for maintaining the cells to produce plant described ch... | 12/04/2001 |
| 6322695 | Ion exchange porous resins for solid phase extraction and chromatography Embodiments of the present invention are directed to porous resins for solid phase extractions. The resins feature at least one hydrophobic component, at least one hydrophilic component and at least one ion exchange functional group. The resins exhibit su... | 11/27/2001 |
| 6315900 | Static separation method using non-porous cellulose beads An affinity separation method and system comprising an affinity separation media with low porosity and low non-specific binding, and a fluid containing a target compound to be isolated which is capable of binding onto the affinity separation media in a fl... | 11/13/2001 |
| 6309549 | Polynucleotide separations on polymeric separation Non-polar polymeric separation media, such as beads or monoliths, are suitable for chromatographic separation of mixtures of polynucleotides when the surfaces of the media are unsubstituted or substituted with a hydrocarbon group having from one to 1,000,... | 10/30/2001 |
| 6306306 | Chromatographic process for obtaining highly purified cyclosporin A and related cyclosporins The present invention relates to a novel chromatographic process which is suitable for the purification of cyclosporin-containing crude extracts on industrial scale. In this process, the conventional preparative chromatographic separation methods are comp... | 10/23/2001 |
| 6296768 | Separating materials for chromatography and electrophoresis applications comprising regiodefined functionalised cyclodextrins chemically bonded to a support via urethane functionalities Novel and improved chiral stationary phases (CSP) materials comprising a support and completely regiodefined derivitised cyclodextrin chemically bonded via single or double urethane linkage(s) universally applicable in HPLC, LC, TLC, and CCE are obtained ... | 10/02/2001 |
| 6290853 | Chromotographic method and device in which a continuous macroporous organic matrix is used A chromatographic method and device for separating one or several organic substances in a liquid sample. According to the method said sample of substances is passed through a chromatographic device containing as separation medium at least one continuous m... | 09/18/2001 |
| 6289286 | Surface regeneration of biosensors and characterization of biomolecules associated therewith Surface regeneration of affinity biosensors and characterization of biomolecules associated therewith by multivariate technique employing cocktails of regeneration agents to optimize regeneration of biosensor surface and/or characterize biomolecules assoc... | 09/11/2001 |
| 6287768 | Polymeric arrays and methods for their use in binding assays Arrays of polymeric targets stably associated with the surface of a rigid solid support are provided. In the subject arrays, the polymeric targets are arranged at least according to size. The polymeric targets of the subject arrays are generally biopolyme... | 09/11/2001 |
| 6287822 | Mutation detection method The present invention is directed to improved methods for detection of mutations in DNA using Denaturing Matched Ion Polynucleotide Chromatography (DMIPC). The invention includes the following aspects: analysis of PCR amplification products to identify fa... | 09/11/2001 |
| 6280616 | Column for chromatography Disclosed is a chromatography column having adapters that include an end-plate and a perforated plate such as to form a gap between the end-plate and the perforated plate. The column is particularly suited for large-scale chromatography in which matrices ... | 08/28/2001 |
| 6277628 | Linear microarrays The present invention provides a method and a composition for detecting the levels of a plurality of biomolecular probes in a sample. In particular, the invention relates to a hybridization composition for detecting the presence or levels of different pol... | 08/21/2001 |
| 6270640 | Polymerized oligopeptide-surfactant chiral micelles Chiral separations can be enhanced through the use of polymerized dipeptide-surfactant or oligopeptide-surfactant chiral micelles. Because polymerized micelles eliminate much of the complex dynamic behavior associated with conventional micelles, polymeriz... | 08/07/2001 |
| 6265168 | Apparatus and method for separating and purifying polynucleotides A method for removing a target DNA fragment having a predetermined base-pair length from a mixture of DNA fragments comprises the following steps. A mixture of DNA fragments which may contain the target DNA fragments is applied to a separation column cont... | 07/24/2001 |
| 6258264 | Non-polar media for polynucleotide separations Nonporous beads having an average diameter of about 0.5-100 microns are suitable for chromatographic separation of mixtures of polynucleotides when the beads comprise a nonporous particle which are coated with a polymer or which have substantially all sur... | 07/10/2001 |
| 6251272 | System and column for performing polynucleotide separations using liquid chromatography Improved liquid chromatography systems having components made of titanium, stainless steel, or organic polymeric material are useful in the separation of polynucleotide fragments, particularly large fragments of double-stranded polynucleotides, by Matched... | 06/26/2001 |
| 6251280 | Imprint-coating synthesis of selective functionalized ordered mesoporous sorbents for separation and sensors The present invention relates generally to mesoporous sorbent materials having high capacity, high selectivity, fast kinetics, and molecular recognition capability. The invention also relates to a process for preparing these mesoporous substrates through ... | 06/26/2001 |
| 6251278 | Process for separating a substance from a mixture Chromatographic material having the general formula S-B-X-Y-L where S is a solid support, B is a binding group, X is a substantially non-ionic hydrophilic organic spacer, Y is a coupling group and L is an affinity ligand. The chromatographic material is s... | 06/26/2001 |
| 6245238 | Purification of peptides and oligonucleotides by sample displacement chromatography process and apparatus Sample displacement chromatography is performed at low operating pressures (less than 30 bar) and/or at high sample loading (in excess of 500 mg/cm2 column area), with product recovery being effected in a non-gradient manner. The low operating ... | 06/12/2001 |
| 6241891 | Method of using stationary phase in reversed phase chromatography, and reversed phase chromatograph apparatus comprising stationary phase A method of using, in a reversed phase chromatography, a stationary phase including, as a main component thereof, an alkyl group having not less than 24 carbon atoms, with a mobile phase including water as a main component thereof. A reversed phase chroma... | 06/05/2001 |
| 6239262 | Low molecular weight displacers for protein purification in hydrophobic interaction and reversed phase chromatographic systems A method for purification of proteins by displacement chromatography in hydrophobic interaction and reversed phase chromatographic systems uses low molecular weight (less than about 10,000) surface-active compounds as displacers. Examples of effective dis... | 05/29/2001 |
| 6238565 | Monolithic matrix for separating bio-organic molecules The present invention provides monolithic polymer matrices for the separation of bio-organic molecules by liquid chromatography. In one embodiment, the matrix is formed from a polymerization mixture including (i) a hydrophobic monomer, (ii) a crosslinking... | 05/29/2001 |
