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| Application No. | Application Title | Issue Date |
| 20120131688 | Reverse Breeding A method for efficiently producing homozygous organisms from a heterozygous non-human starting organism, comprising providing of a heterozygous starting organism; allowing the starting organism to produce haploid cells; creating homozygous organisms from the haploid cel... | 05/24/2012 |
| 20120110683 | NON-HUMAN ANIMAL MODEL OF MYOCARDIAL INFARCTION AND METHOD FOR CREATING THE SAME The present invention provides a non-human animal model of myocardial infarction, which can be created by a less invasive method, shows an extremely low mortality during and after surgical induction of myocardial infarction, ensures the blood reflow after necrosis of ca... | 05/03/2012 |
| 20120084873 | SEX-DETERMINATION AND METHODS OF SPECIFYING SAME The present invention relates generally to the field of sex determination of animals. Provided are methods and agents to manipulate sex determination, particularly in avian animals such as chickens, through a male chromosome-linked testis (sex) regulatory gene. Expressi... | 04/05/2012 |
| 20120047587 | ESTROUS CYCLE MONITORING BY COLOR RESPONSE A method of determining the phase of an estrous cycle that a mammal is in at a given time that a biological sample is obtained from the mammal is provided. The biological sample obtained from the mammal is combined with at least one flavonoid pigment that reacts with th... | 02/23/2012 |
| 20120036589 | VACCINE The present invention is concerned with the development of a vaccine against Aeromonas hydrophila for use especially in fish. The invention provides an immunogenic S-layer protein of approximately 50 kDa of A. hydrophila for use in the development of a vac... | 02/09/2012 |
| 20120023599 | GENOME EDITING OF CYTOCHROME P450 IN ANIMALS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding cytochrome P450 (CYP) proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention ... | 01/26/2012 |
| 20110318367 | NOVEL TARGETS FOR TREATMENT OF HYPERCHOLESTEROLEMIA In certain embodiments this invention this invention pertains to the discovery that inhibition of myosin light chain interacting protein (Mylip) can mitigate one or more symptoms of hypercholesterolemia. Methods of treating hypercholesterolemia and methods of screening ... | 12/29/2011 |
| 20110307965 | METHODS AND COMPOSITIONS FOR DETECTING CANINE DILATED CARDIOMYOPATHY (DCM) This invention provides the identification of a 16 base pair deletion in a splice site region between exons 10 and 11 of the dog PDK4 gene that is linked to dilated cardiomyopathy (DCM). Also provided are methods for detecting DCM and methods of breeding dogs to reduce ... | 12/15/2011 |
| 20110307964 | MOUSE HAVING HUMAN LEUKEMIC STEM CELL AND LEUKEMIC NON-STEM CELL AMPLIFIED THEREIN, AND METHOD FOR PRODUCTION THEREOF The invention relates to a method of selectively expanding human leukemic cells in a non-adult NOD/SCID/IL2rgnull mouse by transplanting a substance containing a leukemic stem cell derived from a human acute myelogenous leukemia patient to the mouse. In addit... | 12/15/2011 |
| 20110302665 | NON-HUMAN MAMMALS WITH T OR B CELLS HAVING PREDEFINED SPECIFICITY The present invention provides non-human mammals, e.g., mice, generated from a T cell or B cell with a predefined specificity or isolated from an organism suffering from a condition of interest. In some embodiments the non-human mammals are not genetically modified. Als... | 12/08/2011 |
| 20110296541 | PRODUCTION OF PROTEINS IN EGGS Methods for preparing recombinant proteins, such as antibodies, in eggs are described. The method offers advantages over existing systems for preparing recombinant proteins including high yield, low cost and compatibility with animal protection regulations. In addition,... | 12/01/2011 |
| 20110296542 | EXOGENOUS MATRIX-SUPPORTED TOPICAL APPLICATION OF STEM CELLS TO ORGAN SURFACE A process of tissue regeneration is provided that includes the administration of a stem cell topically to a surface of a tissue. The tissue being in vivo in a subject or in vitro. The tissue has a biocompatible matrix applied around the stem cell and in contact with the... | 12/01/2011 |
| 20110289607 | METHOD OF INHIBITING GENE EXPRESSION The present invention relates to a method for inhibiting expression of a target gene, which comprises introducing a cell, tissue, or individual organism with a double-stranded polynucleotide comprising DNA and RNA having a substantially identical nucleotide sequence wit... | 11/24/2011 |
| 20110289606 | EQUINE DISEASE MODEL FOR HERPESVIRUS NEUROLOGIC DISEASE AND USES THEREOF Disclosed is an in vivo equine disease model and a method of preparing the disease model for equine herpesvirus-1 neurological disease comprising a horse having a low pre-exposure level of herpesvirus-specific CTL precursors wherein the horse is experimentally infected ... | 11/24/2011 |
| 20110277042 | Mite Composition, Use Thereof, Method for Rearing a Phytoseiid Predatory Mite, Rearing System for Rearing Said Phytoseiid Predatory Mite and Methods for Biological Pest Control on a Crop The present invention relates to a novel mite composition comprising a population of a phytoseiid predatory mite species and a factitious host population, which may be employed for rearing said phytoseiid predatory mite species or for releasing the phytoseiid predatory ... | 11/10/2011 |
| 20110265193 | IDENTIFICATION OF MUTATION AND METHOD FOR DETECTING LAVENDER FOAL SYNDROME IN THE HORSE Provided is a method for determining whether a horse is normal, a carrier, or is affected with Lavender Foal Syndrome (LFS). The method entails, in a biological sample obtained or derived from a horse, determining a single nucleotide deletion which introduces a translat... | 10/27/2011 |
| 20110258712 | MYOSTATIN ISOFORM The present invention provides splice variants of myostatin that promote muscle growth, and include polynucleotides and polypeptide sequences, constructs comprising the sequences and compositions for regulating muscle growth and treating diseases associated with muscle ... | 10/20/2011 |
| 20110258711 | METHOD FOR DIAGNOSTIC MARKER DEVELOPMENT The invention relates to a method for the generation of unique molecular markers in existing breeding material by selecting a marker associated with a trait, identifying the existing variation at the nucleotide level within a set of markers within a germplasm and introd... | 10/20/2011 |
| 20110258715 | ORGAN REGENERATION METHOD UTILIZING iPS CELL AND BLASTOCYST COMPLEMENTATION It is revealed that an organ such as pancreas can be regenerated by utilizing a fact that the deficiency of an organ is complemented by injecting an induced pluripotent stem cell (iPS cell) into a developed blastocyst in a blastocyst complementation method. Thus, the pr... | 10/20/2011 |
| 20110252486 | CHONDROCYTE-LIKE CELL, AND METHOD FOR PRODUCING SAME Disclosed is a cell which enables the reproduction of a cartilage tissue and has a proliferative ability. Also disclosed is a technique for providing a cell supply source which can be used in a definitive treatment of osteochondrosis deformans. A chondrocyte-like cell w... | 10/13/2011 |
| 20110225660 | ORALLY ADMINISTRABLE IMMUNOSTIMULANT PRODUCT FOR AQUACULTURE An orally administrable immunostimulant product comprises a microencapsulated cytokine and an enteric protection polymer to protect the cytokine, the cytokine is a fish, mollusc or crustacean cytokine, preferably a recombinant cytokine such as tumor necrosis factor α (... | 09/15/2011 |
| 20110214193 | BIOMARKER FOR MICRODOMAIN DISEASE The present invention relates to a diagnostic technique related to a biomarker for a microdomain disease and a method for detecting a microdomain disease of which manipulation is easy and which is inexpensive.... | 09/01/2011 |
| 20110207166 | Human bone marrow microenvironments and uses thereof The present invention is directed to an in vitro cultured permissive niche, or human bone marrow microenvironment, comprising a scaffold coated with human mesenchymal stem cells and a culture medium, wherein the stem cells are viable and proliferate in culture and the n... | 08/25/2011 |
| 20110197289 | Storage of Entomopathogenic Nematodes This invention relates to methods of prolonged storage of the species of entomopathogenic nematodes belonging to the genera of Steinernema and Heterorhabditis for use as bio-pesticides wherein storage in surfactant solution or antimicrobial solution on ste... | 08/11/2011 |
| 20110191867 | PEPTIDE VACCINE FOR INFLUENZA VIRUS The invention provides peptide epitopes for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza. The invention also relates to a method for evaluating the potential of a chemical entity, such as an an... | 08/04/2011 |
| 20110191868 | METHODS FOR IDENTIFICATION AND USE OF AGENTS TARGETING CANCER STEM CELLS The invention relates to methods for identifying compounds and compositions that target cancer stem cells. In some aspects, the invention relates to treatment methods that use compounds and compositions that specifically target cancer stem cells for inhibiting the growt... | 08/04/2011 |
| 20110191869 | Method For Characterising The Biological Activity Of Helminth Eggs, In Particular Trichuris Eggs A method for determining the biological activity of embryonated Trichuris eggs is described, in which at least one of the following determinations is carried out:
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| 20110185439 | G PROTEIN COUPLED RECEPTORS AND USES THEREOF The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and... | 07/28/2011 |
| 20110179504 | Method For Coral Tissue Cultivation And Propagation This invention relates to a novel method of culturing coral tissues and polyps in vitro. Coral tissues obtained by the method of the invention may be maintained as heterotypic spheroid tissue balls for a period of at least three months or they may be induced to undergo ... | 07/21/2011 |
| 20110173709 | ECTOPIC, ORTHOTOPIC MODEL FOR REVASCULARIZATION AND TUMOR ASSESSMENT Improved vascularization and tumor models, comprising a test animal having a dorsal skin window chamber, and an exogenous tissue sample implanted ectopically in the skin within the window chamber, are described, as are methods of using the models.... | 07/14/2011 |
| 20110165644 | PRODUCTION OF ALKENES BY ENZYMATIC DECARBOXYLATION OF 3-HYDROXYALKANOIC ACIDS The present invention relates to a method for generating alkenes biologically. It relates more particularly to a method for producing terminal alkenes by enzymatic decarboxylation of 3-hydroxyalkanoate molecules. The invention also relates to the enzymatic systems and t... | 07/07/2011 |
| 20110154514 | Polynucleotide used for releasing recombinant protein to the outside of eukaryotic cell This invention provides a method for efficiently producing a recombinant protein by allowing the recombinant protein to express in a eukaryotic cell and releasing the expressed recombinant protein to the outside of the cell. The invention provides a polynucleotide used ... | 06/23/2011 |
| 20110145938 | METHOD FOR GENERATING MONOCLONAL ANTIBODIES THAT RECOGNIZE PROGENITOR CELLS Method for generating monoclonal antibodies that recognize progenitor cells. Said method comprises immunization of an Armenian hamster with neurospheres obtained from olfactory bulb cells from a 13.5-day mouse embryo and subsequent selection of the antibodies by means o... | 06/16/2011 |
| 20110131668 | IMPROVED GENE SILENCING METHODS Provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are targeted to the same nucleic acid, but which are processed into short interfering RNA molecules through differen... | 06/02/2011 |
| 20110126300 | High Through-Put Method of Screening Compounds for Pharmacological Activity Provided is a method for high through-put screening for physiologic alterations in an altered teleost displaying a phenotype that is characteristic of the alteration and different from a wild-type, unaltered, matched teleost, comprising the steps of contacting the teleo... | 05/26/2011 |
| 20110119774 | COMPOSITIONS OF AQUATIC ORIGIN FOR PREVENTION OF CELL ADHESION AND METHODS OF USING SAME A composition comprising an extract from an aquatic organism is disclosed. The composition is capable of preventing adhesion of a cell to a surface and is devoid of cytotoxic or cytostatic activity. Medical devices comprising same and methods for preventing or treating ... | 05/19/2011 |
| 20110107441 | ANIMALS WITH REDUCED BODY FAT AND INCREASED BONE DENSITY Methods for identifying animals as having reduced body fat and increased bone density are provided herein. Also provided herein are methods for generating animals having reduced body fat and increased bone density. The methods provided herein are based on the effect of ... | 05/05/2011 |
| 20110107444 | NOVEL POLY(ADP-RIBOSE) POLYMERASE GENES The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has
| 05/05/2011 |
| 20110088106 | COMPOSITIONS AND METHODS FOR MEDIATING CELL CYCLE PROGRESSION Hypercellular nonhuman organisms have functionally inactivated expression of a cyclin inhibitor gene, especially p27. The growth rate of nonhuman organisms are increased such that a desired size is attained more quickly than as compared to nonvariant organisms. Inhibito... | 04/14/2011 |
| 20110076264 | IMMUNOGLOBULIN CLEAVAGE FRAGMENTS AS DISEASE INDICATORS AND COMPOSITIONS FOR DETECTING AND BINDING SUCH The invention relates to antibody compositions and use of the composition to detect disease processes associated with elaboration of proteases. The reagents are directed to assessing an IgG breakdown product that is the result of such proteolytic cleavage. The invention... | 03/31/2011 |
