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| Number | Title | Issue Date |
| 8133371 | Scodaphoresis and methods and apparatus for moving and concentrating particles Methods and apparatus for moving and concentrating particles apply an alternating driving field and an alternating field that alters mobility of the particles. The driving field and mobility-varying field are correlated with one another. The methods and apparatus ma... | 03/13/2012 |
| 7365835 | Dark-field laser-scattering microscope for analyzing single macromolecules To further isolate the scattered light 112 of a specific particle from the scattered light of a different particle, a pin hole device 116 can be used. The pin hole device 116 prevents unfocused light from other particles from entering the second... | 04/29/2008 |
| 7338808 | Method and apparatus for determining zeta potential using alternating current electric field and T channel Provided is a method for determining a zeta potential generated between a solid wall and a solution. The method includes (a) injecting an electrolyte solution into a first inlet of a T channel, which is provided with first and second inlet electrodes and a grounded ... | 03/04/2008 |
| 7338583 | Electrophoresis apparatus, and method of analysis Analysis is performed efficiently in an electrophoresis apparatus while avoiding deterioration of samples. A plurality of sample plates are stored in frozen storage. When a particular sample plate is being analyzed, other sample plates are stored in a standby unit. ... | 03/04/2008 |
| 7282127 | Microcapillary devices using high dielectric constant materials and related methods A microcapillary device includes a microcapillary tube. An anode is positioned at a first end of the microcapillary tube. A cathode is positioned at a second end of said microcapillary tube. A plurality of electric field reducing components are spaced apart along a ... | 10/16/2007 |
| 7189316 | Pulsed field electrophoresis chambers, accessories and method of utilization for separation of DNA molecules Methods of use, accessories and chambers, optimal for performing Pulsed Field Gel Electrophoresis (PFGE) of DNA molecules in ‘Contour Clamped Homogeneous Electric Field’ (CHEF) and ‘Transversal Alternating Field Electrophoresis’ (TAFE) systems, are provided ... | 03/13/2007 |
| 7179357 | Serial sample injection in capillary electrophoresis The invention is a method of performing electrophoresis that increases sample throughput and increases the efficiency and speed of the analysis of polynucleotides by electrophoresis. The method is performed by loading and running multiple sequential samples on each ... | 02/20/2007 |
| 7166202 | Matrixes, arrays, systems and methods The present invention relates to matrixes, arrays, systems and methods for analyzing biomolecules by their isoelectric point, optionally, in combination with a second dimension analysis. The assortment of matrixes, arrays and systems provided herein are useful for c... | 01/23/2007 |
| 7163610 | Conductive media for electrophoresis A series of low molarity conductive media based on non-buffering univalent cations, such as sodium chloride-sodium acetate (SCA), sodium boric acid (SB), lithium boric acid, and lithium acetate mitigate the “runaway” positive feedback heating loop produced by co... | 01/16/2007 |
| 7150813 | Isoelectric focusing (IEF) of proteins with sequential and oppositely directed traveling waves in gel electrophoresis Various gel electrophoretic assemblies and techniques are disclosed for providing unique isoelectric focusing (IEF) strategies. Several particular systems, assemblies and methods are provided that significantly reduce processing time, enable the use of reduced opera... | 12/19/2006 |
| 7118661 | Nanolaminate microfluidic device for mobility selection of particles A microfluidic device made from nanolaminate materials that are capable of electrophoretic selection of particles on the basis of their mobility. Nanolaminate materials are generally alternating layers of two materials (one conducting, one insulating) that are made ... | 10/10/2006 |
| 6998094 | Apparatus for and methods of handling biological sample containers Apparatus for handling biological sample containers comprises a conveyor assembly for conveying containers and a lid handling assembly operable to remove lids from and replace lids onto containers while the containers are in motion on the conveyor assembly. The lid ... | 02/14/2006 |
| 6984525 | Method for automated isolation of fractions in multichannel separation systems A method to collect a plurality of target zones from a plurality of channels. The method includes introducing a plurality of compound mixtures into a plurality of microchannels on a microfabricated chip or a capillary tube. Optical signal measured at a detector wind... | 01/10/2006 |
| 6916919 | Isolation of DNA molecules The present invention relates to a process for separating nucleic acid molecules, preferably open circular and supercoiled plasmid DNA and RNA molecules from each other, comprising the steps of providing a solution comprising the molecules; adsorbing the molecules t... | 07/12/2005 |
| 6905585 | Automated system for high-throughput electrophoretic separations A cassette is disclosed for use in performing electrophoretic separations on a solid substrate. The cassette includes reservoirs for containing buffer, electrodes for receiving electrical current and a substrate support. The cassette is designed to connect with exte... | 06/14/2005 |
| 6902657 | Electrophoresis separation media and methods A low molecular weight non-entangled polyvinylpyrrolidone for use as a separation media for microchannel electrophoretic separation. The separation media may be used in a system in which multiple samples of small compounds are injected into a single microchannel at ... | 06/07/2005 |
| 6893546 | Method for separating a chemical or biological compound in a mixture of similar compounds by diffusion in a medium such as a gel A method for separating a chemical or biological compound present in a mixture of similar compounds by diffusion in a medium, the method comprising reacting the compounds of the mixture with a component (P) present in the medium to obtain products (Qi), w... | 05/17/2005 |
| 6866759 | Stepped electrophoresis for movement and concentration of DNA A fluidic channel patterned with a series of thin-film electrodes makes it possible to move and concentrate DNA in a fluid passing through the fluidic channel. The DNA has an inherent negative charge and by applying a voltage between adjacent electrodes the DNA is c... | 03/15/2005 |
| 6827830 | Electrophoretic nucleic acid purification method An electrophoretic method for purifying a nucleic acid sample is disclosed. According to the method, the electrophoresis is effective to substantially reduce the concentration of contaminants relative to the concentration of desired nucleic acid in the nucleic acid ... | 12/07/2004 |
| 6533912 | Increased throughput analysis of small compounds using multiple temporally spaced injections The apparatus and method of the present invention disclose a system in which multiple injections may be made into a capillary array. The injections are spaced in time with each injection followed by an interval of electrophoresis. Once all samples are loa... | 03/18/2003 |
| 6451192 | Simplified electrophoresis apparatus The electrophoresis apparatus comprises rectifier (A) which rectifies an AC current from a universal AC power source and outputs a rectified wave, an electrophoresis cell and an electric controller which applies an electric output from the rectifier (A) t... | 09/17/2002 |
| 6440285 | Method and device for micro particles positioning in field cages In a method for positioning or controlling the motion of an object in a multi-electrode arrangement for forming a field cage, the basic potentials for driving the electrodes are modulated with drive potentials in such a way that the object position in the... | 08/27/2002 |
| 6399389 | High throughput screening assay systems in microscale fluidic devices A method for screening a plurality of compounds is used in conjunction with microfluidic devices for performing high throughput screening assays. A conveyor system is used to transport and dispense libraries of compounds into one or more sample port of a ... | 06/04/2002 |
| 6156178 | Increased throughput analysis of small compounds using multiple temporally spaced injections The apparatus and method of the present invention disclose a system in which multiple injections may be made into a capillary array. The injections are spaced in time with each injection followed by an interval of electrophoresis. Once all samples are loa... | 12/05/2000 |
| 6146511 | Electrophoretic nucleic acid purification method An electrophoretic method for purifying a nucleic acid sample is disclosed. The method generally comprises the steps of (1) providing a nucleic acid sample comprising a desired nucleic acid and one or more contaminants, (2) providing an electrophoresis ma... | 11/14/2000 |
| 6117296 | Electrically controlled contractile polymer composite An electrically controlled polymer composite which, when acted upon by an electric current, contracts or relaxes. It can also serve as a smart drug delivery device. The polymer composite is a series of hydrogel layers, each of which serve a particular pur... | 09/12/2000 |
| 6007689 | Apparatus for preparing gels for use in electrophoretic separations and similar applications An apparatus for the rapid preparation of electrophoresis gels comprises: (a) a housing; (b) a support fixture removably disposed within the housing and adapted to receive a gel holder having an internal gel compartment, the support fixture being optional... | 12/28/1999 |
| 5949899 | Apparatus for measuring and analyzing electrophoresis images A system for measuring and analyzing an image of a gel electrophoresis, includes measuring apparatus and a processor. The measuring apparatus includes a frame mountable in a fixed location relative to the image, including a bar extending along a first axi... | 09/07/1999 |
| 5846394 | Method and apparatus for carrying out electrophoresis in fractal fields A method and apparatus for carrying out electrophoretic separation is provided which imparts a fractal field component to the particles themselves or to the medium in which the particles are to be separated which, in combination with a steady field compon... | 12/08/1998 |
| 5717602 | Automated electrophoresis and analysis system An automated electrophoresis apparatus defining an enclosure that receive a sample gel containing sample material. A voltage is applied to the sample gel and the material migrates through the sample gel. A CCD camera is used to periodically obtain digital... | 02/10/1998 |
| 5650055 | Electrophoresis separation method and apparatus using barrier separation and polarity reversing The method and apparatus for preparative electrophoresis is especially useful for proteins. An electrophoretic potential with an initial polarity is applied across an electrophoretic medium (13) to induce at least two species of macromolecules (1,2) in a ... | 07/22/1997 |
| 5616227 | Method for extending the life of electrophoretic gels A method for extending the useful lifetime and improving the reproducibility of electrophoresis gels, particularly gel-filled capillaries. The polarity of the applied electric field imposed across the gel is periodically reversed between one or more elect... | 04/01/1997 |
| 5549796 | Electrophoresis using contour-clamped electric fields A gel electrophoresis method and apparatus is described in which the shape and orientation of the electric field is controlled by contour clamping. Electrodes are arranged around a closed contour. Two or more electrodes, the driving electrodes, are clampe... | 08/27/1996 |
| 5360523 | DNA sequencing To sequence DNA, DNA samples marked with fluorescent infrared dye are applied at a plurality of locations for electrophoresing in a plurality of channels through a gel electrophoresis slab. The channels are scanned with a laser and a sensor, that include ... | 11/01/1994 |
| 5348636 | Processes for the preparation and separation of macromolecules A process for the electrophoretic separation of charged macromolecules includes applying to the macromolecules a periodic sequence of pulses. Each period comprises a multiplicity of electric field pulses of negative and positive polarities. The negative p... | 09/20/1994 |
| 5328581 | Electrophoresis temperature feedback controller A method of (and apparatus for) electrophoresis in which the gel temperature is controlled automatically. A sensor may measure a gel temperature and a processor may control a power supply for the electrophoresis process in response to that measurement. Me... | 07/12/1994 |
| 5286434 | Processes for the preparation and separation of macromolecules A process for the electrophoretic separation of charged macromolecules includes applying to the macromolecules a periodic sequence of pulses. Each period comprises a multiplicity of electric field pulses of negative and positive polarities. The negative p... | 02/15/1994 |
| 5279721 | Apparatus and method for an automated electrophoresis system An automated electrophoresis and transfer apparatus for separating macromolecules in accordance with their molecular weight and transferring the same to a transfer membrane includes a housing having a perforated intermediate horizontal partition defining ... | 01/18/1994 |
| 5217593 | Nucleic acid purification system and method A process for the purification of DNA and the like comprises a housing having walls forming a reservoir having a chamber for containing a buffer solution, means for circulating a buffer through the reservoir, a disposable cassette within said chamber havi... | 06/08/1993 |
| 5185071 | Programmable electrophoresis with integrated and multiplexed control A user programmable device for horizontal gel eletrophoresis is provided. This device can both accurately and programmably control: (a) the angle between electrical field and gel by use of a rotatable gel bed, (b) magnitude of the electrical field, and (c... | 02/09/1993 |
