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| Application No. | Application Title | Issue Date |
| 20120322739 | Albumin Variants The invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The invention also relates to fusion polypeptides and conjugates comprising said variant albumin.... | 12/20/2012 |
| 20120322884 | EPINEPHRINE NANOPARTICLES, METHODS OF FABRICATION THEREOF, AND METHODS FOR USE THEREOF FOR TREATMENT OF CONDITIONS RESPONSIVE TO EPINEPHRINE The invention provides a composition including epinephrine nanoparticles and methods for therapeutic use of the composition in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrin... | 12/20/2012 |
| 20120315480 | COPPER NANOPARTICLES WITH MAGNETIC PROPERTIES The present invention relates to thiol- or an amine-associated ferromagnetic or superparamagnetic copper nanoparticles with an average diameter less than 30 nm, to the method for obtaining them and their applications in biomedicine and other fields.... | 12/13/2012 |
| 20120315306 | PHARMACEUTICAL COMPOSITION AND PREPARATION FOR ORAL ADMINISTRATION A pharmaceutical composition including drug-containing nanoparticles having an average particle diameter of from 10 nm to 150 nm, the pharmaceutical composition being obtained by mixing water with a poorly water soluble drug-containing, water miscible solution that cont... | 12/13/2012 |
| 20120315320 | USES OF FORMULATIONS OF THYROID HORMONE ANALOGS AND NANOPARTICULATE FORMS THEREOF TO INCREASE CHEMOSENSIVITY AND RADIOSENSITIVITY IN TUMOR OR CANCER CELLS Disclosed are methods of increasing the chemosensitivity of normal and/or chemoresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof. Also disclosed are methods of increasing radiosensitivity of normal and/or rad... | 12/13/2012 |
| 20120315336 | INJECTABLE NANOPARTICULATE OLANZAPINE FORMULATIONS Described are injectable formulations of particulate olanzapine that produce a prolonged duration of action upon administration, and methods of making and using such formulations. The injectable formulations comprise particulate olanzapine.... | 12/13/2012 |
| 20120308623 | COMPOSITION COMPRISING NANOPARTICLES OF TI02 The present invention is directed to a composition comprising nanoparticles of TiO2 having a mean particle diameter (D50) of about 20-50 nm at a concentration of about 1-2000 g/L and H2O2 at a final concentration at about 2.5-... | 12/06/2012 |
| 20120308614 | COMPOSITION FOR THE CONTROLLED RELEASE OF BUPRENORPHINE The present invention relates to a novel aqueous liquid pharmaceutical composition for the controlled release of buprenorphine or of an analogue of buprenorphine, comprising at least one prodrug with low aqueous solubility of said buprenorphine or analogue of buprenorph... | 12/06/2012 |
| 20120308616 | SUBMICRO EMULSION OF PACLITAXEL USING STEROID COMPLEX AS INTERMEDIATE CARRIER A submicron emulsion of paclitaxel, the preparation method and the use thereof are disclosed. Said paclitaxel submicron emulsion comprises paclitaxel/steroid complex, oil for injection, water for injection, emulsifier, assistant emulsifier and isotonic agent, wherein th... | 12/06/2012 |
| 20120308548 | METHIONINE GAMMA LYASE-2-AMINOBUTYRATE DEAMINASE (MEGL-2ABD) AND THERAPEUTIC USES THEREOF The invention relates to a methionine gamma lyase-2-aminobutyrate deaminase (MEGL-2ABD) enzyme and provides an isotopic assay for quantitatively measuring activity of the enzyme. The MEGL-2ABD is a therapeutic target for cancer, particularly in cancer stem cells and the... | 12/06/2012 |
| 20120308657 | MAGNETIC NANOSTRUCTURES AS THERANOSTIC AGENTS The present invention relates to magnetic nanostructures as theranostic agents, which provide dual function as diagnostic and therapeutic agents. In particular, the present invention relates to compositions comprising magnetic nanostructures and their use as targeted th... | 12/06/2012 |
| 20120308612 | COMPOSITIONS AND METHODS FOR PREPARATION OF POORLY WATER SOLUBLE DRUGS WITH INCREASED STABILITY The present invention provides stable pharmaceutical compositions of poorly water soluble pharmaceutical agents and stabilizing agents which function to increase stability of the compositions. The use of stabilizing agents provide extended stability of nanoparticle susp... | 12/06/2012 |
| 20120308662 | PARTICULATE PREPARATION AND METHOD FOR PRODUCING THE SAME The present invention aims to provide a particulate formulation with an effectively controlled dissolution characteristic of a drug even if the average particle diameter is small. The present invention provides a particulate formulation containing drug particles and a f... | 12/06/2012 |
| 20120302499 | STERILIZED, ACELLULAR EXTRACELLULAR MATRIX COMPOSITIONS AND METHODS OF MAKING THEREOF Methods for sterilizing and decellularizing extracellular matrix materials are disclosed. Extracellular matrix compositions produced using the disclosed methods are also disclosed.... | 11/29/2012 |
| 20120301487 | METHOD FOR IN-VIVO BINDING OF CHROMATIN FRAGMENTS A process for substantially reducing levels of circulating chromatin fragments (CCFs) from a medium using binding agents such as antibodies or antibodies complexed with haemocompatible natural polymer substrates like as alginates, chitosan and pullulan to form complexed... | 11/29/2012 |
| 20120294902 | PEPTIDE AMPHIPHILES AND METHODS TO ELECTROSTATICALLY CONTROL BIOACTIVITY OF THE IKVAV PEPTIDE EPITOPE The present invention is directed to peptide amphiphile compounds, compositions and methods of use, wherein nanofiber bundling or epitope aggregation is inhibited. In certain embodiments, the peptide amphiphiles of the present invention have increased solubility and red... | 11/22/2012 |
| 20120294903 | METHODS AND SYSTEMS OF MAKING NANOSTRUCTURES In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making nanostructures (e.g., nanoparticles, nanofibers), systems for making nanostructures, ... | 11/22/2012 |
| 20120288533 | PROTEIN-POLYSACCHARIDE CONJUGATES AND USE FOR ENCAPSULATING NUTRACEUTICALS FOR CLEAR BEVERAGE APPLICATIONS The present invention provides protein (or peptide)-polysaccharide (or oligosaccharide) conjugates (PPC) as nanocapsular vehicles for nanoencapsulation of biologically active compounds, particularly nutraceuticals. The PPCs efficiently protect both hydrophobic (i.e., wa... | 11/15/2012 |
| 20120288535 | RARE EARTH NANOPARTICLES This document provides methods and materials related to rare earth particles such as rare earth nanorods (e.g., inorganic lanthanide hydroxide nanorods). For example, rare earth (e.g., lanthanide) particles such as europium hydroxide nanorods, methods and materials for ... | 11/15/2012 |
| 20120288553 | METHOD FOR CONTROLLING TOXICITY OF METALLIC PARTICLE AND LOW-TOXICITY COMPOSITE OF METALLIC NANOPARTICLE AND INORGANIC CLAY The present invention provides a method for controlling toxicity of metallic particles and a low-toxicity composite of metallic nanoparticles and inorganic clay. The metallic nanoparticles are effective in preventing infection and in skinning over, and thus suitable for... | 11/15/2012 |
| 20120282314 | DERMATOLOGICAL/COSMETIC SKIN DEPIGMENTING COMPOSITIONS Depigmenting compositions having improved effectiveness in the dermatological or cosmetic treatment of pigmentation contain, in a physiologically acceptable medium, at least one compound selected from among rucinol and salts thereof, and at least one retinoid; such comp... | 11/08/2012 |
| 20120282324 | Methods for Promoting the Revascularization and Reenervation of CNS Lesions The present invention provides methods of promoting the revascularization and/or reenervation of central nervous system lesions using an in-situ crosslinkable hydrogel. The present invention also provides methods of treating a spinal cord injury by topically delivering ... | 11/08/2012 |
| 20120282176 | Method and Constructs for the pH Dependent Passage of the Blood-brain-barrier Herein is reported a fusion polypeptide comprising i) at least one binding site, e.g. which comprises an antibody heavy chain variable domain and an antibody light chain variable domain, and which binds to an internalizing cell surface receptor, and ii) at least one pha... | 11/08/2012 |
| 20120282343 | COMPOSITIONS FOR ORAL GENE THERAPY AND METHODS OF USING SAME The present invention provides nanoparticle compositions comprising a cationic biopolymer and at least one biologically active substance, pharmaceutical compositions comprising such nanoparticles and methods for the oral administration of biologically active molecules w... | 11/08/2012 |
| 20120283213 | Aryl/Alkyl Succinic Anhydride Hyaluronan Derivatives The present invention relates to the modification of hyaluronic acid (HA) with aryl/alkyl succinic anhydrides (ASA) to produce aryl/alkyl succinic anhydride HA derivatives, to the derivatives as such, and to their applications and uses, particularly in the cosmetic and ... | 11/08/2012 |
| 20120269888 | BARRIER COMPOSITION The invention is directed to a barrier composition, to a vehicle comprising said barrier composition, to a layer comprising said barrier composition, to a foodstuff comprising said vehicle or layer, to a pharmaceutical or nutraceutical composition comprising said vehicl... | 10/25/2012 |
| 20120269737 | POLYMER COATED FERRITE FINE PARTICLES AND METHOD FOR PREPARING POLYMER COATED FERRITE FINE PARTICLES [Object] To provide a polymer coated ferrite fine particles being possible to control a particle size uniformly while having high aqueous dispersibility and preferred biomolecule immobilization ability and an easy method for preparing the same. 10/25/2012 | |
| 20120263764 | COMPOSITIONS AND METHODS FOR INHIBITING AND/OR MODULATING EFFECTOR T-CELLS INVOLVED IN INFLAMMATORY NEURODEGENERATIVE DISEASE Provided are methods for treating inflammatory neurodegenerative diseases (e.g., multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, stroke/cerebral ischemia, head trauma, spinal cord injury, Huntington's disease, migraine, cereb... | 10/18/2012 |
| 20120263793 | BIO-NANO-PLASMONIC ELEMENTS AND PLATFORMS The invention relates generally to the field of plasmonics, and more specifically, in one embodiment, it relates to fabricating elements in whole or in part using one or more self-assembling elements comprised of purified, synthetic and or recombinant protein molecule e... | 10/18/2012 |
| 20120264802 | PHOTOSENSITIZERS FOR TARGETED PHOTODYNAMIC THERAPY The present invention relates to photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof.... | 10/18/2012 |
| 20120251450 | NANOPARTICLES THAT PREFERENTIALLY ASSOCIATE WITH AND KILL DISEASED CELLS FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS Of the many compositions and methods provided herein, one composition includes a nanoparticle having a first oxide of a first metal and a dopant that includes an ion or an atom of a second metal. A method includes a method comprising providing a plurality of nanoparticl... | 10/04/2012 |
| 20120251521 | Technical field and industrial applicability of the invention The present invention is a solution or colloid of fullerene, SWNTs, or graphene in cyclic terpenes, lactones, terpene-alcohol, fatty-acid alcohols, and lactones following ultrasonication and ultracentrifugation processing, for oil-energy, biological, electrical-thermal ... | 10/04/2012 |
| 20120251437 | MAGNETITE IN NANOPARTICULATE FORM The present invention relates to a process for the polyol-type synthesis of nanoparticulate magnetite starting from mixtures of Fe0 and FelIII in the presence of a mineral acid. The magnetite particles obtainable from the process have uniform size ... | 10/04/2012 |
| 20120244075 | 5 NM Nickel-NTA-Gold Nanoparticles The present disclosure relates to the product, process, and use of 5 nm Nickel-Nitrilotriacetic acid (Ni-NTA) gold nanoparticles. Applications include diagnostic tests, imaging, therapies, detection technologies, gold conjugation to other molecules, and novel material c... | 09/27/2012 |
| 20120244076 | csPCNA Isoform Antibodies And Uses Thereof Antibodies specifically bind only to a cancer specific proliferating cell nuclear antigen (csPCNA) isoform and not to the non-malignant proliferating cell nuclear antigen (nmPCNA) isoform. Methods and compositions to detect the presence of csPCNA isoform are disclosed.... | 09/27/2012 |
| 20120244134 | PROCESS FOR PREPARING AQUEOUS DISPERSIONS CONTAINING HIGH CONCENTRATION OF NANO/SUBMICRON, HYDROPHOBIC, FUNCTIONAL COMPOUNDS The present invention provides a process for preparing an aqueous dispersion containing a high concentration of nano/submicron, hydrophobic, functional compounds. The process is carried out by using a complex stabilizer having an HLB value of about 10 to about 17, compr... | 09/27/2012 |
| 20120244224 | NANOSTRUCTURAL MATERIALS THAT INCREASE MINERALIZATION IN BONE CELLS AND AFFECT GENE EXPRESSION THROUGH miRNA REGULATION AND APPLICATIONS OF SAME A method of inducing mineralization in a bone cell is described. The method comprises contacting a bone cell with a composition comprising nanoparticles. The nanoparticles can be single-walled carbon nanotubes, hydroxyapatite nanoparticles, TiO2 nanoparticles... | 09/27/2012 |
| 20120244225 | Au-Ag Core-Shell Nanorod Particles and Method for Producing Same Disclosed are: Au—Ag core-shell nanorod particles wherein a cationic surfactant such as CTAB is substituted by an other compound; and a method for producing the Au—Ag core-shell nanorod particles. Specifically disclosed are Au—Ag core-shell nanorod particles which... | 09/27/2012 |
| 20120238642 | Polymer Mechanical Damping Composites and Methods of Production A method of reshaping an article comprising a polyelectrolyte complex, the polyelectrolyte complex comprising an intermolecular blend of a predominantly positively-charged polyelectrolyte and a predominantly negatively charged polyelectrolyte by controlling the salt dop... | 09/20/2012 |
| 20120237570 | METHODS AND COMPOSITIONS FOR TREATING DISTRESS DYSFUNCTION AND ENHANCING SAFETY AND EFFICACY OF SPECIFIC MEDICATIONS The present invention relates to methods and compositions for reducing distress dysfunction, including emotional and physical distress. The invention entails co-administration of at least one Receptor Switcher and at least one Endorphin Enhancer. Additionally, at least ... | 09/20/2012 |
