...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 7943027 | Electrophoresis unit and electrophoretic analysis method The object of the present invention is that a dynamic range is extended in an electrophoresis unit and concentration differences among a plurality of samples measured simultaneously are increased. An irradiation time to the samples is adjusted during analysis... | 05/17/2011 |
| 7361260 | Methods, articles and kits for labeling polymer gels The invention provides methods, apparatus and kits for integrally labeling polymeric gels, such as polyacrylamide and agarose gels, with indicia that can serve, inter alia, unambiguously to identify the individual gel, using polymeric film labeled with detectable in... | 04/22/2008 |
| 7347922 | Multi-dimensional proteomic analysis method A multi-dimensional proteomic analysis method utilizing cationic electrophoresis is described. The method includes separating proteins in one direction using cationic electrophoresis and separating the proteins in a second orthogonal direction using other electropho... | 03/25/2008 |
| 7338808 | Method and apparatus for determining zeta potential using alternating current electric field and T channel Provided is a method for determining a zeta potential generated between a solid wall and a solution. The method includes (a) injecting an electrolyte solution into a first inlet of a T channel, which is provided with first and second inlet electrodes and a grounded ... | 03/04/2008 |
| 7312087 | Devices and methods for biochip multiplexing The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a first station of an analysis device, inserting a second biochip into a ... | 12/25/2007 |
| 7312326 | Fluorescent labeled nucleotide derivatives Fluorescent labeled reporter compounds having a modified cyanine dye that is coupled to a nucleotide derivative through a linker are disclosed. The compounds are useful for nucleic acid sequence analysis. The fluorescent labeled reporter compounds are ring-locked cy... | 12/25/2007 |
| 7309323 | Wearable continuous renal replacement therapy device A continuous renal replacement therapy (CRRT) device adapted to be worn on a portion of the body of a patient. The CRRT device is worn by the patient and operates on rechargeable batteries for more than 5 hours. Dialysate is used to remove impurities from the blood.... | 12/18/2007 |
| 7303715 | Horizontal gel casting device and method A horizontal casting tray with one or more slidable blocks for sealing at least one open end of the tray is provided to accommodate the casting of solidifiable separation media in variable lengths for use in electrophoresis. Methods for using the casting device to p... | 12/04/2007 |
| 7287318 | Biosensor A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess cir... | 10/30/2007 |
| 7261812 | Multi-column separation devices and methods Chromatographic separation devices include multiple batch-processed columns joined by a body structure and adapted to perform parallel analyses. Both slurry-packed and monolithic column embodiments are provided. One or more liquid-permeable frits of various types ma... | 08/28/2007 |
| 7211807 | Readout method performed by stripe scanning planar objects with substances emitting fluorescence radiation The subject matter of the invention is a readout method performed by stripe scanning planar objects with substances emitting fluorescence radiation, a detector being provided and said fluorescence radiation being imaged onto said detector, said detector comprising a... | 05/01/2007 |
| 7198754 | Biological material detection element, biological material detection method and apparatus, charged material moving apparatus A biological material detection apparatus which detects a charged biological material such as a gene or protein contained in a sample liquid is disclosed. A biological material detection element includes a substrate, at least one first electrode formed on the substr... | 04/03/2007 |
| 7189366 | Molecular tag reader Near infrared molecular assays can be used to detect small quantities of a molecule of interest in vivo or in vitro using laser dyes. A hand-held portable device is provided which can rapidly read small quantities of selected molecular tags in tissues of fish or oth... | 03/13/2007 |
| 7179357 | Serial sample injection in capillary electrophoresis The invention is a method of performing electrophoresis that increases sample throughput and increases the efficiency and speed of the analysis of polynucleotides by electrophoresis. The method is performed by loading and running multiple sequential samples on each ... | 02/20/2007 |
| 7158224 | Optically active substrates A device for optical examination of biological materials using radiation of a selected wavelength includes a substrate having a first surface and a second surface opposite to the first surface. The first surface includes a dense array of micro-optical elements arran... | 01/02/2007 |
| 7153421 | Frit material and bonding method for microfluidic separation devices A multi-layer microfluidic separation device comprises a polymeric membrane frit that may be securely bonded within the device and minimizes lateral wicking. Stationary phase material having an average particle size is retained by a frit having an average pore size ... | 12/26/2006 |
| 7147762 | Method of electrophoresis The present invention relates a method of electrophoretic separation of protein and/or peptide components of a sample in a convection stabilized medium. More specifically, the method comprises the steps to contact the sample with the separation medium; to apply a vo... | 12/12/2006 |
| 7125644 | Systems and methods for storing data on an optical disk Optical disks include machine readable data that is written with dye that is invisible to the naked eye and a laser-imagable coating that forms marks that are visible to the naked eye. ... | 10/24/2006 |
| 7123338 | Apparatus and method for fabricating liquid crystal display device An apparatus for fabricating a liquid crystal display device includes a controller for providing nitrogen (N2) gas at a constant pressure, a plurality of dispensers receiving the nitrogen gas from the controller, each of the dispensers dotting a silver pa... | 10/17/2006 |
| 7118662 | Electrophoresis apparatus The windows 5a, 5b are configured so that the thickness of the upper and lower parts of the substrate formed therein with the channels becomes thinner in these parts than in other parts. An air space is defined in the vicinity of the one ... | 10/10/2006 |
| 7114404 | System and method for detecting flow in a mass flow controller Systems and methods are provided for detecting flow in a mass flow controller (MFC). The position of a gate in the MFC is sensed or otherwise determined to monitor flow through the MFC and to immediately or nearly immediately detect a flow failure. In one embodiment... | 10/03/2006 |
| 7109495 | Fluorometer with low heat-generating light source This invention concerns a fluorometer preferably combined with a thermal cycler useful in biochemical protocols such as polymerase chain reaction (PCR) and DNA melting curve analysis. The present fluorometer features a low heat-generating light source such as a ligh... | 09/19/2006 |
| 7106938 | Self assembled three-dimensional photonic crystal A method of making a photonic crystal includes obtaining single spheres for use in making a self assembled opal structure. Spherical particles are placed centrifuge and separated from doublets using a relative difference in sedimentation velocity in response to cent... | 09/12/2006 |
| 7099777 | Techniques for identifying confirming mapping and categorizing nucleic acids Systems and methods for identifying, confirming, mapping, and categorizing sample polymers, such as nucleic acid sequences, are provided. An estimation of the fraction of first and second polymers in a sample of polymers can be calculated by inputting a first hybrid... | 08/29/2006 |
| 7087732 | Nucleotides and analogs having photoremovable protecting groups A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are ut... | 08/08/2006 |
| 7074312 | Device for stacking multiple pre-cast horizontal gels A device for vertically stacking multiple pre-cast gels for simultaneous electrophoresis is described. The device comprises a plate of non-electrically conductive material that separates adjacent gels within a vertical stack and facilitates contact between the ends ... | 07/11/2006 |
| 7070949 | Protein mixture analysis by mass spectrometry The invention relates to the analysis of complex protein mixtures such as entire proteomes, and in particular the rapid detection of previously unknown or unusually expressed proteins by common enzymatic digestion, subsequent chromatographic separation and analysis ... | 07/04/2006 |
| 7049070 | Materials and methods for detection and characterization of nucleic acid sequence variability A method for influencing the separation mobility of single stranded nucleic acids in native conditions is disclosed. Temperature changes during the separation of single stranded nucleic acids under native conditions are used as the basis of a novel method of detecti... | 05/23/2006 |
| 7040032 | Method and device for measuring whether a process kit part meets a prescribed tolerance A go no-go gauge and method for verifying whether a process kit part used within a plasma chamber of a plasma processing tool has accumulated excessive wear or deposits. The gauge includes a component for verifying whether a dimension of a process kit part feature v... | 05/09/2006 |
| 7037416 | Method for monitoring flow rate using fluorescent markers Microfluidic methods, devices, and systems are provided for monitoring and controlling flow rates in response to one or more marker signals. The marker signals are used to provide an indication of flow rate in the various channels of the devices. Signals obtained fr... | 05/02/2006 |
| 7028536 | Sealing interface for microfluidic device A threadless interface for a fluidic system includes a microfluidic device having an outer surface and an internal near-surface channel having a first width and disposed at a first depth relative to the outer surface, with the first width being less than about two t... | 04/18/2006 |
| 7010964 | Pressurized microfluidic devices with optical detection regions Microfluidic analytical devices and systems have at least one porous element disposed downstream of one or more optical detection regions in a pressure-based separation system. A porous element elevates the backpressure within an optical detection region, thus suppr... | 03/14/2006 |
| 7009699 | Method for investigating a sample A method for investigating specimens, wherein a spectral splitting of the radiation coming from the specimen is carried out for specimen points or point distributions, for the operation of a laser scanning microscope or a fluorescence screening arrangement or a flow... | 03/07/2006 |
| 7001722 | Parallel primer extension approach to nucleic acid sequence analysis A method of analyzing a polynucleotide of interest, comprising providing one or more sets of consecutive oligonucleotide primers differing within each set by one base at the growing end therof; annealing a single strand of the polynucleotide or a fragment of the pol... | 02/21/2006 |
| 6982029 | Electrophoretic method and system having internal lane standards for color calibration An electrophoretic system having a plurality of separation lanes is provided with an automatic color calibration feature in which each lane is separately calibrated. For each lane, a dye matrix standard is created using reference fragments which migrate either befor... | 01/03/2006 |
| 6963822 | Method and apparatus for separation, analysis and evaluation of data Waveform diagrams of cholesterol and triglyceride, for example, obtained by electrophoresis are overlappedly displayed (superimposed). To compare or overlappedly display two waveform diagrams, one unit of absolute concentration is related to one unit of waveform siz... | 11/08/2005 |
| 6961177 | STEREOSCOPIC IMAGE DISPLAY APPARATUS, DISPLAY APPARATUS, DIVIDED WAVE PLATE FILTER, PLATE-SHARED FILTER, AND FILTER POSITION ADJUSTING MECHANISM ATTACHED TO THE DISPLAY APPARATUS, ALIGNING APPARATUS, FILTER POSITION ADJUSTING METHOD, AND FILTER ALIGNING METHOD A stereoscopic image display apparatus includes: an image display unit 22 for displaying image information corresponding to parallax in a first division and a second division; a divided wave plate filter unit 12 having a frame 41 and disposed ad... | 11/01/2005 |
| 6955878 | Apparatus for analyzing samples using linear probe array There is used at least one probe array obtained by arraying particles having various probes, respectively, fixed thereon (probe particles) in a definite order in a holder. A plurality of capillaries or grooves packed with various kinds, respectively, of probe partic... | 10/18/2005 |
| 6942774 | Electrophoresis apparatus and a method of using the same An apparatus for rehydrating and for performing electrophoresis on a gel strip includes a tray defining a plurality of parallel troughs configured to receive gel strips. Each trough defines a centrally located rehydration area and an electrode area disposed either s... | 09/13/2005 |
| 6936167 | System and method for performing multiple parallel chromatographic separations Systems and methods for performing multiple parallel chromatographic separations are provided. Microfluidic cartridges containing multiple separation columns allow multiple separations to be performed in a limited space by a single instrument containing high-pressur... | 08/30/2005 |