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| Application No. | Application Title | Issue Date |
| 20120109045 | Encapsulation of Microbubbles Within the Aqueous Core of Microcapsules The present invention includes a construct that comprises at least one microbubble encapsulated within the aqueous core of a microcapsule. The present invention also includes a pharmaceutical composition comprising a construct comprising at least one microbubble encapsu... | 05/03/2012 |
| 20120109041 | APPLICATOR DEVICE FOR COSMETIC AND/OR MEDICAL USE The invention relates to an applicator device, comprising an applicator element (9) for applying a substance (27) present in a substance chamber (25, 27) to a skin section. The applicator device (1) comprises an applicator part (2) hav... | 05/03/2012 |
| 20120109043 | Integrated skin-treatment specimen dispenser A device for skin treatment by concurrently applying a series of physical movement such as ultrasound vibration and dispensing a specimen to a target kin area is disclosed. The device includes a skin treatment surface for treating the target skin area, a cartridge conta... | 05/03/2012 |
| 20120109044 | PREVENTION OF MYOCARDIAL INFRACTION INDUCED VENTRICULAR EXPANSION AND REMODELING A method for direct therapeutic treatment of myocardial tissue in a localized region of a heart having a pathological condition. The method includes identifying a target region of the myocardium and applying material directly and substantially only to at least a portion... | 05/03/2012 |
| 20120083727 | DRUG DELIVERY BLADE AND METHODS FOR DELIVERING A DRUG DEPOT TO A TARGET SITE A drug delivery blade for delivering a drug depot to a treatment site in a patient is disclosed. The drug delivery blade includes a shaft defining a longitudinal axis of the blade, a lumen that extends longitudinally from a proximal end of the shaft to a distal end of t... | 04/05/2012 |
| 20120083728 | PHACOEMULSIFICATION HAND PIECE WITH INTEGRATED ASPIRATION PUMP An ophthalmic surgical hand piece comprises a driver coupled to a horn. The horn is coupled to a needle. An aspiration pump is integral with the hand piece and is located close to the needle. A rigid length of aspiration line is located between the aspiration pump and t... | 04/05/2012 |
| 20120072197 | Balanced Phacoemulsification Tip In various embodiments, a phacoemulsification tip may include a shaft and a cutting edge portion having at least a first and second bend. The geometry of the tip may be configured to result in a lateral displacement (ux), perpendicular to the shaft during tor... | 03/22/2012 |
| 20120071812 | Methods and Systems for Submucosal Implantation of a Device for Diagnosis and Treatment with a Therapeutic Agent Instruments, systems, implants, and methods are provided for performing submucosal medical procedures in a desired area of the digestive tract using endoscopy. Instruments include a safe access needle injection instrument, a submucosal tunneling instrument, a submucosal... | 03/22/2012 |
| 20120046601 | Methods for delivering novel cell and cell-based compositions The invention is directed to methods for delivering cells or cytokine-containing solutions into body tissue using ultrasound (sonoporation). Such methods utilize novel compositions including Amnion-derived Multipotent Progenitor cells (herein referred to as AMP cells) a... | 02/23/2012 |
| 20120046600 | HIGH-SPEED ROTATIONAL ATHERECTOMY SYSTEM, DEVICE AND METHOD FOR LOCALIZED APPLICATION OF THERAPEUTIC AGENTS TO A BIOLOGICAL CONDUIT The invention provides a system, device and method for localized application of therapeutic agents within a biological conduit. A preferred biological conduit comprises a blood vessel. A preferred device comprises a high-speed rotational atherectomy device having, in va... | 02/23/2012 |
| 20120046599 | THERAPEUTIC AGENT DELIVERY SYSTEM, DEVICE AND METHOD FOR LOCALIZED APPLICATION OF THERAPEUTIC SUBSTANCES TO A BIOLOGICAL CONDUIT The invention provides a system, device and method for localized application of therapeutic substances within a biological conduit after the lumen wall has been scored by an eccentric scoring head. One embodiment comprises radial scoring with the eccentric scoring head,... | 02/23/2012 |
| 20120041359 | SYSTEMS AND METHODS FOR MIXING THERAPEUTIC AGENTS BEFORE AND/OR DURING ADMINISTRATION The invention provides systems and methods for mixing of therapeutic agents before and/or during the localized application of the therapeutic agents. Most preferably, the present invention provides systems and methods for mixing of therapeutic agents before and/or durin... | 02/16/2012 |
| 20120041358 | One-Hand Device for Ophthalmic Surgery A one-hand device for an ocular irrigation and aspiration has a tube (3), which having a tip (5) at a front end, wherein the tip (5) has an irrigation fluid orifice outlet (5a) for the exit of the irrigation fluid and an aspiration ope... | 02/16/2012 |
| 20120041362 | SYSTEMS AND METHODS FOR POWER AND FLOW RATE CONTROL The invention is generally directed to systems and methods for fluid control, and more particularly to systems and methods for power and flow rate control for aspiration. In accordance with one embodiment, an aspiration system includes an aspiration line having distal a... | 02/16/2012 |
| 20120041360 | SYSTEMS AND METHODS FOR POWER AND FLOW RATE CONTROL The invention is generally directed to systems and methods for fluid control, and more particularly to systems and methods for power and flow rate control for aspiration. In accordance with one embodiment, an aspiration system includes an aspiration line having distal a... | 02/16/2012 |
| 20120041306 | CONTRAST AGENT ADMINISTRATION METHOD AND SYSTEM TO MAINTAIN CONTRAST AGENT AT A LOCALIZED SITE OF DELIVERY In a method and system for administering a dispersible medical agent to a subject, a volume of medical agent is delivered in vivo to a subject in a substantially non-dispersed state, at a localized site in tissue of the subject. Contemporaneously with administration of ... | 02/16/2012 |
| 20120035531 | ON-DEMAND AND REVERSIBLE DRUG RELEASE BY EXTERNAL CUE The invention provides a method to release drugs from a polymer matrix upon demand without degrading the matrix. By applying ultrasound to a self-healable polymer matrix in physiological environment, compounds of both low-molecular and high-molecular weights encapsulate... | 02/09/2012 |
| 20120035530 | DRUG RELEASING COATINGS FOR MEDICAL DEVICES The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive ha... | 02/09/2012 |
| 20120029354 | TISSUE REMOVAL DEVICE WITH ADJUSTABLE DELIVERY SLEEVE FOR NEUROSURGICAL AND SPINAL SURGERY APPLICATIONS A tissue cutting device that is especially suited for neurosurgical applications is disclosed and described. The device includes a handpiece and an outer cannula in which a reciprocating inner cannula is disposed. A delivery sleeve may be selectively provided that is co... | 02/02/2012 |
| 20120029261 | SYSTEMS AND METHODS FOR DELIVERY OF A THERAPEUTIC AGENT Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable t... | 02/02/2012 |
| 20120029421 | MEDICAL DELIVERY SYSTEMS AND APPARATUS A catheter proximal section is preferably formed from a relatively soft part and a relatively rigid part, and includes a proximal terminal end that defines a perimeter of an opening into a lumen of the catheter. The proximal section may further include a feature for int... | 02/02/2012 |
| 20120029422 | SYSTEM AND METHOD FOR PAIN REDUCTION DURING SKIN PUNCTURE AND BREAKABLE TIP THEREFOR An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A rod or lightpipe mounted freely for vibration projects out of the forward end. The article, a s... | 02/02/2012 |
| 20120029423 | Intraocular Pressure Control An improved method of controlling intraocular pressure with a microsurgical system using measured flow rate.... | 02/02/2012 |
| 20120022434 | DISPOSABLE HANDHELD PHACOMORCELLATION DEVICE Disposable handheld phacomorcellation devices and methods for removing lens fragments from an eye of a patient are disclosed. In one embodiment, the phacomorcellation device includes a stationary outer tubular cutting member and a rotatable inner cutting member position... | 01/26/2012 |
| 20120022435 | REMOVABLE TIPS FOR SKIN TREATMENT SYSTEMS An apparatus for treating skin has a console with a user input device and a handpiece assembly. The handpiece assembly is configured to treat skin. A fluid line provides fluid communication between the console and the handpiece assembly. A manifold system is coupled to ... | 01/26/2012 |
| 20120022433 | METHODS FOR INCREASING TRICHOGENICITY OF DERMAL CELLS Methods for increasing trichogenic activity of populations of dermal cells by inducing local trauma to skin tissue that serves as a source of the dermal cells are provided. Methods for obtaining dermal cells with increased trichogenic activity and for using the disclose... | 01/26/2012 |
| 20120022422 | VENOUS CLOSURE CATHETER AND METHOD FOR SCLEROTHERAPY A venous closure catheter is disclosed for performing sclerotherapy which includes an elongated catheter body having opposed proximal and distal end portions, a fluid delivery lumen and a guidewire lumen. A plurality of discharge apertures are associated with the distal... | 01/26/2012 |
| 20120016292 | APPARATUS, ARTICLE AND METHOD FOR REDUCING PAIN DURING SKIN PUNCTURING PROCEDURES An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A lightpipe mounted freely for vibration projects out of the forward end. The article, a single u... | 01/19/2012 |
| 20120010560 | Modulated pulsed ultrasound power delivery system and method A method and apparatus for delivering energy during a surgical procedure such as phacoemulsification is provided. The method and apparatus include applying energy during at least one pulsed energy on period, typically sufficient or intended to rapidly induce and benefic... | 01/12/2012 |
| 20120004594 | METHODS OF TREATING DEGENERATIVE BONE CONDITIONS Methods and articles of manufacture for treating patients with degenerative bone are provided. The methods are useful to improve bone quality in a localized area of a degenerative bone (e.g., osteopenic or osteoporotic bone), such as by improving BMD to be substantially... | 01/05/2012 |
| 20120004593 | ANTISEPTIC BASED ON BISPYRIDINIUM ALKANES An antimicrobially effective composition includes a) at least 0.15% by weight of bispyridinium alkane, b) at least 3.5% by weight of humectant and c) water. Upon dilution with water, the composition produces a solution with an osmolality of from 230 to 350 mOsmol/kg and... | 01/05/2012 |
| 20120004592 | COMPOSITIONS FOR SOLUBILIZING TISSUE Tissue solubilizing compositions are provided. The compositions comprise 3-(decyl dimethyl ammonio) propane sulfonate and polyethylene glycol dodecyl ether, such as tetraethylene glycol dodecyl ether. The compositions may be useful to solubilize tissue, including skin, ... | 01/05/2012 |
| 20120004595 | DEVICES AND METHODS FOR CUTTING AND EVACUATING TISSUE Various medical devices and methods for cutting and/or evacuating tissue are provided. The devices and methods may utilize a reciprocating mechanism or motor powered by suction from a vacuum source. The medical devices and methods may be used on tissue in various region... | 01/05/2012 |
| 20120004597 | MEDICAL DEVICE FOR INJECTING FLUID INTO A BODY The medical device (10) has a prop (12) extending between a proximal end (12A) and a distal end, a nose (16) in the form of a perforating tip, secured to the distal end of the prop (12), a sheath (18), in which the prop (12 | 01/05/2012 |
| 20120004596 | Catheter for Use in Revascularization Procedures and Method of Using Same A method of removing vascular blockage includes providing a catheter system. comprising an outer catheter, a cutting catheter having a serrated distal end, a bypass catheter, and a guidewire. In the catheter system, the bypass catheter is slidably disposed within the cu... | 01/05/2012 |
| 20110319812 | SYSTEM AND METHOD FOR PAIN REDUCTION DURING SKIN PUNCTURE AND BREAKABLE TIP THEREFOR An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A lightpipe mounted freely for vibration projects out of the forward end. The article, a single u... | 12/29/2011 |
| 20110318416 | BIORESORBABLE POLYMER MATRICES AND METHODS OF MAKING AND USING THE SAME A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a dihydrazide, a bioactive agent, and optionally a pH adjusting agent in an amount s... | 12/29/2011 |
| 20110319790 | PHARMACEUTICAL COMPOSITION AND SYSTEM FOR PERMEABILIZING FETAL MEMBRANES Provided is a pharmaceutical composition for permeabilizing fetal membranes including an active ingredient having a log K in the range of 2 to 4, where K is the octanol/water partition coefficient. The active ingredient may be, for example, bupivacaine, sodium lauryl su... | 12/29/2011 |
| 20110319810 | Curved Infusion Sleeve An infusion sleeve, infusion sleeve assembly, and method of making the same are disclosed. An exemplary infusion sleeve assembly may include a tubular body and a tip inserted into the body. The tubular body may include an insertion end and an attachment end. The inserti... | 12/29/2011 |
| 20110319811 | COMBINATION THERAPY WITH CRYOSURGERY AND LOW DOSAGE STRENGTH IMIQUIMOD TO TREAT ACTINIC KERATOSIS The present invention is directed to the use of complementary or combination lesion-directed therapy, such as cryosurgery, and field-directed therapy, such as low dose imiquimod topical therapy with short durations, in combination to treat actinic keratosis (“AK”). ... | 12/29/2011 |
