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| Number | Title | Issue Date |
| 7964075 | Electrodic bridge The present invention relates to an electrode bridge or sample application bridge for use in electrophoresis, preferably isoelectric focusing, IEF. More closely, the invention relates to an electrodic bridge or sample loading bridge for preventing denaturant depleti... | 06/21/2011 |
| 7943029 | Method, composition and kit for isoelectric focusing The present invention relates to a method, composition and a kit for isoelectric focusing. More closely, the present invention involves the use of to modified carrier ampholytes which are easy to separate from the proteins/peptides following finished focusing. The m... | 05/17/2011 |
| 7914656 | Matrixes, arrays, systems and methods The present invention relates to matrixes, arrays, systems and methods for analyzing biomolecules by their isoelectric point, optionally, in combination with a second dimension analysis. The assortment of matrixes, arrays and systems provided herein are useful for c... | 03/29/2011 |
| 7601251 | Methods and apparatus for low resistance electrophoresis of prior-cast, hydratable separation media Methods and apparatus are presented that facilitate electrophoresis of prior-cast, hydratable separation media, usefully immobilized pH gradient (IPG) strips. The method exploits the swelling of prior-cast, hydratable separation media upon rehydration to help lodge ... | 10/13/2009 |
| 7390389 | Apparatus and method for separating an analyte The present invention relates to an apparatus and method for the separation and purification of charged and neutral compounds in an analyte solution by electrophoretic means using a plurality of compartments (1) to contain the analyte solution, an chemical bu... | 06/24/2008 |
| 7347617 | Mixing in microfluidic devices Mixing of liquids in a microfluidic device is accomplished by dispensing the liquids into a first chamber to produce combined liquid. The liquids are thereafter discharged through at least one capillary from the first chamber into a second chamber for complete mixin... | 03/25/2008 |
| 7316320 | Sorting charged particles Charged particles may undergo two different separations within a single device, without manual intervention to effect the transfer of the particles between separations. In some embodiments, the device may be a Micro-Electro-Mechanical System. ... | 01/08/2008 |
| 7316771 | Medium for analytic and preparative electrophoresis The invention relates to a medium for analytic and preparative electrophoresis which includes a content of acids and bases of different pKa values. The medium contains at least two acids, where the difference in pKa values (ΔpKa) of adjacent acids are no greater th... | 01/08/2008 |
| 7282128 | Buffers for electrophoresis and use thereof Various embodiments provide, for example, buffer compositions and/or sieving formulations useful in connection with electrophoresis instruments, such as capillary electrophoresis (CE) devices. In various embodiments, a buffer composition can include Bis-Tris, TAPS a... | 10/16/2007 |
| 7252749 | Deposition method for nanostructure materials A method for depositing a coating of a nanostructure material onto a substrate includes: (1) forming a solution or suspension of containing the nanostructure material; (2) selectively adding “chargers” to the solution; (3) immersing electrodes in the solution, t... | 08/07/2007 |
| 7247224 | Medium for analytic and preparative electrophoresis The invention relates to a medium for analytic and preparative electrophoresis which includes a content of acids and bases of different pKa values. The medium contains at least two acids, where the difference in pKa values (ΔpKa) of adjacent acids are no greater th... | 07/24/2007 |
| 7214299 | Method for separation, identification and evaluation of microbes and cells The method entails using capillary electrophoresis or capillary isoelectric focusing to separate intact microbes. The capillary system can be a conventional capillary tube or a microfluidic device. The method is employed to maintain the microbes intact to ide... | 05/08/2007 |
| 7204923 | Continuous flow dielectrophoretic particle concentrator A continuous-flow filter/concentrator for separating and/or concentrating particles in a fluid is disclosed. The filter is a three-port device an inlet port, an filter port and a concentrate port. The filter separates particles into two streams by the ratio of their... | 04/17/2007 |
| 7169275 | Method for separating particles in free flow electrophoresis A method for separating particles in free-flow electrophoresis FFE includes conveying a separation medium using a dosage pump into a separation chamber; releasing the separation medium via outlets; applying an electrical field in the separation medium; coupling a pa... | 01/30/2007 |
| 7147712 | Method of semiconductor nanoparticle synthesis A method is described for the manufacture of semiconductor nanoparticles. Improved yields are obtained by use of a reducing agent or oxygen reaction promoter. ... | 12/12/2006 |
| 7125711 | Method and apparatus for splitting of specimens into multiple channels of a microfluidic device A microliter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved by capillary forces into one or more metering wells which define the amount of the sample to be analyzed in subseque... | 10/24/2006 |
| 7094354 | Method and apparatus for separation of particles in a microfluidic device A microfluidic device provides separation of particles in a liquid sample, particularly, separation of a sample of whole blood into its components for further analysis. Separation into red blood cells and plasma occurs within a few seconds after the blood sample has... | 08/22/2006 |
| 7077942 | Removal of biological contaminants A method of removing a biological contaminant from a mixture containing a biomolecule and the biological contaminant, the method comprising: (a) placing the biomolecule and contaminant mixture in a first solvent stream, the first solvent stream being separated from ... | 07/18/2006 |
| 7060173 | Removal of biological contaminants A method of removing a biological contaminant from a mixture containing a biomolecule and the biological contaminant, the method comprising: (a) placing the biomolecule and contaminant mixture in a first solvent stream, the first solvent stream being separated from ... | 06/13/2006 |
| 7022214 | Carrier ampholytes of high pH range Carboxylic acid-substituted polyalkylene polyamines in which amine nitrogen atoms on the polyamine backbone structure are replaced by guanidine groups provide a pH range extending into high pH values. These substances are useful as carrier ampholytes in isoelectric ... | 04/04/2006 |
| 6991715 | Prion diagnostic test The claims provide for detecting prions in a sample by (a) subjecting a sample to membrane-based electrophoresis to separate and/or concentrate at least some prions present in the sample; and (b) detecting and or identifying the presence of the separated and/or conc... | 01/31/2006 |
| 6964735 | Method for moving charged particles Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of time so as to move the charged molecules through the medium. The devic... | 11/15/2005 |
| 6926815 | Copolymers for capillary gel electrophoresis This invention relates to an electrophoresis separation medium having a gel matrix of at least one random, linear copolymer comprising a primary comonomer and at least one secondary comonomer, wherein the comonomers are randomly distributed along the copolymer chain... | 08/09/2005 |
| 6923896 | Electrophoresis apparatus and method An electrophoretic apparatus comprising: a first electrolyte chamber containing a first electrode; a second electrolyte chamber containing a second electrode; a first sample chamber disposed between the first and second electrolyte chambers and proximate to the firs... | 08/02/2005 |
| 6833061 | Methods for isoelectric particle separation In order to isoelectrically separate particles with a pH-dependent net charge, the particles are exposed in a guiding liquid to electric field forces. The pH value of the guiding liquid is set in such a way that at least one predetermined type of particle is separat... | 12/21/2004 |
| 6793791 | Variable-volume disposable isoelectric focusing cell and method of isoelectric focusing An elastomeric cell is used as the disposable part of an apparatus for isoelectric focusing in free solution (without gels) in the 0.5 to 5 ml volume range. An inlet port is used for priming the cell and end-connectors for coupling with electrodes. A grid of paralle... | 09/21/2004 |
| 6572751 | Method and apparatus for continuous flow isoelectric focusing for purifying biological substances The invention provides a continuous flow apparatus and method for purifying charged substances from solutions or suspensions by isoelectric focusing on an industrial scale. The apparatus comprises a separating chamber, a pair of vertical electrodes (9) lo... | 06/03/2003 |
| 6464851 | Removal of biological contaminants A method of removing a biological contaminant from a mixture containing a biomolecule and the biological contaminant, the method comprising: (a) placing the biomolecule and contaminant mixture in a first solvent stream, the first solvent stream being sepa... | 10/15/2002 |
| 6294667 | Analysis of carbohydrates The present invention discloses a method of separating or distinguishing carbohydrate substances. More particularly the method includes using fluorescent labeling reagents which have a positive charge when bound to a carbohydrate, involves separating the ... | 09/25/2001 |
| 6258237 | Electrophoretic diamond coating and compositions for effecting same A method of depositing diamond particles on a surface of a substrate is provided. The method is effected by (a) charging the diamond particles by a positive charge to obtain positively charged diamond particles; and (b) electrophoretically depositing the ... | 07/10/2001 |
| 6254754 | Chip for performing an electrophoretic separation of molecules and method using same A chip for performing an electrophoretic separation of micromolecular or macromolecular structures in two dimensions comprises a base substrate comprising a main surface. A channel is formed in the main surface of said base substrate in a first direction,... | 07/03/2001 |
| 5480526 | Methods for the desalting of biological samples: a simple approach to eliminate disturbances in isoelectric focusing caused by the presence of salts The present invention provides new methods for desalting samples of ionic polymers or weak electrolytes, preferable ampholytes (e.g., peptides, proteins and glycoconjugates) or, compounds which can be transformed into these substances by complex formation... | 01/02/1996 |
| 5472582 | Analysis of carbohydrates using 2-aminoacridone The present invention provides for the use of the fluorescent label 2-aminoacridone for use in separating carbohydrate mixtures and analyzing the structure of carbohydrates. Carbohydrates for analysis may be labeled by 2-aminoacridone and subsequently sep... | 12/05/1995 |
| 5447612 | Buffering system and its use in electrophoretic processes A novel pH buffering system which is functionally stable under electrophoretic conditions employs buffering components in complementary buffer pairs. The buffering components are selected from among simple chemically defined ampholytes, weak acids and wea... | 09/05/1995 |
| 5401833 | Method and apparatus for treating chrome leather waste An improved method and apparatus for treating chromium containing leather scrap to recover chromium compounds and to produce a protein hydrolysate. The leather scrap is fed into an upstream mixing zone of a reaction vessel along with an alkali metal solut... | 03/28/1995 |
| 5376249 | Analysis utilizing isoelectric focusing Disclosed are methods and apparatus for determining the presence of one or more analytes in a sample, wherein the presence of a complex of an analyte and an analyte-specific binding moiety is detected at a location in an elongate pH gradient corresponding... | 12/27/1994 |
| 5348633 | Method for quantitating trace amounts of an analyte in a sample by affinity capillary electrophoresis A method for quantitative detection of trace amounts of an analyte in a sample is disclosed. The method in the preferred embodiment includes providing an Fab' fragment of an immunoglobulin labelled at a reactive sulfhydryl group with a fluorescent dye; co... | 09/20/1994 |
| 5322906 | Synthesis of complex polyamines for ampholyte production New synthesis and analysis procedures for novel crosslinked polyamines and ampholytes. Polyamines are crosslinked with tartaric acid ester, malonic acid ester, or polycarboxylic acid esters of the citric acid cycle. The resulting crosslinked polyamine may... | 06/21/1994 |
| 5298143 | Electrophoretic processing An electrophoretic processor for separating proteins and other chemicals exhibiting varying electrophoretic mobilities. The preferred processor includes a rotor which turns within a stator to define a processing chamber therebetween. The rotor and stator ... | 03/29/1994 |
| 5282942 | Methods and apparatus for separating and mobilizing solutes in a solute mixture The present invention provides processes for isoelectric focusing ("IEF") and associated detection, which incorporates a dynamic means of electroosmotic flow ("EOF") control during IEF and/or after IEF to effect solute mobilization. In accordance with the... | 02/01/1994 |
