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| Number | Title | Issue Date |
| 7435322 | Device and method for automatically analysing the constituents of an analyte The invention relates to a device and a method for automatically analysing the constituents of at least one analyte, especially by means of gel electrophoresis and/or isoelectric focussing, comprising at least one separating matrix, especially a gel. Each separating... | 10/14/2008 |
| 7285199 | Apparatus and method for electrophoretic microspot concentration A method and apparatus for concentrating dilute biomolecules in samples using electrophoresis are described. The method involves using the charged nature of the biomolecules to localize them to a microspot containing a dialysis membrane. The method and apparatus may... | 10/23/2007 |
| 7250097 | Device for sequential protein transfer from a gel An apparatus and method for the sequential electroelution of biomolecules is described, the apparatus comprising a separation medium having an outlet, and a collector having at least a first receptacle and a second receptacle that can be sequentially brought into co... | 07/31/2007 |
| 7218500 | High-voltage generator and accelerator using same In a high-voltage generator including a CW circuit (high-voltage circuit), where the CW circuit generates a high voltage through booster circuits that are provided for boosting an input voltage and connected to one another in multiple stages, a conductive shielding ... | 05/15/2007 |
| 7198703 | Chamber-forming electrophoresis cassette cover A multielevational cover for assembling a fluid retaining chamber on a face of an electrophoresis cassette is presented. The cover comprises a cassette-containing member, at least one chamber-defining member, and sealing means, typically sealing means that are capab... | 04/03/2007 |
| 7172864 | Methods for electronically-controlled enzymatic reactions A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridizations, antibody/anti... | 02/06/2007 |
| 7172896 | Integrated portable biological detection system We have performed separation of bacterial and cancer cells from peripheral human blood in microfabricated electronic chips by dielectrophoresis. The isolated cells were examined by staining the nuclei with fluorescent dye followed by laser induced fluorescence imagi... | 02/06/2007 |
| 7166441 | Method and apparatus for the identification and quantification of biomolecules Polypeptides are electroblotted through a digestion membrane to a composite capture membrane that can be directly analyzed using mass spectrometry. The molecular weights of the fragments generated by the digestion membrane are then used to identify the polypeptide f... | 01/23/2007 |
| 7138625 | User customizable plate handling for MALDI mass spectrometry Methods for specifying the layout of a MALDI sample plate are provided. In general, the methods involve creating a file containing sample plate layout parameters that describe the layout of a MALDI sample plate, and storing the file on a computer readable medium pri... | 11/21/2006 |
| 7060974 | Laser desorption ionization mass spectrometric method and sample plate used in such a method The present invention relates to a sample plate that is preferably constituted by a metal plate on which a membrane is affixed by a conductive double-sided tape. In the case where a sample, developed on a medium such as an electrophoresis gel, is transferred onto th... | 06/13/2006 |
| 7053366 | Desalting plate for MALDI mass spectrometry A novel Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) desalting sample support plate is described. The plate comprises a sample presentation surface, wherein the sample presentation surface comprises at least one receiving surface of an ab... | 05/30/2006 |
| 7005294 | Method for producing an array for detecting constituents from a biological sample The invention suggests a method of producing an array for the detection of components from a biological sample, wherein the detection molecules are immobilized on one or more supports, said support(s) is/are embedded and subjected to curing, the support is separated... | 02/28/2006 |
| 6995363 | Reduction of matrix interference for MALDI mass spectrometry analysis A MALDI plate suitable for MS or MS-MS analysis provided with a composite coating that comprises a hydrophobic coating and a thin layer coating of a mixture of a MALDI matrix material and an intercalating agent such as a polymer is disclosed. A MALDI plate produced ... | 02/07/2006 |
| 6905584 | Electrophoresis system and method therefor A method for separating a sample into components by two-dimensional electrophoresis uses an IPG strip, and a gel slab which are spaced apart and carried on a single generally planar support means. The planar support means is first oriented in a generally vertical pl... | 06/14/2005 |
| 6833060 | Electrophoresis gel support The present invention relates generally to the electrophoretic separation of biomolecules, including but not limited to proteins, peptides, DNA and RNA. The methods of this invention are particularly useful when applied to two-dimensional gel electrophoresis. ... | 12/21/2004 |
| 6632339 | Method of identifying polypeptides Polypeptides which have been separated by gel electrophoresis can be identified by electroblotting them through a "sandwich" comprising in order: a) the separation gel; b) at least one hydrophilic membrane, e.g. of carboxyl-modified PVDF, on which... | 10/14/2003 |
| 6602391 | Apparatus and method for combined capillary separation and blotting of biological macromolecules An apparatus and method are described for capillary separation of macromolecules and precise post-separation blotting. Apparatus include disposable separating element (capillary), which contains a sieving or interaction matrix inside, an external layer of... | 08/05/2003 |
| 6426404 | Receptor for intestinal trefoil factor A substantially pure intestinal trefoil factor receptor which is obtainable from intestinal cells and has a molecular weight of about 50 to 60 kD or about 75 to 80 kD.... | 07/30/2002 |
| 5916429 | Direct blot electrophoresis apparatus and method In a horizontal gel, direct blot electrophoresis separation apparatus, device to remove gas dissolved in the buffer solution surrounding the anode at a location remote from the interface between the gel and the moving membrane, such as a gas evolution mem... | 06/29/1999 |
| 5882495 | Electrophoresis system The present invention provides electrophoresis systems and methods for forming at least one gel therein and for conducting electrophoresis on the gel without removing the gel from the electrophoresis system. The systems of the present invention include an... | 03/16/1999 |
| 5864014 | Zonula occludens toxin receptor A membrane-associate protein which is present on the surface of, inter alia, intestinal epithelia cells, is disclosed. The protein acts as a receptor for the zonula occludens toxin of Vibrio cholera, and is related to the modulation of intestinal tight ju... | 01/26/1999 |
| 5840169 | Apparatus and process for electroelution of a gel containing charged macromolecules A process for electroelution of a gel containing charged macromolecules, such as proteins or polynucleotides, comprising the steps of providing a plurality of adjacent parallel chambers having a trapezoidal cross-section, placing a gel containing the char... | 11/24/1998 |
| 5595636 | Method for mass spectrometric analysis of samples from electrophoresis plates The invention relates to the mass spectrometric analysis of separated substance samples on so-called 2-D-gel electrophoresis plates, used particularly for protein determination, with ionization of the substance samples by MALDI. The molecules of the subst... | 01/21/1997 |
| 5593561 | Multiple electrophoresis method and apparatus for migration and transfer of macromolecules A multiple electrophoresis method and apparatus for migrating and transferring macromolecules in a vessel (10) containing a plurality of parallel elongate electrodes (14), membranes (22) disposed vertically in the vessel between the columns of electrodes ... | 01/14/1997 |
| 5514256 | Apparatus for improved DNA sequencing This invention is a means for the rapid sequencing of DNA samples. More specifically, it consists of a new design direct blotting electrophoresis unit. The DNA sequence is deposited on a membrane attached to a rotating drum. Initial data compaction is fac... | 05/07/1996 |
| 5480803 | Apparatus for treating analytes An apparatus includes an enclosed chamber in which a motor-driven cylinder is mounted for rotation about a horizontal axis. The lower half of the cylinder is disposed in a trough. A blot can be attached, analyte side outward, to the surface of the cylinde... | 01/02/1996 |
| 5439573 | Concentrating electroelutinon apparatus An electrophoretic gel elutor and concentrator includes a semi-permeable collecting membrane having a continuously diminishing cross-section terminating in an apex, and a supporting frame of matching configuration. This apparatus is useful in electrophore... | 08/08/1995 |
| 5415758 | Method and apparatus for electro-elution of biological molecules The invention includes methods for electro-elution of a biological molecule from a biological sample matrix, the methods including electro-eluting a negatively charged molecule from each of plural individual sample matrices via corresponding plural electr... | 05/16/1995 |
| 5395498 | Method for separating biological macromolecules and means therfor Macromolecules from a sample are electrophoresed and the obtained electrophoretogram is contacted with a planar matrix of magnetic particles. The magnetic particles having binding specificity to one or more specific species of biological macromolecules, w... | 03/07/1995 |
| 5340449 | Apparatus for electroelution This invention involves the elution of macromolecules such as proteins, deoxyribonucleic acid(DNA), ribonucleic acid(RNA) from solid phase matrix such as polyacrylamide, agarose and membranes such as polyvinyl difluoride (PVDF) in an electric field. The e... | 08/23/1994 |
| 5316638 | Treatment of carbohydrates Charged carbohydrate substances which have been run on an electrophoretic gel are transferred onto a porous membrane by a blotting technique such as an electrotransfer technique. This enables recovery of carbohydrate substances from a gel in a form that i... | 05/31/1994 |
| 5279721 | Apparatus and method for an automated electrophoresis system An automated electrophoresis and transfer apparatus for separating macromolecules in accordance with their molecular weight and transferring the same to a transfer membrane includes a housing having a perforated intermediate horizontal partition defining ... | 01/18/1994 |
| 5275710 | Gel electrophoresis system including optical stage, sample applicator and sample retriever An electrophoretic system is provided which allows for carrying out electrophoresis while monitoring and regulating the temperature and the electrical field gradient in the gel. In addition, photometric monitoring, including use of an optical stage, is pr... | 01/04/1994 |
| 5270162 | Autoradiographic gene-screening method An autoradiographic gene-screening method employing a hybridization process, which comprises: (1) a step of transferring at least a portion of nucleic acids, fragments thereof or derivatives thereof resolved on a medium onto a transfer support to fix them... | 12/14/1993 |
| 5234559 | Apparatus for direct blotting and automated electrophoresis, transfer and detection and processes utilizing the apparatus thereof A separation and direct blot transfer module useful in gel electrophoresis is disclosed in which a transfer membrane stabilized by a frame is moved substantially orthogonally relative to the plane of the separation gel while in minimal contact with the en... | 08/10/1993 |
| 5205917 | Fluorophore assisted carbohydrate electrophoresis diagnosis The subject invention provides methods and kits for conveniently diagnosing various physiological conditions that produce altered levels of specific carbohydrates, known as diagnostic carbohydrates. Measurement of the levels of the diagnostic carbohydrate... | 04/27/1993 |
| 5190856 | Method and apparatus for detecting single base mutations in DNA with denaturing gradient electrophoresis Single base pair differences between otherwise identical DNA fragments can result in an altering of the melting behavior which can be detected by denaturing gradient gelelectrophoresis (DGGE). A method has been developed for efficient transfer of genomic ... | 03/02/1993 |
| 5173159 | Multiple electrophoresis method for the controlled migration of macromolecules through rectangular gel plates A multiple electrophoresis method and device are disclosed for the controlled migration of macromolecules in gel plates stacked in a direction perpendicular to their plane, at least one series of electrodes (20) disposed at the intersections of two series... | 12/22/1992 |
| 5155049 | Blotting technique for membrane assay A technique for passaging liquid through a membrane putatively containing, in its interstices, at least one substance for which detection is desired, comprises positioning donor and acceptor bibulous matrices onto either surface of the membrane and squeez... | 10/13/1992 |
| 5151189 | Cationic charge modified microporous membrane Cationic charge modified microporous hydrophilic membranes are provided, as well as preparation of the same by post-treatment. Typically, as an illustration, a microporous hydrophilic membrane substrate which contains non-leachable polymeric additive havi... | 09/29/1992 |
