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| Number | Title | Issue Date |
| 8163153 | Tool for extracting electrophoretic sample A gel extraction device (10) comprises a hollow cutting member (12) having cutting edge (14) at one end and a squeeze bulb (16) at the other end. In a further embodiment, the air passage between the cutting edge and the bulb has a constri... | 04/24/2012 |
| 7964074 | Electroelution of oligonucleotides from gel matrices The invention can be used to purify and extract a target oligonucleotide from a gel substrate. The current invention extracts the target oligonucleotide so quickly that burn-off against the positive electrode is greatly reduced, yielding high optical density and pur... | 06/21/2011 |
| 7641778 | Gel electroelution and sample separation devices and associated processes A gel electroelution device can have a gel spot column having upstream and downstream openings in fluid communication with an inlet and outlet, respectively. The gel spot column receives a gel spot and negative and positive electrodes are fluid communication with th... | 01/05/2010 |
| 7435322 | Device and method for automatically analysing the constituents of an analyte The invention relates to a device and a method for automatically analysing the constituents of at least one analyte, especially by means of gel electrophoresis and/or isoelectric focussing, comprising at least one separating matrix, especially a gel. Each separating... | 10/14/2008 |
| 7332268 | Layered support sheet for high-yield spot cutting from gels or membranes The excision of sample spots from a gel or membrane by pressing a cutting tool terminating in a hollow cylinder against the gel or membrane supported on a rigid surface is made more reliable by interposing a relatively pliable, intermediate layer on the side of the ... | 02/19/2008 |
| 7250100 | Two dimensional electrophoresis cassette A device for two-dimensional electrophoresis includes a cassette comprising two opposing plates. The two opposing plates form a first elongated portion for receiving a first elongated electrophoretic separation medium and a second portion extending away from the fir... | 07/31/2007 |
| 7250097 | Device for sequential protein transfer from a gel An apparatus and method for the sequential electroelution of biomolecules is described, the apparatus comprising a separation medium having an outlet, and a collector having at least a first receptacle and a second receptacle that can be sequentially brought into co... | 07/31/2007 |
| 7247275 | Gel extraction device A gel extraction device comprising a hollow cutting member and a plunger ejector member. The hollow cutting member has a proximal tubular body terminating at one end in a circular rim having oppositely disposed spring engaging structures and a distal sloped transiti... | 07/24/2007 |
| 7153403 | Protein market pellets and method of making and using the same A protein marker pellet for use in a gel electrophoresis system includes one or more protein markers including a protein of known molecular weight with ionic components to provide electrical conductance, and a non-protein, gel-forming material having a porosity suff... | 12/26/2006 |
| 7153405 | Cassette, system, and 2-D gel electrophoresis method for separating molecules A gel electrophoresis cassette (33) is disclosed which includes two plates (34, 35) and at least one seal (36) which separates these plates. The seal (36) is annular; it may be positioned essentially in the region of the outer edge of the... | 12/26/2006 |
| 7153404 | Gel spot picker The present invention relates to a gel sheet (1) for use in a spot picker device wherein said gel sheet is provide with reference marks (5′–5′″) which can be used to determine if the gel sheet (1) has been deformed between the stages of ... | 12/26/2006 |
| 7147762 | Method of electrophoresis The present invention relates a method of electrophoretic separation of protein and/or peptide components of a sample in a convection stabilized medium. More specifically, the method comprises the steps to contact the sample with the separation medium; to apply a vo... | 12/12/2006 |
| 7077940 | Strip holder, chamber, cassette, and 2-D gel electrophoresis method and system for performing this method for separating molecules A strip holder (1) is disclosed for accommodating a gel strip (3) for separating molecules using gel electrophoresis. The strip holder (1) disclosed is distinguished by including a baseplate (4), at least one stop (5), which is off... | 07/18/2006 |
| 7070682 | Microfluidic apparatus for performing gel protein extractions and methods for using the apparatus The invention relates to an apparatus for performing gel protein extractions and methods of using the apparatus. ... | 07/04/2006 |
| 7037419 | Concentration of protein and/or peptides samples The invention relates to a device for protein and/or peptide concentration, which device comprises electroconcentration means (23); at least two electrodes having a positive (7) and a negative charge (35), respectively; and protein and/or peptid... | 05/02/2006 |
| 7025864 | Method and apparatus for recovering target molecules from a gel containing said target molecules A preparative electrophoresis apparatus suitable for recovery of molecules from gels comprises two spaced apart electrode compartments connected by a conduit that descends from the bottom of the electrode compartments in a V-shaped or U-shaped form. The conduit serv... | 04/11/2006 |
| 6994963 | Methods for recombinatorial nucleic acid synthesis This invention pertains to a method for generating a pool of nucleic acid fragments useful for in vitro recombination and the creation of novel DNA sequences that encode desirable proteins or enzymes. The invention provides a defined mixture of nucleic acids and met... | 02/07/2006 |
| 6991714 | Apparatus and method for taking samples from polymer support material A sample taking apparatus comprises a plurality of separation tools (10) (for example, punching capillaries) on a holding device (20), wherein the separation tools (10) are each provided with actuating means (30) for separate control ther... | 01/31/2006 |
| 6974526 | Plastic microfluidics enabling two-dimensional protein separations in proteome analysis The invention provides a microfluidic apparatus for performing 2-D biomolecular separations. The microfluidic 2-D device may include first and second planar substrates which include at least a first dimension microchannel extending in a first direction and an array ... | 12/13/2005 |
| 6929730 | Two dimensional microfluidic gene scanner One embodiment of the invention relates to a microfluidic apparatus for performing two dimensional biomolecular separations. According to one aspect of the invention, after a first dimension separation in a first microchannel, the sample material is electrokinetical... | 08/16/2005 |
| 6916423 | Device and methods for subdividing and filtering gel material and extracting molecules therefrom An apparatus and method for mincing a gel includes a gel mincing tube and a mesh material. The mesh material extends across the end of the tube. To subdivide a gel using the mincing apparatus, a gel is placed upon the mesh material in the mincing tube, the mincing t... | 07/12/2005 |
| 6905585 | Automated system for high-throughput electrophoretic separations A cassette is disclosed for use in performing electrophoretic separations on a solid substrate. The cassette includes reservoirs for containing buffer, electrodes for receiving electrical current and a substrate support. The cassette is designed to connect with exte... | 06/14/2005 |
| 6793790 | Sample collection system for gel electrophoresis An automatic sample collection system for use with an electrophoretic slab gel system is presented. The collection system can be used with a slab gel have one or more lanes. A detector is used to detect particle bands on the slab gel within a detection zone. Such de... | 09/21/2004 |
| 6783648 | Method and apparatus for unloading gels from isoelectric gel tubes An apparatus for expressing and unloading an isoelectric focusing gel from an electrophoresis gel tube includes a first support for supporting the gel tube, a plunger rod and a second support for supporting the plunger rod. The first support is mounted on a movable ... | 08/31/2004 |
| 6758974 | Device and methods for subdividing and filtering gel material and extracting molecules therefrom An apparatus and method for mincing a gel includes a gel mincing tube and a mesh material. The mesh material extends across the end of the tube. To subdivide a gel using the mincing apparatus, a gel is placed upon the mesh material in the mincing tube, the mincing t... | 07/06/2004 |
| 6699986 | Electrophoretic separation of nucleic acids from proteins at low ph The present invention relates to methods for separating nucleic acids from other cellular debris, especially substances that carry a net positive charge at low pH, by electrophoresis under acid conditions. In the purification method of the present inventi... | 03/02/2004 |
| 6652724 | Automated apparatus for separating a biological sample from a two dimensional electrophoresis gel An automated high-throughput system for excising spots or samples from an electrophoresis slab gel includes a computer controlled robotic arm assembly and a sample plate handling assembly for supplying a sample plate to a loading station. The computer is ... | 11/25/2003 |
| 6632339 | Method of identifying polypeptides Polypeptides which have been separated by gel electrophoresis can be identified by electroblotting them through a "sandwich" comprising in order: a) the separation gel; b) at least one hydrophilic membrane, e.g. of carboxyl-modified PVDF, on which... | 10/14/2003 |
| 6579378 | De-staining composition and apparatus The present invention is drawn to a method for de-staining a substrate that is stained with a dye by bringing the substrate into contact with a de-staining composition and absorbing the dye from the substrate with the de-staining composition, wherein the ... | 06/17/2003 |
| 6540897 | Direct detection of histidine tagged biomolecules on electrophoretic gel A method is disclosed for the detection of a His-tagged target biomolecule while said molecule remains in the gel in which it has been separated from other constituents by electrophoresis. The method involves, while the separated His-tagged biomolecule re... | 04/01/2003 |
| 6482303 | Automated system for two-dimensional electrophoresis The present invention provides an integrated, fully automated, high-throughput system for two-dimensional electrophoresis comprised of gel-making machines, gel processing machines, gel compositions and geometries, gel handling systems, sample preparation ... | 11/19/2002 |
| 6451189 | Automated system for two dimensional electrophoresis The present invention provides an integrated, fully automated, high-throughput system for two-dimensional electrophoresis comprised of gel-making machines, gel processing machines, gel compositions and geometries, gel handling systems, sample preparation ... | 09/17/2002 |
| 6416644 | Automated system for two-dimensional electrophoresis The present invention provides an integrated, fully automated, high-throughput system for two-dimensional electrophoresis comprised of gel-making machines, gel processing machines, gel compositions and geometries, gel handling systems, sample preparation ... | 07/09/2002 |
| 6398932 | Automated system for two-dimensional electrophoresis The present invention provides an integrated, fully automated, high-throughput system for two-dimensional electrophoresis comprised of gel-making machines, gel processing machines, gel compositions and geometries, gel handling systems, sample preparation ... | 06/04/2002 |
| 6342143 | Cutting tool for multiple sample retrieval from gelatinous material The invention relates to a sample retrieval apparatus of particular benefit in the field of molecular biology. The apparatus permits the rapid collection of numerous specified fractions of samples: such as DNA, RNA or protein, that are separated by gel el... | 01/29/2002 |
| 6203680 | Electrophoresis gels The present invention provides electrophoresis apparatus and electrophoresis methods employing gellan gum based gels employing divalent metal cation and diamine cross-linking agents. The gels are reversible under conditions that do not damage the biomolec... | 03/20/2001 |
| 6136551 | Assay for detecting the presence of botulinum toxin neutralizing antibodies in a patient serum sample An assay for the identification of neutralizing botulinum antibodies in sera is provided which includes the steps of separating non-sodium dodecyl sulfate, non-trypsinized complex botulinum toxin in an arylamide gel by electrophoresis, the separation occu... | 10/24/2000 |
| 6136173 | Automated system for two-dimensional electrophoresis The present invention provides an integrated, fully automated, high-throughput system for two-dimensional electrophoresis comprised of gel-making machines, gel processing machines, gel compositions and geometries, gel handling systems, sample preparation ... | 10/24/2000 |
| 6068754 | Multi-tank gel developing apparatus and method The claimed multi-tank gel developing apparatus and method comprises of two inner tanks within one outer tank to develop multiple electrophoresis gels simultaneously. The two inner tanks have openings along the edges of the walls to allow free circulation... | 05/30/2000 |
| 5922186 | Staining, de-staining and quantification of proteins by coomassie-blue and related dyes The present invention presents a novel method for both staining electrophoresis gels, as well as removing the background dye during de-staining. This novel and simple pad-based technique minimizes solvent consumption, is environmentally friendly, and does... | 07/13/1999 |
