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| Number | Title | Issue Date |
| 8029658 | Device and method for filtration and/or separation of molecules, particularly proteins The present invention concerns a device and a method for filtering molecules that is precise, efficient, reliable, and rapid; it has a low rate of molecular loss, it can be upgraded, and it provides for the automated filtration of molecules according to one or more ... | 10/04/2011 |
| 7850835 | Solution phase electrophoresis device, components, and methods A device for fluid phase electrophoresis, particularly solution phase isoelectric focusing, components thereof, and methods for use are presented. ... | 12/14/2010 |
| 7815783 | Multi-compartment filter and method of filtering using same Each embodiment includes a central sample reservoir and a plurality of satellite reservoirs. In a first embodiment, a first electrode in electrical contact with the central reservoir is charged and second electrodes in electrical contact with the satellite reservoir... | 10/19/2010 |
| 7622028 | Solution phase electrophoresis device, components, and methods A device for fluid phase electrophoresis, particularly solution phase isoelectric focusing, components thereof, and methods for use are presented. ... | 11/24/2009 |
| 7390389 | Apparatus and method for separating an analyte The present invention relates to an apparatus and method for the separation and purification of charged and neutral compounds in an analyte solution by electrophoretic means using a plurality of compartments (1) to contain the analyte solution, an chemical bu... | 06/24/2008 |
| 7347617 | Mixing in microfluidic devices Mixing of liquids in a microfluidic device is accomplished by dispensing the liquids into a first chamber to produce combined liquid. The liquids are thereafter discharged through at least one capillary from the first chamber into a second chamber for complete mixin... | 03/25/2008 |
| 7316771 | Medium for analytic and preparative electrophoresis The invention relates to a medium for analytic and preparative electrophoresis which includes a content of acids and bases of different pKa values. The medium contains at least two acids, where the difference in pKa values (ΔpKa) of adjacent acids are no greater th... | 01/08/2008 |
| 7300199 | Retaining microfluidic microcavity and other microfluidic structures A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-ali... | 11/27/2007 |
| 7247224 | Medium for analytic and preparative electrophoresis The invention relates to a medium for analytic and preparative electrophoresis which includes a content of acids and bases of different pKa values. The medium contains at least two acids, where the difference in pKa values (ΔpKa) of adjacent acids are no greater th... | 07/24/2007 |
| 7169278 | Apparatus and separation media for separating particles in free-flow electrophoresis A free-flow electrophoresis (FFE) apparatus and separation medium for separating particles therefore, includes a separation chamber with a dosage pump for conveying medium, electrodes for applying an electric field in the medium and sample injection points for addin... | 01/30/2007 |
| 7141152 | Analyte species separation system A analyte species separation system including a fluid flow field disposed between confining surfaces, the flow field having a first flow component flowing in a first direction and a second flow component flowing in a second, transverse, direction, and an electric fi... | 11/28/2006 |
| 7077942 | Removal of biological contaminants A method of removing a biological contaminant from a mixture containing a biomolecule and the biological contaminant, the method comprising: (a) placing the biomolecule and contaminant mixture in a first solvent stream, the first solvent stream being separated from ... | 07/18/2006 |
| 7060173 | Removal of biological contaminants A method of removing a biological contaminant from a mixture containing a biomolecule and the biological contaminant, the method comprising: (a) placing the biomolecule and contaminant mixture in a first solvent stream, the first solvent stream being separated from ... | 06/13/2006 |
| 7022214 | Carrier ampholytes of high pH range Carboxylic acid-substituted polyalkylene polyamines in which amine nitrogen atoms on the polyamine backbone structure are replaced by guanidine groups provide a pH range extending into high pH values. These substances are useful as carrier ampholytes in isoelectric ... | 04/04/2006 |
| 6977033 | Method and apparatus for programmable fluidic processing A method and apparatus for microfluidic processing by programmably manipulating a packet. A material is introduced onto a reaction surface and compartmentalized to form a packet. A position of the packet is sensed with a position sensor. A programmable manipulation ... | 12/20/2005 |
| 6939452 | Parallel sample loading and injection device for multichannel microfluidic devices A sample load and injection device (10) includes sample introduction capillaries (11) attached to a microfluidic device (12). Sample introduction capillaries (11) are connected to sample introduction channels (18). Sample introduct... | 09/06/2005 |
| 6923896 | Electrophoresis apparatus and method An electrophoretic apparatus comprising: a first electrolyte chamber containing a first electrode; a second electrolyte chamber containing a second electrode; a first sample chamber disposed between the first and second electrolyte chambers and proximate to the firs... | 08/02/2005 |
| 6905585 | Automated system for high-throughput electrophoretic separations A cassette is disclosed for use in performing electrophoretic separations on a solid substrate. The cassette includes reservoirs for containing buffer, electrodes for receiving electrical current and a substrate support. The cassette is designed to connect with exte... | 06/14/2005 |
| 6833061 | Methods for isoelectric particle separation In order to isoelectrically separate particles with a pH-dependent net charge, the particles are exposed in a guiding liquid to electric field forces. The pH value of the guiding liquid is set in such a way that at least one predetermined type of particle is separat... | 12/21/2004 |
| 6793791 | Variable-volume disposable isoelectric focusing cell and method of isoelectric focusing An elastomeric cell is used as the disposable part of an apparatus for isoelectric focusing in free solution (without gels) in the 0.5 to 5 ml volume range. An inlet port is used for priming the cell and end-connectors for coupling with electrodes. A grid of paralle... | 09/21/2004 |
| 6638408 | Method and device for separation of charged molecules by solution isoelectric focusing The invention provides a novel solution isoelectric focusing device and method that can reproducibly fractionate charged molecules into well-defined pools. This approach can be applied to mixtures of charged molecules, such as eukaryotic proteome samples ... | 10/28/2003 |
| 6572751 | Method and apparatus for continuous flow isoelectric focusing for purifying biological substances The invention provides a continuous flow apparatus and method for purifying charged substances from solutions or suspensions by isoelectric focusing on an industrial scale. The apparatus comprises a separating chamber, a pair of vertical electrodes (9) lo... | 06/03/2003 |
| 6254754 | Chip for performing an electrophoretic separation of molecules and method using same A chip for performing an electrophoretic separation of micromolecular or macromolecular structures in two dimensions comprises a base substrate comprising a main surface. A channel is formed in the main surface of said base substrate in a first direction,... | 07/03/2001 |
| 5784154 | Electrophoresis separation in a capillary passage The separations resulting from capillary electrophoresis performed in a microbore capillary tube are detected on-line by focusing a light beam in the form of a line or sheet of light on the capillary passage in which the separations take place so that the... | 07/21/1998 |
| 5540826 | Multi-channel separation device A multi-channel separation device is provided for use in separation technology, particularly in electrophoresis and in isoelectric focusing. The device includes two mating plates, at least one of which contains an array of at least three cavities arranged... | 07/30/1996 |
| 5395502 | Apparatus for performing and universally detecting capillary isoelectric focusing without mobilization using concentration gradient imaging systems The separations resulting from capillary electrophoresis performed in a microbore capillary tube are detected on-line by focusing a light beam in the form of a line or sheet of light on the capillary passage in which the separations take place so that the... | 03/07/1995 |
| 5298143 | Electrophoretic processing An electrophoretic processor for separating proteins and other chemicals exhibiting varying electrophoretic mobilities. The preferred processor includes a rotor which turns within a stator to define a processing chamber therebetween. The rotor and stator ... | 03/29/1994 |
| 5282942 | Methods and apparatus for separating and mobilizing solutes in a solute mixture The present invention provides processes for isoelectric focusing ("IEF") and associated detection, which incorporates a dynamic means of electroosmotic flow ("EOF") control during IEF and/or after IEF to effect solute mobilization. In accordance with the... | 02/01/1994 |
| 5256269 | Method and apparatus for separating biological substances and organic compounds in solution A method and apparatus is described for separating materials on the basis of differences in isoelectric points. In one aspect of the invention an electrochemical cell is provided which has a cell compartment having a plurality of interwaterproof compartme... | 10/26/1993 |
| 5234586 | On-line product identification in a chromatography effluent by subtraction Disclosed is a method and apparatus for the rapid identification of a solute of interest in an effluent stream. The method involves separation of the solutes in the effluent and identification of a particular solute of interest by its selective subtractio... | 08/10/1993 |
| 5200050 | Electrophoretic processor and methods An electrophoretic processor for separating proteins and other chemicals exhibiting varying electrophoretic mobilities. The preferred processor includes a rotor which turns within a stator to define a processing chamber therebetween. The rotor and stator ... | 04/06/1993 |
| 5180480 | Apparatus for the preparation of samples, especially for analytical purposes An apparatus (1) is used for the preparation or extraction of samples, especially for analytical purposes, from a liquid or using a carrier liquid, where only very little liquid and substrate is available or is to be used and where the sample separation i... | 01/19/1993 |
| 5173164 | Multi-modality electrical separator apparatus and method A preparative scale multi-mode electrical separator, which is matrix-free and may be operated in both a batch mode and a continuous, flow-through mode is provided. It may be scaled according to the solution quantities which are to be processed. An interna... | 12/22/1992 |
| 5160594 | Apparatus and methods for isoelectric focusing of amphoteric substances incorporating ion selective membranes in electrode chambers The present invention includes novel isoelectric focusing cells and methods for isoelectric focusing of amphoteric substances within fluids containing carrier ampholytes which inhibit the phenomena known as spiking or acid notching. The apparatus includes... | 11/03/1992 |
| 5114555 | Continuous isoelectric separation A method and apparatus for the continuous separation of a target protein from a protein mixture containing two or more proteins and at a pH equal to the pI of the target protein is disclosed. The method and apparatus employ a non-ionic, non-electrically c... | 05/19/1992 |
| 5104505 | Method and apparatus for electrophoretic separations The present invention relates to electrophoresis. More particularly, the present invention relates to utilization of electrophoresis with controlled cooling. Still more particularly, the invention relates to a method and apparatus for separating chemical ... | 04/14/1992 |
| 5082548 | Isoelectric focusing apparatus Described is an isoelectric focusing electrophoretic process for the separation and purification of an amphoteric or neutral chemical compound from one or more electrically charged chemical compound(s). Said process is illustrated below at the example of ... | 01/21/1992 |
| 5032247 | Method and apparatus for electrophoretic separations A method and apparatus for conducting electrophoretic separations is described in which heat exchange fluid is passed through hollow fibers in the electrophoretic chamber during the separation process and the separations are conducted in the interstices o... | 07/16/1991 |
| 4963236 | Apparatus and methods for isoelectric focusing The present invention includes novel apparatus and methods for isoelectric focusing of amphoteric substances within fluids containing carrier ampholytes. The present invention utilizes multichannel recycling isoelectric focusing techniques which eliminate... | 10/16/1990 |
| 4925545 | Method of generating pH functions in electrophoresis and isoelectric focusing The present invention provides an improved method for forming pH gradients or other pH functions for use in electrophoresis and isoelectric focusing. It also involves electrophoresis and IEF devices created by such methods, and improved reagents suitable ... | 05/15/1990 |
