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| Application No. | Application Title | Issue Date |
| 20120107902 | Processes For Forming Amide Bonds And Compositions Related Thereto The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an O-silylated thionoester and an amine under conditions such that an amide is formed... | 05/03/2012 |
| 20110263869 | METHODS FOR THE PREPARATION OF ARYL AMIDES The present invention relates to methods of initiating a reaction represented by scheme (1), wherein Q is optionally substituted aryl or optionally substituted heteroaryl; X is halogen or a sulphonate; P is an organic radical; R is hydrogen or an organic radical; wherei... | 10/27/2011 |
| 20110237798 | DIRECT CONVERSION OF PHENOLS INTO AMIDES AND ESTERS OF BENZOIC ACID A method is provided for the preparation of an aromatic carboxylic acid aryl ester or an N-aryl aromatic carboxamide. The method comprises contacting an O,O-diaryl thiocarbonate or an O-aryl-N-aryl thiocarbamate with a reactant that regioselectively reacts with sulfur, ... | 09/29/2011 |
| 20110152261 | Organic compounds There are described cyclohexyl amide derivatives useful as corticotropin releasing (CRF1) receptor antagonists.... | 06/23/2011 |
| 20110065760 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES AND USE THEREOF The present invention is related to a compound of the formula (I), (II), (III), (IV), (V): wherein Z1, Z2, Z3 and Z4 are each and independently selected from the group comprising C(O)—, —C(S)—, —C(O)—NR10â... | 03/17/2011 |
| 20110039908 | Inhibiting Amyloid-Beta Peptide/Rage Interaction At The Blood-Brain Barrier Small molecules are used to inhibit specific receptor-ligand interaction between Alzheimer's amyloid-β peptide (Aβ) and Receptor for Advanced Gly-cation Endproducts (RAGE). Objectives include treating Alzheimer's disease and other pathologies involving cerebral amyloi... | 02/17/2011 |
| 20100286149 | NOVEL BENZAMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS This invention relates to novel benzamide derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium ch... | 11/11/2010 |
| 20100216849 | BIPHENYLCARBOXAMIDES This invention relates to novel biphenylcarboxamides of the formula (I)
| 08/26/2010 |
| 20100190777 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR Compounds of formula I active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. Formula (I) wherein Ar is optionally substituted heteroaryl; R2 i... | 07/29/2010 |
| 20100145060 | Schwartz Reagents: Methods of In Situ Generation and Use Embodiments of the invention provide a method of using Schwartz Reagent, Cp2Zr(H)Cl, without accumulating or isolating it. Methods provide mixtures of Cp2ZrCl2, reductants that selectively reduce Cp2ZrCl2, and subst... | 06/10/2010 |
| 20100093733 | AMIDE AND UREA DERIVATIVES FOR THE TREATMENT OF METABOLIC DISEASES Compounds of formula (I): or pharmaceutically acceptable salts and esters thereof, are useful for the treatment of obesity, type II diabetes and the metabolic syndrome. ... | 04/15/2010 |
| 20100076078 | INSECTICIDAL COMPOUNDS Novel compounds of formula (I): wherein A1, A2, A3, A4, R1, R2, G1, G2, Q1 and Q2 are as defined in claim 1; or salts or N-oxides thereof. Furthermore, t... | 03/25/2010 |
| 20100063155 | N-(3-PHENYLPROPYL)BENZAMIDE DERIVATIVES A compound of general formula (I): Also disclosed is a process for preparing this compound, a fungicidal composition comprising a compound of general formula (I), as well as a method for treating plants by ap... | 03/11/2010 |
| 20100056636 | N-Substituted-P-Menthane-3-Carboxamide and Uses Thereof The present invention relates to substances and compositions having a physiological cooling effect on the skin and the mucosa of the body, especially of the oral cavity, throat and nose. More in particular, the present invention relates to N-substituted-p-menthane-3-car... | 03/04/2010 |
| 20100041715 | SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONISTS AND METHODS FOR USE THEREOF The invention provides certain well-defined benzamides that are useful as sphingosine-1-phosphate antagonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors.... | 02/18/2010 |
| 20090286765 | Therapeutic Agents A compound of the formula (I): wherein R1, R2, R3, R4, Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I) are also disclosed as are thei... | 11/19/2009 |
| 20090221820 | Ligands for Transition-Metal-Catalyzed Cross-Couplings, and Methods of Use Thereof Ligands for transition metals are disclosed herein, which may be used in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The disclosed methods provide improvements in many features of the transition-metal-catalyzed reaction... | 09/03/2009 |
| 20090149510 | Compositions and methods for modulating a kinase cascade The invention relates to compounds and methods for modulating one or more components of a kinase cascade.... | 06/11/2009 |
| 20090112004 | SYNTHESIS OF QUATERNARY SALT COMPOUNDS The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists.... | 04/30/2009 |
| 20090105220 | PROCESS FOR THE PREPARATION OF NONPEPTIDE SUBSTITUTED SPIROBENZOAZEPINE DERIVATIVES Novel spirobenzoazepine compounds, novel processes for the preparation of nonpeptide substituted spirobenzoazepine derivatives, and novel processes for the preparation of intermediates in the preparation of such derivatives. Novel intermediates in the preparation of non... | 04/23/2009 |
| 20090062396 | Novel Haloalkoxy-Substituted Salicylic Anilides The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or disorders associated therewith.... | 03/05/2009 |
| 20090060838 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES Substituted n-aryl benzamides, related compounds and their pharmaceutically acceptable salts, their synthesis and labeling, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Al... | 03/05/2009 |
| 20090036420 | BENZAMIDE DERIVATIVES AND THEIR USE FOR TREATING CNS DISORDERS The present invention relates to methods of treating CNS disorders with a compound of formula I wherein
| |
| 20090030212 | Enantioselective ring-opening of aziridines A process for the preparation of a nucleophilic addition product of an aziridine and a nucleophile, the process comprising treating the arizidine with the nucleophile in the presence of a biaryl phosphoric acid catalyst... | 01/29/2009 |
| 20080255221 | NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase act... | 10/16/2008 |
| 20080214654 | Substituted Benzyloxy-Phenylmethylamide Derivatives The present invention relates to novel substituted benzyloxy-phenylmethylamide derivatives, processes for their preparation, and their use in medicaments, especially for the prophylaxis and treatment of diseases associated with Cold Menthol Receptor 1 (CMR-1) activity, ... | 09/04/2008 |
| 20080085924 | Biphenylcaboxamides This invention relates to novel biphenylcarboxamides of the formula (I)
| 04/10/2008 |
| 20070276022 | Optically Active Carboxamides New optically active carboxamides of structure (I) in which R, M and A have the meanings defined in the description, several methods for their preparation of these compounds and their use for the control of detrimental microorganisms as well as new intermediates and... | 11/29/2007 |
| 20070208083 | Alkyl-substituted N-(4-hydroxy-3-methoxy-benzyl)-cinnamamides, pharmaceutical compositions and uses thereof para-Alkyl-substituted N-(4-hydroxy-3-methoxybenzyl)-cinnamic acid amide compounds, processes for the preparation thereof, pharmaceutical compositions containing these compounds, and the use of these compounds for treating or inhibiting specific diseases or disorders. ... | 09/06/2007 |
| 20070082877 | Difluoromethylbenzanilides and use thereof for combating micro-organisms, intermediate products and use thereof Novel difluoromethylbenzanilides of the formula (I) in which
| 04/12/2007 |
| 20050065181 | Process for the synthesis of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application. ... | 03/24/2005 |
