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| Application No. | Application Title | Issue Date |
| 20110286973 | METHODS FOR INTRODUCING HETEROLOGOUS CELLS INTO FISH The invention provides methods of introducing heterologous cells into fish. After introduction cells remain viable, and in some instances proliferate, for sufficient time to conduct a variety of analyses on the heterologous cells or the fish or both. Such methods are us... | 11/24/2011 |
| 20110289604 | Methods for Identifying Modulating Compounds of Lymphangiogenesis, Means Therefore, Compounds and Uses Thereof The invention relates to a method for testing whether a compound is capable of inhibiting the development of lymphatic channels or lymphangiogenesis and/or the migration of lymphangioblasts in an non-human animal, a non-human embryo or a cell culture, comprising steps o... | 11/24/2011 |
| 20110239318 | METHODS FOR PRODUCING FISH WITH HIGH LIPID CONTENT The invention provides methods for producing biofuel from algae, that use fish which have a high capacity of producing and/or accumulating lipids to harvest algae from an algal culture. The invention also provides methods for growing fish that result in a high lipid con... | 09/29/2011 |
| 20110239317 | POLYNUCLEOTIDES ENCODING PROMYOSTATIN POLYPEPTIDES The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can specifically hybridize to such polynucleotides. The present invention also provi... | 09/29/2011 |
| 20110239310 | TRANSGENIC FISH AND USES THEREOF The present invention relates to a transgenic fish having at least one genomically integrated expression cassette containing a 5′-regulatory nucleotide sequence responsive to hormones, particularly estrogenic hormones, connected in a functional manner upstream of a nu... | 09/29/2011 |
| 20110099648 | RECOMBINANT GENE WHICH ENHANCES THE ABILITY OF FISH TO TOLERATE LOW DISSOLVED OXYGEN STRESS AND THE USE THEREOF The invention discloses a recombinant gene which enhances the ability of fish to tolerate low dissolved oxygen (DO) stress and the use thereof. Carp β-actin gene promoter is used as a promoter and Vitreoscilla hemoglobin gene is used as a target gene, so as to c... | 04/28/2011 |
| 20110088106 | COMPOSITIONS AND METHODS FOR MEDIATING CELL CYCLE PROGRESSION Hypercellular nonhuman organisms have functionally inactivated expression of a cyclin inhibitor gene, especially p27. The growth rate of nonhuman organisms are increased such that a desired size is attained more quickly than as compared to nonvariant organisms. Inhibito... | 04/14/2011 |
| 20110083201 | COMPOSITIONS FOR AND METHODS OF GRAZYME B INHIBITION The present invention is related to the discovery that serpina3n, a secreted protein, binds to and inhibits granzyme B activity. The invention thus provides cells that include a polynucleotide encoding a granzyme B inhibitory serpin, pharmaceutical compositions includin... | 04/07/2011 |
| 20110016545 | Xylanases, Nucleic Acids Encoding Them and Methods For Making and Using Them The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo-β-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the inv... | 01/20/2011 |
| 20110010785 | PRODUCTS AND THEIR USE FOR THE DIAGNOSIS, PREVENTION AND/OR CARE OF HUMAN AND/OR ANIMAL PATHOLOGIES CHARACTERISED BY THE ANOMALOUS DEPOSITION OF B-AMYLOID AND/OR AMYLOID-LIKE SUBSTANCE IN HUMAN AND/OR ANIMAL ORGANS AND TISSUES, AND SCREENING METHOD FOR DETERMINING THE RISK OF SUCH PATHOLOGIES The patent refers to a screening method carried out on biological material isolated from human and/or animal organisms for determining the risk of human and/or animal pathologies expressing an anomalous deposition of β-amyloid and/or amyloid-like substance in human and... | 01/13/2011 |
| 20100293624 | ELIMINATION OF N-GLUCOLYLNEURAMINIC ACID FROM ANIMAL PRODUCTS FOR HUMAN USE This application is in the field of sialic acid chemistry, metabolism, antigenicity, and the production of transgenic non-human mammals with altered sialic acid production. More particularly, this application relates to N-glycolylneuraminic acid (Neu5Gc) being an immuno... | 11/18/2010 |
| 20100242123 | MODELS OF ATHEROSCLEROSIS, HYPERLIPIDEMIA, LIPOPROTEIN OXIDATION AND BLOOD VESSEL INFLAMMATION AND METHODS FOR MAKING AND USING THEM The invention provides genetically altered fish of the family Cyprinidae, or genus Danio, including zebrafish (Danio rerio) and host cells from these animals, where the fish have been genetically altered to lack or have a modified gene related to lipid met... | 09/23/2010 |
| 20100212038 | TRANSGENIC FISH WITH TISSUE-SPECIFIC EXPRESSION Disclosed are transgenic fish, and a method of making transgenic fish, which express transgenes in stable and predictable tissue- or developmentally-specific patterns. The transgenic fish contain transgene constructs with homologous expression sequences. Also disclosed ... | 08/19/2010 |
| 20100212039 | INFERTILITY CONTROL OF GENETICALLY MODIFIED FISH A method of inducing male and/or female infertility in a genetically modified (GM) fish is disclosed. Also disclosed is a method of generating an infertile GM fish with a phenotype and/or genotype of interest. The method involves generation of a GM fish whose genome com... | 08/19/2010 |
| 20100150928 | METHODS AND COMPOSITIONS RELATING TO ZPA POLYPEPTIDES The present invention provides ZPA polypeptides, antibodies, nucleic acid molecules, antagonists, agonists, potentiators and compositions relating to ZPA polypeptides, and methods of identifying, making and using the same, that are useful for treating and preventing dis... | 06/17/2010 |
| 20100132056 | Germ Cell Marker Using Fish Vasa Gene In order to examine whether or not a germ cell derived from a donor fish, which has been transplanted into a recipient fish of a different species by a surrogate fish technique, grows or matures in the gonad of the recipient fish, it is necessary to use, as an indicator... | 05/27/2010 |
| 20100050280 | RECOMBINANT CONSTRUCTS AND TRANSGENIC FLUORESCENT ORNAMENTAL FISH THEREFROM The present invention relates to the method and use of reef coral fluorescent proteins in making transgenic red, green and yellow fluorescent zebrafish. Preferably, such fluorescent zebrafish are fertile and used to establish a population of transgenic zebrafish and to ... | 02/25/2010 |
| 20100037331 | RECOMBINANT CONSTRUCTS AND TRANSGENIC FLUORESCENT ORNAMENTAL FISH THEREFROM The present invention relates to the method and use of reef coral fluorescent proteins in making transgenic red, green and yellow fluorescent zebrafish. Preferably, such fluorescent zebrafish are fertile and used to establish a population of transgenic zebrafish and to ... | 02/11/2010 |
| 20100037330 | Efficient Somatic Cell Nuclear Transfer In Fish The present disclosure provides methods of producing enucleated cells by photoablation. Such enucleated cells may be used as recipient cells for Somatic Cell Nuclear Transfer and cloning. The nuclear donor and/or enucleated recipient cells may be any fish cells, such as... | 02/11/2010 |
| 20090320148 | OXYLIPINS FROM STEARIDONIC ACID AND GAMMA-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME Disclosed are novel oxylipins that are derived from γ-linolenic acid (GLA; 18:3n-6) and stearidonic acid (STA or SDA; 18:4n-3), and methods of making and using such oxylipins. Also disclosed is the use of such oxylipins in therapeutic and nutritional or cosmetic applic... | 12/24/2009 |
| 20090255005 | Method for Preparing Fish Embryo An object of the invention is to effectively prepare a fish embryo with a correct chromosomal ploidy by nuclear transplantation in which an exogenous fish nucleus is transplanted in a cytoplasmic recipient. For this object, the invention comprises a step of preparing a ... | 10/08/2009 |
| 20090255006 | Transgenic Zebrafish Transgenic zebrafish containing sqt genomic sequences driving expression of a reporter gene are provided. This line faithfully reproduces the spatiotemporal expression pattern of endogenous sqt, and at the late blastula stage is expressed in the YSL as well as in the bl... | 10/08/2009 |
| 20090210953 | Identification of TRPML3 (MCOLN3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone, and/or vasopressin production or release The present invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals and based thereon high-throughput mammalian and medium-throughput oocyte-based electrophysiological assays for identi... | 08/20/2009 |
| 20090165153 | Modified gene-silencing RNA and uses thereof Methods and means for efficiently downregulating the expression of any gene of interest in eukaryotic cells and organisms are provided. To this end, the invention provides modified antisense and sense RNA molecules, chimeric genes encoding such modified antisense or sen... | 06/25/2009 |
| 20090144841 | Polymorphisms in the human gene for the multidrug resistance-associated protein 1 (MRP-1) and their use in diagnostic and therapeutic applications The present invention relates to a polymorphic MRP-1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, ... | 06/04/2009 |
| 20090133138 | NEW GENE FRAGMENT, NOVEL TRANSGENIC ZEBRAFISH AND METHODS FOR PRODUCING TRANSGENIC ZEBRAFISH The present invention provides a method for producing systemic red fluorescent zebrafish. The present invention also provides a new gene fragment and a systemic red fluorescent zebrafish.... | 05/21/2009 |
| 20090133139 | NUCLEOTIDE SEQUENCE OF SHRIMP ACTIN PROMOTER AND ITS USE IN GENETIC TRANSFORMATION BIOTECHNOLOGY The present invention relates to an isolated β-actin nucleic acid promoter molecule from shrimp; nucleic acid constructs including the β-actin promoter molecule; and expression vectors, host cells, and transgenic animals transduced with the isolated β-actin nucleic a... | 05/21/2009 |
| 20090113565 | Methods for Detecting Fluorescent Proteins and Animals Having Fluorescent Proteins Provided are methods for detecting expression of nucleic acids encoding mutant fluorescent proteins. In the methods, a nucleic acid encoding a mutant fluorescent protein, or a full complement thereof, is introduced into a cell or organism. The cell or organism is allowe... | 04/30/2009 |
| 20090077681 | Methods for Diagnosing and Treating Heart Disease The invention provides methods of diagnosing heart disease, such as heart failure, methods for identifying compounds that can be used to treat or to prevent heart disease, and methods of using these compounds to treat or to prevent heart disease. Also provided in the in... | 03/19/2009 |
| 20090025645 | RECOMBINANT CONSTRUCTS AND TRANSGENIC FLUORESCENT ORNAMENTAL FISH THEREFROM The present invention relates to the method and use of reef coral fluorescent proteins in making transgenic red, green and yellow fluorescent zebrafish. Preferably, such fluorescent zebrafish are fertile and used to establish a population of transgenic zebrafish and to ... | 01/29/2009 |
| 20080320610 | Transgenic fish with increased unsaturated fatty acid content The present invention relates to fish with increased unsaturated fatty acid content by transfer of a fatty acid desaturase gene thereinto, and a production method of these fish with increased unsaturated fatty acid content. The fatty acid desaturase gene is one or more ... | 12/25/2008 |
| 20080289054 | Fish Cancer Model The present invention is directed to fish whose genome has integrated therein an oncogenic nucleic acid operably linked to a promoter. Methods of making the fish and methods for their use are also provided. The fish may advantageously be utilized in methods of screening... | 11/20/2008 |
| 20080201786 | Transgenic Zebrafish Models of Alzheimer's Disease The present invention relates to zebrafish models for Alzheimer's disease that allow recapitulation of pathologies associated with Alzheimer's disease. This invention also relates to methods for screening of compounds for their ability to modulate a pathology associated... | 08/21/2008 |
| 20080178310 | Growth Differentiation Factor-8 Nucleic Acid and Polypeptide from Aquatic Species, and Transgenic Aquatic Species A transgenic non-human aquatic organisms, such as piscine, crustacean, mollusks, and the like, having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the... | 07/24/2008 |
| 20080148418 | Novel Zebrafish This invention relates to novel zebrafish and preparation method thereof. This invention also relates to a novel animal model.... | 06/19/2008 |
| 20080127358 | Compositions and methods for modulating hedgehog signaling Provided herein are nucleic acid constructs encoding Hh regulating proteins, which are proteins that activate or inhibit Hh signaling. Exemplary Hh regulating proteins are N- or C-terminally truncated forms of Gli proteins or a dominant negative form of PKA. The Hh regu... | 05/29/2008 |
| 20080052787 | Chimeric gene constructs for generation of fluorescent transgenic ornamental fish Four zebrafish gene promoters, which are skin specific, muscle specific, skeletal muscle specific and ubiquitously expressed respectively, were isolated and ligated to the 5′ end of the EGFP gene. When the resulting chimeric gene constructs were introduced into zebraf... | 02/28/2008 |
| 20070274952 | Compositions and Methods for Modifying the Content of Polyunsaturated Fatty Acids in Biological Cells The present invention features compositions (e.g., nucleic acids encoding fat-1, optionally and operably linked to a constitutively active or tissue-specific promoter or other regulatory sequence and pharmaceutically acceptable formulations including that nucleic acid o... | 11/29/2007 |
| 20070269459 | Mutant G Genes of the Trout Viral Haemorrhagic Septicaemia Virus (Vhsv) and Applications Thereof The invention relates to mutant G genes of viral haemorrhagic septicaemia virus (VHSV) in rainbow trout, which encode mutant G proteins of VHSV with defective or null binding to cells that can be infected by VHSV. Said mutant G genes of VHSV can be used, among other app... | 11/22/2007 |
| 20070261127 | LIGHT-ACTIVATED CATION CHANNEL AND USES THEREOF The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression ... | 11/08/2007 |
