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| Number | Title | Issue Date |
| 8182666 | Apparatus and methods for concentrating and separating particles such as molecules Particles of interest, such as DNA molecules, are injected into a medium by applying a first field. Once in the medium the particles are concentrated by applying one or more fields that cause mobilities of the particles in the medium to vary in a manner that is corr... | 05/22/2012 |
| 7731828 | Method for rapid typification of microorganisms and set of reagents used A process for rapid typing of yeast, parasites and bacteria is provided. It comprises the following steps: a) Preparing immobilized intact DNA in 5 to 60 minutes aided by a method involving a reagent kit that only contains buffer solution, a detergent, a metal chela... | 06/08/2010 |
| 7425254 | Fractionation of macro-molecules using asymmetric pulsed field electrophoresis A method and apparatus for fractionation of charged macro-molecules such as DNA is provided. DNA solution is loaded into a matrix including an array of obstacles. An alternating electric field having two different fields at different orientations is applied. The alt... | 09/16/2008 |
| 7347923 | Dielectrophoresis device and method having insulating ridges for manipulating particles Embodiments of the present invention provide methods and devices for manipulating particles using dielectrophoresis. Insulating ridges and valleys are used to generate a spatially non-uniform electrical field. Particles may be concentrated, separated, or captured du... | 03/25/2008 |
| 7338808 | Method and apparatus for determining zeta potential using alternating current electric field and T channel Provided is a method for determining a zeta potential generated between a solid wall and a solution. The method includes (a) injecting an electrolyte solution into a first inlet of a T channel, which is provided with first and second inlet electrodes and a grounded ... | 03/04/2008 |
| 7319003 | Arrays of probes for positional sequencing by hybridization This invention is directed to methods and reagents useful for sequencing nucleic acid targets utilizing sequencing by hybridization technology comprising probes, arrays of probes and methods whereby sequence information is obtained rapidly and efficiently in discret... | 01/15/2008 |
| 7314708 | Method and apparatus for electronic synthesis of molecular structures A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antig... | 01/01/2008 |
| 7282127 | Microcapillary devices using high dielectric constant materials and related methods A microcapillary device includes a microcapillary tube. An anode is positioned at a first end of the microcapillary tube. A cathode is positioned at a second end of said microcapillary tube. A plurality of electric field reducing components are spaced apart along a ... | 10/16/2007 |
| 7282129 | Traveling wave algorithms to focus and concentrate proteins in gel electrophoresis An electrophoretic cell configuration and related method are disclosed that employ oppositely directed traveling electrical waves. The waves travel across the cell and samples undergoing separation. Various strategies are used to selectively direct the movement and ... | 10/16/2007 |
| 7241419 | Circuits for the control of output current in an electronic device for performing active biological operations A circuit for control of an output current in a multiple unit cell array includes an array of unit cells arranged in rows and columns. Each unit cell includes a column select transistor being adapted for control by a column selector and a row select transistor being... | 07/10/2007 |
| 7235163 | Loading features for channel array Apparatus and method for loading a channel device for electrophoretic separation including cilia which can be deflected into wells of a multi-well tray. ... | 06/26/2007 |
| 7198701 | Nucleic acid analyzing method To provide a method for analyzing a nucleic acid according to high throughput microcapillary electrophoresis during microchip electrophoresis under non-steady electric field, the method being capable of detecting polymorphism of a large number of genes at a high spe... | 04/03/2007 |
| 7189578 | Methods and systems employing electrothermally induced flow for mixing and cleaning in microsystems A method and system for controlling flow motion in a channel/cavity in a microfluidic system includes positioning at least one pair of electrodes in and/or proximate to the channel/cavity. A buffer solution is placed in the channel/cavity, the buffer solution having... | 03/13/2007 |
| 7189316 | Pulsed field electrophoresis chambers, accessories and method of utilization for separation of DNA molecules Methods of use, accessories and chambers, optimal for performing Pulsed Field Gel Electrophoresis (PFGE) of DNA molecules in ‘Contour Clamped Homogeneous Electric Field’ (CHEF) and ‘Transversal Alternating Field Electrophoresis’ (TAFE) systems, are provided ... | 03/13/2007 |
| 7172864 | Methods for electronically-controlled enzymatic reactions A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridizations, antibody/anti... | 02/06/2007 |
| 7172896 | Integrated portable biological detection system We have performed separation of bacterial and cancer cells from peripheral human blood in microfabricated electronic chips by dielectrophoresis. The isolated cells were examined by staining the nuclei with fluorescent dye followed by laser induced fluorescence imagi... | 02/06/2007 |
| 7166202 | Matrixes, arrays, systems and methods The present invention relates to matrixes, arrays, systems and methods for analyzing biomolecules by their isoelectric point, optionally, in combination with a second dimension analysis. The assortment of matrixes, arrays and systems provided herein are useful for c... | 01/23/2007 |
| 7160423 | Mixed mode microfluidic systems Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks whi... | 01/09/2007 |
| 7153955 | Pentopyranosyl nucleic acid arrays, and uses thereof The invention relates to a pentopyranosylnucleoside of the formula (I) or of the formula (II) their preparation and use for the production of a therapeutic, diagnostic and/or electronic component. ... | 12/26/2006 |
| 7147762 | Method of electrophoresis The present invention relates a method of electrophoretic separation of protein and/or peptide components of a sample in a convection stabilized medium. More specifically, the method comprises the steps to contact the sample with the separation medium; to apply a vo... | 12/12/2006 |
| 7147764 | Dual electrode injection of analyte into a capillary electrophoretic device An injection system including a first electrical circuit for concentration of an analyte and a second electrical circuit for injection of the concentrated analyte into an electrophoretic device is described, as well as methods of using the injection system. ... | 12/12/2006 |
| 7101661 | Apparatus for active programmable matrix devices A system for performing molecular biological diagnosis, analysis and multistep and multiplex reactions utilizes a selfaddressable, selfassembling microelectronic system for actively carrying out controlled reactions in microscopic formats. Preferably, a fluidic syst... | 09/05/2006 |
| 7060224 | Methods for the electronic, homogeneous assembly and fabrication of devices Methods and apparatus are provided for the fabrication of microscale, including micron and sub-micron scale, including nanoscale, devices. Electronic transport of movable component devices is utilized through a fluidic medium to effect transport to a desired target ... | 06/13/2006 |
| 7033475 | Electrophoretic apparatus An electrophoretic apparatus which can analyze multiple tests specimens and being comprised of an electrophoretic member having a relatively simple configuration of passages, such that one or a plurality of passages are formed inside a plate-shaped member therein in... | 04/25/2006 |
| 6977033 | Method and apparatus for programmable fluidic processing A method and apparatus for microfluidic processing by programmably manipulating a packet. A material is introduced onto a reaction surface and compartmentalized to form a packet. A position of the packet is sensed with a position sensor. A programmable manipulation ... | 12/20/2005 |
| 6969453 | Small separation apparatus An electrophoresis apparatus for processing compounds in small sample volumes comprising a cathode in a static cathode buffer zone or compartment, an anode in a static anode buffer zone or compartment. The cathode disposed relative to the anode so as to be adapted t... | 11/29/2005 |
| 6964735 | Method for moving charged particles Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of time so as to move the charged molecules through the medium. The devic... | 11/15/2005 |
| 6942771 | Microfluidic systems in the electrochemical detection of target analytes The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes. ... | 09/13/2005 |
| 6939452 | Parallel sample loading and injection device for multichannel microfluidic devices A sample load and injection device (10) includes sample introduction capillaries (11) attached to a microfluidic device (12). Sample introduction capillaries (11) are connected to sample introduction channels (18). Sample introduct... | 09/06/2005 |
| 6915679 | Multi-reservoir pressure control system Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a s... | 07/12/2005 |
| 6902313 | Micro chaotic mixer A micro mixer for use in a microdevice which utilizes time-varying force fields to induce bulk fluid and/or sample component motion leading to homogenization of sample components. Time-varying force fields employed includes at least one of a physical displacement fi... | 06/07/2005 |
| 6881317 | Fractionation of macro-molecules using asymmetric pulsed field electrophoresis A method and apparatus for fractionation of charged macro-molecules such as DNA is provided. DNA solution is loaded into a matrix including an array of obstacles. An alternating electric field having two different fields at different orientations is applied. The alt... | 04/19/2005 |
| 6866759 | Stepped electrophoresis for movement and concentration of DNA A fluidic channel patterned with a series of thin-film electrodes makes it possible to move and concentrate DNA in a fluid passing through the fluidic channel. The DNA has an inherent negative charge and by applying a voltage between adjacent electrodes the DNA is c... | 03/15/2005 |
| 6638408 | Method and device for separation of charged molecules by solution isoelectric focusing The invention provides a novel solution isoelectric focusing device and method that can reproducibly fractionate charged molecules into well-defined pools. This approach can be applied to mixtures of charged molecules, such as eukaryotic proteome samples ... | 10/28/2003 |
| 6444461 | Microfluidic devices and methods for separation Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, sys... | 09/03/2002 |
| 5879528 | Means and method of detection in chemical separation procedures A means and method for indirect detection of constituent components of a mixture separated in a chemical separation process. Fluorescing ions are distributed across the area in which separation of the mixture will occur to provide a generally uniform back... | 03/09/1999 |
| 5846394 | Method and apparatus for carrying out electrophoresis in fractal fields A method and apparatus for carrying out electrophoretic separation is provided which imparts a fractal field component to the particles themselves or to the medium in which the particles are to be separated which, in combination with a steady field compon... | 12/08/1998 |
| 5795455 | Method for determining the nucleotide size of DNA fragments A method for determining the nucleotide size of DNA fragments separated by gel electrophoresis, comprising the steps of (i) measuring the migration time of each detected DNA fragment, and (ii) correlating the size of each detected DNA fragment with its mi... | 08/18/1998 |
| 5759784 | Method of nucleic acid transfer The present invention is drawn to a method of dosaging a nucleic acid species comprising contacting a solid phase member or members, each member having a predetermined capacity of binding said nucleic acid species, with a sample containing the nucleic aci... | 06/02/1998 |
| 5667654 | Real time in-gel assay Methods are provided for assaying electrophoretically separated components of sample in a gel. Following an initial separation phase of the sample components into distinct bands within separate zones of the gel, the separated components are held stationar... | 09/16/1997 |
