Class 800/18 - Mouse

Subclass of Class 800 - Multicellular living organisms and unmodified parts thereof and related processes
Definition: Subject matter wherein the mammal is a mouse.
No. of applications: 806
Last issue date: 05/03/2012

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Application No.	Application Title	Issue Date
20120110686	Cand45 tRNA-Derived Expression System for Gene Modulation The present invention relates to systems and methods for modulating gene expression and applications thereof. Provided is a novel expression system to generate RNaseZ and RNA polymerase III dependent RNAs to regulate genes and control the timing and the location of the ...	05/03/2012
20120082987	Transgenic Non-Human Animals Expressing Human Blood Clotting Factors and Uses Thereof The present invention relates, in general, to development of non-human transgenic animals expressing a human blood clotting factor, such as Factor VIII, Factor VII, Factor IX and von Willebrand factor. The invention further provides methods of detecting immunogenic even...	04/05/2012
20120070861	Human Lambda Light Chain Mice Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice tha...	03/22/2012
20120070444	IN VIVO SCREENING MODELS FOR TREATMENT OF isoQC-RELATED DISORDERS A transgenic non-human animal for overexpressing isoQC, comprising cells containing a DNA transgene encoding human isoQC, characterized in that said human isoQC comprises the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having at least 75% sequence iden...	03/22/2012
20120073004	Hybrid Light Chain Mice Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice tha...	03/22/2012
20120047585	HCO32 AND HCO27 AND RELATED EXAMPLES The instant invention relates to transgenic non-human animals capable of producing heterologous antibodies, transgenes used to produce such transgenic animals, transgenes capable of functionally rearranging a heterologous D gene in V-D-J recombination, immortalized B-ce...	02/23/2012
20120042400	RTD RECEPTOR Novel polypeptides, designated RTD, which are capable of binding Apo-2 ligand are provided. Compositions including RTD chimeras, nucleic acid encoding RTD, and antibodies to RTD are also provided....	02/16/2012
20120036590	INTERFERON-LIKE PROTEIN ZCYTO21 The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides...	02/09/2012
20120021409	Common Light Chain Mouse A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains...	01/26/2012
20120003231	CELL SURFACE MOLECULE MEDIATING CELL ADHESION AND SIGNAL TRANSMISSION Novel cell surface molecules recognized by monoclonal antibodies against a cell surface molecule of lymphocytic cells that play an important role in autoimmune diseases and allergic diseases have been isolated, identified, and analyzed for their functions. The cell surf...	01/05/2012
20110314565	Method for Isolating Cell-Type Specific mRNAS The invention provides methods for isolating cell-type specific mRNAs by selectively isolating ribosomes or proteins that bind mRNA in a cell type specific manner, and, thereby, the mRNA hound to the ribosomes or proteins that bind mRNA. Ribosomes, which are riboprotein...	12/22/2011
20110314563	ANTIBODY PRODUCTION A non-human mammal containing an endogenous lambda light chain gene locus, an endogenous kappa light chain gene locus and an endogenous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-...	12/22/2011
20110307967	TetO-p16 Transgenic Mice Mice comprising a human p16 transgene operably linked to an inducible promoter and capable of controlled expression of p16 are provided. Also provided are cells, tissues, and organs obtainable from such mice, and methods for producing p16 transgenic mice....	12/15/2011
20110307966	Mice Expressing Human Voltage-Gated Sodium Channels Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a humanization of an extracellular loop of an endogenous Na_Vchannel gene, in particular a humanization of t...	12/15/2011
20110307968	PRODUCTION OF FERTILE XY ANIMALS FROM XY ES CELLS Methods and compositions are described for making phenotypically female fertile animals from XY donor cells and suitable host embryos. Culture media and methods are provided for maintaining XY donor cells in culture that after introduction into a host embryo and gestati...	12/15/2011
20110296546	Human CTLA-4 Antibodies And Their Uses The present invention provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies....	12/01/2011
20110296538	IN VIVO QUANTITATIVE SCREENING TEST FOR ANTI-METASTASIS TREATMENT EFFICACY The present invention is directed to methods for evaluating the efficacy of a cancer treatment for (i) inhibiting metastasis in a subject, (ii) inhibiting local cancer cell movement, and (iii) inhibiting cancer cell proliferation. The present invention is further direct...	12/01/2011
20110296544	COLON CANCER TARGETS AND USES THEREOF The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibo...	12/01/2011
20110288149	Method of protecting against heart failure The present invention relates, in general, to heart failure, and, in particular to a method of reducing the risk of heart failure, particularly in patents with established cardiomyopathy....	11/24/2011
20110287010	Diagnostic methods and markers The present invention relates to methods of detecting, monitoring and treating prostate cancer (PRC) OR prostatic intraepithelial neoplasia (PIN) or a predisposition to same. Provided for use in the methods is a novel cancer marker, PSPU43, as well as bioassays and kits...	11/24/2011
20110283376	Methods of Modifying Eukaryotic Cells A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are ...	11/17/2011
20110277045	METHODS FOR INCREASING BETA CELL MASS COMPRISING ADMINISTERING A RA770 POLYPEPTIDE The present invention discloses polynucleotides which identify and encode DP119, DP444, DP810, DP685, WE474, DP160, RA977, or RA770 as well as novel functions for these proteins of the inventions. The invention provides for compositions for disorders associated with the...	11/10/2011
20110277046	HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity...	11/10/2011
20110277047	Genetically Modified Non-Human Mammals and Cells A genetically modified mouse characterised in that it does not comprise a nucleic acid sequence which itself encodes any endogenous immunoglobulin heavy chain constant region locus polypeptide...	11/10/2011
20110268747	STXBP1 AS PSYCHIATRIC BIOMARKER IN MURINE MODEL SYSTEM AND THEIR USES A non-human transgenic animal having a polynucleotide encoding an STXBP1 polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the STXBP1 polypeptide in at least one brain region, as w...	11/03/2011
20110265197	Signatures and PCDeterminants Associated with Prostate Cancer and Methods of Use Thereof The present invention provides methods of detecting cancer using biomarkers....	10/27/2011
20110265192	NUCLEAR RECEPTOR SENSOR SYSTEM IN TRANSGENIC ANIMAL A sensor system for detecting the activation of specific nuclear receptors in a tissue of an animal is provided. The nuclear receptor sensor system comprises a sensor component comprising a nuclear receptor or part thereof coupled to a DNA-binding domain, and a reporter...	10/27/2011
20110258710	Methods of Modifying Eukaryotic Cells A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are ...	10/20/2011
20110258716	MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146 The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immun...	10/20/2011
20110247090	Synthetic 5'UTRs, Expression Vectors, and Methods for Increasing Transgene Expression The present invention provides synthetic 5′UTRs comprising a first polynucleotide fragment and a second polynucleotide fragment, wherein the first polynucleotide fragment comprises at least one splice site of a first eukaryotic gene, the second polynucleotide fragment...	10/06/2011
20110239314	Gene of porcine alpha-si casein, a promoter of the same and use thereof The present invention relates to a porcine alpha-S1-casein gene, a porcine alpha-S1-casein gene promoter, an expression comprising the same promoter, and a method for the production of a target protein using the same expression vector. The promoter of the present invent...	09/29/2011
20110239312	METHODS OF DIAGNOSING AND TREATING MOTOR NEURON DISEASES Use of an agent which upregulates an activity or amount of miRNA-9 or miRNA-9* is disclosed for the preparation of a medicament for the treatment of a motor neuron disease (MND)....	09/29/2011
20110231944	B CELL-DERIVED IPS CELLS AND APPLICATION THEREOF Provided are a B cell-derived iPS cell generated using a convenient technique, a technology for providing a human antibody at low cost using the iPS cell, an immunologically humanized mouse prepared using cells differentiated from the iPS cell, and the like. Also provid...	09/22/2011
20110230547	Potential Prognostic Markers and Therapeutic Targets for Neurological Disorders We recently found that Satb1 is expressed highly by mature neurons in specific regions of the postnatal brain. Satb2, a homolog of Satb1, is expressed at low levels in the postnatal brain. Neurons respond to external stimuli and rapidly and dynamically change their expr...	09/22/2011
20110214189	G PROTEIN COUPLED RECEPTORS AND USES THEREOF The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and...	09/01/2011
20110214194	COMPOSITIONS AND METHODS FOR MODULATING CELLS VIA CD14 AND TOLL-LIKE RECEPTOR 4 SIGNALING PATHWAY Compositions and methods are provided for screening and identifying compounds which modulate signaling of toll-like receptor 4 (TLR4) pathway via CD 14 and a ligand. Methods are provided for treatment of various disease states such as inflammation or autoimmune disease ...	09/01/2011
20110212459	NOVEL PRESENILIN ASSOCIATED MEMBRANE PROTEIN (PAMP) AND USES THEREOF Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodegenerative diseases. In a specific embodiment, mut...	09/01/2011
20110214190	TRANSGENIC REPORTER MOUSE AND METHOD FOR USE A transgenic mammal, including a transgenic mouse, whose genome comprises a transgene, said transgene comprises a neutrophil gelatinase-associated lipocalin (NGAL) promoter gene operably linked to at least one sequence encoding at least one of a fluorescent or biolumine...	09/01/2011
20110214195	Methods For Treating Clinical Conditions Associated With Lipoprotein Lipase Activity The present invention provides methods for treating a clinical condition associated with lipoprotein lipase activity in the brain of a subject....	09/01/2011
20110209230	Human Monoclonal Antibodies To Programmed Death Ligand 1 (PD-L1) The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to PD-L1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for...	08/25/2011

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Class 800/18 - Mouse