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...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!

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Class 623/1.43 - Antithrombogenic


Subclass of Class 623 - Prosthesis (i.e., artificial body members), parts thereof, or aids and accessories therefor
Definition: Subject matter wherein the treatment agent includes an
No. of applications: 66
Last issue date: 03/22/2012


1    
Application No.Application TitleIssue Date
20120071966DRUG-RELEASING STENT WITH CERAMIC-CONTAINING LAYER
A vascular or endoluminal stent is adapted to be implanted in a vessel, duct or tract of a human body to maintain an open lumen. The stent includes a base layer of a biologically compatible metal. An intermediate metal particle layer of substantial greater radiopacity o...
03/22/2012
20110153004POLY(ESTER AMIDE)-BASED DRUG DELIVERY SYSTEMS WITH CONTROLLED RELEASE RATE AND MORPHOLOGY
A method of forming a coating on a medical device having a controlled morphology is described. A method of treating a disorder in a patient using the medical device is described....
06/23/2011
20110137404INFLATABLE POROUS IMPLANTS AND METHODS FOR DRUG DELIVERY
The present invention provides inflatable porous implants, such as grafts, stent-grafts, and bladders, as well as methods and kits for drug delivery. In particular, the grafts and stent-grafts of the present invention provide for the delivery of a therapeutic agent into...
06/09/2011
201003038965BETA, 14BETA-ANDROSTANE DERIVATIVES USEFUL FOR THE TREATMENT OF RESTENOSIS AFTER ANGIOPLASTIC OR ENDOARTHERECTOMY AND DISEASES DUE TO ORGAN FIBROSIS
Compound of formula (I), wherein the symbol have the meaning reported in the text; for preparing a medicament for the prevention and/or treatment of obstructive vascular lesions following vascular surgery and for the prevention and/or treatment of diseases due to organ ...
12/02/2010
20100234934Balloon Deployable Coronary Stent
A system for treating a vascular condition includes a delivery catheter, a balloon disposed at a distal end of the delivery catheter, a stent having a stent framework, the stent disposed on an outer surface of the balloon; and at least one restraining filament attached ...
09/16/2010
20100150913ORGANIC COMPOUNDS
The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention also relates to methods for screening compounds and compositions useful for inhibiting or reducing p...
06/17/2010
20100082096Tailored Luminal & Abluminal Drug Elution
A stent has a plurality of members made from a first material. At least one of the plurality of members defines at least one hole. Each hole extends from a first surface of a member. Each hole has a first opening and a depth. Each hole has a barrier dividing the hole in...
04/01/2010
20100070022LAYER BY LAYER MANUFACTURING OF A STENT
A stent is provided which has a relatively less porous support structure that includes a first set of consolidated particles and at least one relatively more porous reservoir that includes a second set of consolidated particles that differ in composition from the first ...
03/18/2010
20100047315Stent for Increasing Blood Flow to Ischemic Tissues and a Method of Using the Same
Stents and a method of using the stents to increase blood flow to ischemic tissues in a patient are disclosed....
02/25/2010
20100030325BLOOD ANTICOAGULANT MATERIAL, COATING MATERIAL AND INDWELLING DEVICE COMPRISING THE SAME, AND TREATMENT USING BLOOD ANTICOAGULANT MATERIAL
A blood anticoagulant material is provided which has high expandability, reduced influence on living bodies, and can efficiently prevent blood coagulation.

A multiblock copolymer having at least a structural unit represented by Formula (1),...

02/04/2010
20090326638MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION
According to an aspect of the present invention, at least one ionic therapeutic agent is delivered from an implantable or insertable medical device that comprises an ion-conductive polymeric region that is disposed on a metallic region. The metallic region is in electri...
12/31/2009
20090171453Drug Coated Stent Having a Surface Treatment and Method of Manufacturing
Drug coated stents for implantation in a body vessel are provided. A stent can include a plasma treatment on the luminal surface and a protein-adherence deterring layer on at least a portion of the luminal surface. A further embodiment includes a method of manufacturing...
07/02/2009
20090157172STENTS WITH POLYMER-FREE COATINGS FOR DELIVERING A THERAPEUTIC AGENT
Described herein are implantable medical devices, such as intravascular stents, for delivering therapeutic agents to a patient, and methods for making such medical devices. The medical devices comprise a substrate having at least a cavity therein and a pellet disposed i...
06/18/2009
20090143853AXIALLY-RADIALLY NESTED EXPANDABLE DEVICE
Expandable medical implants for maintaining support of a body lumen are disclosed. These implants comprise an axially-radially nested, diametrically expandable, moveable vascular device for enlarging an occluded portion of a vessel. The device can be configured to allow...
06/04/2009
20090125101POLYMERIC MATERIALS FOR MEDICAL DEVICES
The present invention includes biocompatible polymeric coatings, membranes, matrices, and films to be used with implantable medical devices. Medical devices containing such materials applied to a surface thereof contain a film-forming fluorous homo-polymer or copolymer ...
05/14/2009
20090110713Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices
The present invention is directed to polymeric materials (e.g., coatings) comprising biodegradable copolymers and implantable devices (e.g., drug-delivery stents) formed of such materials. The biodegradable copolymers are derived from at least two relatively polar monom...
04/30/2009
20090088831STENT AND STENT DELIVERY DEVICE
An stent includes an outer stent base layer formed from a metallic material, an inner stent base layer formed from a metallic material and positioned inside the outer stent base layer, and a resinous adhesive layer containing a biodegradable polymer which is placed betw...
04/02/2009
20090076587Stented Vascular Graft
A vascular graft incorporating a stent into a portion of its length. While various materials may be used for the vascular graft, the graft is preferably an ePTFE graft. The stent is preferably a self-expanding stent, although it may alternatively be a balloon expandable...
03/19/2009
20090076595Medical devices having bioerodable layers for the release of therapeutic agents
According to an aspect of the present invention, medical devices are provided which comprise: (a) a substrate and (b) bioerodable polymeric layer over the substrate that contains (i) one or more biodegradable polymers, (ii) one or more therapeutic agents, and (iii) one ...
03/19/2009
20090048667Controlled Drug-Release Composition and Drug-Releasable Medical Device
A drug-releasable medical device contains a controlled drug-release composition comprising 100 parts by weight of an organic polymeric material which is soluble in an organic solvent and insoluble in water, 5 to 60 parts by weight of a lipid-soluble, low molecular weigh...
02/19/2009
20090024200Drug Eluting Medical Device and Method
A drug elution stent includes a stent framework and a drug elution portion disposed on the stent framework. The drug elution portion includes a first sugar layer disposed on the stent framework, at least one therapeutic agent layer disposed on the first sugar layer and ...
01/22/2009
20090018646Coating Employing an Anti-Thrombotic Conjugate
A biodegradable antithrombotic conjugate having heparin and other anti-thrombotic moieties are introduced as side chains to the polymer backbone modified by click chemistry. Various bioabsorbable monomers and dimers such as valerolactone may be used in the monomer deriv...
01/15/2009
20090012595Therapeutic Drug-Eluting Endoluminal Covering
The present invention is of methods of preventing restenosis and promoting vascular re-healing. Specifically, the present invention is of a method of exposing the luminal wall of a blood vessel to a substance by deploying a drug-eluting polymer film inside the lumen of ...
01/08/2009
20090012606BIOBENEFICIAL POLYAMIDE/POLYETHYLENE GLYCOL POLYMERS FOR USE WITH DRUG ELUTING STENTS
This disclosure provides a method device and a method of forming the medical device. The medical device comprises a coating comprising a polymer. The polymer comprises at least two different blocks, at least one L1 block with the formula

<...

01/08/2009
20080319528MODULAR ENDOPROSTHESIS WITH FLEXIBLE INTERCONNECTORS BETWEEN MODULES
A modular endoprosthesis is configured to have improved flexibility during and after deployment by having separate endoprosthetic modules that are interconnected by flexible interconnectors. The modular endoprosthesis includes a plurality of separate endoprosthetic modu...
12/25/2008
20080311173IMPLANTABLE OR INSERTABLE MEDICAL DEVICES FOR CONTROLLED DELIVERY OF A THERAPEUTIC AGENT
The present invention is directed to novel implantable or insertable medical devices that provide release of a therapeutic agent. According to a first aspect of the present invention, a therapeutic-agent-releasing medical device is provided, which comprises: (a) an impl...
12/18/2008
20080294242EXPANDABLE MEDICAL DEVICE WITH DUCTILE HINGES
An expandable tissue supporting device of the present invention employs ductile hinges at selected points in the expandable device. When expansion forces are applied to the device as a whole, the ductile hinges concentrate expansion stresses and strains in small well de...
11/27/2008
20080288059Stent Drug Delivery System
Expandable intraluminal stents are provided as well their method of manufacture. These stents are made of metal, the metal characterized by a desired porosity, with a drug compressed into the pores of the stent. The stents are formed by subjecting one or more powdered m...
11/20/2008
20080269875Coating for a Medical Device Having an Anti-Thrombotic Conjugate
Methods for making comb-type antithrombotic conjugate wherein substantially all side chains of water soluble poly(vinyl alcohol) (PVA) are extended by ring-opening polymerization to form a copolymer wherein substantially all terminals are conjugated to an antithrombotic...
10/30/2008
20080262589Intravascular Implant
The invention has for its object the provision of an intravascular implant that has mechanical characteristics and physiological characteristics and is very low in cell cytotoxicity and provides an intravascular implant having an implant body made of a metal material th...
10/23/2008
20080255659Fabrication method for drug-eluting stent with medicine-compatible loading mechanisms
A MEMS-based fabrication process is disclosed to fabricate a hollow seamless drug-eluting stent. This stent fabrication process is characterized by using a photolithography process, a composite electroplating process, and a polishing process to mass-produce drug-eluting...
10/16/2008
20080255657STENT WITH UNCONNECTED STENT SEGMENTS
This invention generally relates to stents, such as intravascular stents. More particularly, the invention is directed to stents comprising expandable stent segments, such as unconnected expandable stent segments. The invention is also directed to methods for making suc...
10/16/2008
20080242922HYBRID HEMODIALYSIS ACCESS GRAFTS OR A HYBRID FEMORAL ARTERY BYPASS GRAFT AND SYSTEMS AND METHODS FOR PRODUCING OR MODIFYING THE SAME
Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external fl...
10/02/2008
20080242921SYSTEMS AND METHODS OF PROMOTING ENGRAFTMENT OF A HYBRID HEMODIALYSIS ACCESS GRAFT OR A HYBRID FEMORAL ARTERY BYPASS GRAFT IN A MAMMAL
Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external fl...
10/02/2008
20080242923SYSTEMS AND METHODS OF COATING A HYBRID HEMODIALYSIS ACCESS GRAFT OR A HYBRID FEMORAL ARTERY BYPASS GRAFT IN A MAMMAL
Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external fl...
10/02/2008
20080215136DIFFERENTIAL DRUG RELEASE FROM A MEDICAL DEVICE
The invention relates to a medical device, such as an intravascular stent, useful for delivering two or more therapeutic agents to a body tissue of a patient at different rates, and methods for making and using such medical device. The medical device includes a substrat...
09/04/2008
20080215139STENT WITH A COATING FOR DELIVERING A THERAPEUTIC AGENT
The invention relates generally to a medical device for delivering a therapeutic agent to the body tissue of a patient, and methods for making such a medical device. More particularly, the invention is directed to a stent, such as an intravascular stent, having an inner...
09/04/2008
20080195042Medical Devices Comprising Drug-Loaded Capsules For Localized Drug Delivery
A medical device comprising a plurality of capsules, and a method of administering therapeutic agent to a patient using the same. The capsules further comprise a therapeutic agent and a multilayer polyelectrolyte shell. The medical device is adapted to apply a pressure ...
08/14/2008
20080188924HYBRID STENT AND METHOD OF MAKING
A stent is formed by encasing or encapsulating metallic rings in an inner polymeric layer and an outer polymeric layer. At least one polymer link connects adjacent metallic rings. The stent is drug loaded with one or more therapeutic agent or drug, for example, to reduc...
08/07/2008
20080183282Use of lipid conjugates for the coating of stents and catheters
This invention provides inter alia, coated device on at least a portion of a surface of the device. The device coating comprises a lipid or phospholipid moiety bound to a polypyranose. Methods of preventing, inhibiting or treating vessel damage or vessel occlusion, for ...
07/31/2008
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