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| Application No. | Application Title | Issue Date |
| 20120128682 | APOLIPOPROTEIN L- I VARIANTS AND THEIR USE An isolated human Apolipoprotein L-I corresponding to a wild type human Apolipoprotein sequence is modified by a deletion at its C-terminal end.... | 05/24/2012 |
| 20120023599 | GENOME EDITING OF CYTOCHROME P450 IN ANIMALS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding cytochrome P450 (CYP) proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention ... | 01/26/2012 |
| 20110296544 | COLON CANCER TARGETS AND USES THEREOF The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibo... | 12/01/2011 |
| 20110296545 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING CONDITIONS AND DISEASES ASSOCIATED WITH MANNHEIMIA HAEMOLYTICA Particular aspects show that the signal peptide remains intact on the mature CD18 molecule on ruminant leukocytes rendering these cells susceptible to cytolysis by Lkt. Comparative amino acid sequence analysis of the signal peptide of CD18 of eight ruminants and five no... | 12/01/2011 |
| 20110283375 | Transgenic Prothrombin And Related Thrombin Precursors And Transgenics, Methods, Compositions, Uses And The Like Relating Thereto The invention provides, among other things, activatable prothrombin, compositions comprising prothrombin, transgenic organisms for making prothrombin, methods for making the transgenic organisms, methods for making prothrombin-comprising compositions and for further pur... | 11/17/2011 |
| 20110239314 | Gene of porcine alpha-si casein, a promoter of the same and use thereof The present invention relates to a porcine alpha-S1-casein gene, a porcine alpha-S1-casein gene promoter, an expression comprising the same promoter, and a method for the production of a target protein using the same expression vector. The promoter of the present invent... | 09/29/2011 |
| 20110239317 | POLYNUCLEOTIDES ENCODING PROMYOSTATIN POLYPEPTIDES The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can specifically hybridize to such polynucleotides. The present invention also provi... | 09/29/2011 |
| 20110231943 | TRANSGENIC ANIMALS AND USES THEREOF In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prio... | 09/22/2011 |
| 20110209229 | Gene of porcine beta casein, a promoter of the same and the use thereof The present invention provides a porcine beta-casein gene, a porcine beta-casein gene promoter, an expression vector comprising the same promoter, and a method for the production of a target protein using the same expression vector. The promoter of the present invention... | 08/25/2011 |
| 20110191875 | COMPOSITIONS AND METHODS FOR MAKING ANDROSTENEDIONES The invention provides compositions and methods for producing androstenedione (4-androstenedione), of improved purity and for modulating its production, for example by deletion or inactivation of ksdA, cxgA, cxgB, cxgC, or cxgD. The invention also provides methods and c... | 08/04/2011 |
| 20110126297 | TRANSGENIC ANIMAL WITH MONOCYTE CHEMOTACTIC PROTEIN 1 PROMOTER The present invention relates to a transgenic animal, which comprises in its genome a recombinant polynucleotide encoding one or more reporter proteins and a monocyte chemotactic protein-1 (MCP-1) promoter, wherein the one or more reporter proteins are expressed under t... | 05/26/2011 |
| 20110093965 | PHOSPHOLIPASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM The invention provides novel polypeptides having phospholipase activity, including, e.g., phospholipase A, B, C and D activity, patatin activity, phosphatidic acid phosphatases (PAP) and/or lipid acyl hydrolase (LAH) activity, nucleic acids encoding them and antibodies ... | 04/21/2011 |
| 20110077208 | EXPRESSION OF SECRETED HUMAN ALPHA-FETOPROTEIN IN TRANSGENIC ANIMALS The invention features a process of expressing secreted recombinant human alpha-fetoprotein (rHuAFP) in the milk or urine of transgenic mammals.... | 03/31/2011 |
| 20110055938 | TRANSGENIC ANIMAL FOR PRODUCTION OF ANTIBODIES HAVING MINIMAL CDRS A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising: a) a functional immunoglobulin light chain gene comprising a transcribed variable region encoding: i. light chai... | 03/03/2011 |
| 20110055940 | Therapeutic Inhibitors of PAI-1 Function Methods of Their Use The invention relates to mammalian PAI-I ligands and modulators. In particular, the invention relates to polypeptides, polypeptide compositions and polynucleotides that encode polypeptides that are ligands and/or modulators of PAI-I. The invention also relates to polyli... | 03/03/2011 |
| 20110030072 | GENOME EDITING OF IMMUNODEFICIENCY GENES IN ANIMALS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding immunodeficiency proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are m... | 02/03/2011 |
| 20110030078 | TRYPANOSOME RESISTANT NON-HUMAN TRANSGENIC ANIMAL The present invention is directed to a Trypanosome-resistant, non-human transgenic animal whose somatic and germ cells comprise a nucleic acid which encodes an apolipoprotein L-I polypeptide (apoL-I). The apoL-I protein has the amino acid sequence selected from the grou... | 02/03/2011 |
| 20110023151 | GENOME EDITING OF ABC TRANSPORTERS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding ABC transporter proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are me... | 01/27/2011 |
| 20110023150 | GENOME EDITING OF GENES ASSOCIATED WITH SCHIZOPHRENIA IN ANIMALS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences associated with schizophrenia. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provi... | 01/27/2011 |
| 20110023152 | GENOME EDITING OF COGNITION RELATED GENES IN ANIMALS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with cognitive disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing ... | 01/27/2011 |
| 20110023149 | GENOMIC EDITING OF GENES INVOLVED IN TUMOR SUPPRESSION IN ANIMALS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences involved in tumor suppression. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provi... | 01/27/2011 |
| 20110023158 | BOVINE GENOME EDITING WITH ZINC FINGER NUCLEASES The present invention provides a genetically modified bovine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nu... | 01/27/2011 |
| 20110023141 | GENOMIC EDITING OF GENES INVOLVED WITH PARKINSON'S DISEASE The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with Parkinson's disease. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. ... | 01/27/2011 |
| 20110023139 | GENOMIC EDITING OF GENES INVOLVED IN CARDIOVASCULAR DISEASE The present invention provides genetically modified animals and cells comprising edited chromosomal involved in cardiovascular disease. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides z... | 01/27/2011 |
| 20110023145 | GENOMIC EDITING OF GENES INVOLVED IN AUTISM SPECTRUM DISORDERS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with ASD. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided ar... | 01/27/2011 |
| 20110023143 | GENOMIC EDITING OF NEURODEVELOPMENTAL GENES IN ANIMALS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with neurodevelopmental disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated... | 01/27/2011 |
| 20110023147 | GENOMIC EDITING OF PRION DISORDER-RELATED GENES IN ANIMALS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with cognitive disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing ... | 01/27/2011 |
| 20110023148 | GENOME EDITING OF ADDICTION-RELATED GENES IN ANIMALS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with addiction disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. ... | 01/27/2011 |
| 20110023146 | GENOMIC EDITING OF GENES INVOLVED IN SECRETASE-ASSOCIATED DISORDERS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with a secretase disorder. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing... | 01/27/2011 |
| 20110023153 | GENOMIC EDITING OF GENES INVOLVED IN ALZHEIMER'S DISEASE The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with AD. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are... | 01/27/2011 |
| 20110016541 | GENOME EDITING OF SENSORY-RELATED GENES IN ANIMALS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with nociception or taste disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediat... | 01/20/2011 |
| 20110016539 | GENOME EDITING OF NEUROTRANSMISSION-RELATED GENES IN ANIMALS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with neurotransmission disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated ... | 01/20/2011 |
| 20110016543 | GENOMIC EDITING OF GENES INVOLVED IN INFLAMMATION The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding inflammation-related proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided a... | 01/20/2011 |
| 20110016540 | GENOME EDITING OF GENES ASSOCIATED WITH TRINUCLEOTIDE REPEAT EXPANSION DISORDERS IN ANIMALS The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with trinucleotide repeat expansion disorders. In particular, the animals or cells are generated using a zinc finger nucle... | 01/20/2011 |
| 20110016545 | Xylanases, Nucleic Acids Encoding Them and Methods For Making and Using Them The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo-β-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the inv... | 01/20/2011 |
| 20100333218 | TRANSGENIC PROTEINS FROM MULTI-GENE SYSTEMS, METHODS, COMPOSITIONS, USES AND THE LIKE RELATING THERETO A non-human transgenic mammalian animal, as described above, contains one or more exogenous double stranded DNA sequence(s) stably integrated into the genome of the animal, which comprises trans-acting regulatory units controlling expression of DNA sequences encoding pr... | 12/30/2010 |
| 20100293624 | ELIMINATION OF N-GLUCOLYLNEURAMINIC ACID FROM ANIMAL PRODUCTS FOR HUMAN USE This application is in the field of sialic acid chemistry, metabolism, antigenicity, and the production of transgenic non-human mammals with altered sialic acid production. More particularly, this application relates to N-glycolylneuraminic acid (Neu5Gc) being an immuno... | 11/18/2010 |
| 20100281549 | Transgenic Production In Saliva The invention relates to the production of proteins and other substances of interest in saliva of transgenic animals, particularly in mammals that produce large quantities of saliva, particularly monogastric ruminants, and ovine, caprine and bovine mammals. Preferred em... | 11/04/2010 |
| 20100215658 | VACCINIA VIRUS H3L AND B5R SPECIFIC MONOCLONAL ANTIBODIES AND METHODS OF MAKING AND USING SAME The invention relates to antibodies and subsequences thereof that specifically bind to poxvirus B5R envelope protein, antibodies and subsequences thereof that specifically bind to pox virus H3L envelope protein, and combinations thereof.... | 08/26/2010 |
| 20100205681 | PROGNOSTIC MARKER FOR BREAST CANCER AND COMPOSITION FOR INDUCING OBESITY COMPRISING HCCR-1 A prognostic marker for breast cancer and a composition for inducing obesity are provided, wherein said marker and said composition comprise HCCR-1.... | 08/12/2010 |
