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| Number | Title | Issue Date |
| 8163152 | Method and apparatus for high speed carbohydrate analysis A cost-effective multi-channel capillary gel-electrophoresis system for highly efficient, high speed, high throughput, carbohydrate analysis. In one aspect of the present invention, a high-performance capillary electrophoresis analyzer system has been optimized for ... | 04/24/2012 |
| 7862699 | Matrix and dynamic polymer systems and compositions for microchannel separation Matrix polymers and dynamic coating polymers, compositions thereof and related methods, systems and apparatus for microchannel separation. ... | 01/04/2011 |
| 7828948 | Preconcentration and separation of analytes in microchannels Disclosed herein are methods and devices for preconcentrating and separating analytes such as proteins and polynucleotides in microchannels. As disclosed, at least one size-exclusion polymeric element is adjacent to processing area or an assay area in a microchannel... | 11/09/2010 |
| 7517441 | Electrophoretic buffer By using an electrophoretic buffer comprising a polymerized polymer micelle formed by the steps comprising dispersing into an aqueous medium a block copolymer represented by HPLS-HPBS-PLZA, wherein HPLS is a hydrophilic polymer segment, HPBS is a hydrophobic polymer... | 04/14/2009 |
| 7473341 | Denaturant-free electrophoresis of biological molecules under high temperature conditions The present invention relates to a method of separating a sample comprising biological compounds, such as nucleic acids. The nucleic acids are subjected to electrophoresis using a matrix that is essentially free of denaturants and having at least one random, linear ... | 01/06/2009 |
| 7439075 | Method and device for withdrawing suspended microparticles from a fluidic microsystem A method of discharging a fluid flow with suspended microparticles from a fluidic microsystem (10) is described, whereby the fluid flow converges with at least one output flow to form a discharge flow at the end of a discharge channel (14) of the micro... | 10/21/2008 |
| 7419578 | Capillary electrophoresis apparatus A capillary array electrophoresis which can measure fluorescence of a number of capillaries at a time with high sensitivity and can automatically analyze a sample sequentially. An end edge as a sample dissolution edge of a number of capillaries is connected to a pol... | 09/02/2008 |
| 7407568 | Method of using sol-gel coatings for on-line preconcentration of amino acids in capillary electrophoresis A novel on-line method is presented for the extraction and preconcentration of amino acids using a sol-gel coated column coupled to a conventional UV/vis detector. Extraction, stacking and focusing techniques are used in the preconcentration procedures. Sol-gel coat... | 08/05/2008 |
| 7381317 | Methods and compositions for capillary electrophoresis (CE) This invention relates to improved methods and compositions for conducting Capillary Electrophoresis (CE) to separate molecules on the basis of their respective size or charge. ... | 06/03/2008 |
| 7351376 | Integrated active flux microfluidic devices and methods The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting ... | 04/01/2008 |
| 7347922 | Multi-dimensional proteomic analysis method A multi-dimensional proteomic analysis method utilizing cationic electrophoresis is described. The method includes separating proteins in one direction using cationic electrophoresis and separating the proteins in a second orthogonal direction using other electropho... | 03/25/2008 |
| 7347617 | Mixing in microfluidic devices Mixing of liquids in a microfluidic device is accomplished by dispensing the liquids into a first chamber to produce combined liquid. The liquids are thereafter discharged through at least one capillary from the first chamber into a second chamber for complete mixin... | 03/25/2008 |
| 7323140 | Moving microdroplets in a microfluidic device The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations within the microfluidic. The system includes a substrate which forms ... | 01/29/2008 |
| 7316770 | Method of electrophoresis, electrophoresis apparatus and capillary array A method of electrophoresis, an electrophoresis apparatus and a capillary array in which a fluorescently labelled sample is supplied into capillaries in a capillary array constituted by a plurality of capillaries and including a sample supply portion, an electrophor... | 01/08/2008 |
| 7316769 | Length-dependent recoil separation of long molecules Separation of long molecules by length is obtained by forcing such molecules to traverse a boundary between a low free-energy region and a high free-energy region. In one embodiment, the high free-energy region is a dense pillar region or other structure formed on a... | 01/08/2008 |
| 7314550 | Analytical separations with polyelectrolyte layers, molecular micelles, or zwitterionic polymers Polymeric surfactants (molecular micelles) are disclosed for use in open tubular capillary electrochromatography or in high performance liquid chromatography. For example, fused silica capillaries are coated with thin films of charged polymers in a polyelectrolyte m... | 01/01/2008 |
| 7311881 | Chips, and apparatus and method for reaction analysis A chip having a deaerating function and requiring no bonding or welding for forming a channel, and an apparatus and method for the reaction analysis are provided. The chip contains a first substrate, a second substrate having a liquid inlet and a liquid outlet, and ... | 12/25/2007 |
| 7309409 | Multi-channel bio-separation cartridge A bio-separation system using an efficient, compact, portable, interchangeable, reusable, recyclable, multi-channel cartridge, has integrated pre-aligned optics and an integrated reagent reservoir. The cartridge supports, for example, multiple capillaries for CE sep... | 12/18/2007 |
| 7294247 | Electrophoretic separating device and method for using the device The invention concerns to an electrophoretic separation device comprising a separation channel having at least one in- and outlet opening at the beginning and at the end of the channel and one electrode in the region of the inlet opening and one electrode in the reg... | 11/13/2007 |
| 7291263 | Polymeric fiber rods for separation applications A separation element is provided for use in a chromatographic analysis system for the separation of a mixture using a stationary phase and a mobile phase. The separation element comprises a fluid transmissive fiber rod comprising a plurality of fibers entangled to p... | 11/06/2007 |
| 7285421 | Apparatus for capillary electrophoresis and associated method An apparatus and method for capillary zone electrophoresis includes a polyelectrolyte multilayer positioned in a capillary tube for analytical separations of macromolecules. The capillary comprises a passage defined by passage walls comprising fused silica. The poly... | 10/23/2007 |
| 7282129 | Traveling wave algorithms to focus and concentrate proteins in gel electrophoresis An electrophoretic cell configuration and related method are disclosed that employ oppositely directed traveling electrical waves. The waves travel across the cell and samples undergoing separation. Various strategies are used to selectively direct the movement and ... | 10/16/2007 |
| 7282128 | Buffers for electrophoresis and use thereof Various embodiments provide, for example, buffer compositions and/or sieving formulations useful in connection with electrophoresis instruments, such as capillary electrophoresis (CE) devices. In various embodiments, a buffer composition can include Bis-Tris, TAPS a... | 10/16/2007 |
| 7270786 | Methods and systems for processing microfluidic samples of particle containing fluids The present invention relates to a microfluidic system for processing a cell-containing liquid. The system includes a microfabricated substrate having an enrichment channel to prepare an enriched cell sample from the cell-containing liquid. A flow through member is ... | 09/18/2007 |
| 7261812 | Multi-column separation devices and methods Chromatographic separation devices include multiple batch-processed columns joined by a body structure and adapted to perform parallel analyses. Both slurry-packed and monolithic column embodiments are provided. One or more liquid-permeable frits of various types ma... | 08/28/2007 |
| 7259217 | Controlled-architecture polymers and use thereof as separation media Controlled architecture polymers made preferably with acrylamide type monomers are prepared in living-type or semi-living-type free radical polymerizations, with the architecture preferably being other than linear, such as star, branched, grafted or hyper-branched. ... | 08/21/2007 |
| 7217352 | Capillary electrophoresis device An electrophoresis device is disclosed that is capable of reducing waves occurring in a fluid in which the capillary tips of a capillary assay are immersed. A plurality of partition plate members can be provided in a container containing the fluid to divide the surf... | 05/15/2007 |
| 7214299 | Method for separation, identification and evaluation of microbes and cells The method entails using capillary electrophoresis or capillary isoelectric focusing to separate intact microbes. The capillary system can be a conventional capillary tube or a microfluidic device. The method is employed to maintain the microbes intact to ide... | 05/08/2007 |
| 7201844 | Composite matrices with interstital polymer networks The present invention relates in general to the preparation and use of matrices having solid spaces, interstitial spaces and interstitial polymer networks. In particular, the interstitial polymer networks have utility in chemical and biochemical separations, solid p... | 04/10/2007 |
| 7198701 | Nucleic acid analyzing method To provide a method for analyzing a nucleic acid according to high throughput microcapillary electrophoresis during microchip electrophoresis under non-steady electric field, the method being capable of detecting polymorphism of a large number of genes at a high spe... | 04/03/2007 |
| 7195698 | Capillary electrophoretic apparatus, sample plate and sample injection method An electrode plate of a sample plate is set on the body of an electrophoretic apparatus, while a plug is inserted into a migration high voltage line connection hole and connected to a high-tension distribution cable. Each well of a base plate is inserted into a thro... | 03/27/2007 |
| 7192557 | Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids The present invention relates to a microfluidic system for processing a cell-containing liquid. The system includes a lysing zone to receive the cell-containing sample and a positioning element to position the cell-containing sample in a lysing position in the vicin... | 03/20/2007 |
| 7179357 | Serial sample injection in capillary electrophoresis The invention is a method of performing electrophoresis that increases sample throughput and increases the efficiency and speed of the analysis of polynucleotides by electrophoresis. The method is performed by loading and running multiple sequential samples on each ... | 02/20/2007 |
| 7169277 | High throughput separations based analysis systems Devices, systems and methods for use in separating sample materials into different fractions that employ bulk fluid flow for loading of samples followed by electrophoretic separation of the sample material. Devices employ configurations that optionally allow bulk sa... | 01/30/2007 |
| 7169276 | Capillary electrophoresis method and apparatus for reducing peak broadening associated with the establishment of an electric field Methods for reducing peak broadening associated with the establishment of a run field in a capillary electrophoresis process, and apparatus useful for carrying out such methods, are described. Such methods include defining a maximum ramp rate to be used during an in... | 01/30/2007 |
| 7163610 | Conductive media for electrophoresis A series of low molarity conductive media based on non-buffering univalent cations, such as sodium chloride-sodium acetate (SCA), sodium boric acid (SB), lithium boric acid, and lithium acetate mitigate the “runaway” positive feedback heating loop produced by co... | 01/16/2007 |
| 7164107 | Enhanced sample processing devices, systems and methods Devices, systems, and methods for processing sample materials. The sample materials may be located in a plurality of process chambers in the device, which is rotated during heating of the sample materials. ... | 01/16/2007 |
| 7156969 | Microfluidic matrix localization apparatus and methods Multiphasic microfluidic apparatus for performing product fluid manipulation and separation in a single continuous unit are provided. Related methods, kits, and compositions are also provided. ... | 01/02/2007 |
| 7157603 | Method for the separation of oligomeric N-substituted (meth)acrylamide compounds and conjugates thereof which are reversibly thermally precipitating The method of separating reversibly thermally precipitable oligomeric N-substituted (meth)acrylamides and conjugates thereof from aqueous solution includes thermally precipitating the oligomeric N-substituted (meth)acrylamides and the conjugates thereof from an aque... | 01/02/2007 |
| 7150815 | Polymeric microfabricated fluidic device suitable for ultraviolet detection A polymer-based microfluidic device and its manufacturing methods. This microfluidic device is suitable for chromatographic and electrophoretic separations in which the detection of the components in the fluid is by means of ultraviolet (UV) spectroscopy. The device... | 12/19/2006 |
