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| Number | Title | Issue Date |
| 8080145 | Method and apparatus determining the isoelectric point of charged analyte Devices are provided for determining the isoelectric point of a charged analyte, comprising a titration chamber and an electrode chamber. The electrode chamber comprises at least two electrodes, for example, an electrode array. Either or both of the titration chambe... | 12/20/2011 |
| 7931791 | Method of detecting analyte-biomolecule interactions The invention provides methods for detecting an interaction between an analyte and a biomolecule. The method comprises separating at least one biomolecule according to its isoelectric point in the presence of a given analyte and detecting an interaction between the ... | 04/26/2011 |
| 7569130 | Fluorescent detection of proteins in polyacrylamide gels The mechanism of the UV light-induced reaction between the indole moiety of tryptophan and chloroform, and the structure of the modified tryptophan and polypeptides including such modified tryptophan residues. The excited indole moiety, which is formed upon UV light... | 08/04/2009 |
| 7435322 | Device and method for automatically analysing the constituents of an analyte The invention relates to a device and a method for automatically analysing the constituents of at least one analyte, especially by means of gel electrophoresis and/or isoelectric focussing, comprising at least one separating matrix, especially a gel. Each separating... | 10/14/2008 |
| 7416902 | Method and apparatus for airborne particle sorting An apparatus for airborne particle sorting is provided comprising a charging system adapted for applying an electrostatic charge to the particles, such that particles of at least a first group are deflected to a greater extent than particles of a second group are de... | 08/26/2008 |
| 7364907 | Systems and methods for sorting samples Methods and systems for sorting compounds and compound holders into batches for subsequent processing are provided. ... | 04/29/2008 |
| 7316771 | Medium for analytic and preparative electrophoresis The invention relates to a medium for analytic and preparative electrophoresis which includes a content of acids and bases of different pKa values. The medium contains at least two acids, where the difference in pKa values (ΔpKa) of adjacent acids are no greater th... | 01/08/2008 |
| 7309409 | Multi-channel bio-separation cartridge A bio-separation system using an efficient, compact, portable, interchangeable, reusable, recyclable, multi-channel cartridge, has integrated pre-aligned optics and an integrated reagent reservoir. The cartridge supports, for example, multiple capillaries for CE sep... | 12/18/2007 |
| 7247224 | Medium for analytic and preparative electrophoresis The invention relates to a medium for analytic and preparative electrophoresis which includes a content of acids and bases of different pKa values. The medium contains at least two acids, where the difference in pKa values (ΔpKa) of adjacent acids are no greater th... | 07/24/2007 |
| 7238269 | Sample processing device with unvented channel A device includes a substrate having first and second major surfaces and a hub that defines an axis of rotation for the substrate, and an unvented channel having a plurality of connected compartments. Methods for using devices of the invention are also disclosed. | 07/03/2007 |
| 7198703 | Chamber-forming electrophoresis cassette cover A multielevational cover for assembling a fluid retaining chamber on a face of an electrophoresis cassette is presented. The cover comprises a cassette-containing member, at least one chamber-defining member, and sealing means, typically sealing means that are capab... | 04/03/2007 |
| 7195923 | Ratiometric determination of glycated protein The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the glycosylated protein, or the glycoprotein. The method incorporates lateral f... | 03/27/2007 |
| 7166202 | Matrixes, arrays, systems and methods The present invention relates to matrixes, arrays, systems and methods for analyzing biomolecules by their isoelectric point, optionally, in combination with a second dimension analysis. The assortment of matrixes, arrays and systems provided herein are useful for c... | 01/23/2007 |
| 7122791 | Capillaries for mass spectrometry A capillary for a mass spectrometry system is described. The capillary comprises a channel and a tip, and at least one of the channel and the tip comprises a carbon nanotube material that provides a hydrophobic surface. ... | 10/17/2006 |
| 7022214 | Carrier ampholytes of high pH range Carboxylic acid-substituted polyalkylene polyamines in which amine nitrogen atoms on the polyamine backbone structure are replaced by guanidine groups provide a pH range extending into high pH values. These substances are useful as carrier ampholytes in isoelectric ... | 04/04/2006 |
| 6979390 | Method and apparatus for separating biological molecules A system for separating biological molecules includes a chip (10) on which there is an electrophoresis separation microchannel (16). At the start of the channel there is an isoelectric focusing section (14) containing a gel having a pH gradient.... | 12/27/2005 |
| 6942774 | Electrophoresis apparatus and a method of using the same An apparatus for rehydrating and for performing electrophoresis on a gel strip includes a tray defining a plurality of parallel troughs configured to receive gel strips. Each trough defines a centrally located rehydration area and an electrode area disposed either s... | 09/13/2005 |
| 6905584 | Electrophoresis system and method therefor A method for separating a sample into components by two-dimensional electrophoresis uses an IPG strip, and a gel slab which are spaced apart and carried on a single generally planar support means. The planar support means is first oriented in a generally vertical pl... | 06/14/2005 |
| 6875849 | Methods of recovering chaperone proteins and complexes thereof The present invention provides methods for efficient and concomitant recovery of multiple chaperone proteins and/or chaperone protein complexes from a limited sample source. Disclosed are methods involving the use of Free Solution Iso-Electric Focusing (FS-IEF) whic... | 04/05/2005 |
| 6833061 | Methods for isoelectric particle separation In order to isoelectrically separate particles with a pH-dependent net charge, the particles are exposed in a guiding liquid to electric field forces. The pH value of the guiding liquid is set in such a way that at least one predetermined type of particle is separat... | 12/21/2004 |
| 6793791 | Variable-volume disposable isoelectric focusing cell and method of isoelectric focusing An elastomeric cell is used as the disposable part of an apparatus for isoelectric focusing in free solution (without gels) in the 0.5 to 5 ml volume range. An inlet port is used for priming the cell and end-connectors for coupling with electrodes. A grid of paralle... | 09/21/2004 |
| 6783648 | Method and apparatus for unloading gels from isoelectric gel tubes An apparatus for expressing and unloading an isoelectric focusing gel from an electrophoresis gel tube includes a first support for supporting the gel tube, a plunger rod and a second support for supporting the plunger rod. The first support is mounted on a movable ... | 08/31/2004 |
| 6767443 | Method and apparatus for electrophoretic focusing An apparatus and method is described for obtaining a preparative-scale, free-fluid electrophoretic separator with high resolution as well as an analytical capability commensurate with capillary zone electrophoresis. The electrophoretic focusing apparatus and method ... | 07/27/2004 |
| 6761810 | Automated apparatus including a robotic arm for loading samples into wells for first dimension electrophoresis separation An automated assembly for performing first dimension electrophoresis is described herein that includes a supply magazine, an electrophoresis tank and an automated transferring device that robotically transfers biological samples from sample vials retained in the sup... | 07/13/2004 |
| 6685811 | Method for separation of macromolecules The invention relates to a method and a system, suitable for automation, for the, preferably preparative, separation of amphoteric macromolecules, e.g. proteins or peptides, wherein said method comprises the steps of: (a) subjecting said mixture of macrom... | 02/03/2004 |
| 6638408 | Method and device for separation of charged molecules by solution isoelectric focusing The invention provides a novel solution isoelectric focusing device and method that can reproducibly fractionate charged molecules into well-defined pools. This approach can be applied to mixtures of charged molecules, such as eukaryotic proteome samples ... | 10/28/2003 |
| 6558522 | Apparatus for electrophoresis An electrophoresis apparatus for the simultaneous electrophoretic separation of a plurality of component mixtures using a disposable tray having a plurality of parallel troughs shaped to retain an elongate strip of isoelectric focusing medium and sufficie... | 05/06/2003 |
| 6537434 | First dimension electrophoresis separation method and apparatus An automated apparatus for carrying out a first dimension electrophoresis separation of proteins and other macromolecules includes a supply magazine, an automated transferring device and an electrophoresis tank. The supply magazine includes a carousel for... | 03/25/2003 |
| 6537799 | Electrical current for controlling fluid parameters in microchannels A novel method and device for transporting and/or monitoring a fluid in a multi-port device 400, 800, 1000 used in a microfluidic system is provided. The multi-port device includes a substrate having a novel channel configuration. A first channel region 4... | 03/25/2003 |
| 6379970 | Analysis of differential protein expression A method of detecting peptide fragments of protein(s) that are differentially present in biological samples. The identity of the peptides may be determined and correlated with the protein(s) that are differentially present in the samples.... | 04/30/2002 |
| 6294667 | Analysis of carbohydrates The present invention discloses a method of separating or distinguishing carbohydrate substances. More particularly the method includes using fluorescent labeling reagents which have a positive charge when bound to a carbohydrate, involves separating the ... | 09/25/2001 |
| 6277259 | High performance multidimensional proteome analyzer A proteome analyzer includes a separation cassette having a first dimension separation compartment for separation of protein samples by isoelectric focusing and a second dimension separation compartment for separation of protein samples by SDS-polymer net... | 08/21/2001 |
| 6043025 | Difference gel electrophoresis using matched multiple dyes A process and a kit are provided for detecting differences in two or more samples of protein. Protein extracts are prepared, for example, from each of a different group of cell samples to be compared. Each protein extract is labeled with a different one o... | 03/28/2000 |
| 6013165 | Electrophoresis apparatus and method Disclosed are an apparatus, system, and method for two dimensional electrophoresis of analytes of interest, particularly polypeptides. The apparatus includes a sample separation cavity comprising (1) an electrophoresis region located along an upper portio... | 01/11/2000 |
| 5866683 | Isoelectric point markers for isoelectric focusing with fluorescence detection Provided are isoelectric point(pI) markers for isoelectric focusing with fluorescence detection. The markers are fluorescence-labeled oligopeptides which comprise a fluorescence dye bonded chemically to the amino group of N-terminal amino acid of oligopep... | 02/02/1999 |
| 5856298 | Erythropoietin isoforms Erythropoietin isoforms having a specific number of sialic acids per erythropoietin molecule are disclosed. Also disclosed are mixtures of such isoforms, pharmaceutical compositions containing such isoforms or mixtures thereof and methods of obtaining the... | 01/05/1999 |
| 5759370 | Method and device for isoelectric focusing without carrier ampholytes A device and method for isoelectric focusing of ampholytes in a buffer uses a cone-shaped capillary with a positive electrode connected at a narrow end and a negative electrode connected at the wide end of the capillary. The electrical potential across th... | 06/02/1998 |
| 5534121 | Preparative two dimensional gel electrophoresis system A preparative two dimensional gel electrophoresis system which serves as a single procedure for separation and isolation of preparative amounts of proteins from complex biological preparations. The system includes sized-up isoelectric focusing tube gels a... | 07/09/1996 |
| 5512158 | Capillary electrophoresis method and apparatus for electric field uniformity and minimal dispersion of sample fractions A capillary electrophoresis method and apparatus for reducing dispersion of sample fractions are disclosed. The capillary tube in which the electrophoresis is performed has been flared, at least at its sample entrance end, to remove sharp corners which co... | 04/30/1996 |
| 5472582 | Analysis of carbohydrates using 2-aminoacridone The present invention provides for the use of the fluorescent label 2-aminoacridone for use in separating carbohydrate mixtures and analyzing the structure of carbohydrates. Carbohydrates for analysis may be labeled by 2-aminoacridone and subsequently sep... | 12/05/1995 |
