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| Application No. | Application Title | Issue Date |
| 20120082987 | Transgenic Non-Human Animals Expressing Human Blood Clotting Factors and Uses Thereof The present invention relates, in general, to development of non-human transgenic animals expressing a human blood clotting factor, such as Factor VIII, Factor VII, Factor IX and von Willebrand factor. The invention further provides methods of detecting immunogenic even... | 04/05/2012 |
| 20120030780 | TARGETING OF SALL4 FOR THE TREATMENT AND DIAGNOSIS OF PROLIFERATIVE DISORDERS ASSOCIATED WITH MYELODYSPLASTIC SYNDROME (MDS) The present invention discloses nucleic acids, proteins, and antibodies for SALL4 (including isoforms SALL4A, SALL4B, and SALL4C), a zinc finger transcriptional factor. Further, methods are disclosed which demonstrate that constitutive expression of SALL4 increases leuk... | 02/02/2012 |
| 20110307968 | PRODUCTION OF FERTILE XY ANIMALS FROM XY ES CELLS Methods and compositions are described for making phenotypically female fertile animals from XY donor cells and suitable host embryos. Culture media and methods are provided for maintaining XY donor cells in culture that after introduction into a host embryo and gestati... | 12/15/2011 |
| 20110277050 | SYSTEM AND METHODS TO CONTROL TRANSGENE EXPRESSION Embodiments of the present invention describe a novel and versatile inducible binary expression system (the ‘Q system’) and methods for controlling transgene expression in vitro and in vivo, for lineage tracing, for genetic mosaic analysis and for determining gene f... | 11/10/2011 |
| 20110236378 | NON-HUMAN MAMMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES The invention provides knock-in non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing knock-in cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions ... | 09/29/2011 |
| 20110239317 | POLYNUCLEOTIDES ENCODING PROMYOSTATIN POLYPEPTIDES The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can specifically hybridize to such polynucleotides. The present invention also provi... | 09/29/2011 |
| 20110239313 | METHOD FOR PRODUCTION OF TRACP5b Silkworms which have (i) a DNA encoding a transcriptional regulator operably linked downstream of a promoter of a DNA encoding a protein specifically expressed in the silk gland and (ii) a DNA encoding TRACP5 operably linked downstream of a target promoter of the transc... | 09/29/2011 |
| 20110185442 | Method of generating transgenic organisms using transposons The invention relates to a method for generating a transgenic organism. The invention also relates to a method for detecting and characterizing a genetic mutation in a transgenic organism. The invention further relates to a method for isolating a gene which is correlate... | 07/28/2011 |
| 20110154521 | TRANSGENIC ANIMALS EXPRESSING ANTIBODIES SPECIFIC FOR GENES OF INTEREST AND USES THEREOF The invention provides compositions and methods for the generation of novel non-human transgenic animals which contain an alteration in a gene of interest. These transgenic animals are capable of generating antibodies, e.g., human monoclonal antibodies, specific for the... | 06/23/2011 |
| 20110126299 | TRIPLE TRANSGENIC MOUSE MODEL OF AUTOIMMUNE DISEASE AND NF-KAPPA B IN VIVO IMAGING The present invention provides for monitoring of NF-κB-associated inflammation in mice undergoing Id-driven autoimmune disease. The mice are triple transgenic mice expressing both Id+ B cells and Id-specific CD4+ T cells as well as a luciferase re... | 05/26/2011 |
| 20110041195 | Organisms homozygous for targeted modification Disclosed herein are homozygously modified organisms and methods of making and using these organisms.... | 02/17/2011 |
| 20110016548 | CONTROL OF ENDOGENOUS DNMT1 GENE EXPRESSION BY EXOGENOUS BINARY REGULATORY SYSTEMS Provided are methods for controlling endogenous gene expression comprising control of the DNA methyltransferase (Dnmt1) for modulation of DNA methylation and epigenetic mechanisms. Provided are transcriptional regulatory systems involving multiple (e.g., three) exogenou... | 01/20/2011 |
| 20100333216 | Non-human gene-disrupted animal with disrupted Adam11 gene It is an object of the present invention to provide a non-human gene-disrupted animal with a disrupted ADAM11 gene. According to the present invention, a non-human gene-disrupted animal, wherein either one of or both alleles of an ADAM11 gene are disrupted, is provided.... | 12/30/2010 |
| 20100306867 | TRANSGENIC ANIMALS PRODUCING MONOVALENT HUMAN ANTIBODIES AND ANTIBODIES OBTAINABLE FROM THESE ANIMALS The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods f... | 12/02/2010 |
| 20100299771 | MEANS AND METHODS FOR shRNA MEDIATED CONDITIONAL KNOCKDOWN OF GENES The present invention relates to a combination of DNA segments comprising: (a) a first segment comprising in 5′ to 3′ or 3′ to 5′ order: (aa) a promoter; (ab) a first DNA sequence comprising: (i) a DNA sequence giving rise upon transcription to the sense strand ... | 11/25/2010 |
| 20100287632 | Rapid Production of Monoclonal Antibodies The present invention relates to genetically altered hybridomas, myelomas and B cells. The invention also relates to utilizing genetically altered hybridomas, myelomas and B cells in methods of making monoclonal antibodies. The present invention also provides population... | 11/11/2010 |
| 20100287633 | Hyperactive PiggyBac Transposases The present invention provides PiggyBac transposase proteins, nucleic acids encoding the same, compositions comprising the same, kits comprising the same, non-human transgenic animals comprising the same, and methods of using the same.... | 11/11/2010 |
| 20100281554 | TWO STEP CLUSTER DELETION AND HUMANISATION This invention relates to a method for humanising a mouse. In particular, the invention relates to a method for replacing a cluster of mouse genes with single or multiple genes from the corresponding human cluster using a combination of homologous recombination and site... | 11/04/2010 |
| 20100269182 | LEXA-BASED CHEMICAL-INDUCIBLE GENE EXPRESSION SYSTEM FOR USE IN TRANSGENIC ANIMALS The present invention relates generally to chemical-inducible system and to methods of use in transgenic animals. More specifically, the present invention relates to a chimeric transcription factor that binds to a ligand and functions in ligand-dependent manner to induc... | 10/21/2010 |
| 20100263063 | MOUSE MODELS WITH ENHANCED ESSENTIAL TREMOR AND PREPARATION METHOD THEREOF Disclosed herein are an α1/CaV3.1 double knockout mouse or α−/−;Emx1-Cre mouse with enhanced essential tremor and a screening method of therapeutic agents for essential tremor by using the same. The α1/CaV3.1 double knockout mouse or α1−/− 10/14/2010 | |
| 20100223687 | COMPOSITIONS AND METHODS FOR DIAGNOSIS OF GENETIC SUSCEPTIBILITY, RESISTANCE, OR TOLERANCE TO INFECTION BY MYCOBACTERIA AND BOVINE PARATUBERCULOSIS Provided are methods for determining resistance or tolerance of a subject to Mycobacterium avium subspecies paratuberculosis (Map) infection, comprising determining, a presence or absence of a mutation, or the genotype of a single nucleotide polymorphism (... | 09/02/2010 |
| 20100223685 | IL-21 RECEPTOR KNOCKOUT ANIMAL AND METHODS OF USE THEREOF A transgenic non-human mammal with a disruption in its IL-21 receptor gene is provided, along with methods of using the transgenic non-human mammal.... | 09/02/2010 |
| 20100212038 | TRANSGENIC FISH WITH TISSUE-SPECIFIC EXPRESSION Disclosed are transgenic fish, and a method of making transgenic fish, which express transgenes in stable and predictable tissue- or developmentally-specific patterns. The transgenic fish contain transgene constructs with homologous expression sequences. Also disclosed ... | 08/19/2010 |
| 20100212039 | INFERTILITY CONTROL OF GENETICALLY MODIFIED FISH A method of inducing male and/or female infertility in a genetically modified (GM) fish is disclosed. Also disclosed is a method of generating an infertile GM fish with a phenotype and/or genotype of interest. The method involves generation of a GM fish whose genome com... | 08/19/2010 |
| 20100205683 | METHOD FOR ENABLING STABLE EXPRESSION OF TRANSGENE This invention relates to a method for stably expressing a transgene integrated into the genome of an animal cell or of an animal over a long period. Specifically, this invention provides: an approximately 2.5 kb XhoI-BamHI fragment (or XB fragment) derived from the Evx... | 08/12/2010 |
| 20100050276 | Transgenic non-human animal models of apoptosis-mediated conditions A transgenic non-human animal whose genome comprises a stable integration of a transgene that encodes at least one Fas-ligand protein operably-linked to a tetracycline-inducible promoter includes cells that express the transgene and undergo apoptosis. The transgenic non... | 02/25/2010 |
| 20090293139 | DOUBLE-INDUCIBLE GENE ACTIVATION SYSTEM AND ITS APPLICATIONS A double-inducible system for expressing a transgene, preferably comprising an RU486-inducible system integrated with a CID-inducible system. The invention further comprises a gene expression system for use in in vitro cell culture studies, and a gene expression express... | 11/26/2009 |
| 20090276866 | Production of ungulates, preferably bovines that produce human immunoglobulins The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and/or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1 and/or rag-2 eliminated from their genome are unable to conduct the gene r... | 11/05/2009 |
| 20090235372 | Hairless Immunodeficient Mouse Model The invention is directed to a hairless, immunodeficient mouse that is homozygous recessive for a hairless (Hrhr) allele and both B-cell deficient and T-cell deficient. The B-cell and T-cell deficiency is attributed to a homozygous recessive scid allele (Prkd... | 09/17/2009 |
| 20090210952 | Compositions and Methods Related to Controlled Gene Expression Using Viral Vectors Provided herein are methods and compositions related to viral vectors. Also provided herein are methods and compositions for the efficient transfection of a host, for example through the highly efficient lentivector delivery system, and for the exquisite control of the ... | 08/20/2009 |
| 20090205059 | Methods, Compositions and Systems for Production of Recombinant Spider Silk Polypeptides Disclosed are methods, compositions, and systems for transforming silkworms to produce spider silk and analogs of spider silk. In certain embodiments, the method may include inserting a DNA sequence coding for at least a portion of a spider silk fibroin polypeptide, or ... | 08/13/2009 |
| 20090193533 | Conditional-Stop Dimerizable Caspase Transgenic Animals Described are transgenic animals for conditional and inducible cell targeting, that express a dimerizable conditional-STOP caspase 3 transgene.... | 07/30/2009 |
| 20090165156 | METHOD FOR INCREASING THE SALTWATER TOLERANCE OF A FISH The present invention relates to a method for obtaining an indication of the saltwater tolerance of a fish, and methods for increasing the saltwater tolerance of a fish. In particular, the invention relates to methods involving biomarkers in the transferrin gene which a... | 06/25/2009 |
| 20090025097 | SHRNA AND SIRNA AND MIRNA EXPRESSION IN A LIVING ORGANISM UNDER CONTROL OF A CODON-OPTIMIZED REPRESSOR GENE The present invention relates to a biological entity, notably a rat, carrying a regulator construct comprising a specific repressor gene and a responder construct comprising at least one segment corresponding to a short hairpin RNA (shRNA) or corresponding to complement... | 01/22/2009 |
| 20080300202 | SUBTRACTIVE TRANSGENICS Described herein are methods for predictable, highly selective expression of a transgene in a human or non-human animal. The methods comprise subtractive transgenics, wherein the expression pattern of one selective promoter is subtracted from the expression pattern of a... | 12/04/2008 |
| 20080295186 | Neurotrypsin overexpressing animal The invention describes a transgenic non-human animal overexpressing neurotrypsin wherein the animal exhibits symptoms of sarcopenia.... | 11/27/2008 |
| 20080282364 | Phosphodiesterase 9 Inhibition as Treatment for Obesity-Related Conditions The present invention is directed to methods to decrease body weight and/or body fat in an animal, e.g., in the treatment of overweight or obese patients (e.g., humans or companion animals), or as a means to produce leaner meat in food stock animals (e.g., cattle, chick... | 11/13/2008 |
| 20080229438 | Process of making transgenic mammals that produce exogenous proteins in milk and transgenic mammals produced thereby The invention relates to a method of producing a protein of interest, comprising making a non-human transgenic mammal that produces said protein in its milk, obtaining said milk from the non-human transgenic mammal and purifying said protein of interest from the milk. T... | 09/18/2008 |
| 20080229437 | Intergeneric bivalve shellfish hybrid and method for producing Provided by this invention are novel intergeneric bivalve shellfish hybrids, including clams and scallops. Also provided are methods for producing the novel hybrids and their progeny.... | 09/18/2008 |
| 20080209580 | Mouse developing visceral fat type obesity and diabetes An object of the present invention is to provide a mouse which has the characteristics of early developing visceral fat type obesity and also has concurrent diabetes and hyperlipemia and in which the trait is genetically established and recessively inherited. An ICR-der... | 08/28/2008 |
